MX2015014734A - Composiciones y metodos para alterar la señalizacion del segundo mensajero. - Google Patents

Composiciones y metodos para alterar la señalizacion del segundo mensajero.

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Publication number
MX2015014734A
MX2015014734A MX2015014734A MX2015014734A MX2015014734A MX 2015014734 A MX2015014734 A MX 2015014734A MX 2015014734 A MX2015014734 A MX 2015014734A MX 2015014734 A MX2015014734 A MX 2015014734A MX 2015014734 A MX2015014734 A MX 2015014734A
Authority
MX
Mexico
Prior art keywords
compositions
methods
altering
messenger signaling
messenger
Prior art date
Application number
MX2015014734A
Other languages
English (en)
Inventor
Thomas Tuschl
Yang Wu
Yizhou Liu
Winfried Barchet
Gunther Hartmann
Thomas Zillinger
Roger Jones
Barbara L Gaffney
Pu Gao
Dinshaw J Patel
Manuel Ascano Jr
Original Assignee
Sloan Kettering Inst Cancer
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Publication date
Application filed by Sloan Kettering Inst Cancer filed Critical Sloan Kettering Inst Cancer
Publication of MX2015014734A publication Critical patent/MX2015014734A/es

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574Esters of oxyacids of phosphorus
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    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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Abstract

La invención se refiere a composiciones, métodos, kits y ensayos relacionados con el uso y/o explotación de isómeros de cGAMP, así como la estructura de la enzima de cGAS.
MX2015014734A 2013-04-29 2014-04-29 Composiciones y metodos para alterar la señalizacion del segundo mensajero. MX2015014734A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361817269P 2013-04-29 2013-04-29
US201361819369P 2013-05-03 2013-05-03
PCT/US2014/035909 WO2014179335A1 (en) 2013-04-29 2014-04-29 Compositions and methods for altering second messenger signaling

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MX2015014734A true MX2015014734A (es) 2016-06-28

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JP (2) JP2016524593A (es)
KR (1) KR20160024850A (es)
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AP (1) AP2015008746A0 (es)
AU (1) AU2014260015B2 (es)
BR (1) BR112015027327B1 (es)
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CL (1) CL2015003088A1 (es)
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SG11201502796RA (en) 2012-12-13 2015-05-28 Aduro Biotech Inc Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
PL2934598T3 (pl) * 2012-12-19 2018-10-31 Board Of Regents, The University Of Texas System Środek farmaceutyczny ukierunkowany na ssaczy szlak przekazywania sygnału przez cykliczne dinukleotydy
PE20160167A1 (es) 2013-04-29 2016-04-21 Sloan Kettering Inst Cancer Composiciones y metodos para alterar la senalizacion del segundo mensajero
EP2992000B1 (en) * 2013-05-03 2020-07-08 The Regents of The University of California Cyclic di-nucleotide induction of type i interferon
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
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