BR112015027327A2 - composições e métodos para alterar a sinalização do mensageiro secundário - Google Patents

composições e métodos para alterar a sinalização do mensageiro secundário

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Publication number
BR112015027327A2
BR112015027327A2 BR112015027327A BR112015027327A BR112015027327A2 BR 112015027327 A2 BR112015027327 A2 BR 112015027327A2 BR 112015027327 A BR112015027327 A BR 112015027327A BR 112015027327 A BR112015027327 A BR 112015027327A BR 112015027327 A2 BR112015027327 A2 BR 112015027327A2
Authority
BR
Brazil
Prior art keywords
compositions
methods
secondary messenger
messenger signaling
altering secondary
Prior art date
Application number
BR112015027327A
Other languages
English (en)
Other versions
BR112015027327B1 (pt
Inventor
l gaffney Barbara
J Patel Dinshaw
Hartmann Gunther
Ascano Manuel
Gao Pu
Jones Roger
Tuschl Thomas
Zillinger Thomas
Barchet Winfried
Wu Yang
Liu Yizhou
Original Assignee
Memorial Sloan Kettering Cancer Center
Univ Rutgers
Univ Rockefeller
Univ Of Bonn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Memorial Sloan Kettering Cancer Center, Univ Rutgers, Univ Rockefeller, Univ Of Bonn filed Critical Memorial Sloan Kettering Cancer Center
Publication of BR112015027327A2 publication Critical patent/BR112015027327A2/pt
Publication of BR112015027327B1 publication Critical patent/BR112015027327B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Abstract

resumo patente de invenção: "composições e métodos para alterar a sinalização do mensageiro secundário". a presente invenção refere-se a composições, métodos, kits e ensaios relativos ao uso e/ou à exploração de isômeros de cgamp, assim como a estrutura da enzima cgas.
BR112015027327-0A 2013-04-29 2014-04-29 Composto, modulador de cgas, composição farmacêutica compreendendo o referido composto ou modulador BR112015027327B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361817269P 2013-04-29 2013-04-29
US61/817,269 2013-04-29
US201361819369P 2013-05-03 2013-05-03
US61/819,369 2013-05-03
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