|
DE3806565A1
(de)
|
1988-03-01 |
1989-09-14 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen
|
|
DE3922444A1
(de)
|
1988-03-01 |
1991-01-10 |
Deutsches Krebsforsch |
Virusmodifizierte tumorvakzine fuer die immuntherapie von tumormetastasen
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5854037A
(en)
|
1989-08-28 |
1998-12-29 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
US5166057A
(en)
|
1989-08-28 |
1992-11-24 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand rna virus expression-systems
|
|
US5786199A
(en)
|
1989-08-28 |
1998-07-28 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand RNA virus expression systems and vaccines
|
|
ATE411809T1
(de)
|
1993-04-30 |
2008-11-15 |
Wellstat Biologics Corp |
Zusuammensetzungen zur behandlung von krebs mittels viren
|
|
ES2210273T5
(es)
|
1994-07-18 |
2010-03-29 |
Conzelmann, Karl-Klaus, Prof. Dr. |
Virus con arn de cadena negativa no segmentado recombinante infeccioso.
|
|
US5891680A
(en)
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
US7153510B1
(en)
|
1995-05-04 |
2006-12-26 |
Yale University |
Recombinant vesiculoviruses and their uses
|
|
EP0780475B2
(en)
|
1995-08-09 |
2006-07-19 |
SCHWEIZ. SERUM- & IMPFINSTITUT BERN |
Process for the production of infectious negative-strand RNA viruses
|
|
US6264957B1
(en)
|
1995-09-27 |
2001-07-24 |
The United States Of America As Represented By The Department Of Health And Human Services |
Product of infectious respiratory syncytial virus from cloned nucleotide sequences
|
|
CN1200037A
(zh)
|
1995-10-17 |
1998-11-25 |
韦恩州立大学 |
鸡白细胞介素-15及其用途
|
|
WO1998002530A1
(en)
|
1996-07-15 |
1998-01-22 |
The Government Of The United States Of America, As Represented By The Department Of Health And Human Services |
Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
|
|
JP2000517194A
(ja)
|
1996-09-27 |
2000-12-26 |
アメリカン・サイアナミド・カンパニー |
モノネガビラレス(Mononegavirales)と称される目のウイルスにおける弱毒化の原因となる3’ゲノムプロモーター領域およびポリメラーゼ遺伝子の突然変異
|
|
CN1250725C
(zh)
|
1997-05-23 |
2006-04-12 |
美国政府健康及人类服务部 |
从克隆的核苷酸序列制备减毒副流感病毒疫苗的方法
|
|
DE69837764T2
(de)
|
1997-07-11 |
2008-01-31 |
Yale University, New Haven |
Rhabdovirus mit gentechnisch veränderter hülle
|
|
CA2302867A1
(en)
|
1997-09-19 |
1999-04-01 |
American Cyanamid Company |
Attenuated respiratory syncytial viruses
|
|
US7470426B1
(en)
|
1997-10-09 |
2008-12-30 |
Wellstat Biologics Corporation |
Treatment of neoplasms with viruses
|
|
US7780962B2
(en)
|
1997-10-09 |
2010-08-24 |
Wellstat Biologics Corporation |
Treatment of neoplasms with RNA viruses
|
|
CA2305269C
(en)
|
1997-10-09 |
2012-07-03 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
US20030044384A1
(en)
|
1997-10-09 |
2003-03-06 |
Pro-Virus, Inc. |
Treatment of neoplasms with viruses
|
|
WO1999064570A1
(en)
|
1998-06-12 |
1999-12-16 |
Mount Sinai School Of Medicine Of The City University Of New York |
Novel methods and interferon deficient substrates for the propagation of viruses
|
|
EP0974660A1
(en)
|
1998-06-19 |
2000-01-26 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Newcastle disease virus infectious clones, vaccines and diagnostic assays
|
|
US6544785B1
(en)
|
1998-09-14 |
2003-04-08 |
Mount Sinai School Of Medicine Of New York University |
Helper-free rescue of recombinant negative strand RNA viruses
|
|
US6146642A
(en)
|
1998-09-14 |
2000-11-14 |
Mount Sinai School Of Medicine, Of The City University Of New York |
Recombinant new castle disease virus RNA expression systems and vaccines
|
|
US7052685B1
(en)
|
1998-10-15 |
2006-05-30 |
Trustees Of The University Of Pennsylvania |
Methods for treatment of cutaneous T-cell lymphoma
|
|
CN1477964A
(zh)
|
1999-04-15 |
2004-02-25 |
|
应用病毒治疗肿瘤
|
|
US20030224017A1
(en)
|
2002-03-06 |
2003-12-04 |
Samal Siba K. |
Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors
|
|
AU4971500A
(en)
|
1999-05-05 |
2000-11-21 |
University Of Maryland |
Production of novel newcastle disease virus strains from cdnas and improved liveattenuated newcastle disease vaccines
|
|
AU5998400A
(en)
|
1999-07-14 |
2001-01-30 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
In vitro reconstitution of segmented negative-strand rna viruses
|
|
AU7607900A
(en)
|
1999-09-22 |
2001-04-24 |
Mayo Foundation For Medical Education And Research |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
|
|
US6896881B1
(en)
|
1999-09-24 |
2005-05-24 |
Mayo Foundation For Medical Education And Research |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
|
|
AUPQ425699A0
(en)
*
|
1999-11-25 |
1999-12-23 |
University Of Newcastle Research Associates Limited, The |
A method of treating a malignancy in a subject and a pharmaceutical composition for use in same
|
|
ES2246314T3
(es)
|
2000-01-20 |
2006-02-16 |
Universitat Zurich Institut Fur Medizinische Virologie |
Administracion intratumoral de moleculas desnudas de acido nucleico que codifican il-12.
|
|
AU2001257001A1
(en)
|
2000-04-10 |
2001-10-23 |
Mount Sinai School Of Medicine Of New York University |
Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents
|
|
US6818444B2
(en)
|
2000-08-04 |
2004-11-16 |
Heska Corporation |
Canine and feline proteins, nucleic acid molecules and uses thereof
|
|
US7740863B2
(en)
|
2001-04-06 |
2010-06-22 |
Merial |
Recombinant vaccine against West Nile Virus
|
|
FR2823222B1
(fr)
|
2001-04-06 |
2004-02-06 |
Merial Sas |
Vaccin contre le virus de la fievre du nil
|
|
WO2002102404A1
(en)
|
2001-06-18 |
2002-12-27 |
Institut National De La Recherche Agronomique |
Uses of cytokines
|
|
WO2003092579A2
(en)
|
2002-04-29 |
2003-11-13 |
Hadasit Medical Research Services And Development Company Ltd. |
Compositions and methods for treating cancer with an oncolytic viral agent
|
|
JPWO2003102183A1
(ja)
|
2002-06-03 |
2005-09-29 |
株式会社ディナベック研究所 |
抗体をコードするパラミクソウイルスベクターおよびその利用
|
|
US7971030B2
(en)
|
2002-08-07 |
2011-06-28 |
Mmagix Technology Limited |
Method for using multiple processing resources which share multiple co-processor resources
|
|
SE0203159D0
(sv)
|
2002-10-25 |
2002-10-25 |
Electrolux Ab |
Handtag till ett motordrivet handhållet verktyg
|
|
AU2002953436A0
(en)
|
2002-12-18 |
2003-01-09 |
The University Of Newcastle Research Associates Limited |
A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
|
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
ATE516305T1
(de)
|
2004-02-27 |
2011-07-15 |
Inst Nat Sante Rech Med |
Il-15-bindungsstelle für il-15-ralpha und spezifische il-15-mutanten mit wirkung als agonisten/antagonisten
|
|
WO2005087931A1
(en)
|
2004-03-11 |
2005-09-22 |
Virotarg Pty Ltd |
Modified oncolytic viruses
|
|
WO2006017914A1
(en)
|
2004-08-20 |
2006-02-23 |
Viralytics Limited |
Methods and compositions for treatment of hematologic cancers
|
|
ZA200702269B
(en)
*
|
2004-08-20 |
2008-09-25 |
Viralytics Ltd |
Methods and compositions for treatment of hematologic cancers
|
|
NZ591733A
(en)
|
2004-11-12 |
2012-10-26 |
Bayer Schering Pharma Ag |
Recombinant newcastle disease virus comprising a transgene encoding a fusion protein comprising a binding domain and a heterologous domain comprising an enzyme
|
|
US20080160031A1
(en)
|
2005-01-17 |
2008-07-03 |
Viralytics Limited |
Method and Composition for Treatment of Neoplasms
|
|
EP1899364B2
(en)
|
2005-05-17 |
2024-10-30 |
University of Connecticut |
Compositions and methods for immunomodulation in an organism
|
|
US20090214590A1
(en)
|
2005-07-08 |
2009-08-27 |
Wayne State University |
Virus Vaccines Comprising Envelope-Bound Immunomodulatory Proteins and Methods of Use Thereof
|
|
JP2009504687A
(ja)
*
|
2005-08-31 |
2009-02-05 |
オンコリティクス バイオテク,インコーポレーテッド |
新生物に関する免疫系による認識のインビボでの増強のための、腫瘍崩壊ウイルスおよび免疫賦活剤による処置
|
|
EP1777294A1
(en)
|
2005-10-20 |
2007-04-25 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
|
|
SG176468A1
(en)
|
2005-12-02 |
2011-12-29 |
Sinai School Medicine |
Chimeric viruses presenting non-native surface proteins and uses thereof
|
|
WO2007084342A2
(en)
|
2006-01-13 |
2007-07-26 |
The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health |
Codon optimi zed il- 15 and il- 15r-alpha genes for expression in mammalian cells
|
|
EP2007423A2
(en)
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
|
US20090175826A1
(en)
|
2006-06-05 |
2009-07-09 |
Elankumaran Subbiah |
Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same
|
|
WO2008011726A1
(en)
|
2006-07-27 |
2008-01-31 |
Ottawa Health Research Institute |
Staged immune-response modulation in oncolytic therapy
|
|
CA2723320C
(en)
|
2007-05-04 |
2019-06-11 |
University Health Network |
Il-12 immunotherapy for cancer
|
|
CA3028038C
(en)
|
2007-05-11 |
2021-08-10 |
Altor Bioscience Corporation |
Fusion molecules and il-15 variants
|
|
NZ600758A
(en)
|
2007-06-18 |
2013-09-27 |
Merck Sharp & Dohme |
Antibodies to human programmed death receptor pd-1
|
|
DK2173378T3
(da)
|
2007-06-27 |
2014-05-12 |
Admune Therapeutics Llc |
Komplekser af il-15 og il-15ralfa og anvendelser deraf
|
|
EP2085092A1
(en)
|
2008-01-29 |
2009-08-05 |
Bayer Schering Pharma Aktiengesellschaft |
Attenuated oncolytic paramyxoviruses encoding avian cytokines
|
|
RS54233B1
(sr)
|
2008-08-25 |
2015-12-31 |
Amplimmune Inc. |
Kompozicije pd-1 antagonista i postupci za njihovu primenu
|
|
US8475790B2
(en)
|
2008-10-06 |
2013-07-02 |
Bristol-Myers Squibb Company |
Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases
|
|
CN101787373B
(zh)
|
2009-01-23 |
2013-06-19 |
中国人民解放军第二军医大学东方肝胆外科医院 |
一种携带外源基因在包装细胞中高效生产的重组病毒载体、其构建方法及其用途
|
|
WO2010091262A1
(en)
|
2009-02-05 |
2010-08-12 |
Mount Sinai School Of Medicine Of New York University |
Chimeric newcastle disease viruses and uses thereof
|
|
EP2424887B1
(en)
|
2009-04-30 |
2015-09-30 |
The U.S.A. as represented by the Secretary, Department of Health and Human Services |
Inducible interleukin-12
|
|
US20100297072A1
(en)
*
|
2009-05-19 |
2010-11-25 |
Depinho Ronald A |
Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
|
|
ES2598005T3
(es)
|
2009-08-14 |
2017-01-24 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Uso de IL-15 para aumentar la salida del timo y para tratar la linfopenia
|
|
RU2592544C2
(ru)
|
2009-08-21 |
2016-07-20 |
Мериал, Инк. |
Способ получения рекомбинантного вирусного вектора apmv-8
|
|
CN104826106B
(zh)
|
2009-09-30 |
2019-01-11 |
斯隆凯特林防癌纪念中心 |
用于治疗癌症的组合免疫疗法
|
|
EP2550298B1
(en)
|
2010-03-23 |
2015-07-15 |
The Regents of The University of California |
Compositions and methods for self-adjuvanting vaccines against microbes and tumors
|
|
WO2012000188A1
(en)
|
2010-06-30 |
2012-01-05 |
Tot Shanghai Rd Center Co., Ltd. |
Recombinant tumor vaccine and method of producing such
|
|
EP4385570A3
(en)
|
2010-09-21 |
2024-09-11 |
Altor BioScience, LLC |
Multimeric il-15 soluble fusion molecules and methods of making and using same
|
|
CA2836299A1
(en)
|
2011-04-15 |
2012-10-18 |
Genelux Corporation |
Clonal strains of attenuated vaccinia viruses and methods of use thereof
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
AU2012322999B2
(en)
|
2011-10-11 |
2017-08-10 |
Universitat Zurich Prorektorat Mnw |
Combination medicament comprising IL-12 and an agent for blockade of T-cell inhibitory molecules for tumour therapy
|
|
BR112014018331A8
(pt)
|
2012-01-25 |
2017-07-11 |
Univ Texas |
Biomarcadores e terapias combinadas usando vírus oncolítico e imunomodulação
|
|
EP2669381A1
(en)
|
2012-05-30 |
2013-12-04 |
AmVac AG |
Method for expression of heterologous proteins using a recombinant negative-strand RNA virus vector comprising a mutated P protein
|
|
WO2014047350A1
(en)
|
2012-09-20 |
2014-03-27 |
Morningside Technology Ventures Ltd. |
Oncolytic virus encoding pd-1 binding agents and uses of the same
|
|
AU2013334610B2
(en)
|
2012-10-24 |
2018-09-13 |
Novartis Ag |
IL-15R alpha forms, cells expressing IL-15R alpha forms, and therapeutic uses of IL-15R alpha and IL-15/IL-15R alpha complexes
|
|
JP6596411B2
(ja)
|
2013-03-14 |
2019-10-23 |
アイカーン スクール オブ メディシン アット マウント サイナイ |
ニューカッスル病ウイルス及びその使用
|
|
CN109395064A
(zh)
|
2013-04-19 |
2019-03-01 |
赛腾制药 |
降低的血管渗漏综合征的细胞因子衍生治疗
|
|
AU2014284100A1
(en)
|
2013-06-17 |
2015-12-24 |
Viralytics Limited |
Methods for the treatment of bladder cancer
|
|
EP3659622A1
(en)
|
2013-08-08 |
2020-06-03 |
Cytune Pharma |
Combined pharmaceutical composition
|
|
PL3444271T3
(pl)
|
2013-08-08 |
2022-03-07 |
Cytune Pharma |
Modulokiny oparte na il-15 i domenie sushi il-15ralfa
|
|
EA202191926A3
(ru)
|
2013-09-03 |
2022-01-31 |
Медиммун Лимитед |
Композиции, содержащие аттенуированный вирус ньюкаслской болезни, и способы применения для лечения неоплазии
|
|
KR102407019B1
(ko)
*
|
2014-02-27 |
2022-06-08 |
머크 샤프 앤드 돔 코포레이션 |
암의 치료를 위한 결합 방법
|
|
EP2915569A1
(en)
|
2014-03-03 |
2015-09-09 |
Cytune Pharma |
IL-15/IL-15Ralpha based conjugates purification method
|
|
WO2016018920A1
(en)
|
2014-07-29 |
2016-02-04 |
Admune Therapeutics Llc |
Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions
|
|
WO2016048903A1
(en)
|
2014-09-22 |
2016-03-31 |
Intrexon Corporation |
Improved therapeutic control of heterodimeric and single chain forms of interleukin-12
|
|
AU2015360736A1
(en)
|
2014-12-09 |
2017-06-01 |
Merck Sharp & Dohme Corp. |
System and methods for deriving gene signature biomarkers of response to PD-1 antagonists
|
|
CN106166294A
(zh)
|
2015-05-18 |
2016-11-30 |
国科丹蓝生物科技(北京)有限公司 |
一种用于术前介入放疗治疗肿瘤的化合物
|
|
US10344067B2
(en)
|
2016-02-25 |
2019-07-09 |
Deutsches Krebsforschungszentrum |
RNA viruses expressing IL-12 for immunovirotherapy
|
|
CN105734023B
(zh)
|
2016-03-28 |
2019-04-26 |
江苏康缘瑞翱生物医药科技有限公司 |
一种重组新城疫病毒在制备抗肝癌药物中的应用
|