JP2020532532A5 - - Google Patents
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- JP2020532532A5 JP2020532532A5 JP2020512430A JP2020512430A JP2020532532A5 JP 2020532532 A5 JP2020532532 A5 JP 2020532532A5 JP 2020512430 A JP2020512430 A JP 2020512430A JP 2020512430 A JP2020512430 A JP 2020512430A JP 2020532532 A5 JP2020532532 A5 JP 2020532532A5
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- NZWHDUNFHQXOTO-MSBNIHEOSA-N CC1(C=C(C)C(C(Oc2ccc(CSP(OC[C@H]([C@H]3OP(O)(OC4)=O)O[C@@H](C[n]5c(ncnc6N)c6nc5)[C@@H]3F)(O[C@H]3[C@H](N(C=CC(N5)=O)C5=O)O[C@H]4[C@H]3F)=O)cc2)=O)=CC1)O Chemical compound CC1(C=C(C)C(C(Oc2ccc(CSP(OC[C@H]([C@H]3OP(O)(OC4)=O)O[C@@H](C[n]5c(ncnc6N)c6nc5)[C@@H]3F)(O[C@H]3[C@H](N(C=CC(N5)=O)C5=O)O[C@H]4[C@H]3F)=O)cc2)=O)=CC1)O NZWHDUNFHQXOTO-MSBNIHEOSA-N 0.000 description 1
- VWMJPWWSKOUJRY-SOELKDHPSA-N Cc(cc(cc1)O)c1C(Oc1ccc(CSP(OC[C@H]([C@H]([C@H]2F)OP(O)(OC3)=O)O[C@H]2[n]2c(ncnc4N)c4nc2)(O[C@H]2[C@H](N(C=CC(N4)=O)C4=O)O[C@H]3[C@H]2F)=O)cc1)=O Chemical compound Cc(cc(cc1)O)c1C(Oc1ccc(CSP(OC[C@H]([C@H]([C@H]2F)OP(O)(OC3)=O)O[C@H]2[n]2c(ncnc4N)c4nc2)(O[C@H]2[C@H](N(C=CC(N4)=O)C4=O)O[C@H]3[C@H]2F)=O)cc1)=O VWMJPWWSKOUJRY-SOELKDHPSA-N 0.000 description 1
- QTCMGJGOJLFOAG-IJSWPQNOSA-N Cc(cc(cc1)O)c1C(Oc1ccc(CS[P@](OC[C@H]([C@H]2OP(O)(OC[C@H]3O[C@H]4CN(C=CC(N5)=O)C5=O)=O)O[C@@H](C[n]5c(/N=C\N)c(C(N)=C)nc5)[C@@H]2F)(O[C@@H]4[C@@H]3F)=O)cc1)=O Chemical compound Cc(cc(cc1)O)c1C(Oc1ccc(CS[P@](OC[C@H]([C@H]2OP(O)(OC[C@H]3O[C@H]4CN(C=CC(N5)=O)C5=O)=O)O[C@@H](C[n]5c(/N=C\N)c(C(N)=C)nc5)[C@@H]2F)(O[C@@H]4[C@@H]3F)=O)cc1)=O QTCMGJGOJLFOAG-IJSWPQNOSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023070638A JP7673118B2 (ja) | 2017-08-31 | 2023-04-24 | 化合物、組成物、及び疾患の治療方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552473P | 2017-08-31 | 2017-08-31 | |
| US62/552,473 | 2017-08-31 | ||
| US201862664493P | 2018-04-30 | 2018-04-30 | |
| US62/664,493 | 2018-04-30 | ||
| PCT/US2018/048705 WO2019046511A1 (en) | 2017-08-31 | 2018-08-30 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023070638A Division JP7673118B2 (ja) | 2017-08-31 | 2023-04-24 | 化合物、組成物、及び疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532532A JP2020532532A (ja) | 2020-11-12 |
| JP2020532532A5 true JP2020532532A5 (https=) | 2021-10-07 |
| JP7270608B2 JP7270608B2 (ja) | 2023-05-10 |
Family
ID=65526007
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020512430A Active JP7270608B2 (ja) | 2017-08-31 | 2018-08-30 | 化合物、組成物、及び疾患の治療方法 |
| JP2023070638A Active JP7673118B2 (ja) | 2017-08-31 | 2023-04-24 | 化合物、組成物、及び疾患の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023070638A Active JP7673118B2 (ja) | 2017-08-31 | 2023-04-24 | 化合物、組成物、及び疾患の治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11638716B2 (https=) |
| EP (1) | EP3675859A4 (https=) |
| JP (2) | JP7270608B2 (https=) |
| TW (1) | TWI688390B (https=) |
| WO (1) | WO2019046511A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| WO2018156625A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| WO2019123339A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| BR112020024605A2 (pt) | 2018-06-01 | 2021-04-06 | Eisai R&D Management Co., Ltd. | Métodos para o tratamento de câncer de bexiga |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| WO2020092127A1 (en) | 2018-10-29 | 2020-05-07 | Venenum Biodesign, LLC | Novel sting agonists |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| WO2020227421A1 (en) * | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| WO2021007160A1 (en) | 2019-07-05 | 2021-01-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| MX2022014110A (es) | 2020-05-15 | 2023-01-30 | Immunesensor Therapeutics Inc | Tratamientos combinados de agonistas de sting con inhibidores de puntos de control inmunitario. |
| CN116056765A (zh) | 2020-08-07 | 2023-05-02 | 坦伯公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
| JP2024526874A (ja) | 2021-07-23 | 2024-07-19 | イミューンセンサー セラピューティクス、インコーポレイテッド | サイトカインとのｓｔｉｎｇアゴニスト併用療法 |
| GB202304385D0 (en) | 2023-03-24 | 2023-05-10 | Prostate Cancer Res | Combinatorial IL-15 therapy |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2858722B8 (en) | 2012-06-08 | 2018-02-21 | Aduro BioTech, Inc. | Compostions and methods for cancer immunotherapy |
| US9695212B2 (en) | 2012-12-13 | 2017-07-04 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| JP6502267B2 (ja) * | 2013-02-18 | 2019-04-17 | スプリング バンク ファーマシューティカルズ，インコーポレイテッド | ワクチンアジュバントおよび治療剤としての短鎖オリゴヌクレオチドの設計 |
| WO2014189806A1 (en) | 2013-05-18 | 2014-11-27 | Aduro Biotech, Inc. | Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling |
| PE20160080A1 (es) | 2013-05-18 | 2016-02-21 | Aduro Biotech Inc | Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon |
| JP2016538344A (ja) | 2013-11-19 | 2016-12-08 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 癌処置としてのｓｔｉｎｇアゴニストの使用 |
| CA2942245C (en) | 2014-03-12 | 2021-11-02 | Yeda Research And Development Co. Ltd. | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| EP3035126B1 (fr) | 2014-12-18 | 2017-12-13 | The Swatch Group Research and Development Ltd. | Résonateur d'horlogerie à lames croisées |
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| KR102222186B1 (ko) * | 2015-08-13 | 2021-03-03 | 머크 샤프 앤드 돔 코포레이션 | Sting 효능제로서 시클릭 디-뉴클레오티드 화합물 |
| JP2018534295A (ja) * | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| CN107849084B (zh) | 2015-12-03 | 2021-09-14 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为sting调节剂的环状嘌呤二核苷酸 |
| CN106540260A (zh) | 2015-12-09 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 干扰素基因刺激蛋白（sting）激动剂在抗阿尔兹海默症中的应用 |
| US20180369268A1 (en) | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| US10723756B2 (en) | 2016-01-11 | 2020-07-28 | Innate Tumor Immunity Inc. | Cyclic dinucleotides for treating conditions associated with STING activity such as cancer |
| KR102789862B1 (ko) | 2016-01-11 | 2025-04-03 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드 |
| CA3016457A1 (en) | 2016-03-02 | 2017-09-08 | The Board Of Regents Of The University Of Texas System | Sting activating nanovaccine for immunotherapy |
| NZ746112A (en) * | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| EP3448393A1 (en) | 2016-04-25 | 2019-03-06 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| US20190345191A1 (en) | 2016-08-31 | 2019-11-14 | Innate Tumor Immunity, Inc. | Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity |
| PT3523287T (pt) | 2016-10-04 | 2021-10-06 | Merck Sharp & Dohme | Compostos de benzo[b]tiofeno como agonistas de sting |
| PE20210255A1 (es) | 2016-12-01 | 2021-02-10 | Takeda Pharmaceuticals Co | Dinucleotido ciclico como agonistas de sting (estimulador de genes de interferon) |
| AU2017378782A1 (en) | 2016-12-20 | 2019-07-04 | Merck Sharp & Dohme Corp. | Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment |
| WO2018118665A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| WO2018156625A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents,The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| WO2018231752A1 (en) | 2017-06-12 | 2018-12-20 | University Of Miami | Sting-dependent activators for treatment of disease |
| WO2018234807A1 (en) | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
| UA125730C2 (uk) | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
| US20200138827A1 (en) | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| JP2020530838A (ja) | 2017-08-04 | 2020-10-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | がん治療のためのベンゾ［ｂ］チオフェンＳＴＩＮＧアゴニスト |
| RU2020109328A (ru) | 2017-08-04 | 2021-09-06 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
| WO2019035901A1 (en) | 2017-08-15 | 2019-02-21 | University Of Miami | COMPOSITIONS AND METHODS FOR STING PROTEIN MODULATION |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| WO2019067468A1 (en) | 2017-09-26 | 2019-04-04 | La Jolla Institute For Allergy And Immunology | MODULATION OF THE IMMUNE RESPONSE THROUGH THE STING PROTEIN |
| KR20200100081A (ko) | 2017-11-20 | 2020-08-25 | 실리콘 스왓, 인크. | 옥소아크리디닐 아세트산 유도체 및 사용 방법 |
| US11633473B2 (en) | 2017-11-27 | 2023-04-25 | Children's Medical Center Corporation | Stimulator of Interferon Genes (STING) ligands and uses thereof |
| EP3727401A4 (en) | 2017-12-20 | 2022-04-06 | Merck Sharp & Dohme Corp. | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS |
| EP3743103A4 (en) | 2018-01-26 | 2021-03-17 | The Regents of The University of California | INTRANASAL ADMINISTRATION OF CYCLIC DI-NUCLEOTIDE ADJUVED VACCINE FOR TUBERCULOSIS |
| WO2019161171A1 (en) * | 2018-02-16 | 2019-08-22 | Sperovie Biosciences, Inc. | Nanoparticle formulations of sting agonists |
| WO2019165032A1 (en) | 2018-02-21 | 2019-08-29 | The Scripps Research Institute | Agonists of stimulator of interferon genes sting |
| CA3097850A1 (en) | 2018-03-26 | 2019-10-03 | University Of Miami | Recombinant viral vector and uses thereof |
| EP3774765A4 (en) | 2018-04-03 | 2021-12-29 | Merck Sharp & Dohme Corp. | Aza-benzothiophene compounds as sting agonists |
| JP7326319B2 (ja) | 2018-04-03 | 2023-08-15 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｓｔｉｎｇアゴニストとしてのベンゾチオフェン類及び関連する化合物 |
| EP3801579A1 (en) | 2018-06-04 | 2021-04-14 | Aarhus Universitet | Worm products and methods of use |
| US12162863B2 (en) | 2018-06-12 | 2024-12-10 | Ryvu Therapeutics S.A. | Modulators of stimulator of interferon genes (STING) |
| CN108498529A (zh) | 2018-06-20 | 2018-09-07 | 福建师范大学 | 用于肿瘤预防治疗的DNA甲基转移酶抑制剂与cGAMP药物组合物 |
| TW202016081A (zh) | 2018-06-21 | 2020-05-01 | 英商克拉德夫製藥有限公司 | 人類ｓｔｉｎｇ之小分子調節劑、結合物及治療應用 |
| WO2019243823A1 (en) | 2018-06-21 | 2019-12-26 | Curadev Pharma Limited | Azaheterocyclic small molecule modulators of human sting |
| CN120004785A (zh) | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| WO2020010451A1 (en) | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| US20210260069A1 (en) | 2018-07-23 | 2021-08-26 | Fosun Orinove Pharmatech, Inc. | IRE1a INHIBITOR IN COMBINATION WITH CANCER THERAPEUTIC AGENT FOR CANCER TREATMENT |
-
2018
- 2018-08-30 WO PCT/US2018/048705 patent/WO2019046511A1/en not_active Ceased
- 2018-08-30 US US16/643,393 patent/US11638716B2/en active Active
- 2018-08-30 EP EP18850903.8A patent/EP3675859A4/en active Pending
- 2018-08-30 JP JP2020512430A patent/JP7270608B2/ja active Active
- 2018-08-31 TW TW107130548A patent/TWI688390B/zh active
-
2023
- 2023-04-24 JP JP2023070638A patent/JP7673118B2/ja active Active
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