JP2019511483A5 - - Google Patents
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- JP2019511483A5 JP2019511483A5 JP2018545910A JP2018545910A JP2019511483A5 JP 2019511483 A5 JP2019511483 A5 JP 2019511483A5 JP 2018545910 A JP2018545910 A JP 2018545910A JP 2018545910 A JP2018545910 A JP 2018545910A JP 2019511483 A5 JP2019511483 A5 JP 2019511483A5
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- JP
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- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- pharmaceutical composition
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 19
- 108091007433 antigens Proteins 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 12
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 229920000359 diblock copolymer Polymers 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000000277 Splenic Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 206010057644 Testis cancer Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 230000001093 anti-cancer Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 210000004696 endometrium Anatomy 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000000232 gallbladder Anatomy 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 210000004392 genitalia Anatomy 0.000 claims 2
- 210000003128 head Anatomy 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000002429 large intestine Anatomy 0.000 claims 2
- 201000011061 large intestine cancer Diseases 0.000 claims 2
- 210000000867 larynx Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000002200 mouth mucosa Anatomy 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 210000002850 nasal mucosa Anatomy 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 201000002314 small intestine cancer Diseases 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 201000002471 spleen cancer Diseases 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241001115402 Ebolavirus Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 201000010208 Seminoma Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001977 poly(N,N-diethylacrylamides) Polymers 0.000 claims 1
- 229920001510 poly[2-(diisopropylamino)ethyl methacrylate] polymer Polymers 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 CCC(C)(CC)C(OCCN(*)*)=O Chemical compound CCC(C)(CC)C(OCCN(*)*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662302637P | 2016-03-02 | 2016-03-02 | |
| US62/302,637 | 2016-03-02 | ||
| PCT/US2017/020451 WO2017151922A1 (en) | 2016-03-02 | 2017-03-02 | Sting activating nanovaccine for immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019511483A JP2019511483A (ja) | 2019-04-25 |
| JP2019511483A5 true JP2019511483A5 (https=) | 2020-04-09 |
Family
ID=59743242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545910A Pending JP2019511483A (ja) | 2016-03-02 | 2017-03-02 | 免疫療法のためのｓｔｉｎｇ活性化ナノワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11376324B2 (https=) |
| EP (1) | EP3423044A4 (https=) |
| JP (1) | JP2019511483A (https=) |
| KR (1) | KR20180114946A (https=) |
| CN (1) | CN109069440A (https=) |
| AU (1) | AU2017225769B2 (https=) |
| CA (1) | CA3016457A1 (https=) |
| MX (1) | MX2018010586A (https=) |
| WO (1) | WO2017151922A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ746112A (en) | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| IL264049B2 (en) | 2016-07-06 | 2023-11-01 | Sperovie Biosciences Inc | Compounds, preparations and methods for treating the disease |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US20210177964A1 (en) * | 2017-11-06 | 2021-06-17 | Memorial Sloan Kettering Cancer Center | Heat-inactivated vaccinia virus as a vaccine immune adjuvant |
| WO2019136118A2 (en) * | 2018-01-04 | 2019-07-11 | Academia Sinica | Cell-associating immunologic adjuvants for treatment enhancement |
| WO2019145475A2 (en) | 2018-01-25 | 2019-08-01 | Acm Biolabs Pte Ltd | Polymersomes comprising a soluble encapsulated antigen as well as methods of making and uses thereof |
| EP3743103A4 (en) * | 2018-01-26 | 2021-03-17 | The Regents of The University of California | INTRANASAL ADMINISTRATION OF CYCLIC DI-NUCLEOTIDE ADJUVED VACCINE FOR TUBERCULOSIS |
| JP7570235B2 (ja) | 2018-05-25 | 2024-10-21 | インサイト・コーポレイション | Ｓｔｉｎｇ活性化剤としての三環式複素環式化合物 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2020014127A1 (en) | 2018-07-10 | 2020-01-16 | Sperovie Biosciences, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2020028566A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
| CN109453364B (zh) * | 2018-09-30 | 2021-10-15 | 郑州大学第一附属医院 | 一种双重响应性纳米颗粒及其在肿瘤抑制中的应用 |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| WO2020146237A1 (en) | 2019-01-07 | 2020-07-16 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| EP3934757B1 (en) * | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| SG11202113178QA (en) * | 2019-05-28 | 2021-12-30 | Univ Texas | pH RESPONSIVE COMPOSITIONS AND USES THEREOF |
| JP7676331B2 (ja) | 2019-06-22 | 2025-05-14 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 生分解性超ｐＨ感受性ポリマー |
| KR102769095B1 (ko) * | 2019-11-07 | 2025-02-18 | 주식회사 삼양홀딩스 | 면역유도용 고분자 나노입자 조성물 및 그 제조방법 |
| CA3158471A1 (en) * | 2019-11-18 | 2021-05-27 | Tian ZHAO | Ph responsive compositions, formulations, and methods of imaging a tumor |
| GB201918963D0 (en) | 2019-12-20 | 2020-02-05 | Provost Fellows Scholars And Other Members Of Board Of Trinity College Dublin | Polymeric nanoparticles as vaccine adjuvants |
| CN111184738B (zh) * | 2020-03-04 | 2021-05-28 | 北京大学 | 一种二嵌段共聚物或其药学上可接受的盐在制备抗病毒药物中的应用、药物组合物 |
| CN113577255B (zh) * | 2020-04-30 | 2023-09-08 | 中国科学院上海药物研究所 | 肿瘤纳米疫苗、其制备方法及用途 |
| AU2021340623A1 (en) * | 2020-09-08 | 2023-04-13 | The Board Of Regents Of The University Of Texas System | Polyvalent STING activating compositions and uses thereof |
| CA3197125A1 (en) * | 2020-11-03 | 2022-05-12 | Tian ZHAO | Therapeutic ph responsive compositions |
| US20250127921A1 (en) * | 2021-08-10 | 2025-04-24 | Wisconsin Alumni Research Foundation | Ph-responsive nano particle for delivery of ribonucleoproteins |
| CN118695870A (zh) * | 2022-01-26 | 2024-09-24 | 深圳湾实验室坪山生物医药研发转化中心 | 肿瘤免疫治疗 |
| CN114456331A (zh) * | 2022-02-16 | 2022-05-10 | 北京大学 | 能够与膜结合的聚合物及其制备方法和用途 |
| WO2024226815A2 (en) * | 2023-04-28 | 2024-10-31 | University Of Washington | B-cell epitopes of treponema pallidum antigens for use in a syphilis vaccine |
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| US4579945A (en) | 1982-04-29 | 1986-04-01 | Ribi Immunochem Research, Inc. | Purification of trehalose dimycolates |
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| WO2017048789A1 (en) * | 2015-09-14 | 2017-03-23 | The Board Of Regents Of The University Of Texas System | Lipocationic dendrimers and uses thereof |
| CN105214097A (zh) * | 2015-10-30 | 2016-01-06 | 中国科学院福建物质结构研究所 | 一种口服纳米疫苗运载体的免疫实施与检测技术 |
| US11096899B2 (en) * | 2018-09-07 | 2021-08-24 | Wisconsin Alumni Research Foundation | Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment |
-
2017
- 2017-03-02 CA CA3016457A patent/CA3016457A1/en active Pending
- 2017-03-02 US US16/081,911 patent/US11376324B2/en active Active
- 2017-03-02 MX MX2018010586A patent/MX2018010586A/es unknown
- 2017-03-02 EP EP17760821.3A patent/EP3423044A4/en active Pending
- 2017-03-02 CN CN201780027045.XA patent/CN109069440A/zh active Pending
- 2017-03-02 AU AU2017225769A patent/AU2017225769B2/en active Active
- 2017-03-02 WO PCT/US2017/020451 patent/WO2017151922A1/en not_active Ceased
- 2017-03-02 KR KR1020187027939A patent/KR20180114946A/ko not_active Ceased
- 2017-03-02 JP JP2018545910A patent/JP2019511483A/ja active Pending
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