JP2018537975A5 - - Google Patents

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Publication number
JP2018537975A5
JP2018537975A5 JP2018527739A JP2018527739A JP2018537975A5 JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5 JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5
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JP
Japan
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seq
amino acid
acid sequence
heavy chain
light chain
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JP2018527739A
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Japanese (ja)
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JP2018537975A (ja
JP6979950B2 (ja
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Priority claimed from PCT/IB2016/057017 external-priority patent/WO2017093844A1/en
Publication of JP2018537975A publication Critical patent/JP2018537975A/ja
Publication of JP2018537975A5 publication Critical patent/JP2018537975A5/ja
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Publication of JP6979950B2 publication Critical patent/JP6979950B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018527739A 2015-11-30 2016-11-22 部位特異的ｈｅｒ２抗体薬物コンジュゲート Expired - Fee Related JP6979950B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562260854P 2015-11-30 2015-11-30
US62/260,854 2015-11-30
US201662289727P 2016-02-01 2016-02-01
US201662289744P 2016-02-01 2016-02-01
US62/289,744 2016-02-01
US62/289,727 2016-02-01
US201662409105P 2016-10-17 2016-10-17
US62/409,105 2016-10-17
PCT/IB2016/057017 WO2017093844A1 (en) 2015-11-30 2016-11-22 Site specific her2 antibody drug conjugates

Publications (3)

Publication Number Publication Date
JP2018537975A JP2018537975A (ja) 2018-12-27
JP2018537975A5 true JP2018537975A5 (https=) 2020-01-16
JP6979950B2 JP6979950B2 (ja) 2021-12-15

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ID=57485830

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JP2018527739A Expired - Fee Related JP6979950B2 (ja) 2015-11-30 2016-11-22 部位特異的ｈｅｒ２抗体薬物コンジュゲート

Country Status (17)

Country Link
US (2) US10689458B2 (https=)
EP (1) EP3383918A1 (https=)
JP (1) JP6979950B2 (https=)
KR (2) KR102208317B1 (https=)
CN (1) CN108473591B (https=)
AU (1) AU2016363373A1 (https=)
BR (1) BR112018010102A2 (https=)
CA (1) CA2949032A1 (https=)
CO (1) CO2018005433A2 (https=)
IL (1) IL259651B2 (https=)
MX (1) MX2018006582A (https=)
PH (1) PH12018501043A1 (https=)
RU (1) RU2745565C2 (https=)
SG (2) SG11201803676PA (https=)
TW (3) TWI727380B (https=)
WO (1) WO2017093844A1 (https=)
ZA (1) ZA201803205B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015502397A (ja) 2011-12-23 2015-01-22 ファイザー・インク 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
SG11201903400WA (en) 2016-10-17 2019-05-30 Pfizer Anti-edb antibodies and antibody-drug conjugates
WO2019057772A1 (en) 2017-09-19 2019-03-28 Paul Scherrer Institut METHOD FOR CONJUGATING TRANSGLUTAMINASE AND BINDING SEQUENCE
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
JOP20200268A1 (ar) 2018-06-01 2020-10-26 Eisai R&D Man Co Ltd تضفير مترافقات عقار جسم مضاد معدل وطرق استخدامها
WO2020128893A1 (en) 2018-12-21 2020-06-25 Pfizer Inc. Combination treatments of cancer comprising a tlr agonist
WO2021086981A1 (en) * 2019-10-29 2021-05-06 Cspc Dophen Corporation Compositions and methods for treating cancer using anti-her2 antibody drug conjugate
WO2021124210A1 (en) 2019-12-20 2021-06-24 Pfizer Inc. Treatment with site specific her2 antibody-drug conjugates
CN115052632B (zh) * 2020-01-15 2025-01-14 北京海步医药科技有限公司 靶向多肽-药物缀合物及其用途
CA3190798A1 (en) 2020-08-04 2022-02-10 Pfizer Inc. Treatment with site specific her2 antibody-drug conjugates
CN112202628B (zh) * 2020-09-08 2022-09-02 杭州涂鸦信息技术有限公司 一种WiFi模块串口协议自动化测试系统及方法
CN112285361B (zh) * 2020-09-27 2023-12-05 中国人民解放军空军军医大学 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂
CA3196218A1 (en) 2020-10-25 2022-04-28 Philipp SPYCHER Means and methods for producing antibody-linker conjugates
JP2024506708A (ja) * 2021-02-18 2024-02-14 レメゲン シーオー．，エルティーディー． 特定の乳癌の治療におけるｈｅｒ２を標的とする抗体薬物複合体の使用
CN118434759A (zh) * 2021-10-10 2024-08-02 安立玺荣生医(香港)有限公司 用抗-pd-l1/il-10融合蛋白治疗疾病的方法
CN118159298A (zh) * 2021-10-25 2024-06-07 阿拉里斯生物技术股份公司 生产抗体-接头偶联物的方法
CN118804932A (zh) * 2022-01-26 2024-10-18 百奥赛图(北京)医药科技股份有限公司 抗her2/trop2抗体及其用途
WO2024162772A1 (ko) * 2023-02-01 2024-08-08 주식회사 에이티지씨 생체 내 지속성이 증가된 생리활성물질의 결합체
WO2026025013A2 (en) 2024-07-26 2026-01-29 Pfizer Inc. Combination therapy using cdk4 inhibitors for cancer treatments
CN120738196B (zh) * 2025-09-03 2025-12-16 浙江博锐生物制药有限公司 编码抗her2抗体的核酸分子及其应用

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
EP1158997A2 (en) 1999-03-09 2001-12-05 University Of Southern California Method of promoting myocyte proliferation and myocardial tissue repair
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
AU2001257577A1 (en) 2000-02-28 2001-09-03 Shearwater Corporation Water-soluble polymer conjugates of artelinic acid
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
KR20140032004A (ko) 2004-07-22 2014-03-13 제넨테크, 인크. Ｈｅｒ２ 항체 조성물
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
WO2006094269A2 (en) 2005-03-03 2006-09-08 Covx Technologies Ireland Limited Anti-angiogenic compounds
BRPI0617546A2 (pt) 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
WO2008032833A1 (en) 2006-09-14 2008-03-20 Medical & Biological Laboratories Co., Ltd. Antibody having enhanced adcc activity and method for production thereof
US20090098115A1 (en) * 2006-10-20 2009-04-16 Lisa Michele Crocker Cell lines and animal models of HER2 expressing tumors
MX2010003718A (es) 2007-10-19 2010-04-21 Genentech Inc Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo.
JP2011509675A (ja) 2008-01-18 2011-03-31 メディミューン，エルエルシー 部位特異的コンジュゲーションのためのシステイン操作抗体
SG187517A1 (en) 2008-01-31 2013-02-28 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
AU2010270979B2 (en) 2009-06-22 2015-04-23 Medimmune, Llc Engineered Fc regions for site-specific conjugation
BR112012030311A2 (pt) 2010-06-08 2017-01-24 Genentech Inc anticorpo
NZ607337A (en) 2010-08-20 2015-06-26 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
US9676871B2 (en) 2010-11-05 2017-06-13 Pfizer Inc. Engineered polypeptide conjugates and methods for making thereof using transglutaminase
WO2012075581A1 (en) 2010-12-06 2012-06-14 Ym Biosciences Inc. Antibodies selective for cells presenting erbb2 at high density
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
AU2012335205A1 (en) 2011-11-11 2014-05-29 Rinat Neuroscience Corp. Antibodies specific for Trop-2 and their uses
MY168297A (en) * 2011-11-17 2018-10-23 Pfizer Cytotoxic Peptides and Antibody Drug Conjugates Thereof
JP2015502397A (ja) 2011-12-23 2015-01-22 ファイザー・インク 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
WO2013165690A1 (en) 2012-04-30 2013-11-07 Medimmune, Llc Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
KR102557309B1 (ko) 2012-05-15 2023-07-20 씨젠 인크. 자가-안정화 링커 접합체
CN104684928A (zh) 2012-08-02 2015-06-03 Jn生物科学有限责任公司 通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白
WO2014022846A1 (en) 2012-08-03 2014-02-06 Board Of Regents Of The University Of Nebraska Cancer biomarkers and methods of use thereof
AU2013328674B2 (en) 2012-10-12 2017-06-22 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
SI2906252T1 (sl) 2012-10-12 2017-10-30 Adc Therapeutics Sa Pirolobenzodiazepin-anti-HER2 protitelesni konjugati
CN104936621A (zh) 2012-11-07 2015-09-23 辉瑞公司 抗IL-13受体α2抗体和抗体-药物缀合物
KR102447350B1 (ko) * 2013-02-08 2022-09-23 노파르티스 아게 면역접합체의 제조를 위한 항체의 변형에 사용되는 특정 부위
SG11201507214SA (en) 2013-03-13 2015-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR101899306B1 (ko) 2013-07-03 2018-10-04 서울대학교산학협력단 시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합
EP3033111B1 (en) 2013-08-12 2019-03-13 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
WO2015038426A1 (en) 2013-09-13 2015-03-19 Asana Biosciences, Llc Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
US9239324B2 (en) 2013-12-06 2016-01-19 Gang Chen Antibody-binding protein-drug conjugate and methods of use
PL3086814T3 (pl) 2013-12-23 2020-12-28 Bayer Pharma Aktiengesellschaft Koniugaty środka wiążącego (ADC) z inhibitorami KSP
CN106459055B (zh) 2014-01-27 2019-11-01 辉瑞大药厂 双功能细胞毒类药剂
IL301147A (en) * 2014-02-28 2023-05-01 Merus Nv An antibody that binds to ErbB-2 and ErbB-3
MX2016012830A (es) 2014-04-11 2017-01-05 Medimmune Llc Anticuerpos contra el receptor 2 del factor de crecimiento epidermico humano (her2) biespecificos.
WO2015187428A1 (en) * 2014-06-06 2015-12-10 Redwood Bioscience, Inc. Anti-her2 antibody-maytansine conjugates and methods of use thereof
US10870706B2 (en) 2015-03-20 2020-12-22 Pfizer Inc. Bifunctional cytotoxic agents containing the CTI pharmacophore
TWI812873B (zh) 2015-11-30 2023-08-21 美商輝瑞股份有限公司 用於部位專一性接合之抗體和抗體片段

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