JP2018537975A5 - - Google Patents
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- JP2018537975A5 JP2018537975A5 JP2018527739A JP2018527739A JP2018537975A5 JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5 JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5
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- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260854P | 2015-11-30 | 2015-11-30 | |
| US62/260,854 | 2015-11-30 | ||
| US201662289744P | 2016-02-01 | 2016-02-01 | |
| US201662289727P | 2016-02-01 | 2016-02-01 | |
| US62/289,744 | 2016-02-01 | ||
| US62/289,727 | 2016-02-01 | ||
| US201662409105P | 2016-10-17 | 2016-10-17 | |
| US62/409,105 | 2016-10-17 | ||
| PCT/IB2016/057017 WO2017093844A1 (en) | 2015-11-30 | 2016-11-22 | Site specific her2 antibody drug conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537975A JP2018537975A (ja) | 2018-12-27 |
| JP2018537975A5 true JP2018537975A5 (https=) | 2020-01-16 |
| JP6979950B2 JP6979950B2 (ja) | 2021-12-15 |
Family
ID=57485830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527739A Expired - Fee Related JP6979950B2 (ja) | 2015-11-30 | 2016-11-22 | 部位特異的her2抗体薬物コンジュゲート |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10689458B2 (https=) |
| EP (1) | EP3383918A1 (https=) |
| JP (1) | JP6979950B2 (https=) |
| KR (2) | KR102312149B1 (https=) |
| CN (1) | CN108473591B (https=) |
| AU (1) | AU2016363373A1 (https=) |
| BR (1) | BR112018010102A2 (https=) |
| CA (1) | CA2949032A1 (https=) |
| CO (1) | CO2018005433A2 (https=) |
| IL (1) | IL259651B2 (https=) |
| MX (1) | MX2018006582A (https=) |
| PH (1) | PH12018501043A1 (https=) |
| RU (1) | RU2745565C2 (https=) |
| SG (2) | SG11201803676PA (https=) |
| TW (3) | TWI727380B (https=) |
| WO (1) | WO2017093844A1 (https=) |
| ZA (1) | ZA201803205B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| ES3007557T3 (en) * | 2016-10-17 | 2025-03-20 | Pfizer | Anti-edb antibodies and antibody-drug conjugates |
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| CN119405832A (zh) | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| CN114901308A (zh) * | 2019-10-29 | 2022-08-12 | 石药集团巨石生物制药有限公司 | 使用抗her2抗体药物缀合物治疗癌症的组合物和方法 |
| BR112022011848A2 (pt) | 2019-12-20 | 2022-11-22 | Pfizer | Tratamento com conjugados de anticorpo-fármaco her2 específicos de sítio |
| WO2021143741A1 (zh) * | 2020-01-15 | 2021-07-22 | 北京海步医药科技有限公司 | 靶向多肽-药物缀合物及其用途 |
| WO2022029591A1 (en) | 2020-08-04 | 2022-02-10 | Pfizer Inc. | Treatment with site specific her2 antibody-drug conjugates |
| CN112202628B (zh) * | 2020-09-08 | 2022-09-02 | 杭州涂鸦信息技术有限公司 | 一种WiFi模块串口协议自动化测试系统及方法 |
| CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
| KR20230096052A (ko) | 2020-10-25 | 2023-06-29 | 아라리스 바이오테크 아게 | 항체-링커 접합체를 생성하기 위한 수단 및 방법 |
| WO2022174775A1 (en) * | 2021-02-18 | 2022-08-25 | Remegen Co., Ltd. | Use of antibody-drug conjugate targeting her2 in treatment of specific breast cancer |
| KR20240074772A (ko) * | 2021-10-10 | 2024-05-28 | 엘릭시론 이뮤노테라퓨틱스 (홍콩) 리미티드 | 항-pd-l1/il-10 융합 단백질을 이용한 질병 치료 방법 |
| WO2023072934A1 (en) * | 2021-10-25 | 2023-05-04 | Araris Biotech Ag | Methods for producing antibody-linker conjugates |
| EP4469485A4 (en) * | 2022-01-26 | 2026-04-08 | Biocytogen Pharmaceuticals Beijing Co Ltd | ANTI-HER2/TROP2 ANTIBODIES AND THEIR USES |
| WO2024162772A1 (ko) * | 2023-02-01 | 2024-08-08 | 주식회사 에이티지씨 | 생체 내 지속성이 증가된 생리활성물질의 결합체 |
| WO2026025013A2 (en) | 2024-07-26 | 2026-01-29 | Pfizer Inc. | Combination therapy using cdk4 inhibitors for cancer treatments |
| CN120738196B (zh) * | 2025-09-03 | 2025-12-16 | 浙江博锐生物制药有限公司 | 编码抗her2抗体的核酸分子及其应用 |
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| US20090098115A1 (en) * | 2006-10-20 | 2009-04-16 | Lisa Michele Crocker | Cell lines and animal models of HER2 expressing tumors |
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| BRPI0907046A2 (pt) | 2008-01-18 | 2015-07-28 | Medimmune Llc | Anticorpo de cisteína engenheirada, ácido nucleico isolado, vetor, célula hospedeira, conjugado de anticorpo, composição farmacêutica, métodos de detecção de câncer, doenças ou distúrbios autoimunes, inflamatórios ou infecciosos em um indivíduo e de inibição de proliferação de uma célula alvo |
| KR101607346B1 (ko) | 2008-01-31 | 2016-03-29 | 제넨테크, 인크. | 항-cd79b 항체 및 면역접합체 및 사용 방법 |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
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| AU2011290672B2 (en) | 2010-08-20 | 2015-07-09 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (HER3) |
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| CA2813411C (en) | 2010-11-05 | 2016-08-02 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| US10208129B2 (en) | 2010-12-06 | 2019-02-19 | National Research Council Of Canada | Antibodies selective for cells presenting ErbB2 at high density |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| TWI495644B (zh) | 2011-11-11 | 2015-08-11 | Rinat Neuroscience Corp | 營養層細胞表面抗原(Trop-2)之專一性抗體類及彼等之用途 |
| CN104185477B (zh) * | 2011-11-17 | 2017-05-24 | 辉瑞公司 | 细胞毒性肽及其抗体‑药物缀合物 |
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| US10011660B2 (en) | 2012-04-30 | 2018-07-03 | Medimmune, Llc | Molecules with reduced effector function and extended half-lives, compositions, and uses thereof |
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| WO2014022846A1 (en) | 2012-08-03 | 2014-02-06 | Board Of Regents Of The University Of Nebraska | Cancer biomarkers and methods of use thereof |
| SI2906252T1 (sl) | 2012-10-12 | 2017-10-30 | Adc Therapeutics Sa | Pirolobenzodiazepin-anti-HER2 protitelesni konjugati |
| HRP20190366T1 (hr) | 2012-10-12 | 2019-04-19 | Medimmune Limited | Pirolobenzodiazepini i njihovi konjugati |
| KR101763499B1 (ko) | 2012-11-07 | 2017-07-31 | 화이자 인코포레이티드 | 항-il-13 수용체 알파 2 항체 및 항체-약물 접합체 |
| EP2953976B1 (en) * | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| TWI680766B (zh) | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| EP3018143B1 (en) | 2013-07-03 | 2019-05-29 | Seoul National University R&DB Foundation | Chicken antibody transformed into cysteine and site-specific conjugation using same |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
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| KR102486180B1 (ko) * | 2014-06-06 | 2023-01-11 | 레드우드 바이오사이언스 인코포레이티드 | 항-her2 항체-메이탄신 컨쥬게이트 및 이것의 사용 방법 |
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| TWI812873B (zh) | 2015-11-30 | 2023-08-21 | 美商輝瑞股份有限公司 | 用於部位專一性接合之抗體和抗體片段 |
-
2016
- 2016-11-21 TW TW108126399A patent/TWI727380B/zh not_active IP Right Cessation
- 2016-11-21 TW TW105138129A patent/TWI726942B/zh not_active IP Right Cessation
- 2016-11-21 TW TW110100847A patent/TWI778491B/zh not_active IP Right Cessation
- 2016-11-21 US US15/356,750 patent/US10689458B2/en active Active
- 2016-11-21 CA CA2949032A patent/CA2949032A1/en not_active Abandoned
- 2016-11-22 KR KR1020207030005A patent/KR102312149B1/ko not_active Expired - Fee Related
- 2016-11-22 WO PCT/IB2016/057017 patent/WO2017093844A1/en not_active Ceased
- 2016-11-22 SG SG11201803676PA patent/SG11201803676PA/en unknown
- 2016-11-22 MX MX2018006582A patent/MX2018006582A/es unknown
- 2016-11-22 KR KR1020187018244A patent/KR102208317B1/ko not_active Expired - Fee Related
- 2016-11-22 SG SG10202005102YA patent/SG10202005102YA/en unknown
- 2016-11-22 CN CN201680072749.4A patent/CN108473591B/zh not_active Expired - Fee Related
- 2016-11-22 RU RU2018119683A patent/RU2745565C2/ru active
- 2016-11-22 EP EP16806285.9A patent/EP3383918A1/en not_active Withdrawn
- 2016-11-22 AU AU2016363373A patent/AU2016363373A1/en not_active Abandoned
- 2016-11-22 JP JP2018527739A patent/JP6979950B2/ja not_active Expired - Fee Related
- 2016-11-22 BR BR112018010102-8A patent/BR112018010102A2/pt not_active IP Right Cessation
-
2018
- 2018-05-15 ZA ZA2018/03205A patent/ZA201803205B/en unknown
- 2018-05-16 PH PH12018501043A patent/PH12018501043A1/en unknown
- 2018-05-24 CO CONC2018/0005433A patent/CO2018005433A2/es unknown
- 2018-05-28 IL IL259651A patent/IL259651B2/en unknown
-
2020
- 2020-06-03 US US16/891,460 patent/US20200377615A1/en not_active Abandoned
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