JP2023545096A5 - - Google Patents

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Publication number
JP2023545096A5
JP2023545096A5 JP2023521678A JP2023521678A JP2023545096A5 JP 2023545096 A5 JP2023545096 A5 JP 2023545096A5 JP 2023521678 A JP2023521678 A JP 2023521678A JP 2023521678 A JP2023521678 A JP 2023521678A JP 2023545096 A5 JP2023545096 A5 JP 2023545096A5
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JP
Japan
Prior art keywords
cancer
pharmaceutical product
product according
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023521678A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023545096A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2021/059232 external-priority patent/WO2022074617A1/en
Publication of JP2023545096A publication Critical patent/JP2023545096A/ja
Publication of JP2023545096A5 publication Critical patent/JP2023545096A5/ja
Pending legal-status Critical Current

Links

JP2023521678A 2020-10-09 2021-10-08 抗体-薬物コンジュゲート及びparp1選択的阻害薬の組み合わせ Pending JP2023545096A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063089859P 2020-10-09 2020-10-09
US63/089,859 2020-10-09
PCT/IB2021/059232 WO2022074617A1 (en) 2020-10-09 2021-10-08 Combination of antibody-drug conjugate and parp1 selective inhibitor

Publications (2)

Publication Number Publication Date
JP2023545096A JP2023545096A (ja) 2023-10-26
JP2023545096A5 true JP2023545096A5 (https=) 2024-10-10

Family

ID=78179469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023521678A Pending JP2023545096A (ja) 2020-10-09 2021-10-08 抗体-薬物コンジュゲート及びparp1選択的阻害薬の組み合わせ

Country Status (13)

Country Link
US (1) US20230372527A1 (https=)
EP (1) EP4225314A1 (https=)
JP (1) JP2023545096A (https=)
KR (1) KR20230084163A (https=)
CN (1) CN116348115A (https=)
AU (1) AU2021356762A1 (https=)
BR (1) BR112023006337A2 (https=)
CA (1) CA3195117A1 (https=)
IL (1) IL301921A (https=)
MX (1) MX2023004047A (https=)
TW (1) TW202222350A (https=)
WO (1) WO2022074617A1 (https=)
ZA (1) ZA202305073B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11591331B2 (en) * 2021-04-19 2023-02-28 Xinthera, Inc. PARP1 inhibitors and uses thereof
CN115702156A (zh) * 2021-04-23 2023-02-14 南京明德新药研发有限公司 吡啶酰胺类化合物
WO2023051716A1 (zh) * 2021-09-30 2023-04-06 海思科医药集团股份有限公司 杂芳基衍生物parp抑制剂及其用途
AU2022392822A1 (en) * 2021-11-18 2024-05-02 Astrazeneca Uk Limited Combination of antibody-drug conjugate and parp1 selective inhibitor
AU2023235233A1 (en) 2022-03-14 2024-09-12 Slap Pharmaceuticals Llc Multicyclic compounds
EP4534537A4 (en) * 2022-05-25 2025-12-10 Xizang Haisco Pharmaceutical Co Ltd BICYCLE-DERIVED PARP INHIBITOR AND ITS USE
WO2024067694A1 (zh) * 2022-09-30 2024-04-04 中国医药研究开发中心有限公司 含氮杂环类化合物及其医药用途
CN120936382A (zh) * 2023-02-16 2025-11-11 阿斯利康(瑞典)有限公司 采用治疗性结合分子治疗癌症的组合疗法
TW202535479A (zh) 2023-12-05 2025-09-16 英商阿斯特捷利康英國股份有限公司 抗體藥物結合物與血腦屏障穿透性parp1選擇性抑制劑之組合

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IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
ATE198623T1 (de) 1994-08-12 2001-01-15 Myriad Genetics Inc Verfahren zum nachweis von prädisposition von ovarial- und brustkrebs
ATE201445T1 (de) 1994-08-12 2001-06-15 Myriad Genetics Inc Mutationen des mit 17q verbundenen ovarial- und brustkrebs empfindlichkeitsgens
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
CN100340575C (zh) 1999-06-25 2007-10-03 杰南技术公司 人源化抗ErbB2抗体及其在制备药物中的应用
CA2953239A1 (en) 2000-10-06 2002-04-18 Kyowa Hakko Kirin Co., Ltd. Antibody composition-producing cell
PL1633724T3 (pl) 2003-03-12 2011-10-31 Kudos Pharm Ltd Pochodne ftalazynonu
US9707302B2 (en) * 2013-07-23 2017-07-18 Immunomedics, Inc. Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
WO2007133855A2 (en) 2006-03-27 2007-11-22 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
IN2014DN06806A (https=) 2012-02-10 2015-05-22 Univ Maryland
ES2773710T3 (es) 2012-10-11 2020-07-14 Daiichi Sankyo Co Ltd Enlazadores para conjugados de anticuerpo - fármaco
AU2014371934B2 (en) 2013-12-25 2020-01-23 Daiichi Sankyo Company, Limited Anti-TROP2 antibody-drug conjugate
IL310627B2 (en) 2014-01-31 2026-04-01 Daiichi Sankyo Co Ltd Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof
KR102445502B1 (ko) 2014-04-10 2022-09-21 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
CN116059395A (zh) 2015-06-29 2023-05-05 第一三共株式会社 用于选择性制造抗体-药物缀合物的方法
TW202532104A (zh) 2017-05-15 2025-08-16 日商第一三共股份有限公司 抗體-藥物結合物及其用途
IL324591A (en) 2017-08-31 2026-01-01 Daiichi Sankyo Co Ltd Improved antibody-drug conjugate production methods
SG11202100653YA (en) * 2018-07-25 2021-02-25 Daiichi Sankyo Co Ltd Effective method for manufacturing antibody-drug conjugate
EA202190471A1 (ru) * 2018-08-06 2021-05-24 Дайити Санкио Компани, Лимитед Комбинация конъюгата антитела-лекарственного средства и ингибитора тубулина
KR102905497B1 (ko) * 2018-12-11 2025-12-30 다이이찌 산쿄 가부시키가이샤 항체-약물 컨쥬게이트와 parp 저해제의 조합
SI3999506T1 (sl) 2019-07-19 2025-06-30 Astrazeneca Ab Zaviralci PARP1

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