|
US713485A
(en)
|
1902-05-15 |
1902-11-11 |
Joseph Neumeier |
Well-tube lifter.
|
|
EP0383919A4
(en)
|
1988-02-04 |
1992-08-05 |
Kyowa Hakko Kogyo Co., Ltd. |
Staurosporin derivatives
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
|
DE69536015D1
(de)
|
1995-03-30 |
2009-12-10 |
Pfizer Prod Inc |
Chinazolinone Derivate
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
FR2741881B1
(fr)
|
1995-12-01 |
1999-07-30 |
Centre Nat Rech Scient |
Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
|
|
US5989591A
(en)
|
1997-03-14 |
1999-11-23 |
American Home Products Corporation |
Rapamycin formulations for oral administration
|
|
US6002008A
(en)
|
1997-04-03 |
1999-12-14 |
American Cyanamid Company |
Substituted 3-cyano quinolines
|
|
CO4940418A1
(es)
|
1997-07-18 |
2000-07-24 |
Novartis Ag |
Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
ME00275B
(me)
|
1999-01-13 |
2011-02-10 |
Bayer Corp |
ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
EP1169038B9
(en)
|
1999-04-15 |
2013-07-10 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
|
CN100340575C
(zh)
|
1999-06-25 |
2007-10-03 |
杰南技术公司 |
人源化抗ErbB2抗体及其在制备药物中的应用
|
|
TWI262914B
(en)
|
1999-07-02 |
2006-10-01 |
Agouron Pharma |
Compounds and pharmaceutical compositions for inhibiting protein kinases
|
|
US6762180B1
(en)
|
1999-10-13 |
2004-07-13 |
Boehringer Ingelheim Pharma Kg |
Substituted indolines which inhibit receptor tyrosine kinases
|
|
KR100881105B1
(ko)
|
1999-11-05 |
2009-02-02 |
아스트라제네카 아베 |
Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체
|
|
DE60037345T2
(de)
|
1999-12-10 |
2008-11-13 |
Pfizer Products Inc., Groton |
Pyrrolo(2,3-d)pyrimidin-Verbindungen
|
|
HUP0204126A3
(en)
|
2000-01-18 |
2006-02-28 |
Aventis Pharma Inc |
Pseudopolymorph of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-one, process for their preparation and pharmaceutical compositions containing them
|
|
JP3663382B2
(ja)
|
2000-02-15 |
2005-06-22 |
スージェン・インコーポレーテッド |
ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
|
|
GB0004888D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
PE20011178A1
(es)
|
2000-04-07 |
2001-11-19 |
Takeda Chemical Industries Ltd |
Compuestos heterociclicos y su produccion
|
|
CA2953239A1
(en)
|
2000-10-06 |
2002-04-18 |
Kyowa Hakko Kirin Co., Ltd. |
Antibody composition-producing cell
|
|
AU9598601A
(en)
|
2000-10-20 |
2002-04-29 |
Eisai Co Ltd |
Nitrogenous aromatic ring compounds
|
|
DE10063435A1
(de)
|
2000-12-20 |
2002-07-04 |
Boehringer Ingelheim Pharma |
Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
BR0116452A
(pt)
|
2000-12-21 |
2003-09-30 |
Glaxo Group Ltd |
Composto, composição farmacêutica, uso de um composto
|
|
US7235576B1
(en)
|
2001-01-12 |
2007-06-26 |
Bayer Pharmaceuticals Corporation |
Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
DK1382604T3
(da)
|
2001-04-27 |
2006-04-18 |
Kirin Brewery |
Quinolinderivater med en azolylgruppe og quinazolinderivater
|
|
MXPA04002445A
(es)
|
2001-09-14 |
2005-07-25 |
Univ Arizona |
Analogos de wortmanina y metodos para utilizar los mismos.
|
|
DE60213842T2
(de)
|
2001-10-30 |
2007-09-06 |
Novartis Ag |
Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
|
|
MXPA04005939A
(es)
|
2002-01-22 |
2005-01-25 |
Warner Lambert Co |
2-(piridin-2-ilamino)-pirido[2,3-d]pirimidin-7-onas.
|
|
KR100984595B1
(ko)
|
2002-03-13 |
2010-09-30 |
어레이 바이오파마 인크. |
Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
|
US7119200B2
(en)
|
2002-09-04 |
2006-10-10 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
|
ATE411996T1
(de)
|
2002-09-30 |
2008-11-15 |
Bayer Healthcare Ag |
Kondensierte azolpyrimidinderivate
|
|
EP2210607B1
(en)
|
2003-09-26 |
2011-08-17 |
Exelixis Inc. |
N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
|
|
DE10349423A1
(de)
|
2003-10-16 |
2005-06-16 |
Schering Ag |
Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
|
|
CN1925855B
(zh)
|
2003-12-19 |
2010-06-16 |
普莱希科公司 |
开发Ret调节剂的化合物和方法
|
|
KR20080095915A
(ko)
|
2004-05-06 |
2008-10-29 |
워너-램버트 캄파니 엘엘씨 |
4-페닐아미노-퀴나졸린-6-일-아미드
|
|
AU2005243175B2
(en)
|
2004-05-14 |
2011-12-01 |
Millennium Pharmaceuticals, Inc. |
Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase
|
|
US7378423B2
(en)
|
2004-06-11 |
2008-05-27 |
Japan Tobacco Inc. |
Pyrimidine compound and medical use thereof
|
|
CA2574491C
(en)
|
2004-07-19 |
2011-05-24 |
Onconova Therapeutics, Inc. |
Formulations for parenteral administration of (e)-2,6-dialkoxystryryl 4-substituted benzylsulfones
|
|
DE602005020465D1
(de)
|
2004-08-26 |
2010-05-20 |
Pfizer |
Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer
|
|
ZA200703912B
(en)
|
2004-10-20 |
2008-09-25 |
Serono Lab |
3-arylamino pyridine derivatives
|
|
CN101080227B
(zh)
*
|
2004-12-15 |
2011-08-31 |
诺瓦提斯公司 |
用于治疗癌症的治疗剂的组合
|
|
CA2618218C
(en)
|
2005-07-21 |
2015-06-30 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
|
SI1934174T1
(sl)
|
2005-10-07 |
2011-08-31 |
Exelixis Inc |
Inhibitorji MEK in postopki za njihovo uporabo
|
|
US7989622B2
(en)
|
2005-10-07 |
2011-08-02 |
Exelixis, Inc. |
Phosphatidylinositol 3-kinase inhibitors and methods of their use
|
|
WO2007058627A1
(en)
|
2005-11-16 |
2007-05-24 |
S*Bio Pte Ltd |
Oxygen linked pyrimidine derivatives
|
|
SG10202003901UA
(en)
|
2005-12-13 |
2020-05-28 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
|
|
EA034598B1
(ru)
|
2005-12-23 |
2020-02-25 |
Ариад Фармасьютикалз, Инк. |
Применение бициклических гетероарильных соединений для лечения рака
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
WO2007133855A2
(en)
|
2006-03-27 |
2007-11-22 |
University Of Maryland Biotechnology Institute |
Glycoprotein synthesis and remodeling by enzymatic transglycosylation
|
|
CA2649288C
(en)
|
2006-04-19 |
2015-11-24 |
Novartis Ag |
6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling
|
|
WO2007129161A2
(en)
|
2006-04-26 |
2007-11-15 |
F. Hoffmann-La Roche Ag |
Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor
|
|
JP5498782B2
(ja)
|
2006-06-21 |
2014-05-21 |
ピラマル エンタープライジーズ リミテッド |
増殖性疾患治療用のエナンチオマー的に純粋なフラボン誘導体の調製方法
|
|
UA95641C2
(xx)
|
2006-07-06 |
2011-08-25 |
Эррей Биофарма Инк. |
Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
|
|
DK2526933T3
(en)
|
2006-09-22 |
2015-05-18 |
Pharmacyclics Inc |
Inhibitors of Bruton's tyrosine kinase
|
|
RS54510B1
(sr)
|
2006-11-22 |
2016-06-30 |
Incyte Holdings Corporation |
Imidazotriazini i imidazopirimidini kao inhibitori kinaze
|
|
MX2009005950A
(es)
|
2006-12-07 |
2009-10-12 |
Genentech Inc |
Compuestos inhibidores de fosfoinositido 3-quinasas y metodos de uso.
|
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
|
KR101598229B1
(ko)
|
2007-02-16 |
2016-02-26 |
메리맥 파마슈티컬즈, 인크. |
Ｅｒｂｂ3에 대한 항체 및 이의 용도
|
|
US8163923B2
(en)
|
2007-03-14 |
2012-04-24 |
Advenchen Laboratories, Llc |
Spiro substituted compounds as angiogenesis inhibitors
|
|
DE102007032507A1
(de)
|
2007-07-12 |
2009-04-02 |
Merck Patent Gmbh |
Pyridazinonderivate
|
|
PT2176231T
(pt)
|
2007-07-20 |
2016-12-09 |
Nerviano Medical Sciences Srl |
Derivados de indazol substituídos activos como inibidores de quinases
|
|
JO3240B1
(ar)
|
2007-10-17 |
2018-03-08 |
Janssen Pharmaceutica Nv |
c-fms مثبطات كيناز
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
HUE029767T2
(en)
|
2008-03-11 |
2017-04-28 |
Incyte Holdings Corp |
JAK inhibitor azetidine and cyclobutane derivatives
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
MX353308B
(es)
|
2008-05-21 |
2018-01-08 |
Ariad Pharma Inc |
Derivados fosforosos como inhibidores de cinasa.
|
|
LT2294072T
(lt)
|
2008-05-23 |
2017-06-12 |
Wyeth Llc |
Triazino junginiai, kaip p13 kinazės ir mtor inhibitoriai
|
|
UA104147C2
(uk)
|
2008-09-10 |
2014-01-10 |
Новартис Аг |
Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
|
|
CN102239171B
(zh)
|
2008-12-05 |
2014-06-11 |
艾伯维巴哈马有限公司 |
作为激酶抑制剂用于治疗癌症的噻吩并[3,2-c]吡啶衍生物
|
|
PA8852901A1
(es)
|
2008-12-22 |
2010-07-27 |
Lilly Co Eli |
Inhibidores de proteina cinasa
|
|
ES2575084T3
(es)
|
2009-06-10 |
2016-06-24 |
Chugai Seiyaku Kabushiki Kaisha |
Compuesto tetracíclico
|
|
AR077975A1
(es)
|
2009-08-28 |
2011-10-05 |
Irm Llc |
Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
|
|
CN102020639A
(zh)
|
2009-09-14 |
2011-04-20 |
上海恒瑞医药有限公司 |
6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用
|
|
TWI500617B
(zh)
|
2010-05-31 |
2015-09-21 |
Ono Pharmaceutical Co |
Purine ketone derivatives
|
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
|
MX338327B
(es)
|
2010-10-25 |
2016-04-12 |
G1 Therapeutics Inc |
Inhibidores de cdk.
|
|
US20120115878A1
(en)
|
2010-11-10 |
2012-05-10 |
John Vincent Calienni |
Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
|
|
EP3689878B1
(en)
|
2011-07-19 |
2021-10-06 |
Merck Sharp & Dohme B.V. |
4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors
|
|
EP4119551A1
(en)
|
2011-07-27 |
2023-01-18 |
Astrazeneca AB |
2-(2,4,5-substituted-anilino)pyrimidine compounds
|
|
AU2012323890A1
(en)
|
2011-10-14 |
2014-05-29 |
Array Biopharma Inc. |
Polymorphs of arry-380, a selective ErbB2 inhibitor and pharmaceutical compositions containing them
|
|
BR112014015720B1
(pt)
|
2011-12-30 |
2020-03-17 |
Hanmi Pharm. Co., Ltd. |
Derivados de tieno[3,2-d]pirimidina, composição farmacêutica e uso dos mesmos para a prevenção ou tratamento de uma doença causada por ativação anormal de uma proteína quinase
|
|
IN2014DN06806A
(https=)
|
2012-02-10 |
2015-05-22 |
Univ Maryland |
|
|
NZ629684A
(en)
|
2012-03-05 |
2016-10-28 |
Gilead Calistoga Llc |
Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one
|
|
DK2822953T5
(en)
|
2012-03-06 |
2017-09-11 |
Pfizer |
Macrocyclic derivatives for the treatment of proliferative diseases
|
|
WO2014022975A1
(zh)
|
2012-08-07 |
2014-02-13 |
上海创诺医药集团有限公司 |
N-(4-(3-氨基-1h-吲唑-4-基)苯基)-n'-(2-氟-5-甲基苯基)脲及其中间体的制备方法
|
|
ES2773710T3
(es)
|
2012-10-11 |
2020-07-14 |
Daiichi Sankyo Co Ltd |
Enlazadores para conjugados de anticuerpo - fármaco
|
|
WO2014061277A1
(ja)
|
2012-10-19 |
2014-04-24 |
第一三共株式会社 |
親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
|
|
KR20140096571A
(ko)
|
2013-01-28 |
2014-08-06 |
한미약품 주식회사 |
1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
|
|
MX2015009952A
(es)
|
2013-02-08 |
2015-10-05 |
Celgene Avilomics Res Inc |
Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos.
|
|
MX2015011438A
(es)
|
2013-03-13 |
2016-02-03 |
Hoffmann La Roche |
Procedimiento para preparar compuestos benzoxazepina.
|
|
TWI731317B
(zh)
|
2013-12-10 |
2021-06-21 |
美商健臻公司 |
原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
|
|
AU2014371934B2
(en)
*
|
2013-12-25 |
2020-01-23 |
Daiichi Sankyo Company, Limited |
Anti-TROP2 antibody-drug conjugate
|
|
IL310627B2
(en)
*
|
2014-01-31 |
2026-04-01 |
Daiichi Sankyo Co Ltd |
Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof
|
|
JP2017114763A
(ja)
|
2014-03-26 |
2017-06-29 |
第一三共株式会社 |
抗ｃｄ９８抗体−薬物コンジュゲート
|
|
KR102445502B1
(ko)
*
|
2014-04-10 |
2022-09-21 |
다이이찌 산쿄 가부시키가이샤 |
항her3 항체-약물 콘주게이트
|
|
EP3130608B1
(en)
|
2014-04-10 |
2019-09-04 |
Daiichi Sankyo Co., Ltd. |
(anti-her2 antibody)-drug conjugate
|
|
TWI704151B
(zh)
|
2014-12-22 |
2020-09-11 |
美商美國禮來大藥廠 |
Ｅｒｋ抑制劑
|
|
KR102608921B1
(ko)
|
2015-05-18 |
2023-12-01 |
스미토모 파마 온콜로지, 인크. |
생체 이용률이 증가된 알보시딥 프로드러그
|
|
CN116059395A
(zh)
|
2015-06-29 |
2023-05-05 |
第一三共株式会社 |
用于选择性制造抗体-药物缀合物的方法
|
|
AU2016287463B2
(en)
|
2015-07-02 |
2020-07-02 |
F. Hoffmann-La Roche Ag |
Benzoxazepin oxazolidinone compounds and methods of use
|
|
PT3497103T
(pt)
|
2016-08-15 |
2021-06-17 |
Pfizer |
Inibidores de piridopirimidinona cdk2/4/6
|
|
CN117982673A
(zh)
*
|
2017-02-28 |
2024-05-07 |
第一三共株式会社 |
抗her3抗体-药物偶联物的应用
|
|
TW202532104A
(zh)
|
2017-05-15 |
2025-08-16 |
日商第一三共股份有限公司 |
抗體－藥物結合物及其用途
|
|
IL324591A
(en)
|
2017-08-31 |
2026-01-01 |
Daiichi Sankyo Co Ltd |
Improved antibody-drug conjugate production methods
|