JP2019519503A5 - - Google Patents
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- Publication number
- JP2019519503A5 JP2019519503A5 JP2018560135A JP2018560135A JP2019519503A5 JP 2019519503 A5 JP2019519503 A5 JP 2019519503A5 JP 2018560135 A JP2018560135 A JP 2018560135A JP 2018560135 A JP2018560135 A JP 2018560135A JP 2019519503 A5 JP2019519503 A5 JP 2019519503A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- alkanediyl
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 174
- 229910052739 hydrogen Inorganic materials 0.000 claims description 159
- 239000001257 hydrogen Substances 0.000 claims description 159
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 152
- 150000002431 hydrogen Chemical class 0.000 claims description 126
- 150000001875 compounds Chemical class 0.000 claims description 101
- 125000004423 acyloxy group Chemical group 0.000 claims description 93
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 51
- 125000003342 alkenyl group Chemical group 0.000 claims description 49
- 125000005843 halogen group Chemical group 0.000 claims description 49
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 39
- 238000006467 substitution reaction Methods 0.000 claims description 36
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 25
- 125000003545 alkoxy group Chemical group 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 16
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 150000007523 nucleic acids Chemical class 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 150000003431 steroids Chemical class 0.000 claims description 8
- 150000002632 lipids Chemical class 0.000 claims description 5
- 150000003904 phospholipids Chemical class 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 3
- -1 amino, hydroxy Chemical group 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000732 arylene group Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 150000001335 aliphatic alkanes Chemical class 0.000 description 39
- 238000000034 method Methods 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 0 C**C(NC(C)C)=O Chemical compound C**C(NC(C)C)=O 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 125000005415 substituted alkoxy group Chemical group 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000003837 Second Primary Neoplasms Diseases 0.000 description 1
- 201000010208 Seminoma Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 208000000277 Splenic Neoplasms Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 108091027544 Subgenomic mRNA Proteins 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 201000011061 large intestine cancer Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 201000002314 small intestine cancer Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 201000002471 spleen cancer Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022084888A JP7480220B2 (ja) | 2016-05-16 | 2022-05-25 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
| JP2024070491A JP2024091896A (ja) | 2016-05-16 | 2024-04-24 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662337196P | 2016-05-16 | 2016-05-16 | |
| US62/337,196 | 2016-05-16 | ||
| PCT/US2017/032950 WO2017201076A1 (en) | 2016-05-16 | 2017-05-16 | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022084888A Division JP7480220B2 (ja) | 2016-05-16 | 2022-05-25 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519503A JP2019519503A (ja) | 2019-07-11 |
| JP2019519503A5 true JP2019519503A5 (https=) | 2020-06-25 |
| JP7080826B2 JP7080826B2 (ja) | 2022-06-06 |
Family
ID=60326218
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560135A Active JP7080826B2 (ja) | 2016-05-16 | 2017-05-16 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
| JP2022084888A Active JP7480220B2 (ja) | 2016-05-16 | 2022-05-25 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
| JP2024070491A Pending JP2024091896A (ja) | 2016-05-16 | 2024-04-24 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022084888A Active JP7480220B2 (ja) | 2016-05-16 | 2022-05-25 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
| JP2024070491A Pending JP2024091896A (ja) | 2016-05-16 | 2024-04-24 | カチオン性スルホンアミドアミノ脂質および両親媒性両性イオンアミノ脂質 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US10562849B2 (https=) |
| EP (1) | EP3458032A4 (https=) |
| JP (3) | JP7080826B2 (https=) |
| CN (2) | CN114656378A (https=) |
| AU (3) | AU2017267634C1 (https=) |
| CA (1) | CA3024129A1 (https=) |
| WO (1) | WO2017201076A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3024129A1 (en) * | 2016-05-16 | 2017-11-23 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
| CN109414451B (zh) * | 2016-05-16 | 2022-08-12 | 德克萨斯大学系统董事会 | 用于作为纳米粒递送tRNA的组合物及其使用方法 |
| JP7074843B6 (ja) | 2017-08-30 | 2023-12-26 | エコラボ ユーエスエー インコーポレイティド | １つの疎水基と２つの同一の親水性イオン基とを有する分子、およびその組成物 |
| WO2019133190A1 (en) * | 2017-12-29 | 2019-07-04 | Texas Tech University System | High efficient delivery of plasmid dna into human and vertebrate primary cells in vitro and in vivo by nanocomplexes |
| US11058111B2 (en) | 2018-08-29 | 2021-07-13 | Ecolab Usa Inc. | Use of multiple charged cationic compounds derived from primary amines or polyamines for microbial fouling control in a water system |
| CA3110365C (en) | 2018-08-29 | 2023-05-09 | Ecolab Usa Inc. | Use of multiple charged ionic compounds derived from polyamines for waste water clarification |
| AU2019327459C1 (en) | 2018-08-29 | 2023-06-01 | Ecolab Usa Inc. | Multiple charged ionic compounds derived from polyamines and compositions thereof and use thereof as reverse emulsion breakers in oil and gas operations |
| CA3110686C (en) | 2018-08-29 | 2025-11-04 | Ecolab Usa Inc. | IONIC COMPOUNDS WITH MULTIPLE CHARGES DERIVED FROM POLYAMINES AND COMPOSITIONS BASED ON THESE COMPOUNDS AND ASSOCIATED PREPARATION PROCESSES |
| US11084974B2 (en) | 2018-08-29 | 2021-08-10 | Championx Usa Inc. | Use of multiple charged cationic compounds derived from polyamines for clay stabilization in oil and gas operations |
| EP3897143A1 (en) | 2019-01-29 | 2021-10-27 | Ecolab USA Inc. | Use of cationic sugar-based compounds for microbial fouling control in a water system |
| CN113840945B (zh) | 2019-04-16 | 2023-09-26 | 埃科莱布美国股份有限公司 | 衍生自多胺的带多个电荷的阳离子化合物及其组合物用于水系统中的腐蚀抑制的用途 |
| KR20220044816A (ko) * | 2019-08-12 | 2022-04-11 | 인티그레이티드 나노테라퓨틱스 아이엔씨. | 하전 물질 전달을 위한 지질, 이의 제형 및 그 제조 방법 |
| CA3180101A1 (en) | 2020-05-29 | 2021-12-02 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods relating thereto |
| CA3182026A1 (en) | 2020-05-29 | 2021-12-02 | Flagship Pioneering Innovations Vi, Llc. | Trem compositions and methods relating thereto |
| AU2021327782A1 (en) * | 2020-08-21 | 2023-03-23 | The Board Of Regents Of The University Of Texas System | Functional ionizable phospholipids |
| MX2023003345A (es) * | 2020-09-23 | 2023-07-24 | Translate Bio Inc | Lípidos catiónicos basados en tes. |
| IL303886A (en) | 2020-12-23 | 2023-08-01 | Flagship Pioneering Inc | Compositions of modified trems and uses thereof |
| JP2024511463A (ja) | 2021-03-22 | 2024-03-13 | リコード セラピューティクス，インク． | 細胞への標的送達のための組成物および方法 |
| JP2024511437A (ja) | 2021-03-23 | 2024-03-13 | リコード セラピューティクス，インク． | ポリヌクレオチド組成物、関連製剤、およびその使用方法 |
| US12104181B2 (en) | 2021-03-31 | 2024-10-01 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections targeting TRIM7 |
| JP2024520834A (ja) | 2021-06-09 | 2024-05-24 | レコード・セラピューティクス・インコーポレイテッド | ポリヌクレオチド組成物、関連する製剤及びその使用方法 |
| WO2023009547A1 (en) | 2021-07-26 | 2023-02-02 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and uses thereof |
| CN113461577B (zh) * | 2021-09-01 | 2021-12-14 | 中山大学附属第七医院(深圳) | 一种氨基脂质及其应用 |
| CN113816991B (zh) * | 2021-10-17 | 2023-12-15 | 拓新药业集团股份有限公司 | 一种氯化磷酸胆碱钙的制备方法 |
| US20250295687A1 (en) | 2022-05-09 | 2025-09-25 | Flagship Pioneering Innovations Vi, Llc | Trem compositions and methods of use for treating proliferative disorders |
| JP2025518282A (ja) * | 2022-06-03 | 2025-06-12 | バイオ－トリップ ベーフェー | 核酸送達のための多価分子に基づく脂質ナノ粒子 |
| US20250179492A1 (en) | 2022-06-22 | 2025-06-05 | Flagship Pioneering Innovations Vi, Llc | Compositions of modified trems and uses thereof |
| EP4569112A1 (en) | 2022-08-12 | 2025-06-18 | Remix Therapeutics Inc. | Methods and compositions for modulating splicing at alternative splice sites |
| JP2025534494A (ja) | 2022-12-23 | 2025-10-15 | グリーン・クロス・コーポレイション | イオン化可能な脂質及びその使用 |
| WO2024216191A1 (en) | 2023-04-12 | 2024-10-17 | Flagship Pioneering Innovations Vi, Llc | Modified trems, compositions, and related methods thereof |
| WO2024216128A1 (en) | 2023-04-12 | 2024-10-17 | Flagship Pioneering Innovations Vi, Llc | Trems for use in correction of missense mutations |
| WO2024216243A2 (en) * | 2023-04-14 | 2024-10-17 | The Johns Hopkins University | Peptide-based vaccines and methods for treatment |
| WO2025059107A1 (en) * | 2023-09-11 | 2025-03-20 | The Trustees Of The University Of Pennsylvania | Degradable, branched lipid compounds, methods of preparation thereof, lipid nanoparticles (lnps) comprising the same, and methods of use thereof |
| WO2025080867A1 (en) * | 2023-10-10 | 2025-04-17 | The Board Of Regents Of The University Of Texas System | Ionizable lipids for improved mrna delivery |
| WO2025084582A1 (ko) * | 2023-10-19 | 2025-04-24 | 주식회사 삼양홀딩스 | 양이온성 지질 및 이의 제조방법 |
| TW202525812A (zh) | 2023-10-24 | 2025-07-01 | 南韓商綠十字股份有限公司 | 可離子化脂質及其用途 |
| AR134145A1 (es) | 2023-10-24 | 2025-12-03 | Green Cross Corp | Lípidos ionizables y sus usos |
| CN117482066B (zh) * | 2023-11-02 | 2024-08-13 | 深圳市易瑞生物技术股份有限公司 | 脂质组合物和用于脂质组合物的化合物 |
| WO2025097659A1 (en) * | 2023-11-08 | 2025-05-15 | Longuide Biopharma Corporation | Lipids and lipid nanoparticle formulations |
| CN118930449A (zh) * | 2024-07-18 | 2024-11-12 | 深圳厚存纳米药业有限公司 | 一种脂质化合物、脂质纳米粒及其制备方法和应用 |
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