JP2019511483A - 免疫療法のためのｓｔｉｎｇ活性化ナノワクチン - Google Patents

免疫療法のためのｓｔｉｎｇ活性化ナノワクチン Download PDF

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JP2019511483A
JP2019511483A JP2018545910A JP2018545910A JP2019511483A JP 2019511483 A JP2019511483 A JP 2019511483A JP 2018545910 A JP2018545910 A JP 2018545910A JP 2018545910 A JP2018545910 A JP 2018545910A JP 2019511483 A JP2019511483 A JP 2019511483A
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antigen
composition
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substituted
cycloalkyl
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JP2019511483A5 (https=
Inventor
ジンミン ガオ
ジンミン ガオ
ジーチアン チェン
ジーチアン チェン
ミン ルオ
ミン ルオ
チャオホイ ワン
チャオホイ ワン
ホワ ワン
ホワ ワン
ハオチェン カイ
ハオチェン カイ
ガン ファン
ガン ファン
ヤン−シン フー
ヤン−シン フー
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University of Texas System
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University of Texas System
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
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    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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JP2018545910A 2016-03-02 2017-03-02 免疫療法のためのｓｔｉｎｇ活性化ナノワクチン Pending JP2019511483A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662302637P 2016-03-02 2016-03-02
US62/302,637 2016-03-02
PCT/US2017/020451 WO2017151922A1 (en) 2016-03-02 2017-03-02 Sting activating nanovaccine for immunotherapy

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JP2019511483A true JP2019511483A (ja) 2019-04-25
JP2019511483A5 JP2019511483A5 (https=) 2020-04-09

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US (1) US11376324B2 (https=)
EP (1) EP3423044A4 (https=)
JP (1) JP2019511483A (https=)
KR (1) KR20180114946A (https=)
CN (1) CN109069440A (https=)
AU (1) AU2017225769B2 (https=)
CA (1) CA3016457A1 (https=)
MX (1) MX2018010586A (https=)
WO (1) WO2017151922A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2022534497A (ja) * 2019-05-28 2022-08-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ｐＨ応答性組成物およびその使用法
JP2023502998A (ja) * 2019-11-18 2023-01-26 オンコナノ・メディスン・インコーポレイテッド ｐＨ応答性組成物、製剤、及び腫瘍画像化の方法
JP2023546316A (ja) * 2020-09-08 2023-11-02 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 多価ｓｔｉｎｇ活性化組成物およびその使用法
JP2025504688A (ja) * 2022-01-26 2025-02-14 ピンサン トランスレーショナル メディシン センター シェンチェン ベイ ラボラトリー 腫瘍免疫療法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ746112A (en) 2016-03-18 2023-01-27 Immune Sensor Llc Cyclic di-nucleotide compounds and methods of use
IL264049B2 (en) 2016-07-06 2023-11-01 Sperovie Biosciences Inc Compounds, preparations and methods for treating the disease
WO2019046511A1 (en) 2017-08-31 2019-03-07 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
US11707531B2 (en) 2017-09-11 2023-07-25 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
US11584774B2 (en) 2017-09-11 2023-02-21 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
US20210177964A1 (en) * 2017-11-06 2021-06-17 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
WO2019136118A2 (en) * 2018-01-04 2019-07-11 Academia Sinica Cell-associating immunologic adjuvants for treatment enhancement
WO2019145475A2 (en) 2018-01-25 2019-08-01 Acm Biolabs Pte Ltd Polymersomes comprising a soluble encapsulated antigen as well as methods of making and uses thereof
EP3743103A4 (en) * 2018-01-26 2021-03-17 The Regents of The University of California INTRANASAL ADMINISTRATION OF CYCLIC DI-NUCLEOTIDE ADJUVED VACCINE FOR TUBERCULOSIS
JP7570235B2 (ja) 2018-05-25 2024-10-21 インサイト・コーポレイション Ｓｔｉｎｇ活性化剤としての三環式複素環式化合物
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
WO2020014127A1 (en) 2018-07-10 2020-01-16 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
WO2020028566A1 (en) 2018-07-31 2020-02-06 Incyte Corporation Heteroaryl amide compounds as sting activators
US11008344B2 (en) 2018-07-31 2021-05-18 Incyte Corporation Tricyclic heteroaryl compounds as STING activators
CN109453364B (zh) * 2018-09-30 2021-10-15 郑州大学第一附属医院 一种双重响应性纳米颗粒及其在肿瘤抑制中的应用
US11596692B1 (en) 2018-11-21 2023-03-07 Incyte Corporation PD-L1/STING conjugates and methods of use
WO2020146237A1 (en) 2019-01-07 2020-07-16 Incyte Corporation Heteroaryl amide compounds as sting activators
EP3934757B1 (en) * 2019-03-07 2023-02-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
JP7676331B2 (ja) 2019-06-22 2025-05-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 生分解性超ｐＨ感受性ポリマー
KR102769095B1 (ko) * 2019-11-07 2025-02-18 주식회사 삼양홀딩스 면역유도용 고분자 나노입자 조성물 및 그 제조방법
GB201918963D0 (en) 2019-12-20 2020-02-05 Provost Fellows Scholars And Other Members Of Board Of Trinity College Dublin Polymeric nanoparticles as vaccine adjuvants
CN111184738B (zh) * 2020-03-04 2021-05-28 北京大学 一种二嵌段共聚物或其药学上可接受的盐在制备抗病毒药物中的应用、药物组合物
CN113577255B (zh) * 2020-04-30 2023-09-08 中国科学院上海药物研究所 肿瘤纳米疫苗、其制备方法及用途
CA3197125A1 (en) * 2020-11-03 2022-05-12 Tian ZHAO Therapeutic ph responsive compositions
US20250127921A1 (en) * 2021-08-10 2025-04-24 Wisconsin Alumni Research Foundation Ph-responsive nano particle for delivery of ribonucleoproteins
CN114456331A (zh) * 2022-02-16 2022-05-10 北京大学 能够与膜结合的聚合物及其制备方法和用途
WO2024226815A2 (en) * 2023-04-28 2024-10-31 University Of Washington B-cell epitopes of treponema pallidum antigens for use in a syphilis vaccine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543489A (ja) * 2010-09-22 2013-12-05 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 新規ブロックコポリマーおよびミセル組成物ならびにその使用法
WO2015188157A1 (en) * 2014-06-06 2015-12-10 The Board Of Regents Of The University Of Texas System Library of ph responsive polymers and nanoprobes thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520019A (en) 1982-04-29 1985-05-28 Ribi Immunochem Research, Inc. Stable composition and preparation thereof
US4579945A (en) 1982-04-29 1986-04-01 Ribi Immunochem Research, Inc. Purification of trehalose dimycolates
US4435386A (en) 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4505900A (en) 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4505899A (en) 1982-05-26 1985-03-19 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US4950645A (en) 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
US5416070A (en) 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
US5980912A (en) 1997-03-25 1999-11-09 Zonagen, Inc. Chitosan induced immunopotentiation
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
PL360944A1 (en) 2000-10-12 2004-09-20 Merck & Co, Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
CN1370601A (zh) * 2001-02-22 2002-09-25 中国科学院成都有机化学研究所 单剂基因工程乙肝疫苗缓释微球的制备方法
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
CA2492160A1 (en) * 2002-07-12 2004-01-22 The Johns Hopkins University Mesothelin vaccines and model systems
ES2259914B1 (es) * 2005-03-14 2007-06-16 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de quitosano y polietilenglicol como sistema de administracion de moleculas biologicamente activas.
WO2006122223A2 (en) * 2005-05-10 2006-11-16 Emory University Strategies for delivery of active agents using micelles and particles
WO2008117313A1 (en) 2007-03-28 2008-10-02 National Institute Of Immunology Polymer particles based vaccine
EP2167480A2 (en) 2007-05-23 2010-03-31 Vical Incorporated Cationic lipids compositions and methods for enhancing immune responses to vaccines
US9532956B2 (en) * 2009-04-18 2017-01-03 Massachusetts Institute Of Technology PH sensitive biodegradable polymeric particles for drug delivery
BRPI1012036A2 (pt) * 2009-05-27 2017-10-10 Selecta Biosciences Inc nanocarreadores que possuem componentes com diferentes taxas de liberação
US20140308363A1 (en) * 2011-05-31 2014-10-16 Bind Therapeutics, Inc. Drug loaded polymeric nanoparticles and methods of making and using same
US9511152B2 (en) * 2012-04-05 2016-12-06 The Board Of Regents Of The University Of Texas System Multicolored pH-activatable fluorescence nanoplatform
US9695212B2 (en) * 2012-12-13 2017-07-04 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
EP3083556B1 (en) 2013-12-19 2019-12-25 Novartis AG Lipids and lipid compositions for the delivery of active agents
WO2017048789A1 (en) * 2015-09-14 2017-03-23 The Board Of Regents Of The University Of Texas System Lipocationic dendrimers and uses thereof
CN105214097A (zh) * 2015-10-30 2016-01-06 中国科学院福建物质结构研究所 一种口服纳米疫苗运载体的免疫实施与检测技术
US11096899B2 (en) * 2018-09-07 2021-08-24 Wisconsin Alumni Research Foundation Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543489A (ja) * 2010-09-22 2013-12-05 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 新規ブロックコポリマーおよびミセル組成物ならびにその使用法
WO2015188157A1 (en) * 2014-06-06 2015-12-10 The Board Of Regents Of The University Of Texas System Library of ph responsive polymers and nanoprobes thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOMACROMOLECULES, vol. 16, JPN6021009051, 2015, pages 3103 - 3111, ISSN: 0004839520 *
J.AM.CHEM.SOC., vol. 134, JPN6021009047, 2012, pages 7803 - 7811, ISSN: 0004839521 *
J.AM.CHEM.SOC., vol. 136, JPN6021009050, 2014, pages 11085 - 11092, ISSN: 0004463955 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534497A (ja) * 2019-05-28 2022-08-01 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ｐＨ応答性組成物およびその使用法
JP2023502998A (ja) * 2019-11-18 2023-01-26 オンコナノ・メディスン・インコーポレイテッド ｐＨ応答性組成物、製剤、及び腫瘍画像化の方法
JP7752110B2 (ja) 2019-11-18 2025-10-09 オンコナノ・メディスン・インコーポレイテッド ｐＨ応答性組成物、製剤、及び腫瘍画像化の方法
JP2023546316A (ja) * 2020-09-08 2023-11-02 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 多価ｓｔｉｎｇ活性化組成物およびその使用法
JP2025504688A (ja) * 2022-01-26 2025-02-14 ピンサン トランスレーショナル メディシン センター シェンチェン ベイ ラボラトリー 腫瘍免疫療法

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