JP2017186337A5 - - Google Patents
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- JP2017186337A5 JP2017186337A5 JP2017073900A JP2017073900A JP2017186337A5 JP 2017186337 A5 JP2017186337 A5 JP 2017186337A5 JP 2017073900 A JP2017073900 A JP 2017073900A JP 2017073900 A JP2017073900 A JP 2017073900A JP 2017186337 A5 JP2017186337 A5 JP 2017186337A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- chain variable
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723772P | 2012-11-07 | 2012-11-07 | |
| US61/723,772 | 2012-11-07 | ||
| US201361889744P | 2013-10-11 | 2013-10-11 | |
| US61/889,744 | 2013-10-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540262A Division JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017186337A JP2017186337A (ja) | 2017-10-12 |
| JP2017186337A5 true JP2017186337A5 (https=) | 2017-11-24 |
Family
ID=49585464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540262A Pending JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
| JP2017073900A Withdrawn JP2017186337A (ja) | 2012-11-07 | 2017-04-03 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540262A Pending JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9433687B2 (https=) |
| EP (1) | EP2917240A1 (https=) |
| JP (2) | JP2016505513A (https=) |
| KR (1) | KR20150082548A (https=) |
| CN (1) | CN104903351A (https=) |
| AR (1) | AR093377A1 (https=) |
| AU (1) | AU2013343045A1 (https=) |
| BR (1) | BR112015010436A2 (https=) |
| CA (1) | CA2890571A1 (https=) |
| HK (1) | HK1214282A1 (https=) |
| IL (1) | IL238567A0 (https=) |
| MX (1) | MX2015005810A (https=) |
| PE (1) | PE20150892A1 (https=) |
| PH (1) | PH12015501000A1 (https=) |
| RU (1) | RU2015116480A (https=) |
| SA (1) | SA515360395B1 (https=) |
| SG (1) | SG11201503469WA (https=) |
| TW (3) | TWI589590B (https=) |
| WO (1) | WO2014072897A1 (https=) |
Families Citing this family (81)
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| US9339278B2 (en) | 2006-02-27 | 2016-05-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
| US8092465B2 (en) | 2006-06-09 | 2012-01-10 | Biomet Manufacturing Corp. | Patient specific knee alignment guide and associated method |
| US8608748B2 (en) | 2006-02-27 | 2013-12-17 | Biomet Manufacturing, Llc | Patient specific guides |
| US9918740B2 (en) | 2006-02-27 | 2018-03-20 | Biomet Manufacturing, Llc | Backup surgical instrument system and method |
| US9113971B2 (en) | 2006-02-27 | 2015-08-25 | Biomet Manufacturing, Llc | Femoral acetabular impingement guide |
| US8535387B2 (en) | 2006-02-27 | 2013-09-17 | Biomet Manufacturing, Llc | Patient-specific tools and implants |
| US9173661B2 (en) | 2006-02-27 | 2015-11-03 | Biomet Manufacturing, Llc | Patient specific alignment guide with cutting surface and laser indicator |
| US8568487B2 (en) | 2006-02-27 | 2013-10-29 | Biomet Manufacturing, Llc | Patient-specific hip joint devices |
| US8591516B2 (en) | 2006-02-27 | 2013-11-26 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
| US8603180B2 (en) | 2006-02-27 | 2013-12-10 | Biomet Manufacturing, Llc | Patient-specific acetabular alignment guides |
| US8407067B2 (en) | 2007-04-17 | 2013-03-26 | Biomet Manufacturing Corp. | Method and apparatus for manufacturing an implant |
| US10278711B2 (en) | 2006-02-27 | 2019-05-07 | Biomet Manufacturing, Llc | Patient-specific femoral guide |
| US7967868B2 (en) | 2007-04-17 | 2011-06-28 | Biomet Manufacturing Corp. | Patient-modified implant and associated method |
| US20150335438A1 (en) | 2006-02-27 | 2015-11-26 | Biomet Manufacturing, Llc. | Patient-specific augments |
| US8377066B2 (en) | 2006-02-27 | 2013-02-19 | Biomet Manufacturing Corp. | Patient-specific elbow guides and associated methods |
| US9907659B2 (en) | 2007-04-17 | 2018-03-06 | Biomet Manufacturing, Llc | Method and apparatus for manufacturing an implant |
| US8608749B2 (en) | 2006-02-27 | 2013-12-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
| US9345548B2 (en) | 2006-02-27 | 2016-05-24 | Biomet Manufacturing, Llc | Patient-specific pre-operative planning |
| US9289253B2 (en) | 2006-02-27 | 2016-03-22 | Biomet Manufacturing, Llc | Patient-specific shoulder guide |
| US9795399B2 (en) | 2006-06-09 | 2017-10-24 | Biomet Manufacturing, Llc | Patient-specific knee alignment guide and associated method |
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| US8632547B2 (en) | 2010-02-26 | 2014-01-21 | Biomet Sports Medicine, Llc | Patient-specific osteotomy devices and methods |
| US9271744B2 (en) | 2010-09-29 | 2016-03-01 | Biomet Manufacturing, Llc | Patient-specific guide for partial acetabular socket replacement |
| US8420338B2 (en) | 2010-11-05 | 2013-04-16 | University Of Medicine And Dentistry Of New Jersey | Serum MG53 as a diagnostic marker for tissue injury |
| US9968376B2 (en) | 2010-11-29 | 2018-05-15 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
| US9241745B2 (en) | 2011-03-07 | 2016-01-26 | Biomet Manufacturing, Llc | Patient-specific femoral version guide |
| US8715289B2 (en) | 2011-04-15 | 2014-05-06 | Biomet Manufacturing, Llc | Patient-specific numerically controlled instrument |
| US8668700B2 (en) | 2011-04-29 | 2014-03-11 | Biomet Manufacturing, Llc | Patient-specific convertible guides |
| US8956364B2 (en) | 2011-04-29 | 2015-02-17 | Biomet Manufacturing, Llc | Patient-specific partial knee guides and other instruments |
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| US8532807B2 (en) | 2011-06-06 | 2013-09-10 | Biomet Manufacturing, Llc | Pre-operative planning and manufacturing method for orthopedic procedure |
| US9084618B2 (en) | 2011-06-13 | 2015-07-21 | Biomet Manufacturing, Llc | Drill guides for confirming alignment of patient-specific alignment guides |
| US8764760B2 (en) | 2011-07-01 | 2014-07-01 | Biomet Manufacturing, Llc | Patient-specific bone-cutting guidance instruments and methods |
| US8597365B2 (en) | 2011-08-04 | 2013-12-03 | Biomet Manufacturing, Llc | Patient-specific pelvic implants for acetabular reconstruction |
| US9066734B2 (en) | 2011-08-31 | 2015-06-30 | Biomet Manufacturing, Llc | Patient-specific sacroiliac guides and associated methods |
| US9295497B2 (en) | 2011-08-31 | 2016-03-29 | Biomet Manufacturing, Llc | Patient-specific sacroiliac and pedicle guides |
| US9386993B2 (en) | 2011-09-29 | 2016-07-12 | Biomet Manufacturing, Llc | Patient-specific femoroacetabular impingement instruments and methods |
| US9554910B2 (en) | 2011-10-27 | 2017-01-31 | Biomet Manufacturing, Llc | Patient-specific glenoid guide and implants |
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| US9451973B2 (en) | 2011-10-27 | 2016-09-27 | Biomet Manufacturing, Llc | Patient specific glenoid guide |
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| US9060788B2 (en) | 2012-12-11 | 2015-06-23 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
| US9204977B2 (en) | 2012-12-11 | 2015-12-08 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
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| US9839438B2 (en) | 2013-03-11 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid guide with a reusable guide holder |
| US9579107B2 (en) | 2013-03-12 | 2017-02-28 | Biomet Manufacturing, Llc | Multi-point fit for patient specific guide |
| US9498233B2 (en) | 2013-03-13 | 2016-11-22 | Biomet Manufacturing, Llc. | Universal acetabular guide and associated hardware |
| US9826981B2 (en) | 2013-03-13 | 2017-11-28 | Biomet Manufacturing, Llc | Tangential fit of patient-specific guides |
| EP3611189A1 (en) * | 2013-03-14 | 2020-02-19 | Novartis AG | Antibodies against notch 3 |
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| US9517145B2 (en) | 2013-03-15 | 2016-12-13 | Biomet Manufacturing, Llc | Guide alignment system and method |
| US20150112349A1 (en) | 2013-10-21 | 2015-04-23 | Biomet Manufacturing, Llc | Ligament Guide Registration |
| US10282488B2 (en) | 2014-04-25 | 2019-05-07 | Biomet Manufacturing, Llc | HTO guide with optional guided ACL/PCL tunnels |
| US9408616B2 (en) | 2014-05-12 | 2016-08-09 | Biomet Manufacturing, Llc | Humeral cut guide |
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| US9839436B2 (en) | 2014-06-03 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid depth control |
| US9561040B2 (en) | 2014-06-03 | 2017-02-07 | Biomet Manufacturing, Llc | Patient-specific glenoid depth control |
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| US9833245B2 (en) | 2014-09-29 | 2017-12-05 | Biomet Sports Medicine, Llc | Tibial tubercule osteotomy |
| US9826994B2 (en) | 2014-09-29 | 2017-11-28 | Biomet Manufacturing, Llc | Adjustable glenoid pin insertion guide |
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| US9820868B2 (en) | 2015-03-30 | 2017-11-21 | Biomet Manufacturing, Llc | Method and apparatus for a pin apparatus |
| US10226262B2 (en) | 2015-06-25 | 2019-03-12 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
| US10568647B2 (en) | 2015-06-25 | 2020-02-25 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
| US11661438B2 (en) * | 2015-12-21 | 2023-05-30 | Pfizer, Inc. | Purification of antibody drug conjugates using a sodium phosphate gradient |
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| US10858443B2 (en) | 2017-05-31 | 2020-12-08 | Trustees Of Boston University | Synthetic notch protein for modulating gene expression |
| AU2018383709B2 (en) | 2017-12-12 | 2025-09-11 | Pionyr Immunotherapeutics, Inc. | Anti-TREM2 antibodies and related methods |
| CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
| WO2019242505A1 (zh) | 2018-06-17 | 2019-12-26 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用 |
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| US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
| AU2011342799B2 (en) | 2010-12-15 | 2016-06-09 | Wyeth Llc | Anti-Notch1 antibodies |
| WO2012080891A1 (en) | 2010-12-15 | 2012-06-21 | Rinat Neuroscience Corp. | Anti-notch-1 antibodies |
| WO2012112792A2 (en) | 2011-02-17 | 2012-08-23 | The Administrators Of The Tulane Educational Fund | Multicomponent compositions and their uses |
| WO2012131527A1 (en) * | 2011-04-01 | 2012-10-04 | Wyeth Llc | Antibody-drug conjugates |
| CN104185477B (zh) * | 2011-11-17 | 2017-05-24 | 辉瑞公司 | 细胞毒性肽及其抗体‑药物缀合物 |
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
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2013
- 2013-11-04 CA CA2890571A patent/CA2890571A1/en active Pending
- 2013-11-04 AU AU2013343045A patent/AU2013343045A1/en not_active Abandoned
- 2013-11-04 TW TW104121691A patent/TWI589590B/zh not_active IP Right Cessation
- 2013-11-04 MX MX2015005810A patent/MX2015005810A/es unknown
- 2013-11-04 TW TW106112626A patent/TW201726746A/zh unknown
- 2013-11-04 KR KR1020157015019A patent/KR20150082548A/ko not_active Abandoned
- 2013-11-04 BR BR112015010436A patent/BR112015010436A2/pt not_active IP Right Cessation
- 2013-11-04 WO PCT/IB2013/059893 patent/WO2014072897A1/en not_active Ceased
- 2013-11-04 HK HK16102254.9A patent/HK1214282A1/zh unknown
- 2013-11-04 SG SG11201503469WA patent/SG11201503469WA/en unknown
- 2013-11-04 RU RU2015116480A patent/RU2015116480A/ru not_active Application Discontinuation
- 2013-11-04 TW TW102139960A patent/TW201431880A/zh unknown
- 2013-11-04 EP EP13792099.7A patent/EP2917240A1/en not_active Ceased
- 2013-11-04 JP JP2015540262A patent/JP2016505513A/ja active Pending
- 2013-11-04 CN CN201380069303.2A patent/CN104903351A/zh active Pending
- 2013-11-04 PE PE2015000604A patent/PE20150892A1/es not_active Application Discontinuation
- 2013-11-06 US US14/073,273 patent/US9433687B2/en not_active Expired - Fee Related
- 2013-11-06 AR ARP130104060A patent/AR093377A1/es unknown
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2015
- 2015-04-30 IL IL238567A patent/IL238567A0/en unknown
- 2015-05-05 PH PH12015501000A patent/PH12015501000A1/en unknown
- 2015-05-06 SA SA515360395A patent/SA515360395B1/ar unknown
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2016
- 2016-07-27 US US15/221,049 patent/US20170014526A1/en not_active Abandoned
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2017
- 2017-04-03 JP JP2017073900A patent/JP2017186337A/ja not_active Withdrawn
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