|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
US4698420A
(en)
|
1985-02-25 |
1987-10-06 |
Xoma Corporation |
Antibody hybrid molecules and process for their preparation
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
TW552261B
(en)
|
1996-07-03 |
2003-09-11 |
Japan Energy Corp |
Novel purine derivative
|
|
ZA977103B
(en)
*
|
1996-08-09 |
1999-02-08 |
Eisai Co Ltd |
Benzopiperidine derivatives
|
|
TW572758B
(en)
|
1997-12-22 |
2004-01-21 |
Sumitomo Pharma |
Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
|
|
US7425541B2
(en)
|
1998-12-11 |
2008-09-16 |
Medarex, Inc. |
Enzyme-cleavable prodrug compounds
|
|
CN102766210B
(zh)
|
1999-08-24 |
2015-07-08 |
E.R.施贵宝&圣斯有限责任公司 |
人ctla-4抗体及其应用
|
|
US7402556B2
(en)
|
2000-08-24 |
2008-07-22 |
Medarex, Inc. |
Prodrugs activated by plasmin and their use in cancer chemotherapy
|
|
JP4331944B2
(ja)
|
2001-04-17 |
2009-09-16 |
大日本住友製薬株式会社 |
新規アデニン誘導体
|
|
US7087600B2
(en)
|
2001-05-31 |
2006-08-08 |
Medarex, Inc. |
Peptidyl prodrugs and linkers and stabilizers useful therefor
|
|
US6897034B2
(en)
|
2001-06-11 |
2005-05-24 |
Medarex, Inc. |
CD10-activated prodrug compounds
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
EP1440072A4
(en)
|
2001-10-30 |
2005-02-02 |
Conforma Therapeutic Corp |
PURINE ANALOGS HAVING HSP90 INHIBITORY ACTIVITY
|
|
JP4562395B2
(ja)
|
2002-01-09 |
2010-10-13 |
メダレックス, インク. |
Cd30に対するヒトモノクローナル抗体
|
|
KR101111085B1
(ko)
|
2002-09-27 |
2012-04-12 |
다이닛본 스미토모 세이야꾸 가부시끼가이샤 |
신규 아데닌 화합물 및 그 용도
|
|
JP2004137157A
(ja)
|
2002-10-16 |
2004-05-13 |
Sumitomo Pharmaceut Co Ltd |
新規アデニン誘導体を有効成分として含有する医薬
|
|
TW200510454A
(en)
|
2003-04-15 |
2005-03-16 |
Smithkline Beecham Corp |
Conjugates comprising human IL-18 and substitution mutants thereof
|
|
JP4680902B2
(ja)
|
2003-07-22 |
2011-05-11 |
バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト |
Rg1抗体及びその使用
|
|
WO2005051976A2
(en)
|
2003-11-20 |
2005-06-09 |
Ansata Therapeutics, Inc. |
Protein and peptide ligation processes and one-step purification processes
|
|
KR101374514B1
(ko)
|
2003-12-10 |
2014-03-13 |
메다렉스, 인코포레이티드 |
Ip―10 항체 및 그의 용도
|
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
WO2005092925A2
(en)
|
2004-03-24 |
2005-10-06 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
|
EP1728792A4
(en)
|
2004-03-26 |
2010-12-15 |
Dainippon Sumitomo Pharma Co |
8-OXOADENINVERBINDUNG
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
US7517903B2
(en)
|
2004-05-19 |
2009-04-14 |
Medarex, Inc. |
Cytotoxic compounds and conjugates
|
|
ES2579805T3
(es)
|
2004-09-23 |
2016-08-16 |
Genentech, Inc. |
Anticuerpos y conjugados modificados por ingeniería genética con cisteína
|
|
CN101160324B
(zh)
|
2005-02-18 |
2013-04-24 |
米德列斯公司 |
缺乏岩藻糖残基的抗前列腺特异性膜抗原(psma)单克隆抗体
|
|
MX2007009878A
(es)
|
2005-02-18 |
2007-10-03 |
Medarex Inc |
Anticuerpos monoclonales para antigeno de membrana especifica para prostata (amep).
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
MX2007013780A
(es)
|
2005-05-04 |
2008-02-05 |
Pfizer Ltd |
Derivados 2 amido-6-amino-8-oxo purina como moduladores del receptor como tipo peaje (toll) para el tratamiento del cancer y las infecciones virales tal como la hepatitis c.
|
|
PL2161336T5
(pl)
|
2005-05-09 |
2017-10-31 |
Ono Pharmaceutical Co |
Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
|
|
CA2612241C
(en)
|
2005-07-01 |
2018-11-06 |
Medarex, Inc. |
Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
|
|
SI1912671T1
(en)
|
2005-07-18 |
2018-01-31 |
Seattle Genetics, Inc. |
Conjugates beta-glucuronide linker-drug
|
|
US20090105212A1
(en)
|
2005-09-22 |
2009-04-23 |
Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan |
Novel adenine compound
|
|
US20090118263A1
(en)
|
2005-09-22 |
2009-05-07 |
Dainippon Sumitomo Pharma Co., Ltd. |
Novel Adenine Compound
|
|
AU2006294554B2
(en)
|
2005-09-26 |
2013-03-21 |
E. R. Squibb & Sons, L.L.C. |
Antibody-drug conjugates and methods of use
|
|
NZ566395A
(en)
|
2005-09-26 |
2012-03-30 |
Medarex Inc |
Human monoclonal antibodies to CD70
|
|
CN101365679B
(zh)
|
2005-10-26 |
2012-11-14 |
梅达莱克斯公司 |
制备cc-1065类似物的方法和化合物
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
AU2006321841C1
(en)
|
2005-12-08 |
2013-01-24 |
E. R. Squibb & Sons, L.L.C. |
Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use
|
|
NZ568015A
(en)
|
2005-12-08 |
2012-03-30 |
Medarex Inc |
Human monoclonal antibodies to O8E
|
|
AU2007325952B8
(en)
|
2006-06-29 |
2013-06-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Cell-free synthesis of proteins containing unnatural amino acids
|
|
EP2054436A1
(en)
|
2006-08-18 |
2009-05-06 |
Novo Nordisk Health Care AG |
Transglutaminase variants with improved specificity
|
|
US20100093082A1
(en)
|
2006-09-08 |
2010-04-15 |
Ambrx, Inc. |
Site Specific Incorporation of Non-Natural Amino Acids by Vertebrate Cells
|
|
ES2625798T3
(es)
|
2006-10-02 |
2017-07-20 |
E. R. Squibb & Sons, L.L.C. |
Anticuerpos humanos que se unen a CXCR4 y usos de los mismos
|
|
EP2097097B1
(en)
|
2006-12-01 |
2018-05-30 |
E. R. Squibb & Sons, L.L.C. |
Antibodies, in particular human antibodies, that bind cd22 and uses thereof
|
|
UY30776A1
(es)
|
2006-12-21 |
2008-07-03 |
Medarex Inc |
Anticuerpos cd44
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
ES2456964T3
(es)
|
2007-02-07 |
2014-04-24 |
The Regents Of The University Of California |
Conjugados de agonistas de TLR sintéticos y usos de los mismos
|
|
KR20090122439A
(ko)
|
2007-02-21 |
2009-11-30 |
메다렉스, 인코포레이티드 |
단일 아미노산을 갖는 화학적 링커 및 이의 접합체
|
|
JP2010518842A
(ja)
|
2007-02-22 |
2010-06-03 |
ノボ ノルディスク ヘルス ケア アーゲー |
改善された特異性を有するトランスグルタミナーゼ変異体
|
|
AR065784A1
(es)
|
2007-03-20 |
2009-07-01 |
Dainippon Sumitomo Pharma Co |
Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
|
|
SI2170888T1
(sl)
*
|
2007-06-29 |
2015-10-30 |
Gilead Sciences, Inc. |
Purinski derivati in njihova uporaba kot modulatorjev receptorja tipa toll-7
|
|
EP2185188B1
(en)
|
2007-08-22 |
2014-08-06 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
|
|
SI2195017T1
(sl)
|
2007-10-01 |
2015-01-30 |
Bristol-Myers Squibb Company |
Človeška protitelesa, ki vežejo mezotelin in njihova uporaba
|
|
AU2009333559B2
(en)
|
2008-12-09 |
2015-03-12 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors
|
|
WO2010087994A2
(en)
|
2009-01-30 |
2010-08-05 |
Whitehead Institute For Biomedical Research |
Methods for ligation and uses thereof
|
|
WO2010093436A2
(en)
|
2009-02-11 |
2010-08-19 |
Carson Dennis A |
Toll-like receptor modulators and treatment of diseases
|
|
MX2012004706A
(es)
*
|
2009-10-22 |
2012-06-08 |
Gilead Sciences Inc |
Derivados de purina o deazapurina utiles para el tratamiento de (inter alia) infecciones virales.
|
|
WO2011134668A1
(en)
|
2010-04-30 |
2011-11-03 |
Telormedix Sa |
Phospholipid drug analogs
|
|
EP2563366A4
(en)
|
2010-04-30 |
2013-11-20 |
Univ California |
USE OF PHOSPHOLIPID CONJUGATES FROM SYNTHETIC TLR7 AGONISTS
|
|
EP2563401A1
(en)
|
2010-04-30 |
2013-03-06 |
Telormedix SA |
Methods for inducing an immune response
|
|
WO2012038058A1
(en)
|
2010-09-21 |
2012-03-29 |
Telormedix Sa |
Treatment of conditions by toll-like receptor modulators
|
|
CA2930801C
(en)
|
2010-11-05 |
2019-05-28 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
WO2012122396A1
(en)
|
2011-03-08 |
2012-09-13 |
Baylor Research Institute |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
|
|
US20130028857A1
(en)
|
2011-07-29 |
2013-01-31 |
Selecta Biosciences, Inc. |
Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
|
|
UA116083C2
(uk)
|
2011-11-09 |
2018-02-12 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Похідні пурину для лікування вірусних інфекцій
|
|
PT2872515T
(pt)
|
2012-07-13 |
2016-07-27 |
Janssen Sciences Ireland Uc |
Purinas macrocíclicas para o tratamento de infeções virais
|
|
EP2732825B1
(en)
|
2012-11-19 |
2015-07-01 |
Invivogen |
Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist
|
|
LT2956173T
(lt)
|
2013-02-14 |
2017-06-26 |
Bristol-Myers Squibb Company |
Tubulizino junginiai, gavimo ir panaudojimo būdai
|
|
US9295732B2
(en)
|
2013-02-22 |
2016-03-29 |
Invivogen |
Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
|
|
US20160199499A1
(en)
|
2013-08-16 |
2016-07-14 |
The Regents Of The University Of California |
Uses of phospholipid conjugates of synthetic tlr7 agonists
|
|
WO2015036044A1
(en)
|
2013-09-13 |
2015-03-19 |
Telormedix Sa |
Cationic lipid vehicles for delivery of tlr7 agonists for specific targeting of human cd14+ monocytes in whole blood
|
|
SG11201608299TA
(en)
|
2014-05-01 |
2016-11-29 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
KR102139847B1
(ko)
|
2014-05-01 |
2020-07-31 |
노파르티스 아게 |
톨-유사 수용체 7 효능제로서의 화합물 및 조성물
|
|
MX386981B
(es)
|
2014-08-15 |
2025-03-19 |
Chia Tai Tianqing Pharmaceutical Group Co Ltd |
Compuestos de pirrolopirimidina usados como agonistas del receptor de tipo toll 7 (tlr7).
|
|
CN105732635A
(zh)
|
2014-12-29 |
2016-07-06 |
南京明德新药研发股份有限公司 |
一类Toll样受体7激动剂
|
|
ES2736106T3
(es)
|
2015-03-10 |
2019-12-26 |
Bristol Myers Squibb Co |
Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos
|
|
JP2018531935A
(ja)
|
2015-10-02 |
2018-11-01 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
抗体を結合させるためのトランスグルタミナーゼバリアント
|
|
SG11201802769RA
(en)
|
2015-10-29 |
2018-05-30 |
Novartis Ag |
Antibody conjugates comprising toll-like receptor agonist
|
|
CN108349982B
(zh)
|
2015-11-05 |
2020-05-05 |
正大天晴药业集团股份有限公司 |
作为tlr7激动剂的7-(噻唑-5-基)吡咯并嘧啶化合物
|
|
US20170166384A1
(en)
|
2015-12-11 |
2017-06-15 |
Graphic Packaging International, Inc. |
Container with absorption features
|