JP2020519641A - ニューカッスル病ウイルス及びその使用 - Google Patents

ニューカッスル病ウイルス及びその使用 Download PDF

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JP2020519641A
JP2020519641A JP2019562399A JP2019562399A JP2020519641A JP 2020519641 A JP2020519641 A JP 2020519641A JP 2019562399 A JP2019562399 A JP 2019562399A JP 2019562399 A JP2019562399 A JP 2019562399A JP 2020519641 A JP2020519641 A JP 2020519641A
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ndv
cancer
antibody
amino acid
composition
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JP2020519641A5 (enExample
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パレセ ピーター
パレセ ピーター
ガルシア‐サストレ アドルフォ
ガルシア‐サストレ アドルフォ
ザマリン ドミトリー
ザマリン ドミトリー
サデコバ スベトラナ
サデコバ スベトラナ
アリソン アルツナ レイチェル
アリソン アルツナ レイチェル
プハン ウェン
プハン ウェン
ビー． ヘインズ ブライアン
ビー． ヘインズ ブライアン
ディー． ウォルチョク ジェド
ディー． ウォルチョク ジェド
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アイカーン スクール オブ メディシン アット マウント サイナイ
アイカーン スクール オブ メディシン アット マウント サイナイ
メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
メルク シャープ アンド ドーメ コープ．
メルク シャープ アンド ドーメ コープ．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18133—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18141—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
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  • Plant Pathology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019562399A 2017-05-12 2018-05-11 ニューカッスル病ウイルス及びその使用 Pending JP2020519641A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762505759P 2017-05-12 2017-05-12
US62/505,759 2017-05-12
US201762507690P 2017-05-17 2017-05-17
US62/507,690 2017-05-17
PCT/US2018/032255 WO2018209194A2 (en) 2017-05-12 2018-05-11 Newcastle disease viruses and uses thereof

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JP2020519641A true JP2020519641A (ja) 2020-07-02
JP2020519641A5 JP2020519641A5 (enExample) 2021-08-05

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US (2) US12042534B2 (enExample)
EP (1) EP3621639A2 (enExample)
JP (1) JP2020519641A (enExample)
KR (1) KR20200004408A (enExample)
CN (1) CN111246877A (enExample)
AU (2) AU2018266881A1 (enExample)
BR (1) BR112019023758A2 (enExample)
CA (1) CA3061770A1 (enExample)
CL (1) CL2019003233A1 (enExample)
CO (1) CO2019012568A2 (enExample)
EC (1) ECSP19080602A (enExample)
JO (1) JOP20190256A1 (enExample)
MA (1) MA49298A (enExample)
MX (1) MX2019013276A (enExample)
PE (1) PE20200496A1 (enExample)
PH (1) PH12019550229A1 (enExample)
TW (1) TW201900191A (enExample)
WO (1) WO2018209194A2 (enExample)

Cited By (1)

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JP2024516370A (ja) * 2021-04-13 2024-04-15 チャンスー カニオンレアル バイオメディカル テクノロジー カンパニー リミテッド 組換えニューカッスル病ウイルスｒＮＤＶ－ＶＥＧＦ－Ｔｒａｐ、そのゲノム、そのための調製方法及びその使用

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JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
EP3837277A4 (en) 2018-08-17 2022-05-11 Icahn School of Medicine at Mount Sinai RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION
USD1083956S1 (en) * 2018-12-10 2025-07-15 Icahn School Of Medicine At Mount Sinai Display screen with a graphical user interface
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CN112409484B (zh) * 2019-08-22 2023-03-21 盛禾(中国)生物制药有限公司 多功能抗体、其制备及其用途
CN116574183A (zh) * 2019-08-22 2023-08-11 盛禾(中国)生物制药有限公司 多功能抗体、其制备及其用途
CA3150891A1 (en) * 2019-09-19 2021-03-25 Arno Thaller New oncolytic newcastle disease viruses and recombinant ndv strains
EP3795160A1 (en) * 2019-09-19 2021-03-24 Arno Thaller Recombinant oncolytic newcastle disease viruses with increased activity
EP3795161A1 (en) * 2019-09-19 2021-03-24 Arno Thaller Recombinant oncolytic newcastle disease viruses with increased activity and improved viral safety
WO2021174121A1 (en) * 2020-02-27 2021-09-02 Icahn School Of Medicine At Mount Sinai Vegfr-3-activating agents and oncolytic viruses and uses thereof for the treatment of cancer
CN113462657A (zh) * 2020-03-30 2021-10-01 江苏康缘瑞翱生物医药科技有限公司 重组新城疫病毒及制备方法、重组质粒、及其应用
WO2021229270A1 (es) * 2020-05-13 2021-11-18 Laboratorio Avi-Mex, S.A. De C.V. Vacuna recombinante contra covid-19 en vector viral
CN112159799A (zh) * 2020-06-04 2021-01-01 华农（肇庆）生物产业技术研究院有限公司 一种NDVVIId突变型感染性克隆病毒DHN3-mF及其制备方法和疫苗
JP2023548746A (ja) 2020-10-13 2023-11-21 クリヤ セラピューティクス インコーポレイテッド サイトカインをコードする核酸を送達するためのウイルスベクターコンストラクトおよびがんを処置するためのその使用
CN114712495B (zh) * 2021-01-06 2024-08-20 盛禾(中国)生物制药有限公司 一种多功能抗体的组合物
CN114712494B (zh) * 2021-01-06 2024-09-17 盛禾(中国)生物制药有限公司 一种靶向pd-1的多功能抗体的组合物
CA3161532A1 (en) * 2021-06-03 2022-12-03 University Of Guelph Engineered newcastle disease virus vector and uses thereof
KR102476901B1 (ko) * 2021-08-06 2022-12-14 리벤텍 주식회사 대장암 세포 특이적 감염 뉴캐슬병 바이러스를 이용한 대장암 치료용 암용해성 바이러스 및 이를 이용한 대장암 치료용 조성물
WO2024062098A1 (en) * 2022-09-23 2024-03-28 Transgene Recombinant pseudocowpox virus encoding an interleukin-12
CN117050158B (zh) * 2023-10-10 2023-12-29 云南农业大学 一种红嘴鸥IFN-γ基因及其编码的重组蛋白的应用
CN120290572A (zh) * 2025-04-09 2025-07-11 梅尔顿(深圳)生物医药技术有限公司 一种重组新城疫病毒及其制备方法和在抗肿瘤中的应用

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JP7680564B2 (ja) 2021-04-13 2025-05-20 ジァンスー カニオン ファーマシューティカル カンパニー，リミテッド 組換えニューカッスル病ウイルスｒＮＤＶ－ＶＥＧＦ－Ｔｒａｐ、そのゲノム、そのための調製方法及びその使用

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