JP2020517698A5 - - Google Patents
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- Publication number
- JP2020517698A5 JP2020517698A5 JP2019558390A JP2019558390A JP2020517698A5 JP 2020517698 A5 JP2020517698 A5 JP 2020517698A5 JP 2019558390 A JP2019558390 A JP 2019558390A JP 2019558390 A JP2019558390 A JP 2019558390A JP 2020517698 A5 JP2020517698 A5 JP 2020517698A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- pyrimidin
- amine
- pyridine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1cc*(Cc2c(C)ncnc2)cc1 Chemical compound Cc1cc*(Cc2c(C)ncnc2)cc1 0.000 description 3
- RIKMMFOAQPJVMX-UHFFFAOYSA-O Cc1c[nH][nH+]c1 Chemical compound Cc1c[nH][nH+]c1 RIKMMFOAQPJVMX-UHFFFAOYSA-O 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022144957A JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491484P | 2017-04-28 | 2017-04-28 | |
| US201762491475P | 2017-04-28 | 2017-04-28 | |
| US201762491573P | 2017-04-28 | 2017-04-28 | |
| US201762491526P | 2017-04-28 | 2017-04-28 | |
| US62/491,573 | 2017-04-28 | ||
| US62/491,526 | 2017-04-28 | ||
| US62/491,484 | 2017-04-28 | ||
| US62/491,475 | 2017-04-28 | ||
| US201862650232P | 2018-03-29 | 2018-03-29 | |
| US62/650,232 | 2018-03-29 | ||
| PCT/IB2018/052919 WO2018198077A2 (en) | 2017-04-28 | 2018-04-26 | 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022144957A Division JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517698A JP2020517698A (ja) | 2020-06-18 |
| JP2020517698A5 true JP2020517698A5 (https=) | 2021-06-10 |
| JP7247102B2 JP7247102B2 (ja) | 2023-03-28 |
Family
ID=62148436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558390A Active JP7247102B2 (ja) | 2017-04-28 | 2018-04-26 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
| JP2022144957A Pending JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022144957A Pending JP2022188056A (ja) | 2017-04-28 | 2022-09-13 | ６－６縮合二環式ヘテロアリール化合物及びｌａｔｓ阻害剤としてのその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11458138B2 (https=) |
| EP (1) | EP3615537B1 (https=) |
| JP (2) | JP7247102B2 (https=) |
| KR (1) | KR20190142776A (https=) |
| CN (3) | CN114621222B (https=) |
| AU (2) | AU2018260495B2 (https=) |
| BR (1) | BR112019022512A2 (https=) |
| CA (1) | CA3056906A1 (https=) |
| CL (1) | CL2019003049A1 (https=) |
| CO (1) | CO2019011873A2 (https=) |
| CR (1) | CR20190483A (https=) |
| CU (2) | CU20190086A7 (https=) |
| DO (1) | DOP2019000273A (https=) |
| EC (1) | ECSP19076732A (https=) |
| ES (1) | ES2983611T3 (https=) |
| IL (2) | IL269293B (https=) |
| JO (1) | JOP20190257A1 (https=) |
| MA (1) | MA49285A (https=) |
| MX (1) | MX2019012756A (https=) |
| PE (1) | PE20200292A1 (https=) |
| PH (1) | PH12019502436A1 (https=) |
| SG (1) | SG11201908615RA (https=) |
| TW (1) | TW201843140A (https=) |
| UY (1) | UY37703A (https=) |
| WO (1) | WO2018198077A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201891338A1 (ru) | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| WO2018175636A2 (en) | 2017-03-22 | 2018-09-27 | Novartis Ag | Compositions and methods for immunooncology |
| JOP20190257A1 (ar) | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| SI3687996T1 (sl) | 2017-09-27 | 2022-04-29 | Incyte Corporation | Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM |
| WO2019235569A1 (ja) | 2018-06-08 | 2019-12-12 | 日産化学株式会社 | キナーゼ阻害剤 |
| MD3813800T2 (ro) | 2018-06-29 | 2025-10-31 | Incyte Corp | Formulări de inhibitor al AXL/MER |
| AU2019361962B2 (en) * | 2018-10-16 | 2025-03-27 | Northeastern University | Bioadhesive for soft tissue repair |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
| WO2020122104A1 (ja) | 2018-12-11 | 2020-06-18 | 国立大学法人京都大学 | ゲノムｄｎａに欠失を誘導する方法 |
| US20220144775A1 (en) | 2019-01-30 | 2022-05-12 | Nissan Chemical Corporation | Hydrazide compound and kinase inhibitor |
| CN112707905B (zh) * | 2019-10-25 | 2024-07-02 | 武汉誉祥医药科技有限公司 | 一种三并杂环化合物及其制备方法和用途 |
| GB201915831D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| GB201915829D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| TW202128699A (zh) * | 2019-11-27 | 2021-08-01 | 美商建南德克公司 | 治療性化合物 |
| CA3170121A1 (en) * | 2020-02-05 | 2021-08-12 | The Rockefeller University | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss |
| CN111443068B (zh) * | 2020-03-06 | 2023-06-27 | 天津大学 | 具有多重刺激响应特性的纯有机室温磷光材料及筛选方法和应用 |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| CN115667504A (zh) | 2020-04-27 | 2023-01-31 | 诺华股份有限公司 | 用于眼细胞疗法的方法和组合物 |
| AU2021263818A1 (en) * | 2020-04-28 | 2022-11-03 | Global Blood Therapeutics, Inc. | Cycloalkyl pyrimidines as ferroportin inhibitors |
| CN112305126A (zh) * | 2020-11-02 | 2021-02-02 | 宁夏贝利特生物科技有限公司 | 一种硝酸胍含量的测定方法 |
| JP2024521929A (ja) * | 2021-06-04 | 2024-06-04 | ジェネンテック， インコーポレイテッド | ２，８－ジアザスピロ［４．５］デカン化合物 |
| WO2023027978A1 (en) * | 2021-08-23 | 2023-03-02 | Emd Millipore Corporation | System and method for photopolymerizing electrophoretic gels |
| CN115974868B (zh) * | 2022-11-07 | 2024-04-12 | 安徽理工大学 | 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用 |
| EP4687896A1 (en) * | 2023-04-04 | 2026-02-11 | Children's Hospital Los Angeles | Lats kinase inhibitor to treat retinal degeneration |
| CN119462609B (zh) * | 2024-10-25 | 2025-12-26 | 烟台皓元生物医药科技有限公司 | 一种lats抑制剂vt02956的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065392A1 (en) | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| AU2006217744A1 (en) | 2005-02-25 | 2006-08-31 | Kudos Pharmaceuticals Limited | 2,4-diamino-pyridopyrimidine derivatives and their use as MTOR inhibitors |
| MX2009010696A (es) | 2007-04-06 | 2009-10-20 | Novartis Ag | Derivados de 2,6-naftiridina como moduladores de cinasa de proteina. |
| AR073354A1 (es) | 2008-07-31 | 2010-11-03 | Genentech Inc | Compuestos de pirimidina, composiciones farmaceuticas y su uso en el tratamiento del cancer. |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| US9347041B2 (en) | 2011-07-15 | 2016-05-24 | Osaka University | Method for preparing corneal endothelial cell |
| AR088061A1 (es) | 2011-09-27 | 2014-05-07 | Hoffmann La Roche | Compuestos de pirazol-4-il-heterociclil-carboxamida y metodos de uso |
| US9914730B2 (en) | 2012-09-28 | 2018-03-13 | Cancer Research Technology Limited | Azaquinazoline inhibitors of Atypical protein Kinase C |
| AU2014361781B2 (en) * | 2013-12-12 | 2021-04-01 | Massachusetts Institute Of Technology | Delivery, use and therapeutic applications of the CRISPR -Cas systems and compositions for genome editing |
| TWI675836B (zh) | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑 |
| US20170298360A1 (en) | 2014-09-24 | 2017-10-19 | Friedrich Miescher Institute For Biomedical Research | Lats and breast cancer |
| PE20181366A1 (es) | 2015-08-03 | 2018-08-27 | Bristol Myers Squibb Co | Compuestos heterociclicos utiles como moduladores de factor de necrosis tumoral (tnf) alfa |
| US20200216906A1 (en) | 2015-08-25 | 2020-07-09 | President And Fellows Of Harvard College | Methods and compositions relating to the diagnosis and treatment of cancer |
| JOP20190257A1 (ar) | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
-
2017
- 2017-06-16 JO JOP/2019/0257A patent/JOP20190257A1/ar unknown
-
2018
- 2018-04-26 BR BR112019022512-9A patent/BR112019022512A2/pt not_active IP Right Cessation
- 2018-04-26 CR CR20190483A patent/CR20190483A/es unknown
- 2018-04-26 CU CU2019000086A patent/CU20190086A7/es unknown
- 2018-04-26 MA MA049285A patent/MA49285A/fr unknown
- 2018-04-26 EP EP18723981.9A patent/EP3615537B1/en active Active
- 2018-04-26 MX MX2019012756A patent/MX2019012756A/es unknown
- 2018-04-26 WO PCT/IB2018/052919 patent/WO2018198077A2/en not_active Ceased
- 2018-04-26 PE PE2019002107A patent/PE20200292A1/es unknown
- 2018-04-26 CA CA3056906A patent/CA3056906A1/en active Pending
- 2018-04-26 ES ES18723981T patent/ES2983611T3/es active Active
- 2018-04-26 AU AU2018260495A patent/AU2018260495B2/en not_active Ceased
- 2018-04-26 TW TW107114216A patent/TW201843140A/zh unknown
- 2018-04-26 SG SG11201908615R patent/SG11201908615RA/en unknown
- 2018-04-26 CU CU2020000080A patent/CU20200080A7/es unknown
- 2018-04-26 US US15/963,816 patent/US11458138B2/en active Active
- 2018-04-26 JP JP2019558390A patent/JP7247102B2/ja active Active
- 2018-04-26 CN CN202210409770.6A patent/CN114621222B/zh active Active
- 2018-04-26 UY UY0001037703A patent/UY37703A/es not_active Application Discontinuation
- 2018-04-26 KR KR1020197034688A patent/KR20190142776A/ko not_active Withdrawn
- 2018-04-26 CN CN202210409194.5A patent/CN114703144A/zh not_active Withdrawn
- 2018-04-26 CN CN201880027586.7A patent/CN110573511B/zh active Active
-
2019
- 2019-09-11 IL IL269293A patent/IL269293B/en unknown
- 2019-10-24 CL CL2019003049A patent/CL2019003049A1/es unknown
- 2019-10-24 DO DO2019000273A patent/DOP2019000273A/es unknown
- 2019-10-25 EC ECSENADI201976732A patent/ECSP19076732A/es unknown
- 2019-10-25 CO CONC2019/0011873A patent/CO2019011873A2/es unknown
- 2019-10-28 PH PH12019502436A patent/PH12019502436A1/en unknown
-
2021
- 2021-12-14 AU AU2021286281A patent/AU2021286281A1/en not_active Abandoned
-
2022
- 2022-05-09 IL IL292857A patent/IL292857A/en unknown
- 2022-08-18 US US17/820,613 patent/US20230190751A1/en not_active Abandoned
- 2022-09-13 JP JP2022144957A patent/JP2022188056A/ja active Pending
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