JP2020513824A5 - - Google Patents
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- JP2020513824A5 JP2020513824A5 JP2019551949A JP2019551949A JP2020513824A5 JP 2020513824 A5 JP2020513824 A5 JP 2020513824A5 JP 2019551949 A JP2019551949 A JP 2019551949A JP 2019551949 A JP2019551949 A JP 2019551949A JP 2020513824 A5 JP2020513824 A5 JP 2020513824A5
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- sequence
- nucleic acid
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims 151
- 150000007523 nucleic acids Chemical class 0.000 claims 94
- 239000012634 fragment Substances 0.000 claims 87
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 62
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 56
- 108020004707 nucleic acids Proteins 0.000 claims 42
- 102000039446 nucleic acids Human genes 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108091033409 CRISPR Proteins 0.000 claims 14
- 238000010354 CRISPR gene editing Methods 0.000 claims 13
- 108020005004 Guide RNA Proteins 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 108091026890 Coding region Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 8
- 101150050733 Gnas gene Proteins 0.000 claims 7
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- 108010077850 Nuclear Localization Signals Proteins 0.000 claims 6
- 108091006230 SLC7A3 Proteins 0.000 claims 6
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- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 4
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- 101000936262 Homo sapiens ATP synthase subunit alpha, mitochondrial Proteins 0.000 claims 4
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- 238000001415 gene therapy Methods 0.000 claims 4
- 229940029575 guanosine Drugs 0.000 claims 4
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- 101000657066 Homo sapiens 40S ribosomal protein S9 Proteins 0.000 claims 2
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- 101001111225 Homo sapiens Cytochrome c oxidase subunit NDUFA4 Proteins 0.000 claims 2
- 101001065295 Homo sapiens Fas-binding factor 1 Proteins 0.000 claims 2
- 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 claims 2
- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 claims 2
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 claims 2
- 101001045218 Homo sapiens Peroxisomal multifunctional enzyme type 2 Proteins 0.000 claims 2
- 101001089120 Homo sapiens Proteasome subunit beta type-3 Proteins 0.000 claims 2
- 101000797903 Homo sapiens Protein ALEX Proteins 0.000 claims 2
- 101100245221 Mus musculus Prss8 gene Proteins 0.000 claims 2
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- 102100022587 Peroxisomal multifunctional enzyme type 2 Human genes 0.000 claims 2
- 102100033755 Proteasome subunit beta type-3 Human genes 0.000 claims 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 2
- 101150047050 Tubb4b gene Proteins 0.000 claims 2
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- 102100023777 60S ribosomal protein L31 Human genes 0.000 claims 1
- 101150058750 ALB gene Proteins 0.000 claims 1
- 102100029772 ATP synthase subunit ATP5MJ, mitochondrial Human genes 0.000 claims 1
- 102100024005 Acid ceramidase Human genes 0.000 claims 1
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- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims 1
- 101100441244 Caenorhabditis elegans csp-1 gene Proteins 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102100031649 Cytochrome c oxidase subunit 6B1 Human genes 0.000 claims 1
- 101001113162 Homo sapiens 60S ribosomal protein L31 Proteins 0.000 claims 1
- 101000975753 Homo sapiens Acid ceramidase Proteins 0.000 claims 1
- 101000922367 Homo sapiens Cytochrome c oxidase subunit 6B1 Proteins 0.000 claims 1
- 101000601616 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Proteins 0.000 claims 1
- 101000713613 Homo sapiens Tubulin beta-4B chain Proteins 0.000 claims 1
- 101100101580 Homo sapiens UBQLN2 gene Proteins 0.000 claims 1
- 101000607639 Homo sapiens Ubiquilin-2 Proteins 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
- 102100037508 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091036407 Polyadenylation Proteins 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
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- 101150006282 RPL31 gene Proteins 0.000 claims 1
- 101150061207 RPL32 gene Proteins 0.000 claims 1
- 239000008156 Ringer's lactate solution Substances 0.000 claims 1
- 108091027544 Subgenomic mRNA Proteins 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 102100036821 Tubulin beta-4B chain Human genes 0.000 claims 1
- 102100039933 Ubiquilin-2 Human genes 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 150000003838 adenosines Chemical class 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- 229920006317 cationic polymer Polymers 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
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- 208000016361 genetic disease Diseases 0.000 claims 1
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- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023219252A JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2017/057110 | 2017-03-24 | ||
| EP2017057110 | 2017-03-24 | ||
| EP2017076775 | 2017-10-19 | ||
| EPPCT/EP2017/076775 | 2017-10-19 | ||
| PCT/EP2018/057552 WO2018172556A1 (en) | 2017-03-24 | 2018-03-23 | Nucleic acids encoding crispr-associated proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023219252A Division JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020513824A JP2020513824A (ja) | 2020-05-21 |
| JP2020513824A5 true JP2020513824A5 (enExample) | 2021-04-30 |
Family
ID=61801946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551949A Pending JP2020513824A (ja) | 2017-03-24 | 2018-03-23 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
| JP2023219252A Pending JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023219252A Pending JP2024038121A (ja) | 2017-03-24 | 2023-12-26 | Ｃｒｉｓｐｒ関連タンパク質をコードする核酸、及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11739335B2 (enExample) |
| EP (1) | EP3601576A1 (enExample) |
| JP (2) | JP2020513824A (enExample) |
| KR (1) | KR102842382B1 (enExample) |
| CN (1) | CN110914433A (enExample) |
| AU (1) | AU2018240515B2 (enExample) |
| BR (1) | BR112019015244A2 (enExample) |
| CA (1) | CA3050616A1 (enExample) |
| MX (1) | MX2019011215A (enExample) |
| SG (2) | SG11201906297QA (enExample) |
| WO (1) | WO2018172556A1 (enExample) |
Families Citing this family (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| BR112013024337A2 (pt) | 2011-03-23 | 2017-09-26 | Du Pont | locus de traço transgênico complexo em uma planta, planta ou semente, método para produzir em uma planta um locus de traço transgênico complexo e construto de expressão |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| ES2969742T3 (es) | 2012-03-27 | 2024-05-22 | CureVac SE | Moléculas artificiales de ácido nucleico para la expresión mejorada de proteínas o péptidos |
| US9974845B2 (en) | 2013-02-22 | 2018-05-22 | Curevac Ag | Combination of vaccination and inhibition of the PD-1 pathway |
| CN105473157A (zh) | 2013-08-21 | 2016-04-06 | 库瑞瓦格股份公司 | 组合疫苗 |
| CN110195072A (zh) | 2013-08-21 | 2019-09-03 | 库瑞瓦格股份公司 | 狂犬病疫苗 |
| ES2747762T3 (es) | 2013-08-21 | 2020-03-11 | Curevac Ag | Vacuna contra el virus respiratorio sincitial (RSV) |
| EP3611268A1 (en) | 2013-08-22 | 2020-02-19 | E. I. du Pont de Nemours and Company | Plant genome modification using guide rna/cas endonuclease systems and methods of use |
| ES2754239T3 (es) | 2014-03-12 | 2020-04-16 | Curevac Ag | Combinación de vacunación y agonistas de OX40 |
| WO2016040030A1 (en) | 2014-09-12 | 2016-03-17 | E. I. Du Pont De Nemours And Company | Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use |
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| AU2015342749B2 (en) | 2014-11-07 | 2022-01-27 | Editas Medicine, Inc. | Methods for improving CRISPR/Cas-mediated genome-editing |
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| WO2016193206A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | A method for producing and purifying rna, comprising at least one step of tangential flow filtration |
| WO2016201047A1 (en) | 2015-06-09 | 2016-12-15 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for improving transplantation |
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| US11413346B2 (en) | 2015-11-09 | 2022-08-16 | Curevac Ag | Rotavirus vaccines |
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| MX2018009917A (es) | 2016-02-17 | 2019-08-14 | Curevac Ag | Vacuna contra el virus del zika. |
| US11920174B2 (en) | 2016-03-03 | 2024-03-05 | CureVac SE | RNA analysis by total hydrolysis and quantification of released nucleosides |
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| EP4477662A3 (en) | 2016-05-04 | 2025-03-19 | CureVac SE | Nucleic acid molecules and uses thereof |
| EP3452101A2 (en) | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
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| CN110023494A (zh) | 2016-09-30 | 2019-07-16 | 加利福尼亚大学董事会 | Rna指导的核酸修饰酶及其使用方法 |
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2018
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- 2018-03-23 CA CA3050616A patent/CA3050616A1/en active Pending
- 2018-03-23 WO PCT/EP2018/057552 patent/WO2018172556A1/en not_active Ceased
- 2018-03-23 MX MX2019011215A patent/MX2019011215A/es unknown
- 2018-03-23 EP EP18713883.9A patent/EP3601576A1/en active Pending
- 2018-03-23 BR BR112019015244A patent/BR112019015244A2/pt unknown
- 2018-03-23 SG SG11201906297Q patent/SG11201906297QA/en unknown
- 2018-03-23 JP JP2019551949A patent/JP2020513824A/ja active Pending
- 2018-03-23 SG SG10202110491PA patent/SG10202110491PA/en unknown
- 2018-03-23 CN CN201880020941.8A patent/CN110914433A/zh active Pending
- 2018-03-23 KR KR1020197030080A patent/KR102842382B1/ko active Active
- 2018-03-23 AU AU2018240515A patent/AU2018240515B2/en active Active
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2023
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2025
- 2025-06-16 US US19/239,908 patent/US20250304976A1/en active Pending
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