|
US5767242A
(en)
|
1994-04-20 |
1998-06-16 |
Boehringer Ingelheim Int'l Gmbh |
Isolated dimeric fibroblast activation protein alpha, and uses thereof
|
|
US5851775A
(en)
|
1997-03-20 |
1998-12-22 |
Johns Hopkins University |
β-catenin, Tcf-4, and APC interact to prevent cancer
|
|
US20020004490A1
(en)
|
1999-04-12 |
2002-01-10 |
Dean Nicholas M. |
Antisense modulation of Fas mediated signaling
|
|
WO1999047152A2
(en)
|
1998-03-20 |
1999-09-23 |
Sloan Kettering Institute For Cancer Research |
Use of dipeptidyl peptidase (dpp4) of fibroblast activating protein alpha for suppressing the malignant phenotype of cancer cells
|
|
EP0953639A1
(en)
*
|
1998-04-30 |
1999-11-03 |
Boehringer Ingelheim International GmbH |
FAPalpha-specific antibody with improved producibility
|
|
GB9827430D0
(en)
|
1998-12-11 |
1999-02-03 |
Ludwig Inst Cancer Res |
Differential expression in primary breast cancer
|
|
CA2391534A1
(en)
*
|
1999-11-15 |
2001-05-25 |
Drug Innovation & Design, Inc. |
Selective cellular targeting: multifunctional delivery vehicles
|
|
JP2003530092A
(ja)
|
2000-03-17 |
2003-10-14 |
ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト |
ヒトＦＡＰ−α−特異抗体
|
|
US20090010919A1
(en)
|
2004-07-29 |
2009-01-08 |
Bayer Healthcare Ag |
Diagnostics and Therapeutics for Diseases Associated With Fibroblast Activation Protein (Fap)
|
|
US7374898B2
(en)
|
2004-10-12 |
2008-05-20 |
The Research Foundation Of State University Of New York |
Peptide inhibitors against seprase
|
|
US20090238862A1
(en)
|
2004-10-27 |
2009-09-24 |
Wen-Tien Chen |
Methods and Compositions for Seprase Inactivation
|
|
EP1943257A2
(en)
|
2005-05-19 |
2008-07-16 |
Genentech, Inc. |
Fibroblast activation protein inhibitor compounds and methods
|
|
KR20080030079A
(ko)
|
2005-07-05 |
2008-04-03 |
트러스티즈 오브 터프츠 칼리지 |
섬유아세포 활성 단백질 알파의 억제제
|
|
EP1760076A1
(en)
|
2005-09-02 |
2007-03-07 |
Ferring B.V. |
FAP Inhibitors
|
|
EP1963537A4
(en)
|
2005-12-14 |
2009-11-11 |
Ludwig Inst For Cancer Res Ltd |
METHOD FOR DIAGNOSING RHEUMATOID ARTHRITIS BY TESTING MYOFIBROBLASTIC-SIMILAR SYNOVOCYTES FOR A FIBROBLAST ACTIVATION PROTEIN
|
|
WO2007087131A2
(en)
|
2006-01-05 |
2007-08-02 |
The Johns Hopkins University |
Peptide prodrugs
|
|
CA2658331A1
(en)
|
2006-06-07 |
2007-12-21 |
Patrick A. Mckee |
Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use
|
|
PL2035581T3
(pl)
|
2006-06-21 |
2013-01-31 |
Scripps Research Inst |
Kompozycja DNA przeciwko FAP - antygenowi zrębowemu nowotworu i sposoby jej stosowania
|
|
EP1882741B1
(en)
|
2006-07-25 |
2010-06-30 |
Institut Pasteur |
Recombinant Mycobacterium strain expressing a mycobacterial FAP protein under the control of a promoter active under hypoxia and its application for cancer therapy
|
|
BRPI0716368A2
(pt)
|
2006-08-29 |
2013-10-01 |
Molecular Insight Pharm Inc |
porÇÕes de radioimageamento acopladas a porÇÕes de ligaÇço Á peptidase para imageamento de tecidos e àrgços que expressam peptidases
|
|
WO2008116053A2
(en)
|
2007-03-20 |
2008-09-25 |
Trustees Of Tufts College |
Fap-activated chemotherapeutic compounds, and methods of use thereof
|
|
WO2008116054A1
(en)
|
2007-03-20 |
2008-09-25 |
Trustees Of Tufts College |
Inhibitors of fibroblast activation protein, and methods of use thereof
|
|
EP4464384A3
(en)
|
2007-08-17 |
2025-01-08 |
Purdue Research Foundation |
Psma binding ligand-linker conjugates and methods for using
|
|
BRPI0815405A2
(pt)
|
2007-08-17 |
2015-02-03 |
Boehringer Ingelheim Int |
Compostos derivados de purina, processo para a preparação de uma composição farmacêutica e uso dos mesmos
|
|
MX2010004671A
(es)
|
2007-12-10 |
2010-05-27 |
Hoffmann La Roche |
Seprasa como marcador para cancer.
|
|
EP2285989B1
(en)
|
2008-05-15 |
2016-11-16 |
The University of North Carolina At Chapel Hill |
Novel targets for regulation of angiogenesis
|
|
DK2291640T3
(en)
*
|
2008-05-20 |
2019-03-11 |
Univ Health Network |
Device and method for fluorescence-based imaging and monitoring
|
|
WO2010036814A1
(en)
|
2008-09-25 |
2010-04-01 |
Molecular Insight Pharmaceuticals, Inc. |
Selective seprase inhibitors
|
|
WO2010083570A1
(en)
|
2009-01-23 |
2010-07-29 |
The University Of Sydney |
Novel metabolic disease therapy
|
|
US10815517B2
(en)
|
2009-04-28 |
2020-10-27 |
Roche Diagnostics Operations, Inc. |
Use of DPPIV/seprase as a marker for cancer
|
|
EP2483316A1
(en)
|
2009-10-02 |
2012-08-08 |
Ludwig Institute for Cancer Research Ltd. |
Anti-fibroblast activation protein antibodies and methods and uses thereof
|
|
WO2011040973A2
(en)
*
|
2009-10-02 |
2011-04-07 |
Ludwig Institute For Cancer Research Ltd. |
Tnf-immunoconjugates with fibroblast activation protein antibodies and methods and uses thereof
|
|
EP2397466B1
(en)
|
2010-06-15 |
2012-11-28 |
Centre National De La Recherche Scientifique CNRS |
X-ray and gamma-photon activatable organic compounds, their preparation and their uses
|
|
AU2011295030B2
(en)
|
2010-08-27 |
2016-01-28 |
University Of Zurich |
A novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases
|
|
CN108383893A
(zh)
|
2011-08-30 |
2018-08-10 |
塔夫茨大学信托人 |
用于治疗实体瘤的fap-活化的蛋白酶体抑制剂
|
|
WO2013107820A1
(en)
*
|
2012-01-17 |
2013-07-25 |
Universiteit Antwerpen |
Novel fap inhibitors
|
|
US9688722B2
(en)
|
2012-05-04 |
2017-06-27 |
The Board Of Regents Of The University Of Oklahoma |
Substrates and inhibitors of prolyl oligopeptidase and methods of use
|
|
US20150320892A1
(en)
|
2012-06-29 |
2015-11-12 |
Ge Healthcare Limited |
Imaging fibrosis
|
|
WO2014022636A1
(en)
|
2012-08-02 |
2014-02-06 |
Trustees Of Tufts College |
Broad spectrum inhibitors of the post proline cleaving enzymes for treatment of hepatitis c virus infections
|
|
WO2014055442A2
(en)
*
|
2012-10-01 |
2014-04-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeting stromal cells for the treatment of cancer
|
|
WO2014072465A1
(en)
|
2012-11-09 |
2014-05-15 |
Roche Diagnostics Gmbh |
In vitro capture and analysis of circulating tumor cells
|
|
US9402888B2
(en)
|
2013-03-14 |
2016-08-02 |
The Wistar Institute Of Anatomy And Biology |
Methods and compositions for treating cancer
|
|
WO2014149069A1
(en)
*
|
2013-03-15 |
2014-09-25 |
Purdue Research Foundation |
Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
|
|
UA118028C2
(uk)
|
2013-04-03 |
2018-11-12 |
Рош Глікарт Аг |
Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
|
|
WO2014167083A1
(en)
|
2013-04-12 |
2014-10-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method for predicting the risk of developing a colonic neoplasia
|
|
EP3001813B1
(en)
|
2013-05-13 |
2019-03-27 |
Vision Global Holdings Ltd. |
Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging
|
|
CN103267852B
(zh)
|
2013-05-15 |
2015-03-25 |
中国医学科学院北京协和医院 |
成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途
|
|
EP3102242A2
(en)
*
|
2014-02-03 |
2016-12-14 |
Philochem AG |
Targeted drug conjugates
|
|
US9737556B2
(en)
|
2014-06-13 |
2017-08-22 |
Trustees Of Tufts College |
FAP-activated therapeutic agents, and uses related thereto
|
|
JP6744826B2
(ja)
*
|
2014-06-13 |
2020-08-19 |
バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC |
Ｆａｐ活性化治療剤及びそれに関連する使用
|
|
EP3204412B1
(en)
|
2014-10-08 |
2020-08-19 |
F.Hoffmann-La Roche Ag |
Combination therapy of bispecific antibodies specific for fap and dr5 and chemotherapeutic agents
|
|
WO2016089879A1
(en)
*
|
2014-12-01 |
2016-06-09 |
Endocyte, Inc. |
Conjugates of garftase inhibitors
|
|
CA2973040A1
(en)
|
2015-01-09 |
2016-07-14 |
Mabimmune Diagnostics Ag |
Novel anti-fibroblast activation protein (fap) antibodies and uses derived thereof
|
|
WO2016146174A1
(en)
|
2015-03-17 |
2016-09-22 |
Biontech Ag |
Compositions and methods for diagnosis and treatment of cancer
|
|
WO2016164815A1
(en)
|
2015-04-10 |
2016-10-13 |
Applied Proteomics, Inc. |
Protein biomarker panels for detecting colorectal cancer and advanced adenoma
|
|
US20160303251A1
(en)
*
|
2015-04-17 |
2016-10-20 |
Endocyte, Inc. |
Conjugates of garftase inhibitors
|
|
HRP20240215T1
(hr)
|
2016-03-22 |
2024-04-26 |
The Johns Hopkins University |
Sredstva sa visokim afinitetom za ciljani učinak na membranski antigen specifičan za prostatu za endoradioterapiju raka prostate
|
|
WO2017189569A1
(en)
|
2016-04-25 |
2017-11-02 |
Trustees Of Tufts College |
Multimediator dpp4 and fap inhibitors, and uses related thereto
|
|
CN105949282B
(zh)
|
2016-06-20 |
2020-06-16 |
郑州大学 |
一种靶向fap的抗血管生成肽z-gp-v2及其应用
|
|
CN106046121B
(zh)
|
2016-06-20 |
2020-06-16 |
郑州大学 |
一种靶向fap的抗血管生成肽z-gp-v1及其应用
|
|
JP2018035137A
(ja)
|
2016-07-13 |
2018-03-08 |
マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ |
新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
|
|
CN116474108A
(zh)
|
2016-12-14 |
2023-07-25 |
普渡研究基金会 |
成纤维细胞活化蛋白(fap)-靶向成像和治疗
|
|
EP3606939A4
(en)
|
2017-04-04 |
2021-01-20 |
F. Hoffmann-La Roche AG |
SUBSTRATES RECOGNIZED BY FIBROBLAST ACTIVATION PROTEIN (FAP) AND METHOD OF USING THEM
|
|
EA202090776A1
(ru)
*
|
2017-10-23 |
2020-07-27 |
Дзе Джонс Хопкинс Юниверсити |
Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha)
|
|
CN109796532B
(zh)
|
2017-11-17 |
2024-09-10 |
恺兴生命科技(上海)有限公司 |
靶向成纤维激活蛋白α的结合单元及其应用
|
|
CN108152258A
(zh)
|
2017-12-13 |
2018-06-12 |
清华大学 |
一种检测待测溶液中氨基糖苷类抗生素的含量的方法
|
|
JP2021506972A
(ja)
|
2017-12-15 |
2021-02-22 |
プラクシス バイオテック エルエルシー |
線維芽細胞活性化タンパク質の阻害剤
|
|
CN108333365B
(zh)
|
2018-01-24 |
2020-09-04 |
南开大学 |
金-长余辉纳米粒子免原位激发检测成纤维细胞激活蛋白
|
|
WO2019154859A1
(en)
|
2018-02-06 |
2019-08-15 |
Universität Heidelberg |
Fap inhibitor
|
|
US11426472B2
(en)
|
2018-10-17 |
2022-08-30 |
Purdue Research Foundation |
Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis
|
|
GB201820320D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for FAPalpha
|
|
BR112021011861A2
(pt)
|
2019-01-04 |
2021-09-08 |
Praxis Biotech LLC |
Inibidores da proteína de ativação de fibroblastos
|
|
CN110368496B
(zh)
|
2019-07-11 |
2020-12-29 |
同济大学 |
成纤维细胞激活蛋白抑制剂在制备药物中的用途
|
|
CN111574634B
(zh)
|
2019-12-16 |
2022-04-19 |
四川大学华西医院 |
同时靶向间皮素和fap的双靶点嵌合抗原受体及其用途
|
|
CN111235221B
(zh)
|
2020-01-22 |
2022-08-05 |
北京大学第一医院 |
一种fap抑制剂的活性检测方法
|