JP7162592B2 - 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 - Google Patents

線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 Download PDF

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JP7162592B2
JP7162592B2 JP2019531797A JP2019531797A JP7162592B2 JP 7162592 B2 JP7162592 B2 JP 7162592B2 JP 2019531797 A JP2019531797 A JP 2019531797A JP 2019531797 A JP2019531797 A JP 2019531797A JP 7162592 B2 JP7162592 B2 JP 7162592B2
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フィリップ・ステュワート・ロウ
ジョティ・ロイ
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JP2019531797A 2016-12-14 2017-12-13 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 Active JP7162592B2 (ja)

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Application Number Priority Date Filing Date Title
US201662434380P 2016-12-14 2016-12-14
US62/434,380 2016-12-14
US201762575050P 2017-10-20 2017-10-20
US62/575,050 2017-10-20
PCT/US2017/065995 WO2018111989A1 (en) 2016-12-14 2017-12-13 Fibroblast activation protein (fap)-targeted imaging and therapy

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JP2020502130A JP2020502130A (ja) 2020-01-23
JP2020502130A5 JP2020502130A5 (https=) 2021-01-28
JP7162592B2 true JP7162592B2 (ja) 2022-10-28

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US (4) US20200237936A1 (https=)
EP (1) EP3555627B1 (https=)
JP (1) JP7162592B2 (https=)
CN (2) CN116474108A (https=)
ES (1) ES2972577T3 (https=)
WO (1) WO2018111989A1 (https=)

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EA202090776A1 (ru) 2017-10-23 2020-07-27 Дзе Джонс Хопкинс Юниверсити Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha)
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CN114901315B (zh) * 2019-09-17 2025-04-29 普渡研究基金会 癌症和其他纤维化和炎性疾病的成纤维细胞活化蛋白(fap)靶向的成像和治疗
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TW202304469A (zh) * 2021-03-24 2023-02-01 美商杜夫特學院信託管理公司 酸化合物、組合物及方法
US12599683B2 (en) * 2021-05-19 2026-04-14 Ferronova Pty Ltd Mapping nanoparticles
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CN113521313A (zh) * 2021-07-22 2021-10-22 戴格普瑞生物科技(苏州)有限公司 靶向造影剂、产品、制备方法及应用
CN117460826A (zh) * 2021-09-14 2024-01-26 菲柏生物医学技术（广州）有限公司 靶向FAP阳性细胞的siRNA缀合物及其药物组合物和应用
KR20240093543A (ko) 2021-10-04 2024-06-24 필로켐 아게 방사성 표지된 섬유모세포 활성화 단백질 리간드
KR20240109256A (ko) * 2021-11-03 2024-07-10 애드센트릭스 테라퓨틱스 잉크. 약물 접합체 및 이의 제조 및 사용 방법
US20250177582A1 (en) 2022-01-30 2025-06-05 Philochem Ag High-affinity ligands of fibroblast activation protein for targeted delivery applications
CN114214061B (zh) * 2022-02-22 2022-05-17 北京大学 一种聚乙二醇修饰的两性离子化荧光探针、制剂及其应用
CA3266566A1 (en) 2022-09-06 2024-03-14 Philochem Ag MULTIVALENT FIBROBLAST ACTIVATING PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
KR20250073273A (ko) 2022-09-23 2025-05-27 누클리디움 아게 고순도 구리 방사성 의약 조성물 및 이의 진단 및 치료 용도
WO2024102956A1 (en) * 2022-11-09 2024-05-16 Purdue Research Foundation Keto-amide-based fibroblast activation protein-targeted ligand linked to an imaging or therapeutic agent, compositions and methods of use
CN120957982A (zh) * 2023-05-08 2025-11-14 江苏恒瑞医药股份有限公司 靶向成纤维细胞活化蛋白的配体
CN116621823B (zh) * 2023-07-06 2023-10-31 南京诺源医疗器械有限公司 诊断转移淋巴结近红外荧光示踪剂、合成方法及应用
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