JP7162592B2 - 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 - Google Patents

線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 Download PDF

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JP7162592B2
JP7162592B2 JP2019531797A JP2019531797A JP7162592B2 JP 7162592 B2 JP7162592 B2 JP 7162592B2 JP 2019531797 A JP2019531797 A JP 2019531797A JP 2019531797 A JP2019531797 A JP 2019531797A JP 7162592 B2 JP7162592 B2 JP 7162592B2
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フィリップ・ステュワート・ロウ
ジョティ・ロイ
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JP2019531797A 2016-12-14 2017-12-13 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 Active JP7162592B2 (ja)

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US201662434380P 2016-12-14 2016-12-14
US62/434,380 2016-12-14
US201762575050P 2017-10-20 2017-10-20
US62/575,050 2017-10-20
PCT/US2017/065995 WO2018111989A1 (en) 2016-12-14 2017-12-13 Fibroblast activation protein (fap)-targeted imaging and therapy

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JP2020502130A JP2020502130A (ja) 2020-01-23
JP2020502130A5 JP2020502130A5 (https=) 2021-01-28
JP7162592B2 true JP7162592B2 (ja) 2022-10-28

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US (4) US20200237936A1 (https=)
EP (1) EP3555627B1 (https=)
JP (1) JP7162592B2 (https=)
CN (2) CN116474108A (https=)
ES (1) ES2972577T3 (https=)
WO (1) WO2018111989A1 (https=)

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EA202090776A1 (ru) 2017-10-23 2020-07-27 Дзе Джонс Хопкинс Юниверсити Визуализирующие и радиотерапевтические агенты, нацеленные на фибробласт-активирующий белок-альфа (fapalpha)
JP2021506972A (ja) 2017-12-15 2021-02-22 プラクシス バイオテック エルエルシー 線維芽細胞活性化タンパク質の阻害剤
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EP4313033A4 (en) * 2021-03-24 2025-04-23 Trustees Of Tufts College BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS
AU2022275579C1 (en) * 2021-05-19 2024-08-22 Ferronova Pty Ltd Mapping nanoparticles
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CN113521313A (zh) * 2021-07-22 2021-10-22 戴格普瑞生物科技(苏州)有限公司 靶向造影剂、产品、制备方法及应用
WO2023040828A1 (zh) * 2021-09-14 2023-03-23 菲柏生物医学技术（广州）有限公司 靶向FAP阳性细胞的siRNA缀合物及其药物组合物和应用
MX2024004077A (es) 2021-10-04 2024-04-18 Philochem Ag Ligandos de proteina de activacion de fibroblastos radioetiquetados.
CN118574618A (zh) * 2021-11-03 2024-08-30 艾德森特克斯治疗股份有限公司 药物偶联物及其制备与使用方法
US20250177582A1 (en) 2022-01-30 2025-06-05 Philochem Ag High-affinity ligands of fibroblast activation protein for targeted delivery applications
CN114214061B (zh) * 2022-02-22 2022-05-17 北京大学 一种聚乙二醇修饰的两性离子化荧光探针、制剂及其应用
CN119816493A (zh) 2022-09-06 2025-04-11 菲罗化学股份公司 用于靶向递送应用的多价成纤维细胞激活蛋白配体
TW202426433A (zh) 2022-09-23 2024-07-01 瑞士商紐利迪姆股份公司 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途
AU2023347470A1 (en) 2022-09-23 2025-04-10 Nuclidium Ag High-purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof
WO2024102956A1 (en) * 2022-11-09 2024-05-16 Purdue Research Foundation Keto-amide-based fibroblast activation protein-targeted ligand linked to an imaging or therapeutic agent, compositions and methods of use
KR20260006628A (ko) * 2023-05-08 2026-01-13 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 섬유아세포 활성화 단백질을 표적화하는 리간드
CN116621823B (zh) * 2023-07-06 2023-10-31 南京诺源医疗器械有限公司 诊断转移淋巴结近红外荧光示踪剂、合成方法及应用
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