JP2019535829A - 大型薬剤の経皮送達 - Google Patents

大型薬剤の経皮送達 Download PDF

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Publication number
JP2019535829A
JP2019535829A JP2019547574A JP2019547574A JP2019535829A JP 2019535829 A JP2019535829 A JP 2019535829A JP 2019547574 A JP2019547574 A JP 2019547574A JP 2019547574 A JP2019547574 A JP 2019547574A JP 2019535829 A JP2019535829 A JP 2019535829A
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Japan
Prior art keywords
skin
composition
antibody
site
drug
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JP2019547574A
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English (en)
Japanese (ja)
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JPWO2018093465A5 (enExample
JP2019535829A5 (enExample
Inventor
ジョナサン エデルソン，
ジョナサン エデルソン，
Original Assignee
エイリオン セラピューティクス， インコーポレイテッド
エイリオン セラピューティクス， インコーポレイテッド
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Application filed by エイリオン セラピューティクス， インコーポレイテッド, エイリオン セラピューティクス， インコーポレイテッド filed Critical エイリオン セラピューティクス， インコーポレイテッド
Publication of JP2019535829A publication Critical patent/JP2019535829A/ja
Publication of JP2019535829A5 publication Critical patent/JP2019535829A5/ja
Priority to JP2022134512A priority Critical patent/JP2022164750A/ja
Publication of JPWO2018093465A5 publication Critical patent/JPWO2018093465A5/ja
Priority to JP2024150911A priority patent/JP2024167362A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2019547574A 2016-11-21 2017-09-25 大型薬剤の経皮送達 Withdrawn JP2019535829A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022134512A JP2022164750A (ja) 2016-11-21 2022-08-25 大型薬剤の経皮送達
JP2024150911A JP2024167362A (ja) 2016-11-21 2024-09-02 大型薬剤の経皮送達

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424937P 2016-11-21 2016-11-21
US62/424,937 2016-11-21
PCT/US2017/053333 WO2018093465A1 (en) 2016-11-21 2017-09-25 Transdermal delivery of large agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022134512A Division JP2022164750A (ja) 2016-11-21 2022-08-25 大型薬剤の経皮送達

Publications (3)

Publication Number Publication Date
JP2019535829A true JP2019535829A (ja) 2019-12-12
JP2019535829A5 JP2019535829A5 (enExample) 2020-11-12
JPWO2018093465A5 JPWO2018093465A5 (enExample) 2024-07-10

Family

ID=60037726

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019547574A Withdrawn JP2019535829A (ja) 2016-11-21 2017-09-25 大型薬剤の経皮送達
JP2022134512A Pending JP2022164750A (ja) 2016-11-21 2022-08-25 大型薬剤の経皮送達
JP2024150911A Pending JP2024167362A (ja) 2016-11-21 2024-09-02 大型薬剤の経皮送達

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022134512A Pending JP2022164750A (ja) 2016-11-21 2022-08-25 大型薬剤の経皮送達
JP2024150911A Pending JP2024167362A (ja) 2016-11-21 2024-09-02 大型薬剤の経皮送達

Country Status (12)

Country Link
US (2) US11311496B2 (enExample)
EP (1) EP3541358A1 (enExample)
JP (3) JP2019535829A (enExample)
KR (1) KR102487144B1 (enExample)
CN (2) CN117731591A (enExample)
AU (1) AU2017360346B2 (enExample)
BR (1) BR112019010131A2 (enExample)
CA (1) CA3044219A1 (enExample)
IL (1) IL266733A (enExample)
MX (2) MX2019005833A (enExample)
WO (1) WO2018093465A1 (enExample)
ZA (1) ZA201903467B (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US11311496B2 (en) 2016-11-21 2022-04-26 Eirion Therapeutics, Inc. Transdermal delivery of large agents
BR112019025402A2 (pt) * 2017-05-31 2020-06-23 Allergan, Inc. Neurotoxina botulínica para tratamento de distúrbios associados a hiperatividade de melanócito e/ou melanina em excesso
US20210275691A1 (en) * 2018-05-30 2021-09-09 Allergan, Inc. Screening assay to assess topical delivery of biological therapeutic agents
CN113286579A (zh) * 2018-08-23 2021-08-20 埃里克·F·伯恩斯坦 应用抗vegf化合物和使用这类化合物治疗皮肤病的系统、装置和方法
AU2019391791A1 (en) * 2018-12-03 2021-06-03 Eirion Therapeutics, Inc. Improved delivery of large agents
JP2022533113A (ja) * 2019-05-14 2022-07-21 エイリオン セラピューティクス， インコーポレイテッド ピーク効果の遅延および／または応答持続時間の延長
WO2022182738A1 (en) * 2021-02-23 2022-09-01 Nanomed Skincare, Inc. Method of administering a dual therapeutic and cosmetic agent
US20240261552A1 (en) * 2021-05-21 2024-08-08 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
US20240390660A1 (en) * 2021-09-29 2024-11-28 University Of Iowa Research Foundation Apparatus, systems and methods for transdermal drug delivery, permeability enhancement and augmentation
CN116925213B (zh) * 2023-09-12 2024-03-15 中国人民解放军军事科学院军事医学研究院 一种中和a型肉毒毒素的纳米抗体

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2009518307A (ja) * 2005-12-01 2009-05-07 ユニバーシティ オブ マサチューセッツ ロウエル ボツリヌス菌ナノエマルジョン
JP2010502268A (ja) * 2006-08-29 2010-01-28 ナノメド ディヴァイシーズ， インコーポレイテッド 活性物質の経皮送達及びサンプリングのための高アスペクト比マイクロデバイス及びその方法
JP2012514003A (ja) * 2008-12-31 2012-06-21 ルバンス セラピュティックス インク． 注射用ボツリヌス毒素製剤

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