JP2012514003A - 注射用ボツリヌス毒素製剤 - Google Patents
注射用ボツリヌス毒素製剤 Download PDFInfo
- Publication number
- JP2012514003A JP2012514003A JP2011543704A JP2011543704A JP2012514003A JP 2012514003 A JP2012514003 A JP 2012514003A JP 2011543704 A JP2011543704 A JP 2011543704A JP 2011543704 A JP2011543704 A JP 2011543704A JP 2012514003 A JP2012514003 A JP 2012514003A
- Authority
- JP
- Japan
- Prior art keywords
- botulinum toxin
- positively charged
- gly
- complex
- toxin complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
本願は、2008年12月31日に出願された米国仮特許出願第61/142,063号の、米国特許法第119条の下での優先権の利益を主張し、その内容全体は、参照により本明細書に組み込まれている。
この実施例は、RT003又はBOTOX(登録商標)を注射されたマウスにおける局所筋肉麻痺の継続時間を比較する。RT003は、タイプAボツリヌス毒素(精製されて、すべての内因性非毒素タンパク質が除去された)、及び配列RKKRRQRRRG−(K)15−GRKKRRQRRRを有する正に帯電した担体を含有する、本発明による例示的な注射用製剤である。BOTOX(登録商標)も、タイプAボツリヌス毒素を含有するが、タイプAボツリヌス毒素分子を安定化するために、外因性アルブミンが添加されている。
過去数十年にわたって、ボツリヌス毒素では、しわ、多汗症、及び筋痙攣を含めた様々な状態を治療するための治療剤としての用途が見出された。しかし、ボツリヌス毒素は、ヒトに知られている最も強力な天然に存在する毒素であり、毒素の不適切な投与は、極度に危険となり得る。例えば、ボツリヌス毒素の偶発的な全身送達は、麻痺、困難呼吸、及び死亡にさえ至る場合がある。さらに、ボツリヌス毒素が、治療的処置の一部として、体の局所領域に適切に送達されたとしても、毒素は、経時的に拡散する自然の傾向を有し、それによって、体の他の部分における望まれない麻痺のリスクを増大させる。例えば、ボツリヌス毒素が、しわを治療するために眼の周囲に注射される場合、これは、眼瞼の移動を制御する筋肉に拡散する場合がある。これが起こると、眼瞼筋が部分的に麻痺する場合があり、「眼瞼下垂」として知られる周知の状態に至り、眼瞼が部分的に閉じられ、正常な視野を妨害する。
しわなどの望まれない状態を治療するために、ボツリヌス毒素が患者中に定期的に注射される場合、ボツリヌス毒素の効力の継続時間は同じままである場合があっても、ボツリヌス毒素の効力が連続的な注射とともに減少することが観察されることが多い。この現象は、患者の免疫系によるボツリヌス毒素に対する抗体の形成の結果であると考えられている。治療の展望から、患者によるボツリヌス毒素に対する抗体の形成は望ましくなく、その理由はつまり、同じ効果を実現するのに、ますますより大用量のボツリヌス毒素が必要とされるためであり、これは、安全性及び費用の両方に関係した重大な問題を提示する。
この実施例は、本発明の注射用ボツリヌス毒素製剤中に使用される正に帯電した担体分子は、製剤の安全性プロファイルを増強するだけでなく(実施例2)、その安定性も改善することを実証する。表3は、RT003製剤及びRTT150製剤が、様々な時間間隔の間、4℃(RT003のみ)及び40℃(RT003及びRTT150の両方)でエージングされる、エージング実験の結果を示す。指定した温度で指定した時間エージングした後、RT003及びRTT150製剤の効力を、一連のマウスIP LD50アッセイによって測定した。表3に要約した結果は、RT003の効力は、6カ月後でさえ、4℃でエージングした後に本質的に変化しないことを示す。さらに、RT003製剤の効力は、製剤の、マウスIP LD50アッセイにおいて標的動物を殺す能力によって測定した場合、RT003製剤が、高温(40℃)で6カ月間エージングされる場合でさえ、わずかに減少するだけである。一方、RTT150製剤は、40℃で1カ月だけエージングした後に効力の著しい減少を示した。RT003製剤及びRTT150製剤は、RT003製剤が、式RKKRRQRRRG−(K)15−GRKKRRQRRRを有する正に帯電した担体分子も含有することを除いて同一であるので、これらのデータは、正に帯電した担体分子は、RT003製剤中のボツリヌス毒素の安定性を改善することを示す。
Claims (23)
- 治療効果又は美容効果を実現するために、その必要のある個体にボツリヌス毒素を投与する方法であって、
治療効果又は美容効果を実現するために、前記個体中に有効量の組成物を注射するステップを含み、
前記組成物が、
複数の効率基が付着した正に帯電した主鎖を含む、正に帯電した担体と、
ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素と
を含み、前記正に帯電した担体が、前記ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素と非共有結合的に会合している方法。 - ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素が、C.ボツリヌスの血清型A、B、C、D、E、F、又はGから得られる、請求項1に記載の方法。
- 正に帯電した主鎖がポリアミノ酸を含む、請求項1に記載の方法。
- ポリアミノ酸が、ポリリジン、ポリアルギニン、ポリヒスチジン、及びポリオルニチンからなる群から選択される、請求項3に記載の方法。
- 効率基が、(gly)n1−(arg)n2、HIV−TAT若しくはその断片、アンテナペディアのタンパク質トランスダクションドメイン若しくはその断片、(gly)p−RGRDDRRQRRR−(gly)q、(gly)p−YGRKKRRQRRR−(gly)q又は(gly)p−RKKRRQRRR−(gly)q、及びSGRQIKIWFQNRRMKWKKCからなる群から選択されるアミノ酸配列を含み;
式中、添字n1は、0〜20の整数であり、添字n2は、独立して、約5〜約25、より好ましくは約7〜約17、最も好ましくは約7〜約13の奇整数であり、
式中、添字p及びqは、それぞれ独立に、0〜8の整数である、請求項1に記載の方法。 - 正に帯電した担体が、分解に対してボツリヌス毒素を安定化させる、請求項1に記載の方法。
- 正に帯電した担体が、注射後のボツリヌス毒素の局所的拡散を低減する、請求項1に記載の方法。
- 正に帯電した担体がアミノ酸配列RKKRRQRRRG−(K)15−GRKKRRQRRRを有する、請求項1に記載の方法。
- 組成物が、BOTOX(登録商標)と比較して、対象の体内に注射した後に抗体産生を誘発する傾向が低減されている、請求項1に記載の方法。
- 美容効果がしわの治療である、請求項1に記載の方法。
- 治療効果が、片側顔面痙攣、成人発症型痙性斜頚、裂肛、眼瞼痙攣、脳性麻痺、頭痛、斜視、側頭下顎関節障害、神経性疼痛、過活動膀胱、鼻炎、副鼻腔炎、ざ瘡、ジストニア、ジストニア収縮、多汗症、及びコリン作動性神経系によって制御される腺の過分泌からなる群から選択される障害に関連する症状の低減である、請求項1に記載の方法。
- 注射用ボツリヌス毒素製剤を調製する方法であって、
有効量のボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素を提供するステップと;
複数の効率基が付着した正に帯電した主鎖を含む、正に帯電した担体を提供するステップと;
前記ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素を、前記正に帯電した担体及び薬学的に許容される希釈剤と組み合わせるステップと
を含む方法。 - ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素が、C.ボツリヌスの血清型A、B、C、D、E、F、又はGから得られる、請求項11に記載の方法。
- 正に帯電した主鎖がポリアミノ酸を含む、請求項11に記載の方法。
- ポリアミノ酸が、ポリリジン、ポリアルギニン、ポリヒスチジン、及びポリオルニチンからなる群から選択される、請求項11に記載の方法。
- 効率基が、(gly)n1−(arg)n2、HIV−TAT若しくはその断片、アンテナペディアのタンパク質トランスダクションドメイン若しくはその断片、(gly)p−RGRDDRRQRRR−(gly)q、(gly)p−YGRKKRRQRRR−(gly)q又は(gly)p−RKKRRQRRR−(gly)q、及びSGRQIKIWFQNRRMKWKKCからなる群から選択されるアミノ酸配列であり;
式中、添字n1は、0〜20の整数であり、添字n2は、独立して、約5〜約25、より好ましくは約7〜約17、最も好ましくは約7〜約13の奇整数であり;
式中、添字p及びqは、それぞれ独立に、0〜8の整数である、請求項9に記載の方法。 - 正に帯電した担体が、分解に対してボツリヌス毒素を安定化させる、請求項1に記載の方法。
- 正に帯電した担体が、注射後のボツリヌス毒素の局所的拡散を低減する、請求項1に記載の方法。
- 正に帯電した担体がアミノ酸配列RKKRRQRRRG−(K)15−GRKKRRQRRRを有する、請求項1に記載の方法。
- 製剤が、BOTOX(登録商標)と比較して、対象の体内に注射した後に抗体産生を誘発する傾向が低減されている、請求項1に記載の方法。
- 有効量のボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素と;
複数の効率基が付着した正に帯電した主鎖を含む、正に帯電した担体と
を含む滅菌注射用組成物であって;
前記ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素が、前記正に帯電した担体と非共有結合的に会合する組成物。 - 有効量のボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素と;
複数の効率基が付着した正に帯電した主鎖を含む、正に帯電した担体とを含むシリンジであって;
前記ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素が、前記正に帯電した担体と非共有結合的に会合するシリンジ。 - 有効量のボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素と;
複数の効率基が付着した正に帯電した主鎖を含む、正に帯電した担体と;
薬学的に許容される水性液体希釈剤と
を含む再構成されたボツリヌス毒素組成物であって、
前記ボツリヌス毒素複合体、低減されたボツリヌス毒素複合体、又はボツリヌス毒素が、前記正に帯電した担体と非共有結合的に会合し、
前記再構成されたボツリヌス毒素組成物が約0.4〜約2.0cPの範囲の粘度を有する組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14206308P | 2008-12-31 | 2008-12-31 | |
US61/142,063 | 2008-12-31 | ||
PCT/US2009/069576 WO2010078242A1 (en) | 2008-12-31 | 2009-12-28 | Injectable botulinum toxin formulations |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015027842A Division JP6145465B2 (ja) | 2008-12-31 | 2015-02-16 | 注射用ボツリヌス毒素製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012514003A true JP2012514003A (ja) | 2012-06-21 |
JP5866202B2 JP5866202B2 (ja) | 2016-02-17 |
Family
ID=42285690
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011543704A Expired - Fee Related JP5866202B2 (ja) | 2008-12-31 | 2009-12-28 | 注射用ボツリヌス毒素製剤 |
JP2015027842A Expired - Fee Related JP6145465B2 (ja) | 2008-12-31 | 2015-02-16 | 注射用ボツリヌス毒素製剤 |
JP2017096249A Pending JP2017178954A (ja) | 2008-12-31 | 2017-05-15 | 注射用ボツリヌス毒素製剤 |
JP2018141384A Expired - Fee Related JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
JP2019131603A Active JP6976997B2 (ja) | 2008-12-31 | 2019-07-17 | 注射用ボツリヌス毒素製剤 |
JP2021183197A Pending JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015027842A Expired - Fee Related JP6145465B2 (ja) | 2008-12-31 | 2015-02-16 | 注射用ボツリヌス毒素製剤 |
JP2017096249A Pending JP2017178954A (ja) | 2008-12-31 | 2017-05-15 | 注射用ボツリヌス毒素製剤 |
JP2018141384A Expired - Fee Related JP6559849B2 (ja) | 2008-12-31 | 2018-07-27 | 注射用ボツリヌス毒素製剤 |
JP2019131603A Active JP6976997B2 (ja) | 2008-12-31 | 2019-07-17 | 注射用ボツリヌス毒素製剤 |
JP2021183197A Pending JP2022028770A (ja) | 2008-12-31 | 2021-11-10 | 注射用ボツリヌス毒素製剤 |
Country Status (25)
Country | Link |
---|---|
US (5) | US9956435B2 (ja) |
EP (2) | EP3332805B1 (ja) |
JP (6) | JP5866202B2 (ja) |
KR (4) | KR102005930B1 (ja) |
CN (2) | CN107343859A (ja) |
AU (5) | AU2009332947C1 (ja) |
BR (1) | BRPI0923731B1 (ja) |
CA (1) | CA2749757C (ja) |
CO (1) | CO6400199A2 (ja) |
CY (1) | CY1120137T1 (ja) |
DK (2) | DK2379104T3 (ja) |
ES (2) | ES2908616T3 (ja) |
HK (1) | HK1256878A1 (ja) |
HR (1) | HRP20180739T1 (ja) |
HU (1) | HUE037595T2 (ja) |
IL (3) | IL213668A (ja) |
LT (1) | LT2379104T (ja) |
MX (1) | MX2011007059A (ja) |
NO (1) | NO2379104T3 (ja) |
PL (1) | PL2379104T3 (ja) |
PT (1) | PT2379104T (ja) |
RU (1) | RU2011125775A (ja) |
SG (3) | SG10201405582YA (ja) |
SI (1) | SI2379104T1 (ja) |
WO (1) | WO2010078242A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017525749A (ja) * | 2014-09-02 | 2017-09-07 | アメリカン シルヴァー リミテッド ライアビリティ カンパニー | ボツリヌス毒素及びコロイド状銀粒子 |
JP2018531984A (ja) * | 2015-10-29 | 2018-11-01 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 治療効果又は美容効果の長い持続時間を有する、注射用ボツリヌス毒素製剤及びこれらの使用方法 |
JP2019508196A (ja) * | 2016-01-22 | 2019-03-28 | トランスダーム、インク. | マイクロニードルアレイを用いたボツリヌス菌の送達 |
JP2019535829A (ja) * | 2016-11-21 | 2019-12-12 | エイリオン セラピューティクス, インコーポレイテッド | 大型薬剤の経皮送達 |
JP2020520917A (ja) * | 2017-05-18 | 2020-07-16 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 頸部ジストニアの治療方法 |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8974774B2 (en) | 2004-03-03 | 2015-03-10 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
BRPI0720729A2 (pt) * | 2006-12-29 | 2014-04-08 | Revance Therapeutics Inc | Moléculas de transporte que utilizam polipeptídeos hiv-tat de sequência inversa. |
KR101722038B1 (ko) | 2007-07-26 | 2017-04-03 | 레반스 테라퓨틱스, 아이엔씨. | 항미생물 펩티드, 조성물, 및 이용 방법 |
US9656019B2 (en) | 2007-10-02 | 2017-05-23 | Medimop Medical Projects Ltd. | Apparatuses for securing components of a drug delivery system during transport and methods of using same |
US9173997B2 (en) | 2007-10-02 | 2015-11-03 | Medimop Medical Projects Ltd. | External drug pump |
US9345836B2 (en) | 2007-10-02 | 2016-05-24 | Medimop Medical Projects Ltd. | Disengagement resistant telescoping assembly and unidirectional method of assembly for such |
US7967795B1 (en) | 2010-01-19 | 2011-06-28 | Lamodel Ltd. | Cartridge interface assembly with driving plunger |
US10420880B2 (en) | 2007-10-02 | 2019-09-24 | West Pharma. Services IL, Ltd. | Key for securing components of a drug delivery system during assembly and/or transport and methods of using same |
SG2014009112A (en) | 2008-03-14 | 2014-04-28 | Allergan Inc | Immuno-based botulinum toxin serotype a activity assays |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
KR102005930B1 (ko) * | 2008-12-31 | 2019-07-31 | 레반스 테라퓨틱스, 아이엔씨. | 주사용 보툴리눔 독소 제제 |
BRPI1015938A2 (pt) | 2009-06-25 | 2016-09-27 | Revance Therapeutics Inc | formulações da toxina botulínica livre de albumina |
US10071198B2 (en) | 2012-11-02 | 2018-09-11 | West Pharma. Servicees IL, Ltd. | Adhesive structure for medical device |
US8157769B2 (en) | 2009-09-15 | 2012-04-17 | Medimop Medical Projects Ltd. | Cartridge insertion assembly for drug delivery system |
US10071196B2 (en) | 2012-05-15 | 2018-09-11 | West Pharma. Services IL, Ltd. | Method for selectively powering a battery-operated drug-delivery device and device therefor |
CN102666396B (zh) * | 2009-10-21 | 2015-05-13 | 雷文斯治疗公司 | 用于纯化非复合的肉毒杆菌神经毒素的方法和系统 |
US10585098B2 (en) | 2009-11-23 | 2020-03-10 | The Johns Hopkins University | Optimizing diagnostics for galactofuranose containing antigens |
WO2011063395A2 (en) * | 2009-11-23 | 2011-05-26 | The Johns Hopkins University | Lateral flow device for diagnosing microbial infections |
US8348898B2 (en) | 2010-01-19 | 2013-01-08 | Medimop Medical Projects Ltd. | Automatic needle for drug pump |
EP2569031B1 (en) * | 2010-05-10 | 2017-10-11 | Medimop Medical Projects Ltd. | Low volume accurate injector |
KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
JP6444032B2 (ja) * | 2011-01-07 | 2018-12-26 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 治療用又は美容用毒素組成物の局所塗布、除去及び不活化のための方法及びキット |
USD702834S1 (en) | 2011-03-22 | 2014-04-15 | Medimop Medical Projects Ltd. | Cartridge for use in injection device |
US9072827B2 (en) | 2012-03-26 | 2015-07-07 | Medimop Medical Projects Ltd. | Fail safe point protector for needle safety flap |
US20140120077A1 (en) * | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and Methods for Safe Treatment of Rhinitis |
US9421323B2 (en) | 2013-01-03 | 2016-08-23 | Medimop Medical Projects Ltd. | Door and doorstop for portable one use drug delivery apparatus |
US9011164B2 (en) | 2013-04-30 | 2015-04-21 | Medimop Medical Projects Ltd. | Clip contact for easy installation of printed circuit board PCB |
RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
GB201312317D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
US10107822B2 (en) | 2013-12-16 | 2018-10-23 | The Johns Hopkins University | Interferon-gamma release assays for diagnosis of invasive fungal infections |
ES2642916T3 (es) * | 2014-06-06 | 2017-11-20 | Galit KLEINER-FISMAN | Toxina botulínica para su uso en el tratamiento de la paratonia |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
EP3174523B1 (en) * | 2014-07-31 | 2020-07-01 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
ES2788999T3 (es) * | 2014-12-23 | 2020-10-23 | Merz Pharma Gmbh & Co Kgaa | Envase prellenado de toxina botulínica |
US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
KR102099326B1 (ko) * | 2015-04-13 | 2020-04-09 | 주식회사 엘지생활건강 | 폴리페놀 전달용 용해성 마이크로니들 |
US10391289B2 (en) | 2015-04-13 | 2019-08-27 | Lg Household & Health Care Ltd. | Soluble microneedle containing ingredient for controlling release of neurotransmitters |
US10149943B2 (en) | 2015-05-29 | 2018-12-11 | West Pharma. Services IL, Ltd. | Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly |
JP2018516678A (ja) | 2015-06-04 | 2018-06-28 | メディモップ・メディカル・プロジェクツ・リミテッド | 薬物送達装置用カートリッジ挿入 |
US9987432B2 (en) | 2015-09-22 | 2018-06-05 | West Pharma. Services IL, Ltd. | Rotation resistant friction adapter for plunger driver of drug delivery device |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
US11318254B2 (en) | 2015-10-09 | 2022-05-03 | West Pharma. Services IL, Ltd. | Injector needle cap remover |
WO2017127215A1 (en) | 2016-01-21 | 2017-07-27 | Medimop Medical Projects Ltd. | Needle insertion and retraction mechanism |
JP6513297B2 (ja) | 2016-01-21 | 2019-05-22 | ウェスト ファーマ サービシーズ イスラエル リミテッド | 自動注射器、受け入れフレーム及び自動注射器におけるカートリッジの接続方法 |
CN113041432B (zh) | 2016-01-21 | 2023-04-07 | 西医药服务以色列有限公司 | 包括视觉指示物的药剂输送装置 |
US11389597B2 (en) | 2016-03-16 | 2022-07-19 | West Pharma. Services IL, Ltd. | Staged telescopic screw assembly having different visual indicators |
US11103652B2 (en) | 2016-06-02 | 2021-08-31 | West Pharma. Services IL, Ltd. | Three position needle retraction |
WO2018026387A1 (en) | 2016-08-01 | 2018-02-08 | Medimop Medical Projects Ltd. | Anti-rotation cartridge pin |
JP7059251B2 (ja) | 2016-08-01 | 2022-04-25 | ウェスト ファーマ サービシーズ イスラエル リミテッド | ドアの半閉じを防止するスプリング |
CN109803672A (zh) | 2016-09-13 | 2019-05-24 | 阿勒根公司 | 稳定的非蛋白质梭菌毒素组合物 |
US11065428B2 (en) * | 2017-02-17 | 2021-07-20 | Allergan, Inc. | Microneedle array with active ingredient |
CN110691579A (zh) * | 2017-03-22 | 2020-01-14 | 邦蒂公司 | 用于治疗的肉毒杆菌神经毒素 |
CN107185042B (zh) * | 2017-04-29 | 2020-09-01 | 杭州维多利亚医疗美容医院有限公司 | 一种美容注射剂及其制备方法 |
WO2018222521A1 (en) | 2017-05-30 | 2018-12-06 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
EP3675900A4 (en) * | 2017-08-28 | 2021-05-05 | Revance Therapeutics, Inc. | TRANSMUCOSAL BOTULINUM TOXIN COMPOSITIONS, KITS, AND METHODS FOR TREATMENT OF BLADDER DISORDER |
KR20190038292A (ko) * | 2017-09-29 | 2019-04-08 | 한국프라임제약주식회사 | 효능 지속시간이 연장된 보툴리눔 독소 조성물 |
WO2019090257A1 (en) * | 2017-11-03 | 2019-05-09 | Revance Therapeutics, Inc. | Botulinum toxin formulations and methods of use thereof in plantar fasciitis with extended duration of effect |
JP2021505570A (ja) * | 2017-12-04 | 2021-02-18 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 高い応答率及び長い効果の持続期間を有する注射可能なボツリヌス毒素製剤及びその使用方法 |
CN111683703B (zh) | 2017-12-22 | 2022-11-18 | 西氏医药包装(以色列)有限公司 | 适用于不同尺寸的药筒的注射器 |
KR102088104B1 (ko) | 2018-06-29 | 2020-03-11 | 호서대학교 산학협력단 | 개망초 꽃 에센셜 오일을 포함하는 신경 근육 관련 질환 예방 및 치료용 조성물 |
SG11202104838SA (en) | 2018-12-03 | 2021-06-29 | Eirion Therapeutics Inc | Improved delivery of large agents |
SG11202110518XA (en) | 2019-05-14 | 2021-10-28 | Eirion Therapeutics Inc | Delaying peak effect and/or extending duration of response |
WO2021195968A1 (zh) | 2020-03-31 | 2021-10-07 | 台湾浩鼎生技股份有限公司 | A型肉毒杆菌毒素复合物、其配制剂和使用方法 |
US20230165946A1 (en) * | 2020-04-08 | 2023-06-01 | Medytox Inc. | Botulinum toxin pre-filled injectable formulation that facilitates discharge rate control and is stable |
JP7550889B2 (ja) | 2020-06-12 | 2024-09-13 | ケアジェン カンパニー,リミテッド | ペンタペプチドを有効成分として含む組成物 |
KR20220114183A (ko) * | 2021-02-08 | 2022-08-17 | 주식회사 대웅 | 장기 저장이 가능한 보툴리눔 독소 동결건조 제형 조성물 |
WO2023239229A1 (ko) * | 2022-06-10 | 2023-12-14 | (주)메디톡스 | 보툴리눔 독소 안정화 조성물, 이를 포함하는 보툴리눔 독소 제제 및 이에 사용하기 위한 폴리펩티드 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004513075A (ja) * | 2000-07-21 | 2004-04-30 | エッセンシア・バイオシステムズ・インコーポレイテッド | 多成分生物学的輸送システム |
JP2007526340A (ja) * | 2004-03-03 | 2007-09-13 | ルバンス セラピュティックス | ボツリヌストキシンの局所適用及び経皮送達のための組成物及び方法 |
WO2008082889A2 (en) * | 2006-12-29 | 2008-07-10 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat |
JP2008531725A (ja) * | 2005-03-03 | 2008-08-14 | ルバンス セラピュティックス インク. | オリゴペプチドの局所適用及び経皮送達のための組成物及び方法 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US5877278A (en) | 1992-09-24 | 1999-03-02 | Chiron Corporation | Synthesis of N-substituted oligomers |
ATE198277T1 (de) | 1992-10-02 | 2001-01-15 | Genetics Inst | Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator |
AU688452B2 (en) | 1993-12-28 | 1998-03-12 | Allergan, Inc. | Botulinum toxins for treating various disorders and associated pain |
US5756468A (en) | 1994-10-13 | 1998-05-26 | Wisconsin Alumni Research Foundation | Pharmaceutical compositions of botulinum toxin or botulinum neurotoxin and methods of preparation |
US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
GB9508204D0 (en) | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
US6444209B1 (en) | 1996-10-28 | 2002-09-03 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
US20030095927A1 (en) | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating muscular and skeletal disorders |
EP1053014A4 (en) | 1998-01-26 | 2004-11-10 | Univ Massachusetts | BIOLOGICALLY ACTIVE HEMAGGLUTININE TYPE A i (STRIDIUM BOTULINUM) AND METHOD FOR ITS USE |
TW574036B (en) | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
US6358917B1 (en) | 1999-08-24 | 2002-03-19 | Jean D. A. Carruthers | Cosmetic use of botulinum toxin for treatment of downturned mouth |
US6544548B1 (en) * | 1999-09-13 | 2003-04-08 | Keraplast Technologies, Ltd. | Keratin-based powders and hydrogel for pharmaceutical applications |
US6844324B1 (en) | 1999-11-12 | 2005-01-18 | Massachusetts Institute Of Technology | Modular peptide mediated intracellular delivery system and uses therefore |
IL149778A0 (en) | 1999-11-22 | 2002-11-10 | Universal Preservation Technologies Inc | Preservation of sensitive biological material |
US7780967B2 (en) | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
US20030118598A1 (en) | 2000-02-08 | 2003-06-26 | Allergan, Inc. | Clostridial toxin pharmaceutical compositions |
CN1258379C (zh) | 2000-02-08 | 2006-06-07 | 阿勒根公司 | 肉毒杆菌毒素药物组合物 |
US6670322B2 (en) | 2000-06-01 | 2003-12-30 | Wisconsin Alumni Research Foundation | Method of targeting pharmaceuticals to motor neurons |
US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
US20040033241A1 (en) | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
US20030215412A1 (en) * | 2000-07-21 | 2003-11-20 | Essentia Biosystems, Inc. | Induction of hair growth with vascular endothelial growth factor |
US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
US6787517B1 (en) | 2000-12-29 | 2004-09-07 | Allergan, Inc. | Agent and methods for treating pain |
AU2002320127A1 (en) | 2001-06-21 | 2003-01-08 | Surromed, Inc. | Covalent coupling of botulinum toxin with polyethylene glycol |
EP1475101B1 (en) | 2002-02-14 | 2010-10-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing solution pharmaceuticals |
US7691394B2 (en) | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
WO2003101483A1 (en) | 2002-05-31 | 2003-12-11 | Solux Corporation | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
RU2206337C1 (ru) | 2002-10-29 | 2003-06-20 | Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" | Лекарственный препарат для лечения мышечных дистоний и способ его получения |
US20040086532A1 (en) | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
US20060210614A1 (en) * | 2003-12-26 | 2006-09-21 | Nastech Pharmaceutical Company Inc. | Method of treatment of a metabolic disease using intranasal administration of exendin peptide |
US20100266638A1 (en) | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
US8974774B2 (en) | 2004-03-03 | 2015-03-10 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
CA2578250C (en) | 2004-07-26 | 2013-03-05 | Merz Pharma Gmbh & Co. Kgaa | Therapeutic composition with a botulinum neurotoxin |
US20070196364A1 (en) | 2004-07-27 | 2007-08-23 | Human Genome Sciences, Inc. | Pharmaceutical Formulation and Process |
PL1776137T3 (pl) | 2004-08-04 | 2015-03-31 | Ipsen Biopharm Ltd | Kompozycja farmaceutyczna zawierająca neurotoksynę botulinową |
GB2419526A (en) | 2004-10-28 | 2006-05-03 | Ipsen Ltd | Pharmaceutical composition containing botulinum neurotoxin |
EP1778279B1 (en) | 2004-08-04 | 2014-12-03 | Ipsen Biopharm Limited | Pharmaceutical composition containing botulinum neurotoxin a2 |
US7838011B2 (en) | 2005-02-14 | 2010-11-23 | Pankaj Modi | Stabilized protein compositions for topical administration and methods of making same |
US7727537B2 (en) | 2005-02-14 | 2010-06-01 | Dpm Therapeutics Corp. | Stabilized compositions for topical administration and methods of making same |
ES2509872T3 (es) * | 2005-03-03 | 2014-10-20 | Allergan, Inc. | Procedimientos para obtener una toxina clostrídica |
ZA200707352B (en) | 2005-03-03 | 2009-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
CN101228187A (zh) | 2005-03-25 | 2008-07-23 | 特拉维夫大学拉莫特有限公司 | 针对突变p53的共同表位的人合成单链抗体及其用途 |
US8323666B2 (en) | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
US8137677B2 (en) | 2005-10-06 | 2012-03-20 | Allergan, Inc. | Non-protein stabilized clostridial toxin pharmaceutical compositions |
US8518414B2 (en) | 2005-11-17 | 2013-08-27 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
FR2910327B1 (fr) | 2006-12-22 | 2013-04-26 | Scras | Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida. |
MX2009012990A (es) | 2007-06-01 | 2010-04-01 | Merz Pharma Gmbh & Co Kgaa | Proceso para proporcionar un relajante muscular estable a la temperatura sobre la base del componente neurotoxico de toxina botulinica. |
KR101722038B1 (ko) * | 2007-07-26 | 2017-04-03 | 레반스 테라퓨틱스, 아이엔씨. | 항미생물 펩티드, 조성물, 및 이용 방법 |
WO2009056651A1 (en) | 2007-11-02 | 2009-05-07 | Cytos Biotechnology Ag | Angiotensin-carrier formulation |
US9107815B2 (en) | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
KR20090120222A (ko) | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
US20100196445A1 (en) * | 2008-11-12 | 2010-08-05 | David Nathaniel E | Systems and methods for delivery of biologically active agents |
CN105833254A (zh) | 2008-12-10 | 2016-08-10 | 阿勒根公司 | 梭菌毒素药物组合物 |
KR102005930B1 (ko) | 2008-12-31 | 2019-07-31 | 레반스 테라퓨틱스, 아이엔씨. | 주사용 보툴리눔 독소 제제 |
EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
BRPI1015938A2 (pt) | 2009-06-25 | 2016-09-27 | Revance Therapeutics Inc | formulações da toxina botulínica livre de albumina |
CN102666396B (zh) | 2009-10-21 | 2015-05-13 | 雷文斯治疗公司 | 用于纯化非复合的肉毒杆菌神经毒素的方法和系统 |
KR20120120141A (ko) | 2009-10-30 | 2012-11-01 | 듀오젝트 메디컬 시스템즈, 아이엔씨. | 치료 또는 미용 조성물의 국소 투여를 위한 장치 및 방법 |
CA2814054A1 (en) | 2010-10-12 | 2012-04-19 | Merz Pharma Gmbh & Co. Kgaa | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
JP6444032B2 (ja) | 2011-01-07 | 2018-12-26 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 治療用又は美容用毒素組成物の局所塗布、除去及び不活化のための方法及びキット |
RU2574011C2 (ru) | 2011-03-31 | 2016-01-27 | Меди-Токс Инк. | Лиофилизированный препарат ботулотоксина |
US20130224268A1 (en) | 2012-02-27 | 2013-08-29 | Newgen Biopharma Corp. | Topical delivery of hormonal and non hormonal nano formulations, methods of making and using the same |
ES2788999T3 (es) | 2014-12-23 | 2020-10-23 | Merz Pharma Gmbh & Co Kgaa | Envase prellenado de toxina botulínica |
SI3463432T1 (sl) | 2016-05-27 | 2021-02-26 | Ipsen Biopharm Limited | Tekoča nevrotoksinska formulacija, stabilizirana s triptofanom ali tirozinom |
-
2009
- 2009-12-28 KR KR1020177017577A patent/KR102005930B1/ko active IP Right Grant
- 2009-12-28 AU AU2009332947A patent/AU2009332947C1/en active Active
- 2009-12-28 EP EP18150826.8A patent/EP3332805B1/en active Active
- 2009-12-28 ES ES18150826T patent/ES2908616T3/es active Active
- 2009-12-28 CA CA2749757A patent/CA2749757C/en active Active
- 2009-12-28 RU RU2011125775/15A patent/RU2011125775A/ru not_active Application Discontinuation
- 2009-12-28 JP JP2011543704A patent/JP5866202B2/ja not_active Expired - Fee Related
- 2009-12-28 KR KR1020207032582A patent/KR102363878B1/ko active IP Right Grant
- 2009-12-28 CN CN201710199742.5A patent/CN107343859A/zh active Pending
- 2009-12-28 SG SG10201405582YA patent/SG10201405582YA/en unknown
- 2009-12-28 NO NO09837072A patent/NO2379104T3/no unknown
- 2009-12-28 BR BRPI0923731-3A patent/BRPI0923731B1/pt active IP Right Grant
- 2009-12-28 WO PCT/US2009/069576 patent/WO2010078242A1/en active Application Filing
- 2009-12-28 SG SG10202100698QA patent/SG10202100698QA/en unknown
- 2009-12-28 KR KR1020197021987A patent/KR102179926B1/ko active IP Right Grant
- 2009-12-28 PL PL09837072T patent/PL2379104T3/pl unknown
- 2009-12-28 SI SI200931821T patent/SI2379104T1/en unknown
- 2009-12-28 MX MX2011007059A patent/MX2011007059A/es active IP Right Grant
- 2009-12-28 US US13/141,935 patent/US9956435B2/en active Active
- 2009-12-28 DK DK09837072.9T patent/DK2379104T3/en active
- 2009-12-28 LT LTEP09837072.9T patent/LT2379104T/lt unknown
- 2009-12-28 HU HUE09837072A patent/HUE037595T2/hu unknown
- 2009-12-28 ES ES09837072.9T patent/ES2669020T3/es active Active
- 2009-12-28 DK DK18150826.8T patent/DK3332805T3/da active
- 2009-12-28 EP EP09837072.9A patent/EP2379104B1/en active Active
- 2009-12-28 SG SG2011047909A patent/SG172812A1/en unknown
- 2009-12-28 US US12/647,677 patent/US20100168023A1/en not_active Abandoned
- 2009-12-28 PT PT98370729T patent/PT2379104T/pt unknown
- 2009-12-28 KR KR1020117017761A patent/KR101753242B1/ko active IP Right Review Request
- 2009-12-28 CN CN2009801555495A patent/CN102300584A/zh active Pending
-
2011
- 2011-06-20 IL IL213668A patent/IL213668A/en active IP Right Grant
- 2011-07-28 CO CO11094674A patent/CO6400199A2/es not_active Application Discontinuation
-
2015
- 2015-02-16 JP JP2015027842A patent/JP6145465B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-07 AU AU2016238949A patent/AU2016238949C1/en active Active
-
2017
- 2017-05-15 JP JP2017096249A patent/JP2017178954A/ja active Pending
- 2017-09-18 IL IL254558A patent/IL254558B/en active IP Right Grant
-
2018
- 2018-03-27 US US15/937,388 patent/US20180214717A1/en not_active Abandoned
- 2018-04-17 CY CY20181100406T patent/CY1120137T1/el unknown
- 2018-05-14 HR HRP20180739TT patent/HRP20180739T1/hr unknown
- 2018-07-27 JP JP2018141384A patent/JP6559849B2/ja not_active Expired - Fee Related
- 2018-10-26 AU AU2018253620A patent/AU2018253620B2/en active Active
- 2018-12-12 HK HK18115979.3A patent/HK1256878A1/zh unknown
-
2019
- 2019-07-17 JP JP2019131603A patent/JP6976997B2/ja active Active
- 2019-10-17 US US16/656,115 patent/US11471708B2/en active Active
-
2021
- 2021-01-29 AU AU2021200561A patent/AU2021200561B2/en active Active
- 2021-03-21 IL IL281675A patent/IL281675A/en unknown
- 2021-11-10 JP JP2021183197A patent/JP2022028770A/ja active Pending
-
2022
- 2022-09-23 US US17/951,220 patent/US20240058628A1/en active Pending
-
2023
- 2023-09-14 AU AU2023229550A patent/AU2023229550A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004513075A (ja) * | 2000-07-21 | 2004-04-30 | エッセンシア・バイオシステムズ・インコーポレイテッド | 多成分生物学的輸送システム |
JP2007526340A (ja) * | 2004-03-03 | 2007-09-13 | ルバンス セラピュティックス | ボツリヌストキシンの局所適用及び経皮送達のための組成物及び方法 |
JP2008531725A (ja) * | 2005-03-03 | 2008-08-14 | ルバンス セラピュティックス インク. | オリゴペプチドの局所適用及び経皮送達のための組成物及び方法 |
WO2008082889A2 (en) * | 2006-12-29 | 2008-07-10 | Revance Therapeutics, Inc. | Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017525749A (ja) * | 2014-09-02 | 2017-09-07 | アメリカン シルヴァー リミテッド ライアビリティ カンパニー | ボツリヌス毒素及びコロイド状銀粒子 |
JP2018531984A (ja) * | 2015-10-29 | 2018-11-01 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 治療効果又は美容効果の長い持続時間を有する、注射用ボツリヌス毒素製剤及びこれらの使用方法 |
CN109069608A (zh) * | 2015-10-29 | 2018-12-21 | 雷文斯治疗公司 | 具有长的治疗或美容效应持续时间的可注射肉毒杆菌毒素制剂以及其使用方法 |
JP2019508196A (ja) * | 2016-01-22 | 2019-03-28 | トランスダーム、インク. | マイクロニードルアレイを用いたボツリヌス菌の送達 |
JP7162531B2 (ja) | 2016-01-22 | 2022-10-28 | トランスダーム、インク. | マイクロニードルアレイを用いたボツリヌス菌の送達 |
JP2019535829A (ja) * | 2016-11-21 | 2019-12-12 | エイリオン セラピューティクス, インコーポレイテッド | 大型薬剤の経皮送達 |
JP2020520917A (ja) * | 2017-05-18 | 2020-07-16 | ルバンス セラピュティックス インク.Revance Therapeutics,Inc. | 頸部ジストニアの治療方法 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6559849B2 (ja) | 注射用ボツリヌス毒素製剤 | |
KR20180077202A (ko) | 주사용 보툴리눔 독소 제제 및 긴 지속기간의 치료적 또는 미용적 효과를 갖는 이를 이용한 방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20121226 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140120 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140415 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140422 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140515 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140522 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140616 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140623 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140722 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20141016 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150216 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150217 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150417 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150519 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150817 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150915 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151013 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151119 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151215 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160104 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5866202 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |