|
US3906092A
(en)
|
1971-11-26 |
1975-09-16 |
Merck & Co Inc |
Stimulation of antibody response
|
|
CA1335429C
(en)
|
1986-03-07 |
1995-05-02 |
Geoffrey L. Smith |
Processes for the production of hcmv glycoproteins, antibodies thereto and hcmv vaccines, and recombinant vectors therefor
|
|
US6162620A
(en)
|
1986-03-07 |
2000-12-19 |
Cogent Limited |
Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor
|
|
US6207161B1
(en)
|
1986-07-16 |
2001-03-27 |
City Of Hope |
Induction of cytolytic T-lymphocytes with cytomegalovirus polypeptides
|
|
EP0737750B1
(en)
|
1989-03-21 |
2003-05-14 |
Vical, Inc. |
Expression of exogenous polynucleotide sequences in a vertebrate
|
|
JPH07503372A
(ja)
|
1992-01-23 |
1995-04-13 |
バイカル・インコーポレイテッド |
生体外遺伝子導入
|
|
IL112820A0
(en)
|
1994-03-07 |
1995-05-26 |
Merck & Co Inc |
Coordinate in vivo gene expression
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
AU2656295A
(en)
|
1994-06-02 |
1996-01-04 |
Chiron Corporation |
Nucleic acid immunization using a virus-based infection/transfection system
|
|
WO1997040165A1
(en)
|
1996-04-23 |
1997-10-30 |
The Wistar Institute Of Anatomy And Biology |
Novel human cytomegalovirus dna constructs and uses therefor
|
|
US6074645A
(en)
|
1996-11-12 |
2000-06-13 |
City Of Hope |
Immuno-reactive peptide CTL epitopes of human cytomegalovirus
|
|
US6562345B1
(en)
|
1996-11-12 |
2003-05-13 |
City Of Hope |
Immuno-reactive peptide CTL epitopes of human cytomegalovirus
|
|
EP0855184A1
(en)
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
|
US6183752B1
(en)
*
|
1997-02-05 |
2001-02-06 |
Pasteur Merieux Serums Et Vaccins |
Restenosis/atherosclerosis diagnosis, prophylaxis and therapy
|
|
EP1021548A1
(en)
|
1997-10-07 |
2000-07-26 |
University Of Maryland Biotechnology Institute |
Method for introducing and expressing rna in animal cells
|
|
WO1999033982A2
(en)
|
1997-12-23 |
1999-07-08 |
Chiron Corporation |
Human genes and gene expression products i
|
|
DE19910044A1
(de)
|
1999-03-08 |
2000-09-14 |
Bodo Plachter |
Virale Partikel, die nach Infektion durch humanes Cytomegalovirus freigesetzt werden und ihre Verwendung als Impfstoff
|
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
|
DE69943068D1
(de)
|
1999-09-09 |
2011-02-03 |
Curevac Gmbh |
Transfer von mRNA unter Verwendung von polykationischen Verbindungen
|
|
WO2001023002A1
(en)
|
1999-09-30 |
2001-04-05 |
National Jewish Medical And Research Center |
Method for inhibition of pathogenic microorganisms
|
|
US7060291B1
(en)
|
1999-11-24 |
2006-06-13 |
Transave, Inc. |
Modular targeted liposomal delivery system
|
|
US6835383B2
(en)
|
2000-03-23 |
2004-12-28 |
City Of Hope |
Protein kinase deficient, immunologically active CMVpp65 mutants
|
|
CN1254234C
(zh)
|
2000-06-09 |
2006-05-03 |
莱古伦公司 |
质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
|
|
US7204990B1
(en)
|
2000-11-28 |
2007-04-17 |
Medimmune Vaccines, Inc. |
Attenuation of cytomegalovirus virulence
|
|
EP1903054A3
(de)
|
2001-06-05 |
2008-07-23 |
CureVac GmbH |
Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Gentherapie
|
|
DE10162480A1
(de)
|
2001-12-19 |
2003-08-07 |
Ingmar Hoerr |
Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen
|
|
WO2003059381A2
(en)
*
|
2002-01-18 |
2003-07-24 |
Curevac Gmbh |
Immunogenic preparations and vaccines on the basis of mrna
|
|
DE10229872A1
(de)
|
2002-07-03 |
2004-01-29 |
Curevac Gmbh |
Immunstimulation durch chemisch modifizierte RNA
|
|
AU2003301148A1
(en)
*
|
2002-12-23 |
2004-07-22 |
Vical Incorporated |
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
|
|
US20040228842A1
(en)
|
2003-02-27 |
2004-11-18 |
Shan Lu |
Compositions and methods for cytomegalovirus treatment
|
|
ES2562456T3
(es)
*
|
2003-03-24 |
2016-03-04 |
Valneva Austria Gmbh |
Uso de un adyuvante que induce una respuesta inmune Th1 para mejorar las respuestas inmunes
|
|
WO2005009346A2
(en)
|
2003-06-24 |
2005-02-03 |
Mirus Corporation |
Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo
|
|
EP1651666B1
(en)
*
|
2003-07-11 |
2009-05-27 |
Alphavax, Inc. |
Alphavirus-based cytomegalovirus vaccines
|
|
DE10335833A1
(de)
|
2003-08-05 |
2005-03-03 |
Curevac Gmbh |
Transfektion von Blutzellen mit mRNA zur Immunstimulation und Gentherapie
|
|
JP2007509040A
(ja)
|
2003-10-11 |
2007-04-12 |
イネックス ファーマシューティカルズ コーポレイション |
先天性免疫及び抗体依存性細胞傷害を強化するための方法及び組成物
|
|
JP2007512355A
(ja)
|
2003-11-21 |
2007-05-17 |
アルザ コーポレイション |
開裂性のｐｅｇで表面修飾されたリポソーム−ｄｎａ複合体で媒介される遺伝子送達
|
|
WO2005120152A2
(en)
|
2004-06-07 |
2005-12-22 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
|
DE102004035227A1
(de)
|
2004-07-21 |
2006-02-16 |
Curevac Gmbh |
mRNA-Gemisch zur Vakzinierung gegen Tumorerkrankungen
|
|
DE102004042546A1
(de)
|
2004-09-02 |
2006-03-09 |
Curevac Gmbh |
Kombinationstherapie zur Immunstimulation
|
|
WO2006056027A1
(en)
|
2004-11-29 |
2006-06-01 |
The Council Of The Queensland Institute Of Medical Research |
Human cytomegalovirus immunotherapy
|
|
US9068969B2
(en)
|
2004-12-28 |
2015-06-30 |
Ptc Therapeutics, Inc. |
Cell based methods and systems for the identification of RNA regulatory sequences and compounds that modulate their functions
|
|
WO2006095259A2
(en)
|
2005-03-11 |
2006-09-14 |
Novartis Ag |
Biomarkers for cardiovascular side-effects induced by cox-2 inhibitory compounds
|
|
HUE043492T2
(hu)
|
2005-08-23 |
2019-08-28 |
Univ Pennsylvania |
Módosított nukleozidokat tartalmazó RNS és eljárások az alkalmazására
|
|
WO2007051303A1
(en)
|
2005-11-02 |
2007-05-10 |
Protiva Biotherapeutics, Inc. |
MODIFIED siRNA MOLECULES AND USES THEREOF
|
|
US9149543B2
(en)
|
2005-12-15 |
2015-10-06 |
The Trustees Of The University Of Pennsylvania |
Methods and models for rapid, widespread delivery of genetic material to the CNS using non-viral, cationic lipid-mediated vectors
|
|
DE102006007433A1
(de)
|
2006-02-17 |
2007-08-23 |
Curevac Gmbh |
Adjuvanz in Form einer Lipid-modifizierten Nukleinsäure
|
|
CA2654563A1
(en)
|
2006-06-07 |
2007-12-21 |
The Trustees Of Princeton University |
Cytomegalovirus surface protein complex for use in vaccines and as a drug target
|
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤／アジュバントとしての、一般式（Ｉ）：ＧｌＸｍＧｎ、または一般式（ＩＩ）：ＣｌＸｍＣｎで表される核酸
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US8877206B2
(en)
|
2007-03-22 |
2014-11-04 |
Pds Biotechnology Corporation |
Stimulation of an immune response by cationic lipids
|
|
WO2009030254A1
(en)
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
WO2009046739A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating prostate cancer (pca)
|
|
WO2009046738A1
(en)
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating lung cancer, particularly of non-small lung cancers (nsclc)
|
|
CN101932707B
(zh)
|
2008-01-31 |
2013-08-21 |
库瑞瓦格有限责任公司 |
作为免疫刺激剂/佐剂的式(I)(NuGlXmGnNv)a的核酸及其衍生物
|
|
NZ588583A
(en)
|
2008-04-15 |
2012-08-31 |
Protiva Biotherapeutics Inc |
Novel lipid formulations for nucleic acid delivery
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
DK3156069T3
(da)
|
2008-06-20 |
2020-09-21 |
Univ Duke |
Sammensætninger, fremgangsmåder, og kits til fremkaldelse af et immunrespons
|
|
WO2010037408A1
(en)
|
2008-09-30 |
2010-04-08 |
Curevac Gmbh |
Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof
|
|
AU2015210364B2
(en)
|
2008-10-09 |
2017-03-09 |
Arbutus Biopharma Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
|
JP5777519B2
(ja)
|
2008-10-09 |
2015-09-09 |
テクミラ ファーマシューティカルズ コーポレイション |
改良されたアミノ脂質および核酸の送達方法
|
|
EP2349210B1
(en)
|
2008-10-16 |
2015-03-18 |
Marina Biotech, Inc. |
Processes and compositions for liposomal and efficient delivery of gene silencing therapeutics
|
|
MX2011004859A
(es)
|
2008-11-07 |
2011-08-03 |
Massachusetts Inst Technology |
Lipidoides de aminoalcohol y usos de los mismos.
|
|
EP4241767B1
(en)
|
2008-11-10 |
2024-10-23 |
Arbutus Biopharma Corporation |
Novel lipids and compositions for the delivery of therapeutics
|
|
WO2010057203A2
(en)
|
2008-11-17 |
2010-05-20 |
The Board Of Regents Of The University Of Texas System |
Hdl particles for delivery of nucleic acids
|
|
US20120101148A1
(en)
|
2009-01-29 |
2012-04-26 |
Alnylam Pharmaceuticals, Inc. |
lipid formulation
|
|
WO2010088927A1
(en)
|
2009-02-09 |
2010-08-12 |
Curevac Gmbh |
Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
|
|
US9732337B2
(en)
|
2009-06-16 |
2017-08-15 |
The United Stated of America, as represented by the Secretary, Department of Health & Human Services |
RNA nanoparticles and nanotubes
|
|
EP2451475A2
(en)
|
2009-07-06 |
2012-05-16 |
Novartis AG |
Self replicating rna molecules and uses thereof
|
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
|
PL3338765T3
(pl)
|
2009-12-01 |
2019-06-28 |
Translate Bio, Inc. |
Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych
|
|
WO2011069529A1
(en)
|
2009-12-09 |
2011-06-16 |
Curevac Gmbh |
Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
|
|
HRP20161556T1
(hr)
|
2010-04-06 |
2016-12-30 |
Vakzine Projekt Management Gmbh |
Virusna čestica otpuštena nakon infekcije sisavačkih stanica ljudskim citomegalovirusom (hcmv) koji sadrži fuzijski protein i njezina upotreba
|
|
EP2387999A1
(en)
|
2010-05-21 |
2011-11-23 |
CureVac GmbH |
Histidine-containing solution for transfection and/or injection of nucleic acids and uses thereof
|
|
US9192661B2
(en)
|
2010-07-06 |
2015-11-24 |
Novartis Ag |
Delivery of self-replicating RNA using biodegradable polymer particles
|
|
US11291635B2
(en)
|
2010-07-06 |
2022-04-05 |
Glaxosmithkline Biological Sa |
Virion-like delivery particles for self-replicating RNA molecules
|
|
US8968746B2
(en)
|
2010-07-30 |
2015-03-03 |
Curevac Gmbh |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012019630A1
(en)
|
2010-08-13 |
2012-02-16 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
|
|
WO2012031043A1
(en)
|
2010-08-31 |
2012-03-08 |
Novartis Ag |
Pegylated liposomes for delivery of immunogen-encoding rna
|
|
BR112013004879A2
(pt)
|
2010-08-31 |
2018-04-24 |
Novartis Ag |
lipossomas pequenos para entrega de rna que codifica imunogénio
|
|
US20130164289A1
(en)
|
2010-09-09 |
2013-06-27 |
Virginia Commonwealth University |
Human cytomegalovirus vaccine
|
|
ES3005233T3
(en)
|
2010-10-01 |
2025-03-14 |
Modernatx Inc |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
|
EP3520813B1
(en)
*
|
2010-10-11 |
2023-04-19 |
GlaxoSmithKline Biologicals S.A. |
Antigen delivery platforms
|
|
EA033467B1
(ru)
|
2011-01-31 |
2019-10-31 |
Univ Pennsylvania |
Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение
|
|
WO2012116715A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in newborns and infants
|
|
WO2012116714A1
(en)
|
2011-03-02 |
2012-09-07 |
Curevac Gmbh |
Vaccination in elderly patients
|
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
|
CN103687957A
(zh)
|
2011-05-17 |
2014-03-26 |
现代治疗公司 |
工程化核酸及其用于非人类脊椎动物的方法
|
|
PT2717893T
(pt)
|
2011-06-08 |
2019-08-20 |
Translate Bio Inc |
Composições de nanopartículas lipídicas e métodos para transferência de arnm
|
|
US8916696B2
(en)
|
2011-06-12 |
2014-12-23 |
City Of Hope |
Aptamer-mRNA conjugates for targeted protein or peptide expression and methods for their use
|
|
CA2841047A1
(en)
|
2011-07-06 |
2013-01-10 |
Novartis Ag |
Immunogenic compositions and uses thereof
|
|
EP3854413A1
(en)
|
2011-07-06 |
2021-07-28 |
GlaxoSmithKline Biologicals SA |
Immunogenic combination compositions and uses thereof
|
|
TWI570240B
(zh)
|
2011-09-09 |
2017-02-11 |
默沙東公司 |
作為細胞巨大病毒疫苗之條件式複製ｃｍｖ
|
|
WO2013039861A2
(en)
|
2011-09-12 |
2013-03-21 |
modeRNA Therapeutics |
Engineered nucleic acids and methods of use thereof
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US20140271829A1
(en)
|
2011-10-11 |
2014-09-18 |
Anders Lilja |
Recombinant self-replicating polycistronic rna molecules
|
|
EP2766385A2
(en)
|
2011-10-12 |
2014-08-20 |
Novartis AG |
Cmv antigens and uses thereof
|
|
KR20150000461A
(ko)
|
2011-10-27 |
2015-01-02 |
메사추세츠 인스티튜트 오브 테크놀로지 |
약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체
|
|
CN107875382B
(zh)
|
2011-11-11 |
2024-03-08 |
变异生物技术公司 |
用于治疗巨细胞病毒的组合物和方法
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
EP2791159A4
(en)
|
2011-12-14 |
2015-10-14 |
Moderna Therapeutics Inc |
MODIFIED NUCLEIC ACIDS AND ACUTE TREATMENT USES THEREOF
|
|
WO2013130161A1
(en)
|
2011-12-14 |
2013-09-06 |
modeRNA Therapeutics |
Methods of responding to a biothreat
|
|
JP2015501844A
(ja)
|
2011-12-16 |
2015-01-19 |
モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
修飾ヌクレオシド、ヌクレオチドおよび核酸組成物
|
|
CN104968354A
(zh)
|
2011-12-21 |
2015-10-07 |
现代治疗公司 |
增加器官或器官外植体的活力或寿命的方法
|
|
EP2793941A1
(en)
|
2011-12-23 |
2014-10-29 |
F.Hoffmann-La Roche Ag |
Articles of manufacture and methods for co-administration of antibodies
|
|
EP4721752A2
(en)
|
2011-12-30 |
2026-04-08 |
Cellscript, Llc |
Herstellung und verwendung von in vitro-synthetisierter ssrna zur einführung in säugetierzellen zur induktion einer biologischen oder biochemischen wirkung
|
|
WO2013113325A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Negatively charged nucleic acid comprising complexes for immunostimulation
|
|
WO2013120497A1
(en)
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
|
|
WO2013120499A1
(en)
|
2012-02-15 |
2013-08-22 |
Curevac Gmbh |
Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
|
|
US10322089B2
(en)
|
2012-03-14 |
2019-06-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nanoparticles, nanoparticle delivery methods, and systems of delivery
|
|
WO2013151663A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of membrane proteins
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US10501513B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
WO2013185069A1
(en)
|
2012-06-08 |
2013-12-12 |
Shire Human Genetic Therapies, Inc. |
Pulmonary delivery of mrna to non-lung target cells
|
|
JP2015522581A
(ja)
|
2012-07-06 |
2015-08-06 |
ノバルティス アーゲー |
サイトメガロウイルスタンパク質の複合体
|
|
EP2877580B1
(en)
|
2012-07-27 |
2019-01-30 |
City of Hope |
An mva vaccine for delivery of a ul128 complex and preventing cmv infection
|
|
WO2014028429A2
(en)
|
2012-08-14 |
2014-02-20 |
Moderna Therapeutics, Inc. |
Enzymes and polymerases for the synthesis of rna
|
|
SG11201501623PA
(en)
|
2012-10-30 |
2015-05-28 |
Redvax Gmbh |
Recombinant particle based vaccines against human cytomegalovirus infection
|
|
ES2921623T3
(es)
|
2012-11-26 |
2022-08-30 |
Modernatx Inc |
ARN modificado terminalmente
|
|
US20150307850A1
(en)
|
2012-12-04 |
2015-10-29 |
Merck Sharp & Dohme Corp. |
Conditional replicating viral vectors
|
|
US9687448B2
(en)
|
2012-12-07 |
2017-06-27 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid lipid particle formulations
|
|
EP2929035A1
(en)
|
2012-12-07 |
2015-10-14 |
Shire Human Genetic Therapies, Inc. |
Lipidic nanoparticles for mrna delivering
|
|
US20150315541A1
(en)
|
2012-12-13 |
2015-11-05 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for altering cell phenotype
|
|
EP2931319B1
(en)
|
2012-12-13 |
2019-08-21 |
ModernaTX, Inc. |
Modified nucleic acid molecules and uses thereof
|
|
ES2882110T3
(es)
|
2013-03-14 |
2021-12-01 |
Translate Bio Inc |
Métodos y composiciones para administrar anticuerpos codificados con ARNm
|
|
EP2970940B1
(en)
|
2013-03-14 |
2018-07-25 |
Translate Bio, Inc. |
Mrna therapeutic compositions and use to treat diseases and disorders
|
|
US20160032316A1
(en)
|
2013-03-14 |
2016-02-04 |
The Trustees Of The University Of Pennsylvania |
Purification and Purity Assessment of RNA Molecules Synthesized with Modified Nucleosides
|
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
EP2971161B1
(en)
|
2013-03-15 |
2018-12-26 |
ModernaTX, Inc. |
Ribonucleic acid purification
|
|
WO2014144039A1
(en)
|
2013-03-15 |
2014-09-18 |
Moderna Therapeutics, Inc. |
Characterization of mrna molecules
|
|
WO2014172045A1
(en)
|
2013-03-15 |
2014-10-23 |
The University Of British Columbia |
Lipid nanoparticles for transfection and related methods
|
|
EP2971033B8
(en)
|
2013-03-15 |
2019-07-10 |
ModernaTX, Inc. |
Manufacturing methods for production of rna transcripts
|
|
EP2983804A4
(en)
|
2013-03-15 |
2017-03-01 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
|
TW201515650A
(zh)
|
2013-05-06 |
2015-05-01 |
艾爾妮蘭製藥公司 |
遞送經脂質調配之核酸分子之劑量及方法
|
|
TW201534578A
(zh)
|
2013-07-08 |
2015-09-16 |
Daiichi Sankyo Co Ltd |
新穎脂質
|
|
WO2015011633A1
(en)
|
2013-07-23 |
2015-01-29 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for delivering messenger rna
|
|
CA2915728A1
(en)
|
2013-08-21 |
2015-02-26 |
Thomas Kramps |
Respiratory syncytial virus (rsv) vaccine
|
|
WO2015047901A1
(en)
|
2013-09-24 |
2015-04-02 |
Duke University |
Compositions, methods and kits for eliciting an immune response
|
|
WO2015051169A2
(en)
|
2013-10-02 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
WO2015052570A1
(en)
*
|
2013-10-07 |
2015-04-16 |
Medizinische Universität Wien |
Implant and method for improving coaptation of an atrioventricular valve
|
|
US20160243221A1
(en)
|
2013-10-18 |
2016-08-25 |
Moderna Therapeutics, Inc. |
Compositions and methods for tolerizing cellular systems
|
|
WO2015061467A1
(en)
|
2013-10-22 |
2015-04-30 |
Shire Human Genetic Therapies, Inc. |
Lipid formulations for delivery of messenger rna
|
|
AU2014359276B2
(en)
|
2013-12-03 |
2021-01-28 |
Hookipa Biotech Gmbh |
CMV vaccines
|
|
AU2014362234B2
(en)
|
2013-12-11 |
2019-09-12 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. |
Human herpesvirus trimeric glycoprotein B, protein complexes comprising trimeric gB and their use as vaccines
|
|
PT3083556T
(pt)
|
2013-12-19 |
2020-03-05 |
Novartis Ag |
Lípidos e composições lipídicas para a entrega de agentes ativos
|
|
WO2015101415A1
(en)
*
|
2013-12-30 |
2015-07-09 |
Curevac Gmbh |
Artificial nucleic acid molecules
|
|
WO2015110659A1
(en)
|
2014-01-27 |
2015-07-30 |
Bionor Immuno As |
Methods of immunization with a vaccine inducing a humoral immune response and with a vaccine inducing a cellular immune response
|
|
PT3122878T
(pt)
|
2014-03-24 |
2019-02-01 |
Translate Bio Inc |
Terapia de arnm para o tratamento de doenças oculares
|
|
WO2015165480A1
(en)
|
2014-04-30 |
2015-11-05 |
Institute For Research In Biomedicine |
Human cytomegalovirus vaccine compositions and method of producing the same
|
|
US20170119874A1
(en)
|
2014-04-23 |
2017-05-04 |
Institute For Research In Biomedicine |
Human cytomegalovirus vaccine compositions and method of producing the same
|
|
DK3134131T3
(en)
|
2014-04-23 |
2022-02-07 |
Modernatx Inc |
Nucleic acid vaccines
|
|
PE20170301A1
(es)
|
2014-05-08 |
2017-03-30 |
Pfizer |
Medios y metodos para el tratamiento cmv
|
|
WO2015181142A1
(en)
|
2014-05-27 |
2015-12-03 |
Glaxosmithkline Biologicals S.A. |
Cytomegalovirus complexes and uses thereof
|
|
WO2015196128A2
(en)
|
2014-06-19 |
2015-12-23 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
IL316479A
(en)
|
2014-06-25 |
2024-12-01 |
Acuitas Therapeutics Inc |
Novel lipids and lipid nanoparticle compositions for nucleic acid delivery
|
|
CA2953265C
(en)
|
2014-07-02 |
2023-09-26 |
Shire Human Genetic Therapies, Inc. |
Encapsulation of messenger rna
|
|
EP3169693B1
(en)
|
2014-07-16 |
2022-03-09 |
ModernaTX, Inc. |
Chimeric polynucleotides
|
|
EP3169783A4
(en)
|
2014-07-17 |
2018-10-03 |
Modernatx, Inc. |
Terminal modifications of polynucleotides
|
|
CN107072946B
(zh)
|
2014-09-05 |
2022-01-11 |
诺华股份有限公司 |
用于递送活性剂的脂质和脂质组合物
|
|
EP3015475A1
(en)
|
2014-10-31 |
2016-05-04 |
Novartis AG |
Mammalian cells expressing cytomegalovirus antigens
|
|
EP3031822A1
(en)
|
2014-12-08 |
2016-06-15 |
Novartis AG |
Cytomegalovirus antigens
|
|
WO2016118724A1
(en)
|
2015-01-21 |
2016-07-28 |
Moderna Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
EP3048114A1
(en)
|
2015-01-22 |
2016-07-27 |
Novartis AG |
Cytomegalovirus antigens and uses thereof
|
|
EP3047856A1
(en)
|
2015-01-23 |
2016-07-27 |
Novartis AG |
Cmv antigens and uses thereof
|
|
CN114317611A
(zh)
|
2015-02-10 |
2022-04-12 |
俄勒冈健康与科学大学 |
可用于产生非典型cd8+t细胞应答的方法和组合物
|
|
US20180030417A1
(en)
|
2015-02-16 |
2018-02-01 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Method of altering expression of alternative viral glycoprotein complexes
|
|
WO2016164762A1
(en)
|
2015-04-08 |
2016-10-13 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same
|
|
JP6893177B2
(ja)
|
2015-05-15 |
2021-06-23 |
キュアバック アーゲー |
少なくとも１つのｍＲＮＡコンストラクトの投与を含むプライムブーストレジメン（ＰＲＩＭＥ−ＢＯＯＳＴ ＲＥＧＩＭＥＮＳ）
|
|
EP3307305A4
(en)
|
2015-06-10 |
2019-05-22 |
Modernatx, Inc. |
TARGETED ADAPTIVE VACCINES
|
|
WO2016203025A1
(en)
|
2015-06-17 |
2016-12-22 |
Curevac Ag |
Vaccine composition
|
|
HUE067372T2
(hu)
|
2015-06-29 |
2024-10-28 |
Acuitas Therapeutics Inc |
Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
|
|
MA42502A
(fr)
|
2015-07-21 |
2018-05-30 |
Modernatx Inc |
Vaccins contre une maladie infectieuse
|
|
WO2017015457A1
(en)
|
2015-07-21 |
2017-01-26 |
Modernatx, Inc. |
Ebola vaccine
|
|
WO2017019935A1
(en)
|
2015-07-30 |
2017-02-02 |
Modernatx, Inc. |
Multimeric mrna
|
|
WO2017020026A1
(en)
|
2015-07-30 |
2017-02-02 |
Modernatx, Inc. |
Concatemeric peptide epitopes rnas
|
|
US11564893B2
(en)
|
2015-08-17 |
2023-01-31 |
Modernatx, Inc. |
Methods for preparing particles and related compositions
|
|
WO2017031241A1
(en)
|
2015-08-17 |
2017-02-23 |
Modernatx, Inc. |
Rna mapping/fingerprinting
|
|
RS63030B1
(sr)
|
2015-09-17 |
2022-04-29 |
Modernatx Inc |
Jedinjenja i kompozicije za intracelularno isporučivanje terapeutskih sredstava
|
|
EP3359670B2
(en)
|
2015-10-05 |
2024-02-14 |
ModernaTX, Inc. |
Methods for therapeutic administration of messenger ribonucleic acid drugs
|
|
WO2017066789A1
(en)
|
2015-10-16 |
2017-04-20 |
Modernatx, Inc. |
Mrna cap analogs with modified sugar
|
|
MD3718565T2
(ro)
|
2015-10-22 |
2022-09-30 |
Modernatx Inc |
Vaccinuri împotriva virusului respirator
|
|
EP3365009A4
(en)
|
2015-10-22 |
2019-07-03 |
ModernaTX, Inc. |
VACCINES AGAINST HERPES SIMPLEX VIRUS
|
|
CN108430456B
(zh)
|
2015-10-22 |
2022-01-18 |
摩登纳特斯有限公司 |
癌症疫苗
|
|
AU2016342048B2
(en)
|
2015-10-22 |
2022-09-08 |
Modernatx, Inc. |
Broad spectrum influenza virus vaccine
|
|
EP3364950A4
(en)
|
2015-10-22 |
2019-10-23 |
ModernaTX, Inc. |
VACCINES AGAINST TROPICAL DISEASES
|
|
EP3364981A4
(en)
*
|
2015-10-22 |
2019-08-07 |
ModernaTX, Inc. |
VACCINE AGAINST THE HUMAN CYTOMEGALOVIRUS
|
|
WO2017070601A1
(en)
|
2015-10-22 |
2017-04-27 |
Modernatx, Inc. |
Nucleic acid vaccines for varicella zoster virus (vzv)
|
|
AU2016342376A1
(en)
|
2015-10-22 |
2018-06-07 |
Modernatx, Inc. |
Sexually transmitted disease vaccines
|
|
TN2018000154A1
(en)
|
2015-10-22 |
2019-10-04 |
Modernatx Inc |
Respiratory syncytial virus vaccine
|
|
RS63986B1
(sr)
|
2015-10-28 |
2023-03-31 |
Acuitas Therapeutics Inc |
Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
|
|
CA3007955A1
(en)
|
2015-12-10 |
2017-06-15 |
Modernatx, Inc. |
Lipid nanoparticles for delivery of therapeutic agents
|
|
EP3390630B1
(en)
|
2015-12-17 |
2025-01-22 |
ModernaTX, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase
|
|
US10465190B1
(en)
|
2015-12-23 |
2019-11-05 |
Modernatx, Inc. |
In vitro transcription methods and constructs
|
|
EP3405579A1
(en)
|
2016-01-22 |
2018-11-28 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
|
EP3426775A1
(en)
|
2016-03-10 |
2019-01-16 |
Novartis AG |
Chemically modified messenger rna's
|
|
WO2017191274A2
(en)
|
2016-05-04 |
2017-11-09 |
Curevac Ag |
Rna encoding a therapeutic protein
|
|
US20190298657A1
(en)
|
2016-05-18 |
2019-10-03 |
Modernatx, Inc. |
Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency
|
|
US12123030B2
(en)
|
2016-05-18 |
2024-10-22 |
Modernatx, Inc. |
Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia
|
|
MA45053A
(fr)
|
2016-05-18 |
2019-03-27 |
Modernatx Inc |
Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique
|
|
EP3458092A1
(en)
|
2016-05-18 |
2019-03-27 |
Modernatx, Inc. |
Mrna combination therapy for the treatment of cancer
|
|
WO2017201349A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding citrin for the treatment of citrullinemia type 2
|
|
US11001861B2
(en)
|
2016-05-18 |
2021-05-11 |
Modernatx, Inc. |
Polynucleotides encoding galactose-1-phosphate uridylyltransferase for the treatment of galactosemia type 1
|
|
EP3896164A1
(en)
|
2016-05-18 |
2021-10-20 |
ModernaTX, Inc. |
Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease
|
|
JP7088911B2
(ja)
|
2016-05-18 |
2022-06-21 |
モデルナティエックス インコーポレイテッド |
リラキシンをコードするポリヌクレオチド
|
|
US20190382774A1
(en)
|
2016-05-18 |
2019-12-19 |
Modernatx, Inc. |
Polyribonucleotides containing reduced uracil content and uses thereof
|
|
US12128113B2
(en)
|
2016-05-18 |
2024-10-29 |
Modernatx, Inc. |
Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome
|
|
MA45032A
(fr)
|
2016-05-18 |
2019-03-27 |
Fundacion Para La Investig Medica Aplicada |
Polynucléotides codant pour la porphobilinogène désaminase destinés au traitement de la porphyrie intermittente aiguë
|
|
US10967057B2
(en)
|
2016-06-02 |
2021-04-06 |
Glaxosmithkline Biologicals S.A. |
Zika viral antigen constructs
|
|
WO2017218704A1
(en)
|
2016-06-14 |
2017-12-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
JP6983455B2
(ja)
|
2016-09-14 |
2021-12-17 |
モデルナティーエックス， インコーポレイテッド |
高純度ｒｎａ組成物及びその調製のための方法
|
|
AU2017345766A1
(en)
*
|
2016-10-21 |
2019-05-16 |
Modernatx, Inc. |
Human cytomegalovirus vaccine
|
|
MX2019004913A
(es)
|
2016-10-26 |
2019-09-16 |
Curevac Ag |
Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm).
|
|
EP3532070A1
(en)
|
2016-10-26 |
2019-09-04 |
Modernatx, Inc. |
Messenger ribonucleic acids for enhancing immune responses and methods of use thereof
|
|
WO2018081462A1
(en)
|
2016-10-26 |
2018-05-03 |
Modernatx, Inc. |
Methods and compositions for rna mapping
|
|
US11583504B2
(en)
|
2016-11-08 |
2023-02-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
|
CN110167587A
(zh)
|
2016-11-11 |
2019-08-23 |
摩登纳特斯有限公司 |
流感疫苗
|
|
EP3551193A4
(en)
|
2016-12-08 |
2020-08-19 |
Modernatx, Inc. |
NUCLEIC ACID VACCINES AGAINST RESPIRATORY VIRUSES
|
|
EP3555289A1
(en)
|
2016-12-13 |
2019-10-23 |
ModernaTX, Inc. |
Rna affinity purification
|
|
US20180243225A1
(en)
|
2017-01-25 |
2018-08-30 |
Modernatx, Inc. |
Ebola/marburg vaccines
|
|
EP3573649A4
(en)
|
2017-01-27 |
2020-12-30 |
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. |
VACCINE COMPOSITIONS OF HERPESVIRUS ENVELOPE PROTEIN COMBINATIONS INTENDED TO INDUCE AN IMMUNE RESPONSE
|
|
US20200032274A1
(en)
|
2017-02-01 |
2020-01-30 |
Moderna TX, Inc. |
Polynucleotide secondary structure
|
|
EP3576780A1
(en)
|
2017-02-01 |
2019-12-11 |
Modernatx, Inc. |
Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
|
|
RU2768829C2
(ru)
|
2017-02-01 |
2022-03-24 |
МОДЕРНАТиЭкс, ИНК. |
Противораковые рнк-вакцины
|
|
WO2018151816A1
(en)
|
2017-02-16 |
2018-08-23 |
Modernatx, Inc. |
High potency immunogenic compositions
|
|
US20200368162A1
(en)
|
2017-02-24 |
2020-11-26 |
Modernatx, Inc. |
Nucleic Acid-Based Therapy of Muscular Dystrophies
|
|
KR20190132405A
(ko)
|
2017-03-15 |
2019-11-27 |
모더나티엑스, 인크. |
치료제의 세포내 전달을 위한 화합물 및 조성물
|
|
WO2018170245A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Broad spectrum influenza virus vaccine
|
|
WO2018170270A1
(en)
|
2017-03-15 |
2018-09-20 |
Modernatx, Inc. |
Varicella zoster virus (vzv) vaccine
|
|
MA47787A
(fr)
|
2017-03-15 |
2020-01-22 |
Modernatx Inc |
Vaccin contre le virus respiratoire syncytial
|
|
US11752206B2
(en)
|
2017-03-15 |
2023-09-12 |
Modernatx, Inc. |
Herpes simplex virus vaccine
|
|
WO2018170347A1
(en)
|
2017-03-17 |
2018-09-20 |
Modernatx, Inc. |
Zoonotic disease rna vaccines
|
|
WO2018175783A1
(en)
|
2017-03-22 |
2018-09-27 |
Modernatx, Inc. |
Rna bacterial vaccines
|
|
WO2018187590A1
(en)
|
2017-04-05 |
2018-10-11 |
Modernatx, Inc. |
Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
|
|
WO2018200737A1
(en)
|
2017-04-26 |
2018-11-01 |
Modernatx, Inc. |
Herpes simplex virus vaccine
|
|
WO2018232357A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna formulations
|
|
WO2018232355A1
(en)
|
2017-06-15 |
2018-12-20 |
Modernatx, Inc. |
Rna antibodies
|
|
WO2019036685A1
(en)
|
2017-08-18 |
2019-02-21 |
Modernatx, Inc. |
METHODS FOR HPLC ANALYSIS
|
|
WO2019036670A2
(en)
|
2017-08-18 |
2019-02-21 |
Modernatx, Inc. |
EFFECTIVE MRNA VACCINES
|
|
CN111212905A
(zh)
|
2017-08-18 |
2020-05-29 |
摩登纳特斯有限公司 |
Rna聚合酶变体
|
|
WO2019036683A1
(en)
|
2017-08-18 |
2019-02-21 |
Modernatx, Inc. |
ANALYTICAL METHODS BY HPLC
|
|
US10653767B2
(en)
|
2017-09-14 |
2020-05-19 |
Modernatx, Inc. |
Zika virus MRNA vaccines
|
|
US20190192646A1
(en)
|
2017-11-03 |
2019-06-27 |
Modernatx, Inc. |
Salmonella vaccines
|
|
CA3083102A1
(en)
|
2017-11-21 |
2019-05-31 |
Modernatx, Inc. |
Epstein-barr virus vaccines
|
|
WO2019148101A1
(en)
|
2018-01-29 |
2019-08-01 |
Modernatx, Inc. |
Rsv rna vaccines
|
|
SG11202012770RA
(en)
|
2018-06-27 |
2021-01-28 |
Modernatx Inc |
Personalized cancer vaccine epitope selection
|
|
AU2019338557A1
(en)
|
2018-09-13 |
2021-03-25 |
Modernatx, Inc. |
Modified mRNA for the treatment of progressive familial intrahepatic cholestasis disorders
|
|
AU2019345067A1
(en)
|
2018-09-19 |
2021-04-08 |
Modernatx, Inc. |
High-purity peg lipids and uses thereof
|
|
US12151029B2
(en)
|
2018-09-19 |
2024-11-26 |
Modernatx, Inc. |
PEG lipids and uses thereof
|
|
WO2020061367A1
(en)
|
2018-09-19 |
2020-03-26 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
|
CA3118947A1
(en)
|
2018-11-07 |
2020-05-14 |
Modernatx, Inc. |
Rna cancer vaccines
|
|
JP2022521094A
(ja)
|
2019-02-20 |
2022-04-05 |
モデルナティエックス インコーポレイテッド |
共転写キャッピング用ｒｎａポリメラーゼバリアント
|
|
CN113874502A
(zh)
|
2019-03-11 |
2021-12-31 |
摩登纳特斯有限公司 |
补料分批体外转录方法
|
|
WO2020190750A1
(en)
|
2019-03-15 |
2020-09-24 |
Modernatx, Inc. |
Hiv rna vaccines
|
|
JP2022535006A
(ja)
|
2019-05-31 |
2022-08-04 |
モデルナティエックス インコーポレイテッド |
増殖ｔ細胞アッセイ
|
|
CN114269918A
(zh)
|
2019-08-14 |
2022-04-01 |
摩登纳特斯有限公司 |
用于纯化体外转录的下游产物的方法
|
|
JP2022547313A
(ja)
|
2019-09-11 |
2022-11-11 |
モデルナティエックス インコーポレイテッド |
ヒトサイトメガロウイルスワクチン
|
|
CA3155014A1
(en)
|
2019-09-19 |
2021-03-25 |
Modernatx, Inc. |
Cap guides and methods of use thereof for rna mapping
|
|
EP4088281A4
(en)
|
2020-01-10 |
2024-02-21 |
ModernaTX, Inc. |
VARIOUS AUTOCECODER FOR GENERATING BIOLOGICAL SEQUENCE
|
|
US20210228707A1
(en)
|
2020-01-28 |
2021-07-29 |
Modernatx, Inc. |
Coronavirus rna vaccines
|
|
JP2023513073A
(ja)
|
2020-01-30 |
2023-03-30 |
モデルナティエックス インコーポレイテッド |
呼吸器系ウイルス免疫化組成物
|
|
AU2021215938A1
(en)
|
2020-02-07 |
2022-09-01 |
Modernatx, Inc. |
Sars-cov-2 mrna domain vaccines
|
|
WO2021211343A1
(en)
|
2020-04-13 |
2021-10-21 |
Modernatx, Inc. |
Zika virus mrna vaccines
|
|
WO2021222304A1
(en)
|
2020-04-27 |
2021-11-04 |
Modernatx, Inc. |
Sars-cov-2 rna vaccines
|
|
US20230181481A1
(en)
|
2020-05-15 |
2023-06-15 |
Modernatx, Inc. |
Rna formulations for high volume distribution, and methods of using the same for treating covid-19
|
|
WO2021159130A2
(en)
|
2020-05-15 |
2021-08-12 |
Modernatx, Inc. |
Coronavirus rna vaccines and methods of use
|
|
US20230190761A1
(en)
|
2020-05-21 |
2023-06-22 |
Modernatx, Inc. |
Methylene blue stabilized mrna compositions
|
|
AU2021283934A1
(en)
|
2020-06-05 |
2023-01-19 |
Modernatx, Inc. |
Bacterial strains for DNA production
|