JP2014520807A5 - - Google Patents
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- JP2014520807A5 JP2014520807A5 JP2014519091A JP2014519091A JP2014520807A5 JP 2014520807 A5 JP2014520807 A5 JP 2014520807A5 JP 2014519091 A JP2014519091 A JP 2014519091A JP 2014519091 A JP2014519091 A JP 2014519091A JP 2014520807 A5 JP2014520807 A5 JP 2014520807A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- polypeptide
- epitope
- composition
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 164
- 102000036639 antigens Human genes 0.000 claims description 164
- 108091007433 antigens Proteins 0.000 claims description 164
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 110
- 229920001184 polypeptide Polymers 0.000 claims description 98
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 98
- 239000000203 mixture Substances 0.000 claims description 97
- 230000002163 immunogen Effects 0.000 claims description 41
- 244000052769 pathogen Species 0.000 claims description 27
- 230000001717 pathogenic effect Effects 0.000 claims description 27
- 230000037452 priming Effects 0.000 claims description 26
- 230000003612 virological effect Effects 0.000 claims description 22
- 241000701022 Cytomegalovirus Species 0.000 claims description 18
- 125000002091 cationic group Chemical group 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 14
- 239000007908 nanoemulsion Substances 0.000 claims description 13
- 230000004927 fusion Effects 0.000 claims description 12
- 239000002502 liposome Substances 0.000 claims description 12
- 239000011859 microparticle Substances 0.000 claims description 12
- 239000004005 microsphere Substances 0.000 claims description 12
- 239000002077 nanosphere Substances 0.000 claims description 12
- 239000000277 virosome Substances 0.000 claims description 12
- -1 Cationic lipid Chemical class 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 10
- 239000007764 o/w emulsion Substances 0.000 claims description 10
- 239000007762 w/o emulsion Substances 0.000 claims description 10
- 230000004936 stimulating effect Effects 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 7
- 239000003981 vehicle Substances 0.000 claims description 7
- 241000710929 Alphavirus Species 0.000 claims description 6
- 208000035473 Communicable disease Diseases 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 5
- 230000003308 immunostimulating effect Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 230000005847 immunogenicity Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 229940127557 pharmaceutical product Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 239000002356 single layer Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229940126601 medicinal product Drugs 0.000 claims 2
- 208000019802 Sexually transmitted disease Diseases 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 28
- 239000000839 emulsion Substances 0.000 description 4
- 239000002691 unilamellar liposome Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505105P | 2011-07-06 | 2011-07-06 | |
| US61/505,105 | 2011-07-06 | ||
| PCT/US2012/045854 WO2013006842A2 (en) | 2011-07-06 | 2012-07-06 | Immunogenic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016210783A Division JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014520807A JP2014520807A (ja) | 2014-08-25 |
| JP2014520807A5 true JP2014520807A5 (enExample) | 2015-08-20 |
Family
ID=46513884
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519091A Pending JP2014520807A (ja) | 2011-07-06 | 2012-07-06 | 免疫原性組成物およびその使用 |
| JP2016210783A Pending JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016210783A Pending JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11058762B2 (enExample) |
| EP (2) | EP2729168A2 (enExample) |
| JP (2) | JP2014520807A (enExample) |
| CA (1) | CA2841047A1 (enExample) |
| WO (1) | WO2013006842A2 (enExample) |
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-
2012
- 2012-07-06 EP EP12735421.5A patent/EP2729168A2/en not_active Withdrawn
- 2012-07-06 EP EP18209088.6A patent/EP3508219A1/en active Pending
- 2012-07-06 US US14/130,869 patent/US11058762B2/en active Active
- 2012-07-06 WO PCT/US2012/045854 patent/WO2013006842A2/en not_active Ceased
- 2012-07-06 CA CA2841047A patent/CA2841047A1/en not_active Abandoned
- 2012-07-06 JP JP2014519091A patent/JP2014520807A/ja active Pending
-
2016
- 2016-10-27 JP JP2016210783A patent/JP2017025103A/ja active Pending
-
2021
- 2021-05-26 US US17/330,826 patent/US20210290755A1/en not_active Abandoned
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