|
US4369184A
(en)
|
1980-01-24 |
1983-01-18 |
Janssen Pharmaceutica N.V. |
1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
|
|
JPS56110674A
(en)
*
|
1980-01-24 |
1981-09-01 |
Janssen Pharmaceutica Nv |
Novel 11*cyclohexyl**44aryll44piperidine carboxylic acid derivative
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
GB9300194D0
(en)
|
1993-01-06 |
1993-03-03 |
Wyeth John & Brother Ltd |
Piperazine derivatives
|
|
US5446051A
(en)
*
|
1994-05-31 |
1995-08-29 |
Eli Lilly And Company |
Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
|
|
JP2002515008A
(ja)
*
|
1994-10-27 |
2002-05-21 |
メルク エンド カンパニー インコーポレーテッド |
ムスカリン・アンタゴニスト
|
|
US5889006A
(en)
|
1995-02-23 |
1999-03-30 |
Schering Corporation |
Muscarinic antagonists
|
|
IL117149A0
(en)
|
1995-02-23 |
1996-06-18 |
Schering Corp |
Muscarinic antagonists
|
|
WO1997016187A1
(en)
*
|
1995-10-31 |
1997-05-09 |
Merck & Co., Inc. |
Muscarine antagonists
|
|
US5854245A
(en)
|
1996-06-28 |
1998-12-29 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
DE69734774D1
(de)
*
|
1996-08-26 |
2006-01-05 |
Pfizer |
Spirocyclische dopaminrezeptor-subtyp-liganden
|
|
JP2002505684A
(ja)
|
1997-06-18 |
2002-02-19 |
メルク エンド カンパニー インコーポレーテッド |
α１ａアドレナリン受容体拮抗薬
|
|
GB9715892D0
(en)
|
1997-07-29 |
1997-10-01 |
Zeneca Ltd |
Heterocyclic compounds
|
|
WO1999032479A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparation and their use as muscarinic receptor (ant-)agonists
|
|
WO1999032486A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
AU2307999A
(en)
|
1997-12-23 |
1999-07-12 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
WO1999032489A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions
|
|
CZ286152B6
(cs)
|
1998-03-13 |
2000-01-12 |
Miroslav Ing. Csc. Vlček |
Transparentní a semitransparentní difrakční prvky
|
|
WO1999055674A1
(en)
|
1998-04-28 |
1999-11-04 |
Dainippon Pharmaceutical Co., Ltd. |
1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
|
|
BR0010593A
(pt)
|
1999-05-04 |
2002-02-13 |
Schering Corp |
Terapia de combinação com antagonista de ccr5-interferon alfa peguilado para hiv
|
|
KR100439357B1
(ko)
|
1999-05-04 |
2004-07-07 |
쉐링 코포레이션 |
Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체
|
|
US6387930B1
(en)
|
1999-05-04 |
2002-05-14 |
Schering Corporation |
Piperidine derivatives useful as CCR5 antagonists
|
|
US6420364B1
(en)
|
1999-09-13 |
2002-07-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compound useful as reversible inhibitors of cysteine proteases
|
|
ES2199856T3
(es)
*
|
1999-09-13 |
2004-03-01 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Nuevos compuestos heterociclicos, utiles como inhibidores reversibles de cisteina proteasas.
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
US6699880B1
(en)
|
1999-10-13 |
2004-03-02 |
Banyu Pharmaceutical Co., Ltd. |
Substituted imidazolidinone derivatives
|
|
US7163938B2
(en)
|
2000-11-28 |
2007-01-16 |
Eli Lilly And Company |
Substituted carboxamides
|
|
JPWO2002085890A1
(ja)
|
2001-04-20 |
2004-08-12 |
萬有製薬株式会社 |
ベンズイミダゾロン誘導体
|
|
EP1395257A1
(en)
|
2001-06-12 |
2004-03-10 |
Elan Pharmaceuticals, Inc. |
Macrocycles useful in the treatment of alzheimer's disease
|
|
WO2004089942A2
(en)
|
2001-10-02 |
2004-10-21 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
GB0128378D0
(en)
|
2001-11-27 |
2002-01-16 |
Smithkline Beecham Plc |
Novel Compounds
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
ES2251624T3
(es)
|
2001-12-28 |
2006-05-01 |
Acadia Pharmaceuticals Inc. |
Analogos de la tetrahidroquinolina como los agonistas muscarinicos.
|
|
US7256186B2
(en)
|
2002-02-06 |
2007-08-14 |
Schering Corporation |
Gamma secretase inhibitors
|
|
US20040171614A1
(en)
|
2002-02-06 |
2004-09-02 |
Schering-Plough Corporation |
Novel gamma secretase inhibitors
|
|
PT1489078E
(pt)
|
2002-03-28 |
2010-02-24 |
Mitsubishi Tanabe Pharma Corp |
Derivados de benzofurano
|
|
JPWO2003104230A1
(ja)
|
2002-06-07 |
2005-10-06 |
協和醗酵工業株式会社 |
二環性ピリミジン誘導体
|
|
HK1079787A1
(zh)
|
2002-07-31 |
2006-04-13 |
Ranbaxy Laboratories Limited |
用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
|
|
JP4711391B2
(ja)
|
2002-09-30 |
2011-06-29 |
ニューロサーチ、アクティーゼルスカブ |
新規１，４−ジアザビシクロアルカン誘導体及びその製造方法
|
|
RU2342388C2
(ru)
*
|
2002-11-22 |
2008-12-27 |
Джапан Тобакко Инк. |
Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием
|
|
EP1565436B1
(en)
*
|
2002-11-27 |
2012-04-25 |
Incyte Corporation |
3-aminopyrrolidine derivatives as modulators of chemokine receptors
|
|
WO2004069828A1
(ja)
|
2003-02-04 |
2004-08-19 |
Mitsubishi Pharma Corporation |
ピペリジン化合物およびその医薬用途
|
|
MXPA06000441A
(es)
|
2003-07-17 |
2006-04-05 |
Astellas Pharma Inc |
Derivado de 2-acilaminotiazole o sal del mismo.
|
|
JPWO2005037269A1
(ja)
*
|
2003-10-21 |
2006-12-28 |
住友製薬株式会社 |
新規ピペリジン誘導体
|
|
CA2554465A1
(en)
|
2004-02-05 |
2005-08-25 |
Schering Corporation |
Piperidine derivatives useful as ccr3 antagonists
|
|
RU2006132465A
(ru)
|
2004-02-10 |
2008-03-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Модуляторы хемокинового рецептора ccr5
|
|
US7504424B2
(en)
|
2004-07-16 |
2009-03-17 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7488745B2
(en)
|
2004-07-16 |
2009-02-10 |
Schering Corporation |
Compounds for the treatment of inflammatory disorders
|
|
US7786141B2
(en)
|
2004-08-19 |
2010-08-31 |
Vertex Pharmaceuticals Incorporated |
Dihydrospiroindene modulators of muscarinic receptors
|
|
JP2008521821A
(ja)
|
2004-11-29 |
2008-06-26 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ムスカリン受容体のモジュレーター
|
|
JP4774995B2
(ja)
|
2005-01-12 |
2011-09-21 |
アステラス製薬株式会社 |
アシルアミノチアゾール誘導体を有効成分とする医薬組成物
|
|
EP1863490A2
(en)
|
2005-03-28 |
2007-12-12 |
Vertex Pharmaceuticals Incorporated |
Muscarinic modulators
|
|
EP1900732A4
(en)
|
2005-06-24 |
2009-11-18 |
Toyama Chemical Co Ltd |
NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF
|
|
AU2006330866A1
(en)
|
2005-12-22 |
2007-07-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
ES2545907T3
(es)
|
2005-12-29 |
2015-09-16 |
Abbvie Inc. |
Inhibidores de proteína quinasa
|
|
KR20080098070A
(ko)
|
2006-02-22 |
2008-11-06 |
버텍스 파마슈티칼스 인코포레이티드 |
무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘
|
|
AU2007221214A1
(en)
|
2006-02-22 |
2007-09-07 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
AU2007284548A1
(en)
|
2006-08-15 |
2008-02-21 |
Vertex Pharmaceuticals Incorporated |
Modulators of muscarinic receptors
|
|
US20130012485A1
(en)
*
|
2006-12-22 |
2013-01-10 |
Baeschlin Daniel Kaspar |
Organic compounds
|
|
WO2008117229A1
(en)
|
2007-03-23 |
2008-10-02 |
Ranbaxy Laboratories Limited |
Muscarinic receptor antagonists
|
|
US8119661B2
(en)
|
2007-09-11 |
2012-02-21 |
Astrazeneca Ab |
Piperidine derivatives and their use as muscarinic receptor modulators
|
|
UY31672A1
(es)
|
2008-02-28 |
2009-09-30 |
|
"agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
|
|
WO2009118370A1
(en)
|
2008-03-27 |
2009-10-01 |
Janssen Pharmaceutica Nv |
Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
|
|
MX2011004340A
(es)
|
2008-10-29 |
2011-05-23 |
Gruenenthal Gmbh |
Espiroaminas sustituidas.
|
|
CN102256963B
(zh)
|
2008-12-19 |
2014-06-11 |
贝林格尔.英格海姆国际有限公司 |
作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
|
|
EP2419419B1
(en)
*
|
2009-04-17 |
2014-12-03 |
Janssen Pharmaceutica NV |
4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
|
|
FR2945531A1
(fr)
|
2009-05-12 |
2010-11-19 |
Sanofi Aventis |
Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
|
|
WO2011112825A2
(en)
|
2010-03-10 |
2011-09-15 |
Vanderbilt University |
Heterocyclyl-azabicyclo[3.2.1]octane analogs as selective m1 agonists and methods of making and using same
|
|
US8822447B2
(en)
|
2010-04-22 |
2014-09-02 |
Janssen Pharmaceutica Nv |
Indazole compounds useful as ketohexokinase inhibitors
|
|
EP2563127A4
(en)
|
2010-04-27 |
2013-11-06 |
Merck Sharp & Dohme |
PROLYLCARBOXYPEPTIDASE INHIBITORS
|
|
EP2568812B1
(en)
*
|
2010-05-11 |
2016-10-26 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
JP2013528180A
(ja)
|
2010-05-28 |
2013-07-08 |
ジーイー・ヘルスケア・リミテッド |
放射性標識化合物及びその製造方法
|
|
EP2616074A1
(en)
|
2010-09-17 |
2013-07-24 |
Array Biopharma, Inc. |
Piperidinyl-substituted lactams as gpr119 modulators
|
|
EP2685828A4
(en)
*
|
2011-03-17 |
2014-08-13 |
Merck Sharp & Dohme |
SUBSTITUTED 3-AZABICYCLO [3,1,0-] HEXAN DERIVATIVES AS CCR2 ANTAGONISTS
|
|
JP2013010719A
(ja)
*
|
2011-06-30 |
2013-01-17 |
Dainippon Sumitomo Pharma Co Ltd |
ベンズイミダゾロンおよびオキシインドール誘導体ならびにそれらの医薬用途
|
|
EP2780015B1
(en)
|
2011-11-18 |
2017-01-04 |
Heptares Therapeutics Limited |
Muscarinic m1 receptor agonists
|
|
CN107098899B
(zh)
|
2012-09-18 |
2019-09-06 |
赫普泰雅治疗有限公司 |
作为毒蕈碱的m1受体激动剂的二环氮杂化合物
|
|
JP6478923B2
(ja)
|
2013-02-07 |
2019-03-06 |
ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ |
ムスカリンｍ４受容体アゴニストとしてのピペリジン−１−イル及びアゼピン−１−イルカルボキシレート
|
|
JP6199091B2
(ja)
*
|
2013-06-26 |
2017-09-20 |
旭電機化成株式会社 |
ライター点火補助具
|
|
SG11201606269WA
(en)
|
2014-02-06 |
2016-09-29 |
Heptares Therapeutics Ltd |
Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists
|
|
GB201404922D0
(en)
|
2014-03-19 |
2014-04-30 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
SG11201706501VA
(en)
|
2015-02-13 |
2017-09-28 |
Suven Life Sciences Ltd |
AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS
|
|
GB201504675D0
(en)
|
2015-03-19 |
2015-05-06 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201513740D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonist
|
|
GB201513743D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201513742D0
(en)
|
2015-08-03 |
2015-09-16 |
Heptares Therapeutics Ltd |
Muscarinic agonists
|
|
GB201519352D0
(en)
|
2015-11-02 |
2015-12-16 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10259787B2
(en)
|
2016-10-14 |
2019-04-16 |
Heptares Therapeutics Limited |
Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
|
|
GB201709652D0
(en)
|
2017-06-16 |
2017-08-02 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
US10501483B2
(en)
|
2017-10-24 |
2019-12-10 |
Allergan, Inc. |
Enamines and diastereo-selective reduction of enamines
|
|
GB201810239D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201810245D0
(en)
|
2018-06-22 |
2018-08-08 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819961D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB201819960D0
(en)
|
2018-12-07 |
2019-01-23 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202020191D0
(en)
|
2020-12-18 |
2021-02-03 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds
|
|
GB202103211D0
(en)
|
2021-03-08 |
2021-04-21 |
Heptares Therapeutics Ltd |
Pharmaceutical compounds for use in therapy
|