CN109996792B - 在治疗cns疾病和疼痛中具有作为毒蕈碱性m1和/或m4受体调节剂活性的杂环化合物 - Google Patents

在治疗cns疾病和疼痛中具有作为毒蕈碱性m1和/或m4受体调节剂活性的杂环化合物 Download PDF

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CN109996792B
CN109996792B CN201780073082.4A CN201780073082A CN109996792B CN 109996792 B CN109996792 B CN 109996792B CN 201780073082 A CN201780073082 A CN 201780073082A CN 109996792 B CN109996792 B CN 109996792B
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cyano
carboxylic acid
ethyl ester
cyclohexyl
acid ethyl
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CN109996792A (zh
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盖尔斯·艾伯特·布朗
迈尔斯·斯图尔特·康格里夫
马克·皮克沃斯
本杰明·杰拉尔德·特汉
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Nexla Pharmaceuticals Uk Ltd
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Heptares Therapeutics Ltd
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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CN201780073082.4A 2016-10-14 2017-10-16 在治疗cns疾病和疼痛中具有作为毒蕈碱性m1和/或m4受体调节剂活性的杂环化合物 Active CN109996792B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662408468P 2016-10-14 2016-10-14
GB1617454.2 2016-10-14
GBGB1617454.2A GB201617454D0 (en) 2016-10-14 2016-10-14 Pharmaceutical compounds
US62/408,468 2016-10-14
PCT/GB2017/053115 WO2018069732A1 (en) 2016-10-14 2017-10-16 Heterocyclic compounds having activity as modulators of muscarinic m1 and/or m4 receptors in the treatment of cns diseases and pains.

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CN109996792A CN109996792A (zh) 2019-07-09
CN109996792B true CN109996792B (zh) 2023-02-17

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US (1) US11834407B2 (https=)
EP (1) EP3526207B1 (https=)
JP (1) JP7100634B2 (https=)
CN (1) CN109996792B (https=)
DK (1) DK3526207T3 (https=)
ES (1) ES2898206T3 (https=)
GB (1) GB201617454D0 (https=)
WO (1) WO2018069732A1 (https=)

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GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
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