PE20221454A1 - Derivados de 2-azaespiro[3.4]octano como agonistas de m4 - Google Patents
Derivados de 2-azaespiro[3.4]octano como agonistas de m4Info
- Publication number
- PE20221454A1 PE20221454A1 PE2022000586A PE2022000586A PE20221454A1 PE 20221454 A1 PE20221454 A1 PE 20221454A1 PE 2022000586 A PE2022000586 A PE 2022000586A PE 2022000586 A PE2022000586 A PE 2022000586A PE 20221454 A1 PE20221454 A1 PE 20221454A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- agonists
- octane
- azaspyro
- azaspiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Referido a un compuesto derivado de 2-azaespiro[3.4]octano de formula (I), o una sal farmaceutica aceptable del mismo, en donde R1 es halogeno o H; R2 es halogeno o H; R3 es alquilo C1-3 opcionalmente sustituido; R5 es halogeno o H; R7 es heteroarilo de 5 miembros. Un compuesto seleccionado es (S)-7-(4-(5-fluor-2-(oxetan-3-iloxi)fenil)piperidin-1-il)-2-(1,3,4-oxadiazol-2-il)-5-oxa-2-azaspiro[3.4]octano. Dichos compuestos actuan como agonistas del receptor M4. Tambien refiere a una composicion farmaceuticas que los comprende y su uso para el tratamiento de afecciones, enfermedades y trastornos relacionados con el receptor M4, tales como psicosis, disfuncion cognitiva y trastornos por uso de sustancias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962912986P | 2019-10-09 | 2019-10-09 | |
PCT/IB2020/059431 WO2021070091A1 (en) | 2019-10-09 | 2020-10-07 | 5-oxa-2-azaspiro[3.4]octane derivatives as m4 agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221454A1 true PE20221454A1 (es) | 2022-09-21 |
Family
ID=72944206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022000586A PE20221454A1 (es) | 2019-10-09 | 2020-10-07 | Derivados de 2-azaespiro[3.4]octano como agonistas de m4 |
Country Status (20)
Country | Link |
---|---|
US (3) | US11485742B2 (es) |
EP (1) | EP4041737A1 (es) |
JP (1) | JP7349567B2 (es) |
KR (1) | KR20220079608A (es) |
CN (1) | CN114555606A (es) |
AR (1) | AR120169A1 (es) |
AU (1) | AU2020364186B2 (es) |
CA (1) | CA3155589A1 (es) |
CL (1) | CL2022000892A1 (es) |
CO (1) | CO2022004391A2 (es) |
CR (1) | CR20220153A (es) |
EC (1) | ECSP22027784A (es) |
IL (1) | IL291600A (es) |
JO (1) | JOP20220084A1 (es) |
MX (1) | MX2022004215A (es) |
PE (1) | PE20221454A1 (es) |
TW (1) | TW202128703A (es) |
UY (1) | UY38907A (es) |
WO (1) | WO2021070091A1 (es) |
ZA (1) | ZA202202913B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR120170A1 (es) * | 2019-10-09 | 2022-02-02 | Novartis Ag | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 |
WO2024059249A1 (en) * | 2022-09-16 | 2024-03-21 | Cerevel Therapeutics, Llc | M4 activators/modulators and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1597255A1 (en) | 2002-11-13 | 2005-11-23 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
WO2006006490A1 (ja) | 2004-07-08 | 2006-01-19 | Ono Pharmaceutical Co., Ltd. | スピロ化合物 |
WO2006058294A2 (en) * | 2004-11-29 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
WO2008024497A2 (en) | 2006-08-25 | 2008-02-28 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 |
US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
WO2010049146A1 (en) | 2008-10-29 | 2010-05-06 | Grünenthal GmbH | Substituted spiroamines |
RU2506266C2 (ru) * | 2009-01-26 | 2014-02-10 | Израэл Инститьют Фо Байолоджикал Рисерч | Бициклические гетероциклические спиросоединения |
WO2012062752A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | RADIOLABELLED mGLuR2 PET LIGANDS |
EP2675812B1 (en) | 2011-02-18 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
WO2013013308A1 (en) | 2011-07-27 | 2013-01-31 | Beta Pharma Canada Inc. | Spirocyclic molecules as protein kinase inhibitors |
WO2014039489A1 (en) | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic derivatives as antiparasitic agents |
WO2014045031A1 (en) | 2012-09-18 | 2014-03-27 | Heptares Therapeutics Limited | Bicyclic aza compounds as muscarinic m1 receptor agonists |
JP6479029B2 (ja) * | 2014-02-06 | 2019-03-06 | ヘプタレス セラピューティクス リミテッドHeptares Therapeutics Limited | ムスカリンm1受容体アゴニストとしての二環式アザ化合物 |
MA40858A (fr) | 2014-10-31 | 2021-03-31 | Indivior Uk Ltd | Composés antagonistes des récepteurs d3 à la dopamine |
GB201504675D0 (en) | 2015-03-19 | 2015-05-06 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
GB201513740D0 (en) * | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonist |
GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB201513742D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
GB2540998A (en) | 2015-08-04 | 2017-02-08 | Phagenesis Ltd | Catheter |
GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
ES2831084T3 (es) * | 2016-06-10 | 2021-06-07 | Vitae Pharmaceuticals Inc | Inhibidores de la interacción menina-MLL |
GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
CN108456208B (zh) | 2017-02-22 | 2021-04-16 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
US11524954B2 (en) | 2018-03-23 | 2022-12-13 | Pfizer Inc. | Piperazine azaspiro derivatives |
GB201810245D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
-
2020
- 2020-10-07 TW TW109134712A patent/TW202128703A/zh unknown
- 2020-10-07 CR CR20220153A patent/CR20220153A/es unknown
- 2020-10-07 AU AU2020364186A patent/AU2020364186B2/en active Active
- 2020-10-07 AR ARP200102774A patent/AR120169A1/es unknown
- 2020-10-07 JO JOP/2022/0084A patent/JOP20220084A1/ar unknown
- 2020-10-07 CN CN202080070235.1A patent/CN114555606A/zh active Pending
- 2020-10-07 EP EP20793461.3A patent/EP4041737A1/en active Pending
- 2020-10-07 PE PE2022000586A patent/PE20221454A1/es unknown
- 2020-10-07 KR KR1020227015112A patent/KR20220079608A/ko unknown
- 2020-10-07 CA CA3155589A patent/CA3155589A1/en active Pending
- 2020-10-07 WO PCT/IB2020/059431 patent/WO2021070091A1/en active Application Filing
- 2020-10-07 MX MX2022004215A patent/MX2022004215A/es unknown
- 2020-10-07 US US17/065,367 patent/US11485742B2/en active Active
- 2020-10-07 UY UY0001038907A patent/UY38907A/es unknown
- 2020-10-07 JP JP2022520844A patent/JP7349567B2/ja active Active
-
2022
- 2022-03-10 ZA ZA2022/02913A patent/ZA202202913B/en unknown
- 2022-03-22 IL IL291600A patent/IL291600A/en unknown
- 2022-04-06 CO CONC2022/0004391A patent/CO2022004391A2/es unknown
- 2022-04-07 CL CL2022000892A patent/CL2022000892A1/es unknown
- 2022-04-07 EC ECSENADI202227784A patent/ECSP22027784A/es unknown
- 2022-08-08 US US17/818,321 patent/US11820778B2/en active Active
-
2023
- 2023-10-30 US US18/497,296 patent/US20240140959A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220079608A (ko) | 2022-06-13 |
UY38907A (es) | 2021-05-31 |
AR120169A1 (es) | 2022-02-02 |
US11485742B2 (en) | 2022-11-01 |
CA3155589A1 (en) | 2021-04-15 |
JP2022551853A (ja) | 2022-12-14 |
ECSP22027784A (es) | 2022-05-31 |
CO2022004391A2 (es) | 2022-04-29 |
US20220411435A1 (en) | 2022-12-29 |
WO2021070091A1 (en) | 2021-04-15 |
US20240140959A1 (en) | 2024-05-02 |
AU2020364186A1 (en) | 2022-04-21 |
EP4041737A1 (en) | 2022-08-17 |
US11820778B2 (en) | 2023-11-21 |
JP7349567B2 (ja) | 2023-09-22 |
ZA202202913B (en) | 2023-06-28 |
IL291600A (en) | 2022-05-01 |
TW202128703A (zh) | 2021-08-01 |
MX2022004215A (es) | 2022-05-03 |
CN114555606A (zh) | 2022-05-27 |
JOP20220084A1 (ar) | 2023-01-30 |
CR20220153A (es) | 2022-05-03 |
CL2022000892A1 (es) | 2023-01-20 |
AU2020364186B2 (en) | 2023-11-30 |
US20210130365A1 (en) | 2021-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20190329A1 (es) | Compuestos moduladores de fxr (nr1h4) | |
PE20220133A1 (es) | Inhibidores del inflamasoma nlrp3 | |
PE20230249A1 (es) | Compuestos de heteroarilo biciclicos y usos de estos | |
PE20230238A1 (es) | Inhibidores de kras g12c | |
PE20220931A1 (es) | Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina | |
PE20190806A1 (es) | Agonistas heterociclicos del receptor de apelina (apj) y usos de los mismos | |
PE20180227A1 (es) | Benzamidas sustituidas con 1,3-tiazol-2-ilo | |
MY194461A (en) | N-[2-(1-benzylpiperidin-4-yl)4-(pyrazin-2-yl)-piperazine-1-carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases | |
PE20061150A1 (es) | Derivados de n-(n-sulfonilaminoarilmetil)ciclopropanocarboxamida sustituidos como antagonistas del receptor vainilloide tipo 1 (vdr1) | |
AR075729A1 (es) | Derivados de benzofuranilo, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad y/o diabetes. | |
AR056103A1 (es) | Compuestos de(piran-piperidinil)benzimidazol, composiciones farmaceuticas que los comprenden, proceso de preparacion y usos en el tratamiento de afecciones mediadas por agonistas del receptor muscarinico m1 | |
AR072952A1 (es) | Compuestos de 2-imino-3-metilpirrolopirimidinona fenilo-sustituida como inhibidores de bace-1, composiciones y su uso | |
PE20170682A1 (es) | Derivados de pirimidina sustituidos con heterociclilo opcionalmente condensados utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias | |
PE20221454A1 (es) | Derivados de 2-azaespiro[3.4]octano como agonistas de m4 | |
BR112022005674A2 (pt) | Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo | |
PE20161369A1 (es) | Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona sustituidos con tetrazolona | |
CR20200418A (es) | Inhibidores de orginasa y sus mètodos de uso antecedentes | |
PE20240930A1 (es) | Analogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton | |
RU2017117559A (ru) | Бензопроизводные с шестичленным кольцом в качестве ингибитора dpp-4 и их применение | |
AR116880A1 (es) | Compuestos de pirimidinodiona bicíclicos sustituidos con tetrahidropirano, forma polimórfica del mismo y el uso de los mismos para el tratamiento del hcm | |
ZA202104940B (en) | Novel substituted sulfonylurea derivatives | |
PE20190109A1 (es) | Nuevos derivados de [1,2,3]triazolo[4,5-d]pirimidina | |
CL2009001146A1 (es) | Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis. | |
CL2022000893A1 (es) | Derivados de 2-azaspiro[3,4]octano como agonistas de m4 | |
AR118641A1 (es) | Compuestos, composiciones y métodos |