BR112022005674A2 - Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo - Google Patents

Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo

Info

Publication number
BR112022005674A2
BR112022005674A2 BR112022005674A BR112022005674A BR112022005674A2 BR 112022005674 A2 BR112022005674 A2 BR 112022005674A2 BR 112022005674 A BR112022005674 A BR 112022005674A BR 112022005674 A BR112022005674 A BR 112022005674A BR 112022005674 A2 BR112022005674 A2 BR 112022005674A2
Authority
BR
Brazil
Prior art keywords
composition
fused ring
substituted aromatic
aromatic fused
ring derivative
Prior art date
Application number
BR112022005674A
Other languages
English (en)
Inventor
Huanyin Li
Qingfeng Xing
Yihan Wang
Yixin Ai
Original Assignee
Shenzhen Targetrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Targetrx Inc filed Critical Shenzhen Targetrx Inc
Publication of BR112022005674A2 publication Critical patent/BR112022005674A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Abstract

derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo. são fornecidos na presente invenção um derivado de anel fundido aromático substituído, uma composição compreendendo o composto, e uso do mesmo. o derivado de anel fundido aromático substituído é um composto como mostrado como fórmula (i) ou um tautômero, estereoisômero, pró-fármaco, forma cristalina, sal farmaceuticamente aceitável, hidrato ou solvato do mesmo. o composto e a composição da presente invenção podem ser usados para tratar várias doenças ou condições mediadas por proteína tirosina quinase.
BR112022005674A 2019-09-26 2020-09-25 Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo BR112022005674A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910915840 2019-09-26
PCT/CN2020/117586 WO2021057877A1 (zh) 2019-09-26 2020-09-25 取代的芳香稠合环衍生物及其组合物及用途

Publications (1)

Publication Number Publication Date
BR112022005674A2 true BR112022005674A2 (pt) 2022-06-21

Family

ID=75041095

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022005674A BR112022005674A2 (pt) 2019-09-26 2020-09-25 Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo

Country Status (9)

Country Link
US (1) US20220380375A1 (pt)
EP (1) EP4043465A4 (pt)
JP (1) JP7353682B2 (pt)
KR (1) KR20220062366A (pt)
CN (2) CN112552302B (pt)
AU (1) AU2020355359B2 (pt)
BR (1) BR112022005674A2 (pt)
CA (1) CA3151355C (pt)
WO (1) WO2021057877A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7323218B2 (ja) * 2019-02-18 2023-08-08 深▲チェン▼市塔吉瑞生物医薬有限公司 置換された縮合芳香環誘導体、その組成物、およびそれらの使用
BR112022022669A2 (pt) * 2020-05-08 2023-01-17 Halia Therapeutics Inc Inibidores de nek7 quinase
WO2021226547A2 (en) * 2020-05-08 2021-11-11 Halia Therapeutics, Inc. Targeted nek7 inhibition for modulation of the nlrp3 inflammasome
CA3186041A1 (en) * 2020-06-08 2021-12-16 Halia Therapeutics, Inc. Inhibitors of nek7 kinase
CN112778294A (zh) * 2021-01-07 2021-05-11 苏州安睿药业有限公司 5-氨基异噁唑衍生物及其在制备多激酶抑制剂中的应用
WO2022212326A1 (en) * 2021-03-29 2022-10-06 Halia Therapeutics, Inc. Nek7 inhibitors
AU2022255486A1 (en) * 2021-04-05 2023-10-19 Halia Therapeutics, Inc. Nek7 inhibitors
WO2022226182A1 (en) * 2021-04-22 2022-10-27 Halia Therapeutics, Inc. Nek7 inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
UY28931A1 (es) 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
AU2006320440B2 (en) 2005-12-02 2012-04-05 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
MX370814B (es) * 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US20140206681A1 (en) * 2013-01-23 2014-07-24 Ronald M. Kim Btk inhibitors
WO2014187777A1 (en) * 2013-05-21 2014-11-27 Mediapharma S.R.L. Novel inhibitors of pvhl-elongin c binding
CA2922230A1 (en) * 2013-08-30 2015-03-05 Ambit Biosciences Corporation Biaryl acetamide compounds and methods of use thereof
WO2016106623A1 (en) * 2014-12-31 2016-07-07 Merck Sharp & Dohme Corp. Benzamide imidazopyrazine btk inhibitors
CN107176951A (zh) * 2016-03-11 2017-09-19 恩瑞生物医药科技（上海）有限公司 一种脲类化合物、其制备方法及其医药用途
CN109851620B (zh) * 2016-08-17 2020-08-07 深圳市塔吉瑞生物医药有限公司 用于抑制酪氨酸激酶活性的稠合双环类化合物
IL277408B1 (en) * 2018-04-05 2024-04-01 Merck Patent Gmbh Heteroaryl compounds as IRAK type II inhibitors and their use
CN111646995B (zh) * 2019-03-04 2023-03-21 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途

Also Published As

Publication number Publication date
CN112552302A (zh) 2021-03-26
KR20220062366A (ko) 2022-05-16
CA3151355A1 (en) 2021-04-01
EP4043465A1 (en) 2022-08-17
CN112552302B (zh) 2022-05-13
JP2022550070A (ja) 2022-11-30
AU2020355359B2 (en) 2023-08-24
EP4043465A4 (en) 2022-10-26
CN114621233A (zh) 2022-06-14
JP7353682B2 (ja) 2023-10-02
US20220380375A1 (en) 2022-12-01
WO2021057877A1 (zh) 2021-04-01
CA3151355C (en) 2024-02-20
AU2020355359A1 (en) 2022-04-07

Similar Documents

Publication Publication Date Title
BR112022005674A2 (pt) Derivado de anel fundido aromático substituído e composição compreendendo o mesmo, e uso do mesmo
BR112022012641A2 (pt) Compostos tricíclicos substituídos
ECSP20013248A (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
EA201890001A1 (ru) Замещенные гетероциклические производные как ингибиторы циклинзависимой киназы (cdk)
NI201600166A (es) Compuestos de imidazo[4, 5-c]quinolin-2-ona y su uso para tratar cáncer
SV2018005655A (es) "derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer"
BR112022010383A2 (pt) Compostos tricíclicos substituídos
DOP2015000240A (es) 3- pirimidin- 4- il- oxazolidin- 2- onas como inhibidores de idh mutante
EA201891191A1 (ru) 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения
CL2022000619A1 (es) Oxinitruro de piridina, método para su preparación y uso de este
CO2018011408A2 (es) Compuestos de pirimidina como inhibidores de la quinasa jak
CO2020001469A2 (es) Compuestos bicíclicos de pirazol y triazolo como inhibidores de las cinasas jak
PE20181778A1 (es) Derivados de indolina sustituidos como inhibidores de la replicacion viral del dengue
EA202091016A1 (ru) Пиримидиновое соединение в качестве ингибитора jak киназы
PH12016502394A1 (en) 1, 3, 4-thiadiazole compounds and their use in treating cancer
SA519401322B1 (ar) مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2
EA201991355A1 (ru) Производные имидазо[1,5-а]пиразина в качестве ингибиторов pi3kдельта
BR112021011325A2 (pt) Derivados de rapamicina
MX2018011283A (es) Compuestos de cinnolin-4-amina y su uso en el tratamiento del cancer.
BR112015013414A2 (pt) derivados de naftiridona e seu uso no tratamento, melhora ou prevenção de uma doença viral
EA202190322A1 (ru) ИМИДАЗО[1,2-b]ПИРИДАЗИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ TRK
BR112018003335A2 (pt) composições farmacêuticas compreendendo 3-(5-amino-2-metil-4-oxo-4h-quinazolina-3-il)-piperidina-2,6-diona
CO2021001174A2 (es) Inhibidores de ckd8/19
BR112018007720A2 (pt) novos derivados de piridona e seu uso como inibidores da quinase
EA202090241A1 (ru) Новые гетероциклические соединения как ингибиторы cdk8/19