JP2011527684A5 - - Google Patents
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- Publication number
- JP2011527684A5 JP2011527684A5 JP2011517496A JP2011517496A JP2011527684A5 JP 2011527684 A5 JP2011527684 A5 JP 2011527684A5 JP 2011517496 A JP2011517496 A JP 2011517496A JP 2011517496 A JP2011517496 A JP 2011517496A JP 2011527684 A5 JP2011527684 A5 JP 2011527684A5
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- triazole
- diamine
- ethano
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 1,4-ethano-8- Phenyl-1,2,3,4-tetrahydro-1,5-naphthyridin-6-yl Chemical group 0.000 claims description 35
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- NALGRIOLHUTJGF-UHFFFAOYSA-N 3-N-[5-amino-1-(3-phenyl-1,6-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-5-yl)-1,2,4-triazol-3-yl]-5,6,7,8-tetrahydroquinoline-3,6-diamine Chemical compound C1=C2CC(N)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 NALGRIOLHUTJGF-UHFFFAOYSA-N 0.000 claims description 2
- OYKRCBXJLAUWRI-UHFFFAOYSA-N C1=C2CC(NC(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound C1=C2CC(NC(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 OYKRCBXJLAUWRI-UHFFFAOYSA-N 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 9
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- QXAMGWKESXGGNV-UHFFFAOYSA-N 7-(diethylamino)-1-benzopyran-2-one Chemical compound C1=CC(=O)OC2=CC(N(CC)CC)=CC=C21 QXAMGWKESXGGNV-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- YDKLOLUTIIBXKR-UHFFFAOYSA-N 1-(6-chloro-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(Cl)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 YDKLOLUTIIBXKR-UHFFFAOYSA-N 0.000 claims 1
- GYLLFNNZHFQJHW-ZLPCBKJTSA-N 1-(6-chloro-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-3-N-[6-[(3S)-4-(cyclopropylmethyl)-3-methylpiperazin-1-yl]pyridin-3-yl]-1,2,4-triazole-3,5-diamine Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(Cl)=NN=3)=CC=2)CCN1CC1CC1 GYLLFNNZHFQJHW-ZLPCBKJTSA-N 0.000 claims 1
- MNUXODSDJVGUMZ-UHFFFAOYSA-N 1-[6-(1,3-benzodioxol-5-yl)-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl]-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C=C4OCOC4=CC=3)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 MNUXODSDJVGUMZ-UHFFFAOYSA-N 0.000 claims 1
- XIMFQRBXOBKICL-UHFFFAOYSA-N 1-[6-(2-chlorophenyl)-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl]-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C(=CC=CC=3)Cl)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 XIMFQRBXOBKICL-UHFFFAOYSA-N 0.000 claims 1
- PJZULLWNMANBEA-UHFFFAOYSA-N 3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1-(3-phenyl-1,4,6-triazatricyclo[6.2.2.02,7]dodeca-2,4,6-trien-5-yl)-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2N=C(C=3N4CCC(CC4)C=3N=2)C=2C=CC=CC=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 PJZULLWNMANBEA-UHFFFAOYSA-N 0.000 claims 1
- ZSBRPSXTBIZVCN-UHFFFAOYSA-N 3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1-(6-pyridin-4-yl-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C=CN=CC=3)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 ZSBRPSXTBIZVCN-UHFFFAOYSA-N 0.000 claims 1
- NLTFNEOTIGWQDZ-UHFFFAOYSA-N 3-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2-dihydro-1,2,4-triazole-3,5-diamine Chemical compound N1NC(N)=NC1(N)C(C=C1F)=CC=C1N1CCC(N2CCCC2)CC1 NLTFNEOTIGWQDZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- PDOYLWPVRHKQTC-KPQWGBOZSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C(=CC=CC=4)Cl)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C(=CC=CC=4)Cl)=NN=3)=CC=2)CCN1CC1CC1 PDOYLWPVRHKQTC-KPQWGBOZSA-N 0.000 claims 1
- HFHFWMOYBXDKQX-KHRZNOOSSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=C(C)C=CC=4)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=C(C)C=CC=4)=NN=3)=CC=2)CCN1CC1CC1 HFHFWMOYBXDKQX-KHRZNOOSSA-N 0.000 claims 1
- SEFCNRFOIXDHSG-RBKXMNCYSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=CC=CC=4)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=CC=CC=4)=NN=3)=CC=2)CCN1CC1CC1 SEFCNRFOIXDHSG-RBKXMNCYSA-N 0.000 claims 1
- AXVJAULMQQDJGJ-UHFFFAOYSA-N C1=C2CN(C(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound C1=C2CN(C(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 AXVJAULMQQDJGJ-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- LJKHWOQADJHEBF-UHFFFAOYSA-N N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=C(C=CC=3)C(F)(F)F)C=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 Chemical compound N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=C(C=CC=3)C(F)(F)F)C=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 LJKHWOQADJHEBF-UHFFFAOYSA-N 0.000 claims 1
- QFTYPWAATNYFCG-UHFFFAOYSA-N N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=CC=CC=3)C=2)C(N)=NC=1NC(C=C1C2)=CN=C1CCC2NC1CCCC1 Chemical compound N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=CC=CC=3)C=2)C(N)=NC=1NC(C=C1C2)=CN=C1CCC2NC1CCCC1 QFTYPWAATNYFCG-UHFFFAOYSA-N 0.000 claims 1
- TXEZJWJTNHDBKW-UHFFFAOYSA-N NC1=NC(NC=2C=C3CNCCC3=NC=2)=NN1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound NC1=NC(NC=2C=C3CNCCC3=NC=2)=NN1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 TXEZJWJTNHDBKW-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000004321 azepin-2-yl group Chemical group [H]N1C([H])=C([H])C([H])=C([H])C([H])=C1* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000006316 iso-butyl amino group Chemical group [H]N(*)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- HUUBMTMJIQHAEN-UHFFFAOYSA-N triazole-1,4-diamine Chemical compound NC1=CN(N)N=N1 HUUBMTMJIQHAEN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7939808P | 2008-07-09 | 2008-07-09 | |
| US61/079,398 | 2008-07-09 | ||
| PCT/US2009/049627 WO2010005879A1 (en) | 2008-07-09 | 2009-07-02 | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527684A JP2011527684A (ja) | 2011-11-04 |
| JP2011527684A5 true JP2011527684A5 (https=) | 2014-08-21 |
| JP5613156B2 JP5613156B2 (ja) | 2014-10-22 |
Family
ID=41026400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517496A Expired - Fee Related JP5613156B2 (ja) | 2008-07-09 | 2009-07-02 | Ａｘｌ阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8431594B2 (https=) |
| EP (1) | EP2328888B1 (https=) |
| JP (1) | JP5613156B2 (https=) |
| CA (1) | CA2730251C (https=) |
| CY (1) | CY1113642T1 (https=) |
| DK (1) | DK2328888T3 (https=) |
| ES (1) | ES2399319T3 (https=) |
| HR (1) | HRP20130045T1 (https=) |
| PL (1) | PL2328888T3 (https=) |
| PT (1) | PT2328888E (https=) |
| SI (1) | SI2328888T1 (https=) |
| WO (1) | WO2010005879A1 (https=) |
Families Citing this family (33)
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| US7884119B2 (en) * | 2005-09-07 | 2011-02-08 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as Axl inhibitors |
| US8012965B2 (en) | 2006-12-29 | 2011-09-06 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008083353A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌインヒビターとして有用な置換トリアゾール |
| CA2710046C (en) * | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as axl inhibitors |
| EP2078010B1 (en) | 2006-12-29 | 2014-01-29 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| EP2205592B1 (en) * | 2007-10-26 | 2013-05-08 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| JP5613156B2 (ja) * | 2008-07-09 | 2014-10-22 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌ阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
| ES2537480T3 (es) | 2008-07-09 | 2015-06-08 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclicos útiles como inhibidores de Axl |
| JP4644273B2 (ja) * | 2008-07-15 | 2011-03-02 | 本田技研工業株式会社 | 車両周辺監視装置 |
| PL2387395T3 (pl) | 2009-01-16 | 2015-03-31 | Rigel Pharmaceuticals Inc | Inhibitory Axl do zastosowania w terapii skojarzonej do zapobiegania, leczenia lub postępowania z nowotworem przerzutowym |
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| US8885569B2 (en) | 2011-12-19 | 2014-11-11 | Ofinno Technologies, Llc | Beamforming signaling in a wireless network |
| DK2810937T3 (en) | 2012-01-31 | 2017-03-13 | Daiichi Sankyo Co Ltd | PYRIDONE DERIVATIVES |
| EP3184121A3 (en) | 2012-07-25 | 2017-09-27 | Salk Institute For Biological Studies | Lipid membranes with exposed phosphatidylserine as tam ligands, use for treating autoimmune diseases |
| AU2014353006B2 (en) | 2013-11-20 | 2019-04-04 | Signalchem Life Sciences Corp. | Quinazoline derivatives as TAM family kinase inhibitors |
| US10233176B2 (en) * | 2013-11-27 | 2019-03-19 | Signalchem Lifesciences Corporation | Aminopyridine derivatives as TAM family kinase inhibitors |
| SG11201608303QA (en) | 2014-04-04 | 2016-11-29 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| WO2017146236A1 (ja) | 2016-02-26 | 2017-08-31 | 小野薬品工業株式会社 | Ａｘｌ阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬 |
| KR102483020B1 (ko) | 2016-03-28 | 2023-01-04 | 인사이트 코포레이션 | Tam 저해제로서의 피롤로트리아진 화합물 |
| US20200197385A1 (en) | 2017-08-23 | 2020-06-25 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for cancer containing axl inhibitor as active ingredient |
| MA50655B1 (fr) | 2017-09-27 | 2021-11-30 | Incyte Corp | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
| US11826363B2 (en) | 2017-10-13 | 2023-11-28 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient |
| AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2021178779A1 (en) | 2020-03-06 | 2021-09-10 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
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| US8012965B2 (en) * | 2006-12-29 | 2011-09-06 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| CA2710046C (en) * | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as axl inhibitors |
| JP2010514810A (ja) | 2006-12-29 | 2010-05-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌインヒビターとして有用な置換トリアゾール |
| EP2078010B1 (en) | 2006-12-29 | 2014-01-29 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008083353A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| BRPI0813356A2 (pt) | 2007-06-15 | 2014-12-30 | Irm Llc | Inibidores de proteína quinase e métodos para uso dos mesmos |
| EP2205592B1 (en) * | 2007-10-26 | 2013-05-08 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| HUE030912T2 (en) | 2008-02-15 | 2017-06-28 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of yak kinases |
| ES2537480T3 (es) | 2008-07-09 | 2015-06-08 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclicos útiles como inhibidores de Axl |
| JP5613156B2 (ja) * | 2008-07-09 | 2014-10-22 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌ阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
| PL2387395T3 (pl) * | 2009-01-16 | 2015-03-31 | Rigel Pharmaceuticals Inc | Inhibitory Axl do zastosowania w terapii skojarzonej do zapobiegania, leczenia lub postępowania z nowotworem przerzutowym |
-
2009
- 2009-07-02 JP JP2011517496A patent/JP5613156B2/ja not_active Expired - Fee Related
- 2009-07-02 ES ES09790063T patent/ES2399319T3/es active Active
- 2009-07-02 DK DK09790063T patent/DK2328888T3/da active
- 2009-07-02 WO PCT/US2009/049627 patent/WO2010005879A1/en not_active Ceased
- 2009-07-02 US US13/002,488 patent/US8431594B2/en active Active
- 2009-07-02 CA CA2730251A patent/CA2730251C/en active Active
- 2009-07-02 PT PT09790063T patent/PT2328888E/pt unknown
- 2009-07-02 EP EP20090790063 patent/EP2328888B1/en active Active
- 2009-07-02 HR HRP20130045AT patent/HRP20130045T1/hr unknown
- 2009-07-02 SI SI200930487T patent/SI2328888T1/sl unknown
- 2009-07-02 PL PL09790063T patent/PL2328888T3/pl unknown
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2012
- 2012-09-14 US US13/620,010 patent/US8658669B2/en not_active Expired - Fee Related
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2013
- 2013-02-06 CY CY20131100109T patent/CY1113642T1/el unknown
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2014
- 2014-01-08 US US14/150,401 patent/US8933080B2/en active Active
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2015
- 2015-01-09 US US14/593,981 patent/US9206161B2/en active Active
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