BRPI0813356A2 - Inibidores de proteína quinase e métodos para uso dos mesmos - Google Patents

Inibidores de proteína quinase e métodos para uso dos mesmos

Info

Publication number
BRPI0813356A2
BRPI0813356A2 BRPI0813356-5A2A BRPI0813356A BRPI0813356A2 BR PI0813356 A2 BRPI0813356 A2 BR PI0813356A2 BR PI0813356 A BRPI0813356 A BR PI0813356A BR PI0813356 A2 BRPI0813356 A2 BR PI0813356A2
Authority
BR
Brazil
Prior art keywords
methods
protein kinase
kinase inhibitors
same use
same
Prior art date
Application number
BRPI0813356-5A2A
Other languages
English (en)
Inventor
Shenlin Huang
Zuosheng Liu
Pamela A Albaugh
Xing Wang
Shifeng Pan
Yongping Xie
Guobao Zhang
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of BRPI0813356A2 publication Critical patent/BRPI0813356A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0813356-5A2A 2007-06-15 2008-06-10 Inibidores de proteína quinase e métodos para uso dos mesmos BRPI0813356A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94445707P 2007-06-15 2007-06-15
PCT/US2008/066426 WO2008157131A1 (en) 2007-06-15 2008-06-10 Protein kinase inhibitors and methods for using thereof

Publications (1)

Publication Number Publication Date
BRPI0813356A2 true BRPI0813356A2 (pt) 2014-12-30

Family

ID=39672881

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813356-5A2A BRPI0813356A2 (pt) 2007-06-15 2008-06-10 Inibidores de proteína quinase e métodos para uso dos mesmos

Country Status (11)

Country Link
US (1) US20100184765A1 (pt)
EP (1) EP2170867A1 (pt)
JP (1) JP2010529990A (pt)
KR (1) KR20100021452A (pt)
CN (1) CN101707863A (pt)
AU (1) AU2008266290A1 (pt)
BR (1) BRPI0813356A2 (pt)
CA (1) CA2690653A1 (pt)
EA (1) EA200901654A1 (pt)
MX (1) MX2009013782A (pt)
WO (1) WO2008157131A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US7884119B2 (en) 2005-09-07 2011-02-08 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as Axl inhibitors
AU2007342005A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors
JP2010514810A (ja) 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
US7709482B2 (en) 2006-12-29 2010-05-04 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
EP2114955B1 (en) 2006-12-29 2013-02-13 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
ES2406930T3 (es) 2006-12-29 2013-06-10 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico y heteroarilo bicíclico útiles como inhibidores de AXL
WO2009054864A1 (en) 2007-10-26 2009-04-30 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
EP2265574A1 (en) * 2008-02-29 2010-12-29 Array Biopharma, Inc. N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
JP2011513329A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド ＲＡＦ阻害化合物として使用されるイミダゾ［４，５−ｂ］ピリジン誘導体
BRPI0908268A2 (pt) * 2008-02-29 2018-10-30 Array Biopharma Inc compostos do inibidor de raf e seus métodos de uso
JP2011513330A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
JP5613156B2 (ja) 2008-07-09 2014-10-22 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌ阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール
CA2730231C (en) 2008-07-09 2016-10-18 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
AU2010204578B2 (en) 2009-01-16 2016-05-12 Rigel Pharmaceuticals, Inc. AXL inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
JP2017538699A (ja) 2014-12-05 2017-12-28 エーエヌ２エイチ ディスカバリー リミテッド パーキンリガーゼ活性化の方法及び組成物
EP3070084A1 (en) * 2015-03-18 2016-09-21 Rottapharm Biotech S.r.l. New fyn kinase inhibitors
WO2016164754A1 (en) * 2015-04-09 2016-10-13 Eisai R&D Management Co., Ltd. Fgfr4 inhibitors
CN106397432B (zh) * 2015-08-03 2018-03-16 南昌弘益科技有限公司 作为jak抑制剂的一类化合物
EP3423437A4 (en) 2016-03-01 2019-07-24 Propellon Therapeutics Inc. INHIBITORS OF THE LINK BETWEEN THE WDR5 PROTEIN AND ITS LIAISON PARTNERS
MX2018010374A (es) 2016-03-01 2019-03-28 Propellon Therapeutics Inc Inhibidores del enlace proteína-proteína de wdr5.
WO2017210694A1 (en) 2016-06-03 2017-12-07 An2H Discovery Limited Triazole benzamide derivatives and the compositions and methods of treatment regarding the same
US10889553B2 (en) 2017-12-01 2021-01-12 Nysnobio Ireland Dac Asymmetric triazole benzamide derivatives and the compositions and methods of treatment regarding the same
WO2019173761A1 (en) 2018-03-09 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
WO2021115560A1 (en) * 2019-12-09 2021-06-17 Rottapharm Biotech S.R.L. New fyn and vegfr2 kinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335913B (en) * 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
EP1791830B1 (en) * 2004-09-17 2010-12-29 Vertex Pharmaceuticals Incorporated Diaminotriazole compounds useful as protein kinase inhibitors

Also Published As

Publication number Publication date
CN101707863A (zh) 2010-05-12
US20100184765A1 (en) 2010-07-22
JP2010529990A (ja) 2010-09-02
AU2008266290A1 (en) 2008-12-24
KR20100021452A (ko) 2010-02-24
EA200901654A1 (ru) 2010-06-30
CA2690653A1 (en) 2008-12-24
MX2009013782A (es) 2010-02-01
EP2170867A1 (en) 2010-04-07
WO2008157131A1 (en) 2008-12-24

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]