JP2019522050A - 細胞の枯渇のための組成物および方法 - Google Patents

細胞の枯渇のための組成物および方法 Download PDF

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JP2019522050A
JP2019522050A JP2019518185A JP2019518185A JP2019522050A JP 2019522050 A JP2019522050 A JP 2019522050A JP 2019518185 A JP2019518185 A JP 2019518185A JP 2019518185 A JP2019518185 A JP 2019518185A JP 2019522050 A JP2019522050 A JP 2019522050A
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antibody
antigen
optionally substituted
binding fragment
patient
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JP2019522050A5 (enExample
Inventor
ニクソン アンドリュー
ニクソン アンドリュー
モロー ドワイト
モロー ドワイト
ハーティガン アダム
ハーティガン アダム
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Dianthus Therapeutics Inc
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Magenta Therapeutics Inc
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Publication of JP2019522050A publication Critical patent/JP2019522050A/ja
Publication of JP2019522050A5 publication Critical patent/JP2019522050A5/ja
Priority to JP2022116511A priority Critical patent/JP2022163075A/ja
Priority to JP2023208327A priority patent/JP2024037832A/ja
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019513836A (ja) 2016-04-04 2019-05-30 ヘモジェニックス リミテッド ライアビリティ カンパニー 二重特異性抗体を使用して患者の造血幹細胞/造血前駆細胞(hsc/hp)を除去する方法
EP3655534B1 (en) 2017-07-18 2025-07-16 CSL Behring Gene Therapy, Inc. Compositions and methods for treating beta-hemoglobinopathies
KR20200094181A (ko) 2017-11-29 2020-08-06 마젠타 테라퓨틱스 인코포레이티드 Cd5+ 세포를 고갈시키기 위한 조성물 및 방법
US12133884B2 (en) 2018-05-11 2024-11-05 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
CA3098103A1 (en) * 2018-05-23 2019-11-28 Adc Therapeutics Sa Molecular adjuvant
JP2021532116A (ja) * 2018-07-23 2021-11-25 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 同種異系の細胞療法における抗−cd5抗体薬物コンジュゲート(adc)の使用
AU2019310430A1 (en) * 2018-07-23 2021-02-25 Magenta Therapeutics, Inc. Use of an anti-CD2 antibody drug conjugate (ADC) in allogeneic cell therapy
CN113302203A (zh) * 2018-10-30 2021-08-24 美真达治疗公司 抗cd45抗体及其缀合物
WO2020092655A1 (en) * 2018-10-30 2020-05-07 Magenta Therapeutics, Inc. Methods for allogeneic hematopoietic stem cell transplantation
WO2020139796A1 (en) 2018-12-23 2020-07-02 Csl Behring L.L.C. Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome
JP2022518150A (ja) * 2019-01-07 2022-03-14 マジェンタ セラピューティクス インコーポレイテッド 細胞療法での抗cd45抗体-薬物結合体(adc)の使用経験
JP7650819B2 (ja) * 2019-04-24 2025-03-25 ブイオーアール バイオファーマ インコーポレーテッド 抗-cd45抗体薬物コンジュゲート及びその使用
CA3134689A1 (en) * 2019-04-24 2020-10-29 Anthony Boitano Conditioning methods for gene therapy
CA3137568A1 (en) * 2019-04-25 2020-10-29 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
KR20220016922A (ko) * 2019-06-04 2022-02-10 마젠타 테라퓨틱스 인코포레이티드 자가면역 질환을 치료하기 위한 방법 및 조성물
PE20220231A1 (es) * 2019-06-25 2022-02-07 Gilead Sciences Inc Proteinas de fusion flt3l-fc y metodos de uso
TWI877179B (zh) * 2019-06-27 2025-03-21 德商百靈佳殷格翰國際股份有限公司 抗-angpt2抗體
CA3146912A1 (en) * 2019-07-09 2021-01-14 Hemogenyx Pharmaceuticals Llc Method of eliminating hematopoietic stem cells/hematopoietic progenitors (hsc/hp) in a patient using bi-specific antibodies
JP2022543779A (ja) * 2019-07-30 2022-10-14 デンドロサイト バイオテック ピーティーワイ リミテッド イムノコンジュゲート
JP7716399B2 (ja) * 2019-11-01 2025-07-31 ブイオーアール バイオファーマ インコーポレーテッド 抗-cd45抗体及びそのコンジュゲート
CN115397444A (zh) * 2020-02-18 2022-11-25 美真达治疗公司 用于同种异体移植的组合物和方法
KR20240119146A (ko) 2021-12-23 2024-08-06 유니버시타트 바셀 세포 치료에 이용하기 위한 cd45의 식별 가능한 세포 표면 단백질 변이체

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536180A (ja) * 2001-12-03 2005-12-02 アブジェニックス・インコーポレーテッド 自己免疫疾患の治療および移植拒絶の処置に使用する抗cd45rb抗体
JP2016516010A (ja) * 2014-03-10 2016-06-02 ハイデルベルク ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング アマトキシン誘導体
JP2018514520A (ja) * 2015-04-06 2018-06-07 プレジデント アンド フェローズ オブ ハーバード カレッジ 骨髄非破壊性前処置のための組成物および方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6074650A (en) 1985-06-24 2000-06-13 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
AU5186090A (en) 1989-02-23 1990-09-26 Colorado State University Research Foundation Gnrh analogs for destroying gonadotrophs
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US6024957A (en) 1993-06-02 2000-02-15 Research Corporation Technologies, Inc. Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
GB9323199D0 (en) 1993-11-10 1994-01-05 Falkenberg J H F Leukaemia treatment
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
US20110045005A1 (en) 2001-10-19 2011-02-24 Craig Crowley Compositions and methods for the treatment of tumor of hematopoietic origin
KR20060079232A (ko) * 2003-09-18 2006-07-05 노파르티스 아게 치료용 결합 분자
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
EP1661584A1 (en) 2004-11-26 2006-05-31 Heinz Dr. Faulstich Use of conjugates of amatoxins and phallotoxins with macromolecules for cancer and inflammation therapy
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
WO2007092196A2 (en) 2006-01-27 2007-08-16 Cellerant Therapeutics, Inc. Compositions and methods for treating myeloid proliferative disorders
CA2645347A1 (en) 2006-03-10 2007-09-20 Diatos Anticancer drugs conjugated to antibody via an enzyme cleavable linker
ATE521366T1 (de) 2006-05-27 2011-09-15 Faulstich Heinz Dr Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen
HRP20140172T1 (hr) 2006-05-30 2014-03-28 Genentech, Inc. Protutijela i imunokonjugati kao i njihove uporabe
KR20090094814A (ko) * 2006-10-10 2009-09-08 스퀴코어 암의 치료 및 진단을 위한 조성물 및 방법
PL3255061T3 (pl) * 2006-11-03 2021-12-06 The Board Of Trustees Of The Leland Stanford Junior University Selektywna deplecja immunologiczna niszy endogennych komórek macierzystych do wszczepienia
ES2523915T5 (es) 2006-12-01 2022-05-26 Seagen Inc Agentes de unión a la diana variantes y usos de los mismos
RU2583270C2 (ru) * 2009-04-01 2016-05-10 Дженентек, Инк. АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2416805B1 (en) * 2009-04-08 2013-07-24 Heinz Dr. Faulstich Amatoxin antibody conjugates for the treatment of cancer
EP3192529B1 (en) 2009-04-08 2020-03-25 Faulstich, Heinz, Dr. Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
NZ602932A (en) 2010-04-15 2014-08-29 Seattle Genetics Inc Targeted pyrrolobenzodiazapine conjugates
ES2402254T3 (es) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
KR101976882B1 (ko) * 2011-03-23 2019-05-09 프레드 헛친슨 켄서 리서치 센터 세포 면역요법용 방법 및 조성물
BR122020001787A8 (pt) 2011-05-08 2023-04-25 Legochem Biosciences Inc Conjugado de anticorpo-agente ativo, seus métodos de preparação, sua composição e seu uso
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
US9388187B2 (en) 2011-10-14 2016-07-12 Medimmune Limited Pyrrolobenzodiazepines
WO2013093809A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
US9504756B2 (en) 2012-05-15 2016-11-29 Seattle Genetics, Inc. Self-stabilizing linker conjugates
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
WO2014043403A1 (en) 2012-09-12 2014-03-20 Agensys, Inc. Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
US9324898B2 (en) * 2012-09-25 2016-04-26 Alliance For Sustainable Energy, Llc Varying cadmium telluride growth temperature during deposition to increase solar cell reliability
AU2013350802B2 (en) * 2012-11-30 2016-07-14 Novartis Ag Methods for making conjugates from disulfide-containing proteins
WO2014134539A1 (en) 2013-02-28 2014-09-04 President And Fellows Of Harvard College Methods and compositions for mobilizing stem cells
EP2774624A1 (en) 2013-03-04 2014-09-10 Heidelberg Pharma GmbH Amatoxin derivatives
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
WO2014151030A1 (en) * 2013-03-15 2014-09-25 Novartis Ag Cell proliferation inhibitors and conjugates thereof
US9803002B2 (en) 2013-05-31 2017-10-31 Genentench, Inc. Anti-wall teichoic antibodies and conjugates
US11229711B2 (en) 2013-06-06 2022-01-25 Magenta Therapeutics, Inc. Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
US10071170B2 (en) 2013-06-24 2018-09-11 Ablbio Antibody-drug conjugate having improved stability and use thereof
FR3008408B1 (fr) 2013-07-11 2018-03-09 Mc Saf Nouveaux conjugues anticorps-medicament et leur utilisation en therapie
JP6800021B2 (ja) 2014-06-02 2020-12-16 レゲネロン ファーマシューティカルス,インコーポレーテッド 抗体−薬物コンジュゲート、それらの製造、及びそれらの治療用途
EP3174902B1 (en) * 2014-08-01 2019-04-17 Institut National de la Sante et de la Recherche Medicale (INSERM) An anti-cd45rc antibody for use as drug
RU2715905C2 (ru) 2014-10-01 2020-03-04 МЕДИММЬЮН, ЭлЭлСи Способ конъюгации полипептида
US20190209704A1 (en) 2014-10-20 2019-07-11 Igenica Biotherapeutics, Inc. Novel antibody-drug conjugates and related compounds, compositions and methods of use
WO2016071856A1 (en) * 2014-11-06 2016-05-12 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
EP3026060A1 (en) * 2014-11-26 2016-06-01 Miltenyi Biotec GmbH Humanized antibody or fragment thereof specific for CD45R0
US9729129B2 (en) * 2014-12-05 2017-08-08 Bhaskar Gopalan System and method for reducing metastability in CMOS flip-flops
US20160220687A1 (en) 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
PT3268047T (pt) 2015-03-09 2023-12-05 Heidelberg Pharma Res Gmbh Conjugados amatoxina-anticorpo
EP3297684B1 (en) 2015-05-21 2020-12-23 Actinium Pharmaceuticals, Inc. Infusion administration of conjugated monoclonal antibodies
WO2017051249A1 (en) 2015-09-25 2017-03-30 Legochem Biosciences, Inc. Compositions and methods related to anti-cd19 antibody drug conjugates
MA43354A (fr) 2015-10-16 2018-08-22 Genentech Inc Conjugués médicamenteux à pont disulfure encombré
JP2018536666A (ja) 2015-11-27 2018-12-13 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング γ−アマニチンの誘導体
EP3222292A1 (en) 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
WO2017155937A1 (en) 2016-03-07 2017-09-14 Actinium Pharmaceuticals, Inc. Stabilized radiolabeled anti-cd45 immunoglobulin compositions
KR102295190B1 (ko) 2016-04-20 2021-08-30 항저우 디에이씨 바이오테크 씨오, 엘티디 아마니타 독소의 유도체 및 세포 결합 분자와의 그것의 결합
US10464969B2 (en) 2016-05-05 2019-11-05 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
CA3022802A1 (en) 2016-05-27 2017-11-30 Actinium Pharmaceuticals, Inc. Low dose antibody-based methods for treating hematologic malignancies
EP3471771A4 (en) 2016-05-31 2020-04-15 Sorrento Therapeutics, Inc. ANTIBODY CONJUGATES HAVING AMATOXIN DERIVATIVES AS A MEDICINAL PRODUCT
US10111966B2 (en) 2016-06-17 2018-10-30 Magenta Therapeutics, Inc. Methods for the depletion of CD117+ cells
WO2018039810A1 (en) 2016-08-29 2018-03-08 Pdi Pharm Development International Ag Provision of a therapeutically active cell product
US10112266B2 (en) * 2016-09-09 2018-10-30 Baltic Innovation Holding PRO, AS Pressed thermite rod for a self-contained portable cutting device
JP7360323B2 (ja) * 2016-10-13 2023-10-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 骨髄非破壊前処理のための組成物および方法
PT3558390T (pt) 2016-12-23 2024-10-29 Heidelberg Pharma Res Gmbh Conjugados amanitina anticorpo
US10576161B2 (en) 2017-01-20 2020-03-03 Magenta Therapeutics, Inc. Compositions and methods for the depletion of CD137+ cells
BR112019015342A2 (pt) 2017-01-30 2020-03-10 The Board Of Trustees Of The Leland Stanford Junior University Regime de condicionamento não genotóxico para o transplante de células-tronco
EP3661938B1 (en) 2017-08-07 2025-01-15 Heidelberg Pharma Research GmbH Novel method for synthesizing amanitins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536180A (ja) * 2001-12-03 2005-12-02 アブジェニックス・インコーポレーテッド 自己免疫疾患の治療および移植拒絶の処置に使用する抗cd45rb抗体
JP2016516010A (ja) * 2014-03-10 2016-06-02 ハイデルベルク ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング アマトキシン誘導体
JP2018514520A (ja) * 2015-04-06 2018-06-07 プレジデント アンド フェローズ オブ ハーバード カレッジ 骨髄非破壊性前処置のための組成物および方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATURE BIOTECHNOLOGY, 6 JUNE 2016, VOL. 34, NO. 7, PP.738-745, JPN6021022956, ISSN: 0004528487 *

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