CN109641051A - 用于耗尽细胞的组合物和方法 - Google Patents
用于耗尽细胞的组合物和方法 Download PDFInfo
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- CN109641051A CN109641051A CN201780050855.7A CN201780050855A CN109641051A CN 109641051 A CN109641051 A CN 109641051A CN 201780050855 A CN201780050855 A CN 201780050855A CN 109641051 A CN109641051 A CN 109641051A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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| BR112020001059A2 (pt) | 2017-07-18 | 2020-07-14 | Calimmune, Inc. | composições e métodos para o tratamento de beta-hemoglobinopatias |
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| EP3799603A4 (en) | 2018-05-11 | 2022-03-02 | Beam Therapeutics, Inc. | METHODS OF PATHOGENIC AMINO ACID SUBSTITUTION USING PROGRAMMABLE BASE EDITOR SYSTEMS |
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| AU2019311077B2 (en) * | 2018-07-23 | 2025-05-29 | Heidelberg Pharma Research Gmbh | Use of anti-CD5 antibody drug conjugate (ADC) in allogeneic cell therapy |
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| CA3028145A1 (en) | 2017-12-21 |
| EP3471772A1 (en) | 2019-04-24 |
| US20240207428A1 (en) | 2024-06-27 |
| US20190192682A1 (en) | 2019-06-27 |
| AU2020217338A1 (en) | 2020-08-27 |
| JP2022163075A (ja) | 2022-10-25 |
| EP3471772A4 (en) | 2020-03-18 |
| WO2017219025A1 (en) | 2017-12-21 |
| IL263743A (en) | 2019-01-31 |
| MA45407A (fr) | 2019-04-24 |
| AU2017204139A1 (en) | 2018-01-18 |
| AU2018208749B2 (en) | 2020-09-03 |
| AU2017204139B2 (en) | 2018-08-09 |
| MX2018015683A (es) | 2019-05-27 |
| SG11201811292RA (en) | 2019-01-30 |
| BR112018076263A2 (pt) | 2019-03-26 |
| KR20190039085A (ko) | 2019-04-10 |
| US20200376134A1 (en) | 2020-12-03 |
| US20240408168A1 (en) | 2024-12-12 |
| US10624973B2 (en) | 2020-04-21 |
| KR20230082055A (ko) | 2023-06-08 |
| JP2019522050A (ja) | 2019-08-08 |
| US20190328901A1 (en) | 2019-10-31 |
| JP2024037832A (ja) | 2024-03-19 |
| AU2018208749A1 (en) | 2018-08-16 |
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