JP2019517267A5 - - Google Patents
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- JP2019517267A5 JP2019517267A5 JP2018564239A JP2018564239A JP2019517267A5 JP 2019517267 A5 JP2019517267 A5 JP 2019517267A5 JP 2018564239 A JP2018564239 A JP 2018564239A JP 2018564239 A JP2018564239 A JP 2018564239A JP 2019517267 A5 JP2019517267 A5 JP 2019517267A5
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- 239000013598 vector Substances 0.000 claims description 63
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 58
- 210000004027 cell Anatomy 0.000 claims description 42
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 35
- 230000011664 signaling Effects 0.000 claims description 35
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 33
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 150000007523 nucleic acids Chemical group 0.000 claims description 32
- 108020004707 nucleic acids Proteins 0.000 claims description 24
- 102000039446 nucleic acids Human genes 0.000 claims description 24
- 239000012642 immune effector Substances 0.000 claims description 21
- 229940121354 immunomodulator Drugs 0.000 claims description 21
- 230000000139 costimulatory effect Effects 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 108010029180 Sialic Acid Binding Ig-like Lectin 3 Proteins 0.000 claims description 19
- 102000001555 Sialic Acid Binding Ig-like Lectin 3 Human genes 0.000 claims description 19
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 17
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 17
- 102000001301 EGF receptor Human genes 0.000 claims description 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 15
- 108060006698 EGF receptor Proteins 0.000 claims description 10
- 240000007019 Oxalis corniculata Species 0.000 claims description 10
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 8
- 102000004127 Cytokines Human genes 0.000 claims description 8
- 108090000695 Cytokines Proteins 0.000 claims description 8
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 7
- 239000013603 viral vector Substances 0.000 claims description 7
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 6
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 6
- 102000008579 Transposases Human genes 0.000 claims description 6
- 108010020764 Transposases Proteins 0.000 claims description 6
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims description 5
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims description 5
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 5
- 241000713666 Lentivirus Species 0.000 claims description 5
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 5
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims description 5
- 241001430294 unidentified retrovirus Species 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 101150090033 DRB2 gene Proteins 0.000 claims description 3
- 101100117568 Oryza sativa subsp. japonica DRB5 gene Proteins 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 3
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 102000000588 Interleukin-2 Human genes 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000004927 fusion Effects 0.000 claims description 2
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 claims description 2
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims description 2
- 230000004083 survival effect Effects 0.000 claims description 2
- 230000026683 transduction Effects 0.000 claims 3
- 238000010361 transduction Methods 0.000 claims 3
- 210000000173 T-lymphoid precursor cell Anatomy 0.000 claims 1
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 230000005809 anti-tumor immunity Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000013613 expression plasmid Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022110311A JP2022153434A (ja) | 2016-06-08 | 2022-07-08 | Ｃｄ３３特異的キメラ抗原受容体 |
| JP2024097538A JP2024138280A (ja) | 2016-06-08 | 2024-06-17 | Ｃｄ３３特異的キメラ抗原受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347503P | 2016-06-08 | 2016-06-08 | |
| US62/347,503 | 2016-06-08 | ||
| PCT/US2017/036440 WO2017214333A1 (en) | 2016-06-08 | 2017-06-07 | Cd33 specific chimeric antigen receptors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022110311A Division JP2022153434A (ja) | 2016-06-08 | 2022-07-08 | Ｃｄ３３特異的キメラ抗原受容体 |
| JP2024097538A Division JP2024138280A (ja) | 2016-06-08 | 2024-06-17 | Ｃｄ３３特異的キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517267A JP2019517267A (ja) | 2019-06-24 |
| JP2019517267A5 true JP2019517267A5 (enExample) | 2020-07-09 |
| JP7591342B2 JP7591342B2 (ja) | 2024-11-28 |
Family
ID=59071136
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564239A Active JP7591342B2 (ja) | 2016-06-08 | 2017-06-07 | Ｃｄ３３特異的キメラ抗原受容体 |
| JP2022110311A Withdrawn JP2022153434A (ja) | 2016-06-08 | 2022-07-08 | Ｃｄ３３特異的キメラ抗原受容体 |
| JP2024097538A Pending JP2024138280A (ja) | 2016-06-08 | 2024-06-17 | Ｃｄ３３特異的キメラ抗原受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022110311A Withdrawn JP2022153434A (ja) | 2016-06-08 | 2022-07-08 | Ｃｄ３３特異的キメラ抗原受容体 |
| JP2024097538A Pending JP2024138280A (ja) | 2016-06-08 | 2024-06-17 | Ｃｄ３３特異的キメラ抗原受容体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11787848B2 (enExample) |
| EP (1) | EP3468994A1 (enExample) |
| JP (3) | JP7591342B2 (enExample) |
| KR (3) | KR102469703B1 (enExample) |
| CN (2) | CN118652336A (enExample) |
| AU (2) | AU2017279548B2 (enExample) |
| CA (1) | CA3025667A1 (enExample) |
| IL (2) | IL321834A (enExample) |
| SG (1) | SG11201810640RA (enExample) |
| WO (1) | WO2017214333A1 (enExample) |
Families Citing this family (72)
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| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| JP7591342B2 (ja) | 2016-06-08 | 2024-11-28 | プレシゲン，インコーポレイテッド | Ｃｄ３３特異的キメラ抗原受容体 |
| JP7386082B2 (ja) | 2017-02-28 | 2023-11-24 | ブイオーアール バイオファーマ インコーポレーテッド | 系統特異的タンパク質の阻害のための組成物および方法 |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| WO2018226897A1 (en) | 2017-06-07 | 2018-12-13 | Intrexon Corporation | Expression of novel cell tags |
| CA3079264A1 (en) * | 2017-10-18 | 2019-04-25 | Intrexon Corporation | Polypeptide compositions comprising spacers |
| WO2019084234A1 (en) * | 2017-10-26 | 2019-05-02 | St. Jude Childen's Research Hospital, Inc. | METHODS AND COMPOSITIONS FOR TREATING CD33 + CANCERS AND IMPROVING IN VIVO PERSISTENCE OF CHIMERIC ANTIGEN RECEPTOR T CELLS |
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| US20210054409A1 (en) * | 2018-02-09 | 2021-02-25 | National University Of Singapore | Adhesion Receptor Constructs and Uses Thereof in Natural Killer Cell Immunotherapy |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
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2017
- 2017-06-07 JP JP2018564239A patent/JP7591342B2/ja active Active
- 2017-06-07 AU AU2017279548A patent/AU2017279548B2/en active Active
- 2017-06-07 WO PCT/US2017/036440 patent/WO2017214333A1/en not_active Ceased
- 2017-06-07 KR KR1020197000376A patent/KR102469703B1/ko active Active
- 2017-06-07 KR KR1020247010094A patent/KR20240111740A/ko active Pending
- 2017-06-07 CA CA3025667A patent/CA3025667A1/en active Pending
- 2017-06-07 CN CN202410513486.2A patent/CN118652336A/zh active Pending
- 2017-06-07 EP EP17731047.1A patent/EP3468994A1/en active Pending
- 2017-06-07 US US15/616,869 patent/US11787848B2/en active Active
- 2017-06-07 KR KR1020227040331A patent/KR102652827B1/ko active Active
- 2017-06-07 IL IL321834A patent/IL321834A/en unknown
- 2017-06-07 CN CN201780048487.2A patent/CN110191898B/zh active Active
- 2017-06-07 SG SG11201810640RA patent/SG11201810640RA/en unknown
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2018
- 2018-11-22 IL IL263220A patent/IL263220B2/en unknown
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2022
- 2022-07-08 JP JP2022110311A patent/JP2022153434A/ja not_active Withdrawn
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2023
- 2023-09-06 US US18/462,207 patent/US20240254188A1/en active Pending
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2024
- 2024-06-17 JP JP2024097538A patent/JP2024138280A/ja active Pending
- 2024-07-16 AU AU2024204877A patent/AU2024204877A1/en active Pending
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