JP7591342B2 - Ｃｄ３３特異的キメラ抗原受容体 - Google Patents

Ｃｄ３３特異的キメラ抗原受容体 Download PDF

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JP7591342B2
JP7591342B2 JP2018564239A JP2018564239A JP7591342B2 JP 7591342 B2 JP7591342 B2 JP 7591342B2 JP 2018564239 A JP2018564239 A JP 2018564239A JP 2018564239 A JP2018564239 A JP 2018564239A JP 7591342 B2 JP7591342 B2 JP 7591342B2
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cells
car
cell
amino acid
acid sequence
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JP2019517267A (ja
JP2019517267A5 (enExample
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アール． シャー，ルトゥル
チャン，ティム
エムテージ，ピーター
ヤルラガッダ，ラムヤ
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プレシゲン，インコーポレイテッド
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2018564239A 2016-06-08 2017-06-07 Ｃｄ３３特異的キメラ抗原受容体 Active JP7591342B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022110311A JP2022153434A (ja) 2016-06-08 2022-07-08 Ｃｄ３３特異的キメラ抗原受容体
JP2024097538A JP2024138280A (ja) 2016-06-08 2024-06-17 Ｃｄ３３特異的キメラ抗原受容体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662347503P 2016-06-08 2016-06-08
US62/347,503 2016-06-08
PCT/US2017/036440 WO2017214333A1 (en) 2016-06-08 2017-06-07 Cd33 specific chimeric antigen receptors

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022110311A Division JP2022153434A (ja) 2016-06-08 2022-07-08 Ｃｄ３３特異的キメラ抗原受容体
JP2024097538A Division JP2024138280A (ja) 2016-06-08 2024-06-17 Ｃｄ３３特異的キメラ抗原受容体

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JP2019517267A JP2019517267A (ja) 2019-06-24
JP2019517267A5 JP2019517267A5 (enExample) 2020-07-09
JP7591342B2 true JP7591342B2 (ja) 2024-11-28

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JP2018564239A Active JP7591342B2 (ja) 2016-06-08 2017-06-07 Ｃｄ３３特異的キメラ抗原受容体
JP2022110311A Withdrawn JP2022153434A (ja) 2016-06-08 2022-07-08 Ｃｄ３３特異的キメラ抗原受容体
JP2024097538A Pending JP2024138280A (ja) 2016-06-08 2024-06-17 Ｃｄ３３特異的キメラ抗原受容体

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JP2022110311A Withdrawn JP2022153434A (ja) 2016-06-08 2022-07-08 Ｃｄ３３特異的キメラ抗原受容体
JP2024097538A Pending JP2024138280A (ja) 2016-06-08 2024-06-17 Ｃｄ３３特異的キメラ抗原受容体

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US (2) US11787848B2 (enExample)
EP (1) EP3468994A1 (enExample)
JP (3) JP7591342B2 (enExample)
KR (3) KR102652827B1 (enExample)
CN (2) CN118652336A (enExample)
AU (2) AU2017279548B2 (enExample)
CA (1) CA3025667A1 (enExample)
IL (2) IL263220B2 (enExample)
SG (1) SG11201810640RA (enExample)
WO (1) WO2017214333A1 (enExample)

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EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
CN118652336A (zh) 2016-06-08 2024-09-17 普瑞赛格恩公司 Cd33特异性嵌合抗原受体
KR102709603B1 (ko) 2017-02-28 2024-09-27 보르 바이오파마 인크. 계통 특이적 단백질의 억제를 위한 조성물 및 방법
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
MX2019011570A (es) 2017-03-27 2019-11-18 Nat Univ Singapore Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales.
EP3635132A4 (en) * 2017-06-07 2021-05-26 Intrexon Corporation EXPRESSION OF NOVEL CELL MARKERS
KR102742741B1 (ko) * 2017-10-18 2024-12-16 프레시전 인코포레이티드 스페이서를 포함하는 폴리펩타이드 조성물
WO2019084234A1 (en) * 2017-10-26 2019-05-02 St. Jude Childen's Research Hospital, Inc. METHODS AND COMPOSITIONS FOR TREATING CD33 + CANCERS AND IMPROVING IN VIVO PERSISTENCE OF CHIMERIC ANTIGEN RECEPTOR T CELLS
US12083192B2 (en) * 2017-12-04 2024-09-10 Actinium Pharmaceuticals, Inc. Methods for treatment of patients with myelodysplastic syndromes
AU2018393110B2 (en) * 2017-12-20 2023-04-27 Poseida Therapeutics, Inc. VCAR compositions and methods for use
SG11202007183PA (en) * 2018-02-09 2020-08-28 Nat Univ Singapore Adhesion receptor constructs and uses thereof in natural killer cell immunotherapy
JP7360174B2 (ja) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
WO2019160956A1 (en) * 2018-02-13 2019-08-22 Novartis Ag Chimeric antigen receptor therapy in combination with il-15r and il15
CN112004829A (zh) * 2018-03-12 2020-11-27 南克维斯特公司 Cd33car修饰的高亲和力nk细胞(t-hank)用于降低髓系衍生的抑制细胞的抑制活性(或降低对nk细胞活性的负面影响)的用途
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