JP2019515873A5 - - Google Patents
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- Publication number
- JP2019515873A5 JP2019515873A5 JP2018545306A JP2018545306A JP2019515873A5 JP 2019515873 A5 JP2019515873 A5 JP 2019515873A5 JP 2018545306 A JP2018545306 A JP 2018545306A JP 2018545306 A JP2018545306 A JP 2018545306A JP 2019515873 A5 JP2019515873 A5 JP 2019515873A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- core
- moiety
- alkenyl
- terpenoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002245 particle Substances 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 23
- 150000003505 terpenes Chemical class 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- 125000002947 alkylene group Chemical group 0.000 claims 7
- 230000000845 anti-microbial effect Effects 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 229920000620 organic polymer Polymers 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims 4
- 150000004820 halides Chemical class 0.000 claims 4
- -1 polyvinylamine (PVA) Polymers 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 229910010272 inorganic material Inorganic materials 0.000 claims 3
- 239000011147 inorganic material Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 210000000214 mouth Anatomy 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- OOCCDEMITAIZTP-QPJJXVBHSA-N (E)-cinnamyl alcohol Chemical compound OC\C=C\C1=CC=CC=C1 OOCCDEMITAIZTP-QPJJXVBHSA-N 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N Borneol Chemical compound C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims 2
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000004053 dental implant Substances 0.000 claims 2
- 210000004262 dental pulp cavity Anatomy 0.000 claims 2
- 239000000551 dentifrice Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229920000083 poly(allylamine) Polymers 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- UGIJCMNGQCUTPI-UHFFFAOYSA-N 2-aminoethyl prop-2-enoate Chemical compound NCCOC(=O)C=C UGIJCMNGQCUTPI-UHFFFAOYSA-N 0.000 claims 1
- 235000010585 Ammi visnaga Nutrition 0.000 claims 1
- 244000153158 Ammi visnaga Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- WNSKDSPPJMTDLR-UHFFFAOYSA-N CCOCOS(O)(=O)=O Chemical compound CCOCOS(O)(=O)=O WNSKDSPPJMTDLR-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
- 241000723346 Cinnamomum camphora Species 0.000 claims 1
- 241000628997 Flos Species 0.000 claims 1
- 229910004283 SiO 4 Inorganic materials 0.000 claims 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- OOCCDEMITAIZTP-UHFFFAOYSA-N allylic benzylic alcohol Natural products OCC=CC1=CC=CC=C1 OOCCDEMITAIZTP-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000008064 anhydrides Chemical group 0.000 claims 1
- 230000032770 biofilm formation Effects 0.000 claims 1
- VCCBEIPGXKNHFW-UHFFFAOYSA-N biphenyl-4,4'-diol Chemical compound C1=CC(O)=CC=C1C1=CC=C(O)C=C1 VCCBEIPGXKNHFW-UHFFFAOYSA-N 0.000 claims 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims 1
- 229930008380 camphor Natural products 0.000 claims 1
- 229960000846 camphor Drugs 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 239000004568 cement Substances 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 claims 1
- 229940117916 cinnamic aldehyde Drugs 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 claims 1
- 239000003479 dental cement Substances 0.000 claims 1
- 210000003298 dental enamel Anatomy 0.000 claims 1
- 210000004268 dentin Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 150000004760 silicates Chemical class 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 239000012798 spherical particle Substances 0.000 claims 1
- 150000003440 styrenes Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 125000001302 tertiary amino group Chemical group 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 0 CC(*N(*)*)IC* Chemical compound CC(*N(*)*)IC* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IL2016/050219 WO2017145142A1 (en) | 2016-02-25 | 2016-02-25 | Micro and nanoparticulate compositions comprising anti-microbially active groups |
| ILPCT/IL2016/050219 | 2016-02-25 | ||
| PCT/IL2017/050240 WO2017145167A1 (en) | 2016-02-25 | 2017-02-26 | Micro and nanoparticulate compositions comprising anti-microbially active groups |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515873A JP2019515873A (ja) | 2019-06-13 |
| JP2019515873A5 true JP2019515873A5 (cg-RX-API-DMAC7.html) | 2020-04-02 |
| JP7116684B2 JP7116684B2 (ja) | 2022-08-10 |
Family
ID=59684851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545306A Active JP7116684B2 (ja) | 2016-02-25 | 2017-02-26 | 抗微生物活性基を含むマイクロまたはナノ粒子組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11178867B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3419421A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7116684B2 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2017145142A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
| ES2982745T3 (es) | 2017-08-30 | 2024-10-17 | Nobio Ltd | Partículas antimicrobianas y métodos de uso de las mismas |
| JP7109019B2 (ja) * | 2018-07-06 | 2022-07-29 | 国立大学法人 岡山大学 | 抗菌性歯科用接着性組成物および３成分型接着剤キット |
| EP3820454A4 (en) | 2018-11-07 | 2023-03-15 | University of Notre Dame du Lac | PHAGEN MIMICANT NANOPARTICLES |
| CN109529128B (zh) * | 2018-11-30 | 2021-12-14 | 中国科学院长春应用化学研究所 | 一种抗感染涂层及其制备方法 |
| US20220168466A1 (en) * | 2019-02-27 | 2022-06-02 | Nobio Ltd. | Coating comprising anti-microbial particles, methods of preparation and uses thereof |
| BR112021016910A2 (pt) * | 2019-02-27 | 2021-11-03 | Nobio Ltd | Partícula antimicrobiana, composições contendo patrícula antimicrobiana, métodos e dispositivos médicos relacionados |
| CN111388743B (zh) * | 2019-11-27 | 2021-10-08 | 杭州昀鼎医疗科技有限公司 | 一种适用于哺乳期妇女的乳保创口贴及其制备方法 |
| US12194157B2 (en) | 2020-04-09 | 2025-01-14 | Finncure Oy | Carrier for targeted delivery to a host |
| FI20215508A1 (en) | 2020-04-09 | 2021-10-10 | Niemelae Erik Johan | Mimetic nanoparticles to prevent the spread of new coronaviruses and reduce the rate of infection |
| CN117180493B (zh) * | 2023-11-07 | 2024-02-06 | 中日友好医院(中日友好临床医学研究所) | 一种复合水凝胶敷料及其制备方法和应用 |
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-
2016
- 2016-02-25 WO PCT/IL2016/050219 patent/WO2017145142A1/en not_active Ceased
-
2017
- 2017-02-26 WO PCT/IL2017/050240 patent/WO2017145167A1/en not_active Ceased
- 2017-02-26 EP EP17755952.3A patent/EP3419421A4/en active Pending
- 2017-02-26 US US16/079,283 patent/US11178867B2/en active Active
- 2017-02-26 JP JP2018545306A patent/JP7116684B2/ja active Active
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2021
- 2021-11-22 US US17/531,957 patent/US12317892B2/en active Active
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