JP2019514426A5 - - Google Patents
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- Publication number
- JP2019514426A5 JP2019514426A5 JP2019508165A JP2019508165A JP2019514426A5 JP 2019514426 A5 JP2019514426 A5 JP 2019514426A5 JP 2019508165 A JP2019508165 A JP 2019508165A JP 2019508165 A JP2019508165 A JP 2019508165A JP 2019514426 A5 JP2019514426 A5 JP 2019514426A5
- Authority
- JP
- Japan
- Prior art keywords
- oligomeric compound
- antisense oligomeric
- seq
- antisense
- cpp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022000125A JP2022046725A (ja) | 2016-04-29 | 2022-01-04 | ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662330027P | 2016-04-29 | 2016-04-29 | |
| US62/330,027 | 2016-04-29 | ||
| PCT/US2017/030174 WO2017190041A1 (en) | 2016-04-29 | 2017-04-28 | Oligonucleotide analogues targeting human lmna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000125A Division JP2022046725A (ja) | 2016-04-29 | 2022-01-04 | ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514426A JP2019514426A (ja) | 2019-06-06 |
| JP2019514426A5 true JP2019514426A5 (https=) | 2020-05-21 |
| JP7042255B2 JP7042255B2 (ja) | 2022-03-25 |
Family
ID=59285320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508165A Active JP7042255B2 (ja) | 2016-04-29 | 2017-04-28 | ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体 |
| JP2022000125A Pending JP2022046725A (ja) | 2016-04-29 | 2022-01-04 | ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022000125A Pending JP2022046725A (ja) | 2016-04-29 | 2022-01-04 | ヒトｌｍｎａを標的にするオリゴヌクレオチド類縁体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10822608B2 (https=) |
| EP (1) | EP3449000A1 (https=) |
| JP (2) | JP7042255B2 (https=) |
| KR (1) | KR102329187B1 (https=) |
| CN (1) | CN109477109B (https=) |
| AU (2) | AU2017258642B2 (https=) |
| CA (1) | CA3022303A1 (https=) |
| CO (1) | CO2018012873A2 (https=) |
| EA (1) | EA201892467A1 (https=) |
| MA (1) | MA45616A (https=) |
| MX (1) | MX2018013157A (https=) |
| NZ (1) | NZ747685A (https=) |
| SG (1) | SG11201809468XA (https=) |
| WO (1) | WO2017190041A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| CN109477109B (zh) * | 2016-04-29 | 2022-09-23 | 萨勒普塔医疗公司 | 靶向人lmna的寡核苷酸类似物 |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| SI3554554T1 (sl) | 2016-12-19 | 2023-02-28 | Sarepta Therapeutics, Inc. | Oligomerni konjugati, ki preskakujejo ekson za mišično distrofijo |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| TW202020153A (zh) * | 2018-07-27 | 2020-06-01 | 美商薩羅塔治療公司 | 用於肌肉萎縮症之外顯子跳躍寡聚物 |
| US20240173430A1 (en) * | 2018-09-05 | 2024-05-30 | The Broad Institute, Inc. | Base editing for treating hutchinson-gilford progeria syndrome |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| WO2022098014A1 (ko) * | 2020-11-03 | 2022-05-12 | 한국생명공학연구원 | 유전자 교정을 이용한 조로증 및 자연노화의 예방 또는 치료용 조성물 |
| EP4612292A1 (en) * | 2022-11-02 | 2025-09-10 | Sarepta Therapeutics, Inc. | Formulation of an antisense oligomer conjugate |
| CN119101680A (zh) * | 2023-06-09 | 2024-12-10 | 良渚实验室 | 多核苷酸、药物组合物及其用途 |
| WO2025262186A2 (en) * | 2024-06-20 | 2025-12-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Therapeutic oligonucleotides for treating diseases being associated with or caused by a missense, nonsense or in-frame indel mutation |
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| CN109477109B (zh) * | 2016-04-29 | 2022-09-23 | 萨勒普塔医疗公司 | 靶向人lmna的寡核苷酸类似物 |
-
2017
- 2017-04-28 CN CN201780040785.7A patent/CN109477109B/zh active Active
- 2017-04-28 MX MX2018013157A patent/MX2018013157A/es unknown
- 2017-04-28 MA MA045616A patent/MA45616A/fr unknown
- 2017-04-28 WO PCT/US2017/030174 patent/WO2017190041A1/en not_active Ceased
- 2017-04-28 KR KR1020187034615A patent/KR102329187B1/ko active Active
- 2017-04-28 SG SG11201809468XA patent/SG11201809468XA/en unknown
- 2017-04-28 CA CA3022303A patent/CA3022303A1/en active Pending
- 2017-04-28 EA EA201892467A patent/EA201892467A1/ru unknown
- 2017-04-28 US US16/096,524 patent/US10822608B2/en active Active
- 2017-04-28 AU AU2017258642A patent/AU2017258642B2/en active Active
- 2017-04-28 NZ NZ747685A patent/NZ747685A/en unknown
- 2017-04-28 JP JP2019508165A patent/JP7042255B2/ja active Active
- 2017-04-28 EP EP17735676.3A patent/EP3449000A1/en active Pending
-
2018
- 2018-11-27 CO CONC2018/0012873A patent/CO2018012873A2/es unknown
-
2020
- 2020-09-17 US US17/024,100 patent/US11802283B2/en active Active
-
2022
- 2022-01-04 JP JP2022000125A patent/JP2022046725A/ja active Pending
-
2023
- 2023-11-30 AU AU2023274161A patent/AU2023274161A1/en active Pending
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