|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
US7468418B2
(en)
|
2003-04-29 |
2008-12-23 |
Avi Biopharma., Inc. |
Compositions for enhancing transport of molecules into cells
|
|
US20050222068A1
(en)
*
|
2003-10-23 |
2005-10-06 |
Mourich Dan V |
Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
|
|
US20050171044A1
(en)
*
|
2003-12-24 |
2005-08-04 |
Stein David A. |
Oligonucleotide compound and method for treating nidovirus infections
|
|
CA2553104A1
(en)
*
|
2004-01-23 |
2005-08-11 |
Avi Biopharma, Inc. |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
|
|
US20050288246A1
(en)
|
2004-05-24 |
2005-12-29 |
Iversen Patrick L |
Peptide conjugated, inosine-substituted antisense oligomer compound and method
|
|
EP2933332A1
(en)
|
2004-06-28 |
2015-10-21 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
|
EP2351839A3
(en)
|
2004-07-02 |
2011-10-05 |
AVI BioPharma, Inc. |
Antisense antibacterial method and compound
|
|
US8129352B2
(en)
*
|
2004-09-16 |
2012-03-06 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating ssRNA viral infection
|
|
US7524829B2
(en)
*
|
2004-11-01 |
2009-04-28 |
Avi Biopharma, Inc. |
Antisense antiviral compounds and methods for treating a filovirus infection
|
|
EP1855694B1
(en)
|
2005-02-09 |
2020-12-02 |
Sarepta Therapeutics, Inc. |
Antisense composition for treating muscle atrophy
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
US8524676B2
(en)
*
|
2005-09-08 |
2013-09-03 |
Sarepta Therapeutics, Inc. |
Method for treating enterovirus or rhinovirus infection using antisense antiviral compounds
|
|
US8501704B2
(en)
|
2005-11-08 |
2013-08-06 |
Sarepta Therapeutics, Inc. |
Immunosuppression compound and treatment method
|
|
US8785407B2
(en)
*
|
2006-05-10 |
2014-07-22 |
Sarepta Therapeutics, Inc. |
Antisense antiviral agent and method for treating ssRNA viral infection
|
|
US20070265215A1
(en)
*
|
2006-05-11 |
2007-11-15 |
Iversen Patrick L |
Antisense restenosis composition and method
|
|
WO2009005793A2
(en)
|
2007-06-29 |
2009-01-08 |
Avi Biopharma, Inc. |
Tissue specific peptide conjugates and methods
|
|
AU2015200600B2
(en)
*
|
2007-06-29 |
2017-04-20 |
Sarepta Therapeutics, Inc. |
Tissue specific peptide conjugates and methods
|
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
EP2181983A4
(en)
*
|
2007-07-25 |
2013-01-02 |
Ajinomoto Kk |
METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE
|
|
US8076476B2
(en)
*
|
2007-11-15 |
2011-12-13 |
Avi Biopharma, Inc. |
Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
|
|
US8299206B2
(en)
|
2007-11-15 |
2012-10-30 |
Avi Biopharma, Inc. |
Method of synthesis of morpholino oligomers
|
|
RU2606627C2
(ru)
*
|
2007-11-15 |
2017-01-10 |
Серепта Терапьютикс,Инк. |
Способ синтеза морфолиновых олигомеров
|
|
EP2235034B1
(en)
*
|
2007-12-28 |
2016-11-23 |
Sarepta Therapeutics, Inc. |
Immunomodulatory agents and methods of use
|
|
BR122020021379B1
(pt)
|
2008-10-24 |
2021-05-11 |
Sarepta Therapeutics, Inc. |
oligômero morfolino fosforodiamidato, composição que compreende o mesmo e uso do dito oligômero para tratar distrofia muscular
|
|
EP2376633A1
(en)
*
|
2008-12-17 |
2011-10-19 |
AVI BioPharma, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
WO2010141511A2
(en)
|
2009-06-01 |
2010-12-09 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotides for multivalent rna interference, compositions and methods of use thereof
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
US9914745B2
(en)
*
|
2009-08-14 |
2018-03-13 |
Indian Association For The Cultivation Of Science |
Morpholino-based antisense agent
|
|
EP2473624B1
(en)
*
|
2009-08-31 |
2019-05-01 |
Gen-Probe Incorporated |
Dengue virus assay
|
|
TR201816523T4
(tr)
|
2009-11-12 |
2018-11-21 |
Univ Western Australia |
Patolojilerin tedavisine yönelik antisens moleküller ve yöntemler.
|
|
EP2499248B1
(en)
|
2009-11-13 |
2017-01-04 |
Sarepta Therapeutics, Inc. |
Antisense antiviral compound and method for treating influenza viral infection
|
|
EP2542678B1
(en)
|
2010-03-04 |
2017-04-12 |
InteRNA Technologies B.V. |
A MiRNA MOLECULE DEFINED BY ITS SOURCE AND ITS THERAPEUTIC USES IN CANCER ASSOCIATED WITH EMT
|
|
US9068185B2
(en)
|
2010-03-12 |
2015-06-30 |
Sarepta Therapeutics, Inc. |
Antisense modulation of nuclear hormone receptors
|
|
CA3090304A1
(en)
*
|
2010-05-13 |
2011-11-17 |
Sarepta Therapeutics, Inc. |
Antisense modulation of interleukins 17 and 23 signaling
|
|
AU2013202731B2
(en)
*
|
2010-05-28 |
2016-04-21 |
Sarepta Therapeutics, Inc. |
Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
|
|
KR20200133284A
(ko)
*
|
2010-05-28 |
2020-11-26 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
EP2591106A1
(en)
|
2010-07-06 |
2013-05-15 |
InteRNA Technologies B.V. |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
|
US8198429B2
(en)
|
2010-08-09 |
2012-06-12 |
Avi Biopharma, Inc. |
Antisense antiviral compounds and methods for treating a filovirus infection
|
|
TWI541024B
(zh)
|
2010-09-01 |
2016-07-11 |
日本新藥股份有限公司 |
反義核酸
|
|
US10017763B2
(en)
|
2010-09-03 |
2018-07-10 |
Sarepta Therapeutics, Inc. |
dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
|
|
ES2607603T3
(es)
*
|
2010-09-30 |
2017-04-03 |
Nippon Shinyaku Co., Ltd. |
Derivado de ácido morfolino nucleico
|
|
EP2474617A1
(en)
|
2011-01-11 |
2012-07-11 |
InteRNA Technologies BV |
Mir for treating neo-angiogenesis
|
|
WO2012100156A1
(en)
|
2011-01-20 |
2012-07-26 |
Hercules Incorporated |
Enhanced dry strength and drainage performance by combining glyoxalated acrylamide-containing polymers with cationic aqueous dispersion polymers
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
CA3092114A1
(en)
|
2011-05-05 |
2012-11-08 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US10100305B2
(en)
|
2011-07-15 |
2018-10-16 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
|
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
|
HK1201514A1
(en)
*
|
2011-11-18 |
2015-09-04 |
Sarepta Therapeutics, Inc. |
Functionally-modified oligonucleotides and subunits thereof
|
|
US10066228B2
(en)
*
|
2011-11-30 |
2018-09-04 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
|
JP6496549B2
(ja)
*
|
2011-11-30 |
2019-04-03 |
サレプタ セラピューティクス, インコーポレイテッド |
脊髄性筋萎縮症における誘発されたエクソン包含
|
|
ES2935606T3
(es)
|
2011-12-08 |
2023-03-08 |
Sarepta Therapeutics Inc |
Análogos de oligonucleótidos dirigidos a LMNA humana
|
|
EP3369818B1
(en)
|
2011-12-22 |
2021-06-09 |
InteRNA Technologies B.V. |
Mirna for treating head and neck cancer
|
|
CN104411831B
(zh)
|
2012-03-20 |
2020-08-11 |
萨勒普塔医疗公司 |
寡核苷酸类似物的硼酸缀合物
|
|
EP2900821B1
(en)
|
2012-09-25 |
2020-04-01 |
Genzyme Corporation |
Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
|
|
EP2917348A1
(en)
|
2012-11-06 |
2015-09-16 |
InteRNA Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated b-raf pathway
|
|
HK1216902A1
(zh)
|
2012-12-20 |
2016-12-09 |
Sarepta Therapeutics, Inc. |
用作治疗肌肉萎缩的改进外显子跳跃组合物
|
|
CN103060325B
(zh)
*
|
2013-01-14 |
2015-01-07 |
韩健宝 |
抗猪流行性腹泻病毒pedv的反义核酸及肽核酸pna
|
|
CN110218727A
(zh)
|
2013-03-14 |
2019-09-10 |
萨勒普塔医疗公司 |
用于治疗肌营养不良的外显子跳跃组合物
|
|
US20140315977A1
(en)
|
2013-03-14 |
2014-10-23 |
Sarepta Therapeutics, Inc. |
Exon skipping compositions for treating muscular dystrophy
|
|
US20140329762A1
(en)
|
2013-03-15 |
2014-11-06 |
Sarepta Therapeutics, Inc. |
Compositions for treating muscular dystrophy
|
|
US11236338B2
(en)
|
2013-09-05 |
2022-02-01 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
EP3044315B1
(en)
|
2013-09-11 |
2019-02-20 |
Synthena AG |
Nucleic acids and methods for the treatment of pompe disease
|
|
EP3795687A1
(en)
|
2014-05-23 |
2021-03-24 |
Genzyme Corporation |
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
|
|
WO2016060135A1
(ja)
*
|
2014-10-14 |
2016-04-21 |
味の素株式会社 |
モルフォリノオリゴヌクレオチドの製造方法
|
|
MA41795A
(fr)
*
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
|
MA50829A
(fr)
|
2015-06-01 |
2018-04-11 |
Sarepta Therapeutics Inc |
Exclusion d'exon induite pat technologie antisens dans le collagène de type vii
|
|
US11020417B2
(en)
|
2015-06-04 |
2021-06-01 |
Sarepta Therapeutics, Inc |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
|
WO2017035278A1
(en)
|
2015-08-24 |
2017-03-02 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
|
|
US10905709B2
(en)
|
2015-08-28 |
2021-02-02 |
Sarepta Therapeutics, Inc. |
Modified antisense oligomers for exon inclusion in spinal muscular atrophy
|
|
WO2017059131A1
(en)
|
2015-09-30 |
2017-04-06 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy
|
|
EP3858993A1
(en)
|
2015-10-09 |
2021-08-04 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
WO2017184529A1
(en)
|
2016-04-18 |
2017-10-26 |
Sarepta Therapeutics, Inc. |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
MX2018013157A
(es)
|
2016-04-29 |
2019-05-23 |
Sarepta Therapeutics Inc |
Analogos de oligonucleotidos dirigidos a lmna humana.
|
|
BR112018074346B1
(pt)
*
|
2016-05-24 |
2023-01-03 |
Sarepta Therapeutics, Inc. |
Composto oligomérico e processo para preparar um composto oligomérico
|
|
AU2017330276B2
(en)
|
2016-09-20 |
2022-01-20 |
The Regents Of The University Of Colorado, A Body Corporate |
Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry
|
|
KR102810425B1
(ko)
|
2016-12-19 |
2025-05-21 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
근육 이상증에 대한 엑손 스킵핑 올리고머 결합체
|
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
|
EP4707403A2
(en)
|
2017-03-10 |
2026-03-11 |
UCL Business Ltd |
Method relating to myostatin pathway inhibition
|
|
SG10201705285SA
(en)
|
2017-06-27 |
2019-01-30 |
Agency Science Tech & Res |
Antisense oligonucleotides
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
WO2019060862A1
(en)
|
2017-09-25 |
2019-03-28 |
Sarepta Therapeutics, Inc. |
METHODS FOR PREPARING MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS VIA FAST FLOW SYNTHESIS
|
|
EP3691657A4
(en)
|
2017-10-04 |
2021-07-21 |
Avidity Biosciences, Inc. |
NUCLEIC ACID POLYPEPTIDE COMPOSITIONS AND USES THEREOF
|
|
WO2019079386A1
(en)
*
|
2017-10-17 |
2019-04-25 |
Sarepta Therapeutics, Inc. |
CELL PENETRATION PEPTIDES FOR ANTISENSE ADMINISTRATION
|
|
US12502432B2
(en)
|
2017-10-17 |
2025-12-23 |
Sarepta Therapeutics, Inc. |
Bicyclic peptide oligonucleotide conjugates
|
|
US11555189B2
(en)
|
2017-10-18 |
2023-01-17 |
Sarepta Therapeutics, Inc. |
Antisense oligomer compounds
|
|
CN111566212A
(zh)
|
2017-11-03 |
2020-08-21 |
因特尔纳技术有限公司 |
miRNA分子,等同物,安塔够妙或其来源用于治疗和/或诊断与神经元缺陷相关的病症和/或疾病或用于神经元生成和/或再生
|
|
AU2018378812B2
(en)
|
2017-12-06 |
2025-05-22 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
|
JP2021513508A
(ja)
|
2018-02-12 |
2021-05-27 |
インテアールエヌエー テクノロジーズ ビー.ヴイ.InteRNA Technologies B.V. |
抗がんマイクロrna及びその脂質製剤
|
|
EP3765030A4
(en)
*
|
2018-03-16 |
2022-01-26 |
Sarepta Therapeutics, Inc. |
CHIMERIC PEPTIDES FOR ANTISENSE ADMINISTRATION
|
|
CA3099778A1
(en)
|
2018-05-10 |
2019-11-14 |
Nippon Shinyaku Co., Ltd. |
Method for preparing oligonucleic acid compound
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
GB201821269D0
(en)
|
2018-12-28 |
2019-02-13 |
Nippon Shinyaku Co Ltd |
Myostatin signal inhibitor
|
|
EP3918069A1
(en)
|
2019-01-31 |
2021-12-08 |
Bar Ilan University |
Neoantigens created by aberrant-induced splicing and uses thereof in enhancing immunotherapy
|
|
WO2020219820A1
(en)
|
2019-04-25 |
2020-10-29 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
US12006499B2
(en)
|
2019-06-06 |
2024-06-11 |
Avidity Biosciences, Inc. |
Una amidites and uses thereof
|
|
CN114375296A
(zh)
|
2019-06-06 |
2022-04-19 |
艾维迪提生物科学公司 |
核酸多肽组合物及其用途
|
|
JP2022536495A
(ja)
|
2019-06-19 |
2022-08-17 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを治療する方法
|
|
CN114901823A
(zh)
|
2019-12-26 |
2022-08-12 |
日本新药株式会社 |
诱导外显子50的跳读的反义核酸
|
|
IL295967A
(en)
|
2020-02-28 |
2022-10-01 |
Nippon Shinyaku Co Ltd |
Antisense nucleic acids for splicing on exon 51
|
|
WO2021188390A1
(en)
|
2020-03-19 |
2021-09-23 |
Avidity Biosciences, Inc. |
Compositions and methods of treating facioscapulohumeral muscular dystrophy
|
|
SI4126066T1
(sl)
|
2020-03-27 |
2026-04-30 |
Avidity Biosciences, Inc. |
Sestavki in postopki zdravljenja mišične distrofije
|
|
CN115867657A
(zh)
|
2020-05-11 |
2023-03-28 |
斯托克制药公司 |
用于治疗疾患和疾病的opa1反义寡聚物
|
|
CN111575409B
(zh)
*
|
2020-05-23 |
2023-04-18 |
黑龙江八一农垦大学 |
基于整合素配体识别肽抑制猪流行性腹泻病毒感染的研究方法
|
|
EP4247949A1
(en)
|
2020-11-23 |
2023-09-27 |
Alpha Anomeric SAS |
Nucleic acid duplexes
|
|
EP4332223A4
(en)
*
|
2021-04-28 |
2025-12-31 |
Nippon Shinyaku Co Ltd |
ANTIVIRAL NUCLEIC ACID
|
|
US12378267B2
(en)
|
2021-06-17 |
2025-08-05 |
Entrada Therapeutics, Inc. |
Synthesis of FMOC-protected morpholino monomers and oligomers
|
|
WO2022270585A1
(ja)
|
2021-06-23 |
2022-12-29 |
日本新薬株式会社 |
アンチセンスオリゴマーの組み合わせ
|
|
TW202308664A
(zh)
|
2021-07-08 |
2023-03-01 |
日商日本新藥股份有限公司 |
腎毒性減輕劑
|
|
CN118475355A
(zh)
|
2021-07-08 |
2024-08-09 |
日本新药株式会社 |
肾毒性减轻剂
|
|
CA3225573A1
(en)
|
2021-07-08 |
2023-01-12 |
Nippon Shinyaku Co., Ltd. |
Precipitation suppressing agent
|
|
US20250011777A1
(en)
|
2021-09-03 |
2025-01-09 |
Sarepta Therapeutics, Inc. |
Delivery of anitsense oligomers by mirror image peptides
|
|
CN118265544A
(zh)
|
2021-09-16 |
2024-06-28 |
艾维迪提生物科学公司 |
治疗面肩肱型肌营养不良的组合物和方法
|
|
WO2023055774A1
(en)
|
2021-09-30 |
2023-04-06 |
Sarepta Therapeutics, Inc. |
Antisense oligonucleotides having one or more abasic units
|
|
EP4419680A1
(en)
|
2021-10-22 |
2024-08-28 |
Sarepta Therapeutics, Inc. |
Morpholino oligomers for treatment of peripheral myelin protein 22 related diseases
|
|
US12071621B2
(en)
|
2022-04-05 |
2024-08-27 |
Avidity Biosciences, Inc. |
Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
|
|
CN119156395A
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