JP2014520120A5 - - Google Patents

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Publication number
JP2014520120A5
JP2014520120A5 JP2014516044A JP2014516044A JP2014520120A5 JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5 JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5
Authority
JP
Japan
Prior art keywords
amino acid
amino acids
substituted
polypeptide
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014516044A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014520120A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/042719 external-priority patent/WO2012174409A1/en
Publication of JP2014520120A publication Critical patent/JP2014520120A/ja
Publication of JP2014520120A5 publication Critical patent/JP2014520120A5/ja
Pending legal-status Critical Current

Links

JP2014516044A 2011-06-17 2012-06-15 安定化した変異型ｍａｍｌペプチドおよびその使用 Pending JP2014520120A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498477P 2011-06-17 2011-06-17
US61/498,477 2011-06-17
PCT/US2012/042719 WO2012174409A1 (en) 2011-06-17 2012-06-15 Stabilized variant maml peptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2014520120A JP2014520120A (ja) 2014-08-21
JP2014520120A5 true JP2014520120A5 (https=) 2015-07-30

Family

ID=47357495

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516044A Pending JP2014520120A (ja) 2011-06-17 2012-06-15 安定化した変異型ｍａｍｌペプチドおよびその使用

Country Status (4)

Country Link
US (1) US20140256912A1 (https=)
EP (1) EP2721061A4 (https=)
JP (1) JP2014520120A (https=)
WO (1) WO2012174409A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College LIGURE COMBINED POLYPEPTIDES
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3391898A3 (en) 2013-03-13 2019-02-13 President and Fellows of Harvard College Stapled and stitched polypeptides and uses thereof
EP2970418A4 (en) 2013-03-15 2016-08-17 Dana Farber Cancer Inst Inc STABILIZED EZH2 PEPTIDES
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
CA2949535C (en) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
US20190135868A1 (en) * 2016-04-29 2019-05-09 The University Of Chicago Synthetic dna binding domain peptides and uses thereof
AU2018329956A1 (en) 2017-09-07 2020-08-20 Fog Pharmaceuticals, Inc. Agents modulating beta-catenin functions and methods thereof
WO2019136209A1 (en) * 2018-01-05 2019-07-11 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
MX2021001943A (es) 2018-08-20 2021-07-15 Fog Pharmaceuticals Inc Colecciones de péptidos, agentes peptídicos y métodos de uso de los mismos.
CN114174313A (zh) 2019-04-09 2022-03-11 芝加哥大学 采用狄尔斯-阿尔德环加成反应的通用型肽和蛋白质的大环化和多聚化

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2997973A1 (en) * 2006-11-15 2016-03-23 Dana-Farber Cancer Institute, Inc. Stabalized maml peptides and uses thereof
CN102197048A (zh) * 2008-09-22 2011-09-21 爱勒让治疗公司 拟肽大环化合物
CA2737922A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

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