JP2009544660A5 - - Google Patents
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- JP2009544660A5 JP2009544660A5 JP2009521246A JP2009521246A JP2009544660A5 JP 2009544660 A5 JP2009544660 A5 JP 2009544660A5 JP 2009521246 A JP2009521246 A JP 2009521246A JP 2009521246 A JP2009521246 A JP 2009521246A JP 2009544660 A5 JP2009544660 A5 JP 2009544660A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- carbon atoms
- equation
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 22
- 235000001014 amino acid Nutrition 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 235000018102 proteins Nutrition 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 102000004357 Transferases Human genes 0.000 claims 8
- 108090000992 Transferases Proteins 0.000 claims 8
- -1 polyethyleneoxy group Polymers 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical group 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- KRWMERLEINMZFT-UHFFFAOYSA-N O6-benzylguanine Chemical compound C=12NC=NC2=NC(N)=NC=1OCC1=CC=CC=C1 KRWMERLEINMZFT-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims 1
- VFJWZMBJSURNDU-UHFFFAOYSA-N CCN(CC)c1ccc(C=C(C(NCc2ccc(COc3nc(N)ccn3)cc2)=O)C(O2)=O)c2c1 Chemical compound CCN(CC)c1ccc(C=C(C(NCc2ccc(COc3nc(N)ccn3)cc2)=O)C(O2)=O)c2c1 VFJWZMBJSURNDU-UHFFFAOYSA-N 0.000 description 1
- CWIONTDGJVSLDU-PAGQWHICSA-N Nc1ccnc(OCc2ccc(CNC(CCCCCNC(CCCC[C@@H]([C@H]3N4)SCC3NC4=O)=O)=O)cc2)n1 Chemical compound Nc1ccnc(OCc2ccc(CNC(CCCCCNC(CCCC[C@@H]([C@H]3N4)SCC3NC4=O)=O)=O)cc2)n1 CWIONTDGJVSLDU-PAGQWHICSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117779A EP1882688A1 (en) | 2006-07-25 | 2006-07-25 | Labelling of fusion proteins with synthetic probes |
| PCT/EP2007/057597 WO2008012296A1 (en) | 2006-07-25 | 2007-07-24 | Labelling of fusion proteins with synthetic probes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544660A JP2009544660A (ja) | 2009-12-17 |
| JP2009544660A5 true JP2009544660A5 (https=) | 2010-06-24 |
Family
ID=36954295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521246A Pending JP2009544660A (ja) | 2006-07-25 | 2007-07-24 | 合成プローブによる融合タンパク質の標識化 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8227602B2 (https=) |
| EP (2) | EP1882688A1 (https=) |
| JP (1) | JP2009544660A (https=) |
| CN (1) | CN101516857A (https=) |
| WO (1) | WO2008012296A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2553261C (en) | 2004-01-16 | 2014-03-18 | Stefan Barth | Immunokinases |
| WO2007006055A2 (en) | 2005-07-06 | 2007-01-11 | Vascular Pathways Inc. | Intravenous catheter insertion device and method of use |
| EP1800695A1 (en) | 2005-12-21 | 2007-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Immuno-RNA-constructs |
| JP5139518B2 (ja) | 2007-05-07 | 2013-02-06 | バスキュラー・パスウェイズ・インコーポレイテッド | 静脈カテーテル挿入装置 |
| CA2693155A1 (en) * | 2007-07-25 | 2009-01-29 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Self coupling recombinant antibody fusion proteins |
| WO2010031767A2 (en) * | 2008-09-16 | 2010-03-25 | Technische Universität München | Fluorescent-labelled atpases |
| FR2936245B1 (fr) * | 2008-09-23 | 2012-07-06 | Cis Bio Int | Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants. |
| US9950139B2 (en) | 2010-05-14 | 2018-04-24 | C. R. Bard, Inc. | Catheter placement device including guidewire and catheter control elements |
| US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
| US10384039B2 (en) | 2010-05-14 | 2019-08-20 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
| US9872971B2 (en) | 2010-05-14 | 2018-01-23 | C. R. Bard, Inc. | Guidewire extension system for a catheter placement device |
| US11925779B2 (en) | 2010-05-14 | 2024-03-12 | C. R. Bard, Inc. | Catheter insertion device including top-mounted advancement components |
| US8690833B2 (en) | 2011-01-31 | 2014-04-08 | Vascular Pathways, Inc. | Intravenous catheter and insertion device with reduced blood spatter |
| WO2012154277A1 (en) | 2011-02-25 | 2012-11-15 | C.R. Bard, Inc. | Medical component insertion device including a retractable needle |
| USD903101S1 (en) | 2011-05-13 | 2020-11-24 | C. R. Bard, Inc. | Catheter |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| BR112014013745B1 (pt) * | 2011-12-09 | 2022-06-14 | Institut Pasteur | Método de teste in vitro, kit de detecção e seu uso, método in vitro de diagnóstico, método de fabricação de kit, e teste de imunosseleção multiplex |
| US9267117B2 (en) | 2012-03-15 | 2016-02-23 | New England Biolabs, Inc. | Mapping cytosine modifications |
| CA2866933C (en) | 2012-03-21 | 2020-08-18 | Rheinisch-Westfalische Technische Hochschule Aachen | Novel photoimmunoconjugates for use in photodynamic therapy |
| CN108607150B (zh) | 2013-01-30 | 2021-01-12 | 血管通路股份有限公司 | 用于静脉穿刺和导管放置的系统和方法 |
| US9782568B2 (en) | 2013-02-05 | 2017-10-10 | Vascular Pathways, Inc. | Systems and methods for needle and catheter advancement |
| WO2014152298A1 (en) | 2013-03-15 | 2014-09-25 | Promega Corporation | New silicon and germanium dyes for use in genetic identity |
| US9708658B2 (en) | 2013-03-19 | 2017-07-18 | New England Biolabs, Inc. | Enrichment of target sequences |
| WO2016003795A1 (en) | 2014-07-02 | 2016-01-07 | New England Biolabs, Inc. | Universal n-glycan binding reagent |
| WO2016037127A1 (en) | 2014-09-05 | 2016-03-10 | C.R. Bard, Inc. | Catheter insertion device including retractable needle |
| WO2016093838A1 (en) | 2014-12-11 | 2016-06-16 | New England Biolabs, Inc. | Enrichment of target sequences |
| USD903100S1 (en) | 2015-05-01 | 2020-11-24 | C. R. Bard, Inc. | Catheter placement device |
| EP3294380B1 (en) | 2015-05-15 | 2022-03-23 | C. R. Bard, Inc. | Catheter insertion device |
| CN113444046B (zh) | 2016-07-20 | 2023-10-27 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| US10493262B2 (en) | 2016-09-12 | 2019-12-03 | C. R. Bard, Inc. | Blood control for a catheter insertion device |
| JP6953541B2 (ja) | 2017-03-01 | 2021-10-27 | シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ | カテーテル挿入装置 |
| CN109574880B (zh) | 2017-09-29 | 2022-06-17 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| US11389626B2 (en) | 2018-03-07 | 2022-07-19 | Bard Access Systems, Inc. | Guidewire advancement and blood flashback systems for a medical device insertion system |
| CN110498799B (zh) | 2018-05-18 | 2022-07-05 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| USD921884S1 (en) | 2018-07-27 | 2021-06-08 | Bard Access Systems, Inc. | Catheter insertion device |
| CN111748089B (zh) * | 2019-03-28 | 2023-07-18 | 成都先导药物开发股份有限公司 | 一种生物素标记化合物以及确定化合物结合靶标蛋白的方法 |
| US11390915B2 (en) | 2019-04-26 | 2022-07-19 | New England Biolabs, Inc. | Polynucleotide adapter design for reduced bias |
| JP7721504B2 (ja) | 2019-08-19 | 2025-08-12 | ベクトン・ディキンソン・アンド・カンパニー | 正中線カテーテル配置デバイス |
| EP4025288A1 (en) | 2019-09-20 | 2022-07-13 | Bard Peripheral Vascular, Inc. | Intravenous catheter-placement device |
| WO2021183921A1 (en) | 2020-03-12 | 2021-09-16 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
| US11740240B2 (en) * | 2020-07-20 | 2023-08-29 | Bio-Rad Laboratories, Inc. | Immunoassay for SARS-CoV-2 neutralizing antibodies and materials therefor |
| EP4110945A2 (en) | 2020-08-21 | 2023-01-04 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
| WO2023197015A1 (en) | 2022-04-08 | 2023-10-12 | New England Biolabs, Inc. | Compositions and analysis of dephosphorylated oligoribonucleotides |
| CN118165544B (zh) * | 2022-12-11 | 2025-09-05 | 中国科学院大连化学物理研究所 | 适用于细胞膜动态超分辨成像的五甲川菁染料荧光探针合成与应用 |
| WO2025129193A1 (en) | 2023-12-15 | 2025-06-19 | New England Biolabs, Inc. | Glycosyltransferases and related methods |
| GB202400129D0 (en) | 2024-01-04 | 2024-02-21 | Cambridge Entpr Ltd | Nucleic acid barcodes |
| WO2025224010A1 (en) | 2024-04-24 | 2025-10-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Improved o6-alkylguanine-dna alkyltransferase substrates |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19600934A1 (de) * | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
| CN1720332A (zh) * | 2002-10-03 | 2006-01-11 | 洛桑生态综合技术联合公司 | O6－烷基鸟嘌呤－dna烷基转移酶的底物 |
| EP1730298B1 (en) * | 2004-03-02 | 2015-11-11 | EPFL Ecole Polytechnique Fédérale de Lausanne | Specific substrates for o6-alkylguanine-dna alkyltransferase |
| US8178314B2 (en) * | 2005-04-27 | 2012-05-15 | Covalys Biosciences Ag | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein |
-
2006
- 2006-07-25 EP EP06117779A patent/EP1882688A1/en not_active Withdrawn
-
2007
- 2007-07-24 EP EP07787840A patent/EP2049499B1/en active Active
- 2007-07-24 JP JP2009521246A patent/JP2009544660A/ja active Pending
- 2007-07-24 WO PCT/EP2007/057597 patent/WO2008012296A1/en not_active Ceased
- 2007-07-24 US US12/309,554 patent/US8227602B2/en active Active
- 2007-07-24 CN CNA2007800339023A patent/CN101516857A/zh active Pending
-
2012
- 2012-05-31 US US13/484,954 patent/US8623627B2/en active Active
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