JP2016527215A5 - - Google Patents
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- JP2016527215A5 JP2016527215A5 JP2016524705A JP2016524705A JP2016527215A5 JP 2016527215 A5 JP2016527215 A5 JP 2016527215A5 JP 2016524705 A JP2016524705 A JP 2016524705A JP 2016524705 A JP2016524705 A JP 2016524705A JP 2016527215 A5 JP2016527215 A5 JP 2016527215A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- formula
- optionally substituted
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 COC(C(C(Nc(cc1)ccc1C(*)=O)=O)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)C([Rn])=O Chemical compound COC(C(C(Nc(cc1)ccc1C(*)=O)=O)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)C([Rn])=O 0.000 description 2
- WMLWGVVLDSEQNF-UHFFFAOYSA-N CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(c(OC)c2)ccc2C(O)=O)=O)c1O Chemical compound CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(c(OC)c2)ccc2C(O)=O)=O)c1O WMLWGVVLDSEQNF-UHFFFAOYSA-N 0.000 description 1
- NGSYXDCEERWVTK-UHFFFAOYSA-N CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(cc2)ccc2C(O)=O)=O)c1O Chemical compound CC(C)Oc(c(NC(c(cc1)ccc1NC(C(C(C(N)=O)OC)NC(c(cc1)ccc1NC(c(cc1)ccc1[N+]([O-])=O)=O)=O)=O)=O)ccc1C(Nc(cc2)ccc2C(O)=O)=O)c1O NGSYXDCEERWVTK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003539 | 2013-07-12 | ||
| EP13003539.7 | 2013-07-12 | ||
| PCT/EP2014/001925 WO2015003816A2 (en) | 2013-07-12 | 2014-07-14 | Cystobactamides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016527215A JP2016527215A (ja) | 2016-09-08 |
| JP2016527215A5 true JP2016527215A5 (https=) | 2017-08-03 |
| JP6730183B2 JP6730183B2 (ja) | 2020-07-29 |
Family
ID=48792948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016524705A Active JP6730183B2 (ja) | 2013-07-12 | 2014-07-14 | シストバクトアミド（Ｃｙｓｔｏｂａｃｔａｍｉｄｅｓ） |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20160145304A1 (https=) |
| EP (1) | EP3019615B1 (https=) |
| JP (1) | JP6730183B2 (https=) |
| CN (1) | CN105793424B (https=) |
| AU (1) | AU2014289663B2 (https=) |
| CA (1) | CA2917767C (https=) |
| WO (1) | WO2015003816A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105793424B (zh) | 2013-07-12 | 2021-02-19 | 亥姆霍兹感染研究中心有限公司 | 孢囊菌酰胺 |
| GB201402277D0 (en) | 2014-02-10 | 2014-03-26 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| WO2015174747A1 (ko) * | 2014-05-15 | 2015-11-19 | 한국생명공학연구원 | 신규한 항균성 화합물 및 이의 용도 |
| CN107001241B (zh) * | 2014-11-26 | 2020-03-27 | 亥姆霍兹感染研究中心有限公司 | 新型孢囊菌酰胺 |
| CN105712894A (zh) * | 2016-03-23 | 2016-06-29 | 叶芳 | 一种3-甲氧基-4-氨基苯甲酸及其制备方法 |
| JP7037122B2 (ja) * | 2016-09-28 | 2022-03-16 | 日産化学株式会社 | ジアミンおよびその利用 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| EP3655394B1 (en) * | 2017-07-18 | 2023-11-22 | Technische Universität Berlin | Novel albicidin derivatives, their use and synthesis |
| CN110997627B (zh) * | 2017-08-23 | 2023-10-10 | 亥姆霍兹感染研究中心有限公司 | 孢囊菌酰胺衍生物 |
| AU2018346597B2 (en) | 2017-10-06 | 2023-07-13 | Forma Therapeutics, Inc. | Inhibiting Ubiquitin Specific Peptidase 30 |
| KR20200108301A (ko) | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| JP7449242B2 (ja) | 2018-05-17 | 2024-03-13 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的ペプチダーゼ３０（ｕｓｐ３０）阻害剤として有用な縮合二環化合物 |
| SG11202012425QA (en) | 2018-07-13 | 2021-01-28 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| JP7530889B2 (ja) | 2018-10-05 | 2024-08-08 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ３０（ｕｓｐ３０）阻害剤として作用する縮合ピロリン |
| WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| EP3994132A1 (en) | 2019-07-03 | 2022-05-11 | Sumitomo Dainippon Pharma Oncology, Inc. | Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| US12428382B2 (en) * | 2021-03-31 | 2025-09-30 | Medibeacon Inc. | Purification of substituted diaminopyrazine dicarboxylic acids |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| CN113563220B (zh) * | 2021-06-25 | 2023-08-29 | 华中农业大学 | 一种抗菌化合物及其应用 |
| WO2025003147A1 (en) | 2023-06-26 | 2025-01-02 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamid derivatives |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4525354A (en) * | 1983-09-14 | 1985-06-25 | University Of Hawaii | Antibiotic and process for the production thereof |
| US7020622B1 (en) * | 1997-06-10 | 2006-03-28 | Linkshare Corporation | Transaction tracking, managing, assessment, and auditing data processing system and network |
| FR2772025B1 (fr) | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| DK1652926T3 (da) * | 2000-04-28 | 2010-02-15 | Kosan Biosciences Inc | Krystallinsk epothilon D |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| EP1572966B1 (en) * | 2002-10-18 | 2014-04-16 | University of Florida | Complete biosynthetic gene set for synthesis of polyketide antibiotics, including the albicidin family, resistance genes and uses thereof |
| EP1867331A4 (en) | 2005-04-06 | 2009-04-08 | Takeda Pharmaceutical | TRIAZOLE DERIVATIVE AND USE THEREOF |
| US7758972B2 (en) * | 2006-09-26 | 2010-07-20 | Semiconductor Energy Laboratory Co., Ltd. | Stilbene derivative, light emitting element, light emitting device, and electronic appliance |
| JP5379965B2 (ja) * | 2006-09-26 | 2013-12-25 | 株式会社半導体エネルギー研究所 | スチルベン誘導体、発光素子および発光装置 |
| US7816324B2 (en) * | 2007-03-13 | 2010-10-19 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by a peptide receptor |
| US8236983B2 (en) * | 2008-03-13 | 2012-08-07 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by apoptosis |
| WO2013078277A1 (en) * | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| EP2956437B1 (en) * | 2013-02-15 | 2023-05-10 | Technische Universität Berlin | Albicidin derivatives for the treatment of bacterial infections |
| CN105793424B (zh) | 2013-07-12 | 2021-02-19 | 亥姆霍兹感染研究中心有限公司 | 孢囊菌酰胺 |
| WO2015174747A1 (ko) | 2014-05-15 | 2015-11-19 | 한국생명공학연구원 | 신규한 항균성 화합물 및 이의 용도 |
| CN107001241B (zh) * | 2014-11-26 | 2020-03-27 | 亥姆霍兹感染研究中心有限公司 | 新型孢囊菌酰胺 |
-
2014
- 2014-07-14 CN CN201480050439.3A patent/CN105793424B/zh active Active
- 2014-07-14 US US14/904,654 patent/US20160145304A1/en not_active Abandoned
- 2014-07-14 JP JP2016524705A patent/JP6730183B2/ja active Active
- 2014-07-14 EP EP14747296.3A patent/EP3019615B1/en active Active
- 2014-07-14 CA CA2917767A patent/CA2917767C/en active Active
- 2014-07-14 WO PCT/EP2014/001925 patent/WO2015003816A2/en not_active Ceased
- 2014-07-14 AU AU2014289663A patent/AU2014289663B2/en active Active
-
2018
- 2018-07-23 US US16/042,753 patent/US10793600B2/en active Active
-
2020
- 2020-06-10 US US16/897,497 patent/US11225503B2/en active Active
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