JP2019507583A5 - - Google Patents
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- JP2019507583A5 JP2019507583A5 JP2018530754A JP2018530754A JP2019507583A5 JP 2019507583 A5 JP2019507583 A5 JP 2019507583A5 JP 2018530754 A JP2018530754 A JP 2018530754A JP 2018530754 A JP2018530754 A JP 2018530754A JP 2019507583 A5 JP2019507583 A5 JP 2019507583A5
- Authority
- JP
- Japan
- Prior art keywords
- modified clya
- amino acid
- clya nanopore
- nanopore
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000006467 substitution reaction Methods 0.000 claims description 40
- 150000001413 amino acids Chemical class 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 23
- 229920001184 polypeptide Polymers 0.000 claims description 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 22
- 102000040430 polynucleotide Human genes 0.000 claims description 22
- 108091033319 polynucleotide Proteins 0.000 claims description 22
- 239000002157 polynucleotide Substances 0.000 claims description 22
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 7
- 239000000823 artificial membrane Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 230000035772 mutation Effects 0.000 claims description 4
- 239000004475 Arginine Substances 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 102220608443 Suppressor of cytokine signaling 2_D64R_mutation Human genes 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 102000004503 Perforin Human genes 0.000 claims 1
- 108010056995 Perforin Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 description 16
- 108020004414 DNA Proteins 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 14
- 102000053602 DNA Human genes 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 239000012266 salt solution Substances 0.000 description 6
- 102000023732 binding proteins Human genes 0.000 description 4
- 108091008324 binding proteins Proteins 0.000 description 4
- 230000005945 translocation Effects 0.000 description 3
- 108020004682 Single-Stranded DNA Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021198939A JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264709P | 2015-12-08 | 2015-12-08 | |
| US62/264,709 | 2015-12-08 | ||
| PCT/IB2016/001841 WO2017098322A1 (en) | 2015-12-08 | 2016-12-08 | Modified nanopores, compositions comprising the same, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021198939A Division JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507583A JP2019507583A (ja) | 2019-03-22 |
| JP2019507583A5 true JP2019507583A5 (enExample) | 2020-01-30 |
| JP7237586B2 JP7237586B2 (ja) | 2023-03-13 |
Family
ID=58098655
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530754A Active JP7237586B2 (ja) | 2015-12-08 | 2016-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
| JP2021198939A Pending JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021198939A Pending JP2022046503A (ja) | 2015-12-08 | 2021-12-08 | 修飾ナノポア、それを含む組成物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10976300B2 (enExample) |
| EP (1) | EP3387432B1 (enExample) |
| JP (2) | JP7237586B2 (enExample) |
| KR (1) | KR102837999B1 (enExample) |
| CN (1) | CN109072295B (enExample) |
| AU (1) | AU2016369071B2 (enExample) |
| CA (1) | CA3011830C (enExample) |
| WO (1) | WO2017098322A1 (enExample) |
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| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| EP3283887B1 (en) | 2015-04-14 | 2021-07-21 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| KR102222192B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| JP7364333B2 (ja) | 2016-04-06 | 2023-10-18 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 変異体ポア |
| US11531020B2 (en) * | 2017-01-18 | 2022-12-20 | Youhealth Biotech, Limited | Methods and compositions for nanopore sequencing |
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| CN117255945A (zh) * | 2021-03-31 | 2023-12-19 | 伊鲁米纳公司 | 纳米孔传感器装置 |
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| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| CN114768530B (zh) * | 2022-04-29 | 2023-03-28 | 中国工程物理研究院材料研究所 | 二硫化钼在电解分离氢同位素中的应用 |
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| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| EP3283887B1 (en) | 2015-04-14 | 2021-07-21 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| KR102222192B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
-
2016
- 2016-12-08 AU AU2016369071A patent/AU2016369071B2/en active Active
- 2016-12-08 EP EP16838062.4A patent/EP3387432B1/en active Active
- 2016-12-08 KR KR1020187019163A patent/KR102837999B1/ko active Active
- 2016-12-08 JP JP2018530754A patent/JP7237586B2/ja active Active
- 2016-12-08 WO PCT/IB2016/001841 patent/WO2017098322A1/en not_active Ceased
- 2016-12-08 CA CA3011830A patent/CA3011830C/en active Active
- 2016-12-08 CN CN201680081416.8A patent/CN109072295B/zh active Active
- 2016-12-08 US US16/060,762 patent/US10976300B2/en active Active
-
2021
- 2021-12-08 JP JP2021198939A patent/JP2022046503A/ja active Pending
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