|
EP2652153B1
(en)
|
2010-12-17 |
2017-07-05 |
The Trustees of Columbia University in the City of New York |
Dna sequencing by synthesis using modified nucleotides and nanopore detection
|
|
WO2013109970A1
(en)
*
|
2012-01-20 |
2013-07-25 |
Genia Technologies, Inc. |
Nanopore based molecular detection and sequencing
|
|
EP2814983B1
(en)
|
2012-02-16 |
2019-04-24 |
Genia Technologies, Inc. |
Methods for creating bilayers for use with nanopore sensors
|
|
US10246479B2
(en)
|
2012-04-09 |
2019-04-02 |
The Trustees Of Columbia University In The City Of New York |
Method of preparation of nanopore and uses thereof
|
|
GB2510719A
(en)
*
|
2012-06-15 |
2014-08-13 |
Genia Technologies Inc |
Chip set-up and high-accuracy nucleic acid sequencing
|
|
EP2864502B1
(en)
*
|
2012-06-20 |
2019-10-23 |
The Trustees of Columbia University in the City of New York |
Nucleic acid sequencing by nanopore detection of tag molecules
|
|
US10648026B2
(en)
|
2013-03-15 |
2020-05-12 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
|
CN105102627B
(zh)
|
2013-03-15 |
2018-10-19 |
纽约哥伦比亚大学理事会 |
用于检测样品中多种预定化合物的方法
|
|
KR102245192B1
(ko)
*
|
2013-05-06 |
2021-04-29 |
온테라 인크. |
나노포어를 이용한 표적 검출
|
|
ES2704902T3
(es)
*
|
2013-05-06 |
2019-03-20 |
Two Pore Guys Inc |
Un método de detección de objetivos biológicos usando un nanoporo y un agente de unión a proteínas de fusión
|
|
WO2014190299A2
(en)
*
|
2013-05-23 |
2014-11-27 |
Arizona Board Of Regents Acting For And On Behalf Of Arizona State University |
Chemistry, systems and methods of translocation of a polymer through a nanopore
|
|
US9322062B2
(en)
*
|
2013-10-23 |
2016-04-26 |
Genia Technologies, Inc. |
Process for biosensor well formation
|
|
EP3640349A3
(en)
|
2013-10-23 |
2020-07-29 |
Roche Sequencing Solutions, Inc. |
High speed molecular sensing with nanopores
|
|
CA2943952A1
(en)
|
2014-03-24 |
2015-10-01 |
The Trustees Of Columbia University In The City Of New York |
Chemical methods for producing tagged nucleotides
|
|
CN106687574B
(zh)
*
|
2014-06-03 |
2021-06-29 |
亿明达股份有限公司 |
使用对纳米颗粒或纳米颗粒附近锚定的系链检测事件的组合物，系统和方法
|
|
SG10201809900PA
(en)
*
|
2014-07-31 |
2018-12-28 |
Illumina Inc |
Hybrid Nanopore Sensors
|
|
CA2966246C
(en)
|
2014-10-31 |
2020-07-14 |
Genia Technologies, Inc. |
Alpha-hemolysin variants with altered characteristics
|
|
US10036739B2
(en)
|
2015-01-27 |
2018-07-31 |
Genia Technologies, Inc. |
Adjustable bilayer capacitance structure for biomedical devices
|
|
CN104651500B
(zh)
|
2015-01-30 |
2017-06-30 |
华东理工大学 |
气单胞菌溶素纳米孔通道的制备方法及其应用
|
|
CA2974456A1
(en)
|
2015-02-02 |
2016-08-11 |
F. Hoffmann-La Roche Ag |
Polymerase variants
|
|
US9791432B2
(en)
*
|
2015-03-20 |
2017-10-17 |
Genia Technologies, Inc. |
Serpentine flow channels for flowing fluids over chip sensors
|
|
TWI571626B
(zh)
*
|
2015-07-15 |
2017-02-21 |
力晶科技股份有限公司 |
具有奈米腔的集成生物感測器及其製作方法
|
|
US10174371B2
(en)
|
2015-08-05 |
2019-01-08 |
Genia Technologies, Inc. |
Use of titanium nitride as an electrode in non-faradaic electrochemical cell
|
|
US10809243B2
(en)
|
2015-08-31 |
2020-10-20 |
Roche Sequencing Solutions, Inc. |
Small aperture large electrode cell
|
|
WO2017050723A1
(en)
|
2015-09-22 |
2017-03-30 |
Genia Technologies, Inc. |
Pol7 polymerase variants
|
|
US10102338B2
(en)
|
2015-09-24 |
2018-10-16 |
Genia Technologies, Inc. |
Adaptive compression and modification of nanopore measurement data
|
|
EP3766987B1
(en)
|
2015-09-24 |
2023-08-02 |
F. Hoffmann-La Roche AG |
Alpha-hemolysin variants
|
|
US10935512B2
(en)
|
2015-09-24 |
2021-03-02 |
Roche Sequencing Solutions, Inc. |
Encoding state change of nanopore to reduce data size
|
|
CN108521782A
(zh)
*
|
2015-10-21 |
2018-09-11 |
豪夫迈·罗氏有限公司 |
含氟聚合物作为疏水层以支持用于纳米孔的脂质双层形成的用途
|
|
CN105368938B
(zh)
*
|
2015-11-06 |
2018-09-21 |
中国科学院重庆绿色智能技术研究院 |
一种基于电击穿在氮化硅薄膜上精确制备纳米孔的方法
|
|
US10718737B2
(en)
*
|
2016-01-21 |
2020-07-21 |
Roche Sequencing Solutions, Inc. |
Molded flow channel
|
|
EP3423575B1
(en)
|
2016-02-29 |
2021-06-16 |
Genia Technologies, Inc. |
Exonuclease deficient polymerases
|
|
US10465240B2
(en)
*
|
2016-03-30 |
2019-11-05 |
Roche Sequencing Solutions, Inc. |
Electrical enhancement of bilayer formation
|
|
EP3436602B1
(en)
|
2016-03-31 |
2024-08-14 |
Genia Technologies, Inc. |
Nanopore protein conjugates and uses thereof
|
|
WO2017184866A1
(en)
|
2016-04-21 |
2017-10-26 |
F. Hoffmann-La Roche Ag |
Alpha-hemolysin variants and uses thereof
|
|
WO2018001925A1
(en)
|
2016-06-27 |
2018-01-04 |
F. Hoffmann-La Roche Ag |
Osmotic imbalance methods for bilayer formation
|
|
EP3478706B1
(en)
|
2016-06-30 |
2022-02-09 |
F. Hoffmann-La Roche AG |
Long lifetime alpha-hemolysin nanopores
|
|
GB201612458D0
(en)
*
|
2016-07-14 |
2016-08-31 |
Howorka Stefan And Pugh Genevieve |
Membrane spanning DNA nanopores for molecular transport
|
|
CN106443008A
(zh)
*
|
2016-08-31 |
2017-02-22 |
中国科学院重庆绿色智能技术研究院 |
一种基于固态纳米孔的hiv‑1蛋白酶检测方法
|
|
WO2018054970A2
(en)
|
2016-09-22 |
2018-03-29 |
F. Hoffmann-La Roche Ag |
Pol6 polymerase variants
|
|
US10975427B2
(en)
|
2017-01-20 |
2021-04-13 |
Omniome, Inc. |
Process for cognate nucleotide detection in a nucleic acid sequencing workflow
|
|
CN113755319A
(zh)
*
|
2017-02-14 |
2021-12-07 |
阿克斯比尔公司 |
用于大分子的连续诊断的设备和方法
|
|
EP3655423B1
(en)
*
|
2017-07-17 |
2023-12-20 |
President and Fellows of Harvard College |
Nanopore-matched protein shuttle for molecular characterization
|
|
CA3079411C
(en)
|
2017-10-19 |
2023-12-05 |
Omniome, Inc. |
Simultaneous background reduction and complex stabilization in binding assay workflows
|
|
WO2019081442A1
(en)
*
|
2017-10-23 |
2019-05-02 |
F. Hoffmann-La Roche Ag |
REMOVAL AND REINTEGRATION OF PROTEIN NANOPORES IN A MEMBRANE USING AN OSMOTIC IMBALANCE
|
|
CN109709185B
(zh)
*
|
2017-10-25 |
2024-09-24 |
深圳宣泽生物医药有限公司 |
一种修饰生物探针的纳米孔检测装置及制作方法
|
|
WO2019158548A1
(en)
|
2018-02-15 |
2019-08-22 |
F. Hoffmann-La Roche Ag |
Nanopore protein conjugates for detection and analysis of analytes
|
|
EP3759123A1
(en)
|
2018-02-28 |
2021-01-06 |
F. Hoffmann-La Roche AG |
Alpha-hemolysin variants and uses thereof
|
|
CN111919118B
(zh)
*
|
2018-04-13 |
2025-09-05 |
豪夫迈·罗氏有限公司 |
用于检测和分析分析物的方法和组合物
|
|
CN112204154B
(zh)
|
2018-05-28 |
2024-06-25 |
豪夫迈·罗氏有限公司 |
Dna-孔隙-聚合酶复合物的酶促富集
|
|
EP3815092A2
(en)
|
2018-06-29 |
2021-05-05 |
F. Hoffmann-La Roche AG |
Detection of microsatellite instability
|
|
ES3016009T3
(en)
*
|
2018-12-11 |
2025-05-08 |
Hoffmann La Roche |
Systems and methods for self-limiting protein pore insertion in a membrane
|
|
JP7162283B2
(ja)
*
|
2019-05-27 |
2022-10-28 |
国立大学法人山形大学 |
脂質二分子膜チャネル評価チップ及びその製造方法並びに評価装置
|
|
WO2021013805A1
(en)
|
2019-07-22 |
2021-01-28 |
F. Hoffmann-La Roche Ag |
Systems and methods for cell of origin determination from variant calling data
|
|
EP4003382A4
(en)
*
|
2019-07-31 |
2023-10-11 |
Axbio Inc. |
SYSTEMS AND METHODS FOR EVALUATION OF A TARGET MOLECULE
|
|
US20220372566A1
(en)
|
2019-09-20 |
2022-11-24 |
Roche Sequencing Solutions, Inc. |
Immune repertoire profiling by primer extension target enrichment
|
|
EP4051778A4
(en)
*
|
2019-10-30 |
2023-11-22 |
Stratos Genomics Inc. |
METHODS AND COMPOSITIONS FOR ASSEMBLING BIOLOGICAL NANOPORES
|
|
JP7520978B2
(ja)
|
2019-11-21 |
2024-07-23 |
エフ． ホフマン－ラ ロシュ アーゲー |
次世代シーケンシングサンプルにおける汚染検出のためのシステムおよび方法
|
|
EP4158062B1
(en)
|
2020-05-28 |
2024-09-04 |
F. Hoffmann-La Roche AG |
Sequence alignment systems and methods to identify short motifs in high-error single-molecule reads
|
|
CA3191929A1
(en)
*
|
2020-09-08 |
2022-03-17 |
Harold G. Monbouquette |
Lateral flow nucleic acid assay with integrated pore-based detection
|
|
CN114249294B
(zh)
*
|
2020-09-22 |
2025-07-04 |
上海新微技术研发中心有限公司 |
一种多层mems结构及其制作方法与应用
|
|
US12378596B2
(en)
|
2020-12-03 |
2025-08-05 |
Roche Sequencing Solutions, Inc. |
Whole transcriptome analysis in single cells
|
|
JP7646850B2
(ja)
|
2021-02-09 |
2025-03-17 |
エフ． ホフマン－ラ ロシュ アーゲー |
核酸中のメチル化の塩基レベル検出のための方法
|
|
CN117062902A
(zh)
|
2021-03-03 |
2023-11-14 |
豪夫迈·罗氏有限公司 |
用于从生物学样品中电泳提取核酸的装置和方法
|
|
CN115125098B
(zh)
*
|
2021-03-29 |
2025-05-27 |
上海近观科技有限责任公司 |
基于分子封层及加热密封结构的纳米孔检测装置及方法
|
|
CN117730155A
(zh)
|
2021-05-24 |
2024-03-19 |
豪夫迈·罗氏有限公司 |
用于核酸杂交的增强子寡核苷酸
|
|
KR20240099447A
(ko)
|
2021-12-07 |
2024-06-28 |
카리부 바이오사이언시스 인코포레이티드 |
Crispr 엔도뉴클레아제 절단 생성물을 포획하는 방법
|
|
CN114410459A
(zh)
*
|
2022-01-11 |
2022-04-29 |
深圳清华大学研究院 |
基因测序装置和测序方法
|
|
CN119403937A
(zh)
|
2022-06-14 |
2025-02-07 |
豪夫迈·罗氏有限公司 |
表观遗传胞嘧啶修饰的检测
|
|
EP4573207A1
(en)
|
2022-08-18 |
2025-06-25 |
F. Hoffmann-La Roche AG |
Detection of epigenetic modifications
|
|
TWI862997B
(zh)
*
|
2022-09-30 |
2024-11-21 |
國立中興大學 |
微流體感測裝置、微流體感測系統及微流體感測方法
|
|
CN115651821B
(zh)
|
2022-12-07 |
2023-04-07 |
北京齐碳科技有限公司 |
一种分子检测单元、芯片以及制备方法
|
|
CN116381250A
(zh)
*
|
2023-03-03 |
2023-07-04 |
南京大学 |
基于纳米孔道蛋白的高通量检测装置
|
|
EP4689180A1
(en)
|
2023-03-30 |
2026-02-11 |
F. Hoffmann-La Roche AG |
Modulation of target molecule-lipid bilayer interactions
|
|
WO2025024676A1
(en)
|
2023-07-26 |
2025-01-30 |
Caribou Biosciences, Inc. |
In vitro validation methods for cd19-targeting cell therapies
|
|
US20250161882A1
(en)
*
|
2023-11-17 |
2025-05-22 |
Illumina, Inc. |
Fluidic devices, nanopore instruments, and methods
|
|
WO2025193609A1
(en)
|
2024-03-11 |
2025-09-18 |
Caribou Biosciences, Inc. |
Methods and compositions for cost-effective assessment of nucleic acid transcripts and isoforms in cells
|
|
WO2025221988A1
(en)
|
2024-04-17 |
2025-10-23 |
Roche Sequencing Solutions, Inc. |
Systems and methods for somatic small variant calling
|
|
WO2025221998A1
(en)
|
2024-04-17 |
2025-10-23 |
Roche Sequencing Solutions, Inc. |
Systems and methods for variant calling
|
|
WO2025231432A1
(en)
|
2024-05-03 |
2025-11-06 |
Caribou Biosciences, Inc. |
In vivo gene editing with crispr systems
|
|
WO2026039623A1
(en)
|
2024-08-14 |
2026-02-19 |
Roche Sequencing Solutions, Inc. |
Systems and methods for germline snv and indel variant calling
|
|
WO2026050617A1
(en)
|
2024-08-30 |
2026-03-05 |
Roche Sequencing Solutions, Inc. |
Systems and methods for clustering sequencing reads to identify pcr duplicates
|
|
WO2026055639A1
(en)
|
2024-09-06 |
2026-03-12 |
Cepheid |
Sample in sequencing-ready library out automated library preparation solution
|