JP2019501928A - 核酸及びキトサンを含む温度感応性ハイドロゲル組成物 - Google Patents
核酸及びキトサンを含む温度感応性ハイドロゲル組成物 Download PDFInfo
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Abstract
Description
むしろ、ここで紹介される内容が徹底し、完全になり、当業者に本発明の思想を十分に伝達するために提供するものである。
<実施例1.核酸−キトサンハイドロゲルの製造>
<比較例1、比較対象の核酸−キトサンハイドロゲルの製造>
Claims (13)
- 核酸及びキトサンを含み、
前記核酸及びキトサンの重量比が20:1〜10000:1である、温度感応性ハイドロゲル組成物。 - 前記核酸及びキトサンの重量比が50:1〜2000:1である、請求項1に記載の温度感応性ハイドロゲル組成物。
- 前記核酸及びキトサンの重量比が100:1〜1000:1である、請求項2に記載の温度感応性ハイドロゲル組成物。
- 前記核酸の含有量が組成物の総重量を基準として0.01重量%〜3重量%であることを特徴とする、請求項1に記載の温度感応性ハイドロゲル組成物。
- 前記核酸は、デオキシリボ核酸(deoxyribonucleic acid、DNA)、
リボ核酸(ribonucleic acid、RNA)またはこれらの混合物であることを特徴とする、請求項4に記載の温度感応性ハイドロゲル組成物。 - 前記キトサンの含有量が組成物の総重量を基準として、1×10−6重量%〜0.15重量%であることを特徴とする、請求項1に記載の温度感応性ハイドロゲル組成物。
- 前記キトサンは、分子量が3kDa〜1,000kDaであることを特徴とする、請求項6に記載の温度感応性ハイドロゲル組成物。
- 前記温度感応性ハイドロゲル組成物は、高分子物質を追加成分として含むことを特徴とする、請求項1に記載の温度感応性ハイドロゲル組成物。
- 前記高分子物質は、ヒアルロン酸(hyaluronic acid)、ポリガンマグルタミン酸(poly−γ−glutamic acid)、セルロース(cellulose)、ポリアクリル酸(polyacrylic acid)、ポリアミノ酸(polyamino acid)、アルジネート(alginate)、これらの誘導体及びこれらの組合せからなる群から選択される1種以上であることを特徴とする、請求項8に記載の温度感応性ハイドロゲル組成物。
- 請求項1〜9のいずれか1項に記載の温度感応性ハイドロゲル組成物の製造方法であって、
1)核酸の貯蔵溶液を製造するステップ;
2)キトサン貯蔵溶液を製造するステップ;
3)前記ステップ1)の核酸貯蔵溶液及び前記ステップ2)のキトサン貯蔵溶液を核酸及びキトサンの重量比が20:1〜10000:1になるように混合して攪拌するステップ;と
4)前記ステップ3)の核酸−キトサン混合液を攪拌しながら常温に下げるステップ;と
を含むことを特徴とする、温度感応性ハイドロゲル組成物の製造方法。 - 前記製造方法は、
1)核酸を緩衝溶液(buffer)に入れ、60℃〜70℃で攪拌しながら1時間〜2時間溶解させて核酸貯蔵溶液を製造するステップと、
2)キトサンを酸性緩衝溶液に溶解させてキトサン貯蔵溶液を製造するステップと、
3)前記ステップ1)の核酸貯蔵溶液及び前記ステップ2)のキトサン貯蔵溶液を核酸及びキトサンの重量比が20:1〜10000:1になるように混合して55℃〜65℃で1時間〜2時間攪拌するステップと、
4)前記ステップ3)の核酸−キトサン混合液を攪拌しながら常温に下げるステップと、
を含むことを特徴とする、請求項10に記載の温度感応性ハイドロゲル組成物の製造方法。 - 前記温度感応性ハイドロゲル組成物は、浸透圧が100mOsm〜500mOsmであることを特徴とする、請求項10に記載の温度感応性ハイドロゲル組成物の製造方法。
- 前記温度感応性ハイドロゲル組成物は、pHが6〜8であることを特徴とする、請求項10に記載の温度感応性ハイドロゲル組成物の製造方法。
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KR10-2016-0015112 | 2016-02-05 | ||
PCT/KR2016/002013 WO2017135498A1 (ko) | 2016-02-05 | 2016-02-29 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
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JP2019524848A (ja) * | 2016-08-25 | 2019-09-05 | ファーマリサーチ プロダクツ カンパニー リミテッドPharma Research Products Co., Ltd. | 核酸及びキトサンを含む関節腔注射用組成物 |
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KR101666792B1 (ko) | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
KR101959523B1 (ko) * | 2018-01-30 | 2019-03-18 | 주식회사 파마리서치프로덕트 | 핵산, 골 이식재 및 양이온성 고분자를 포함하는 골 이식용 조성물 및 이를 제조하기 위한 골 이식용 키트 |
TW201940967A (zh) | 2018-01-31 | 2019-10-16 | 日商三菱瓦斯化學股份有限公司 | 組成物,以及阻劑圖型之形成方法及絕緣膜之形成方法 |
CN109265758B (zh) * | 2018-09-12 | 2020-12-04 | 南京林业大学 | 一种温度/pH双响应型几丁质纳米纤维水凝胶及其制备方法 |
CN109810265B (zh) * | 2018-12-28 | 2021-08-03 | 天津大学 | 一种溶剂驱动体积变化的dna-多糖杂化水凝胶及制备方法 |
KR102382257B1 (ko) * | 2019-03-21 | 2022-04-05 | 순천향대학교 산학협력단 | 유착방지 온도감응형 셀룰로오스 기반 하이드로겔 및 이의 제조방법 |
EP3733755A1 (en) | 2019-04-30 | 2020-11-04 | Universita Degli Studi di Trieste | Homogeneous hydrogels from chitosan oligosaccharide derivatives and applications thereof |
KR102100506B1 (ko) | 2019-06-27 | 2020-04-13 | 주식회사 메디팹 | 온도 감응성 키토산 하이드로겔 조성물 및 그를 포함하는 바이오 잉크 조성물 |
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CN113368037B (zh) * | 2021-06-15 | 2022-02-18 | 北京农学院 | 一种载牛乳铁蛋白肽纳米粒壳聚糖温敏水凝胶及其制备方法和应用 |
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