FR3029790B1 - Microbille d'hydrogel de chitosane - Google Patents
Microbille d'hydrogel de chitosaneInfo
- Publication number
- FR3029790B1 FR3029790B1 FR1462367A FR1462367A FR3029790B1 FR 3029790 B1 FR3029790 B1 FR 3029790B1 FR 1462367 A FR1462367 A FR 1462367A FR 1462367 A FR1462367 A FR 1462367A FR 3029790 B1 FR3029790 B1 FR 3029790B1
- Authority
- FR
- France
- Prior art keywords
- microbell
- present
- chitosan hydrogel
- hydrogel
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000017 hydrogel Substances 0.000 title abstract 3
- 229920001661 Chitosan Polymers 0.000 title abstract 2
- 239000011325 microbead Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 229920000388 Polyphosphate Polymers 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000001205 polyphosphate Substances 0.000 abstract 1
- 235000011176 polyphosphates Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des microbilles d'hydrogel comprenant au moins de l'eau, du chitosane, au moins un composé polyphosphate, l'eau étant présente à une concentration d'au moins 85% en masse, d'hydrogel, lesdites microbilles présentant un diamètre moyen en nombre allant de 100 à 900 µm. La présente invention concerne également leur procédé de fabrication et leurs utilisations, en particulier dans des compositions pharmaceutiques ou des dispositifs médicaux, plus particulièrement pour le traitement d'une pathologie d'une articulation.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1462367A FR3029790B1 (fr) | 2014-12-12 | 2014-12-12 | Microbille d'hydrogel de chitosane |
EP15807844.4A EP3229777A1 (fr) | 2014-12-12 | 2015-12-07 | Microbille d'hydrogel de chitosane |
PCT/EP2015/078770 WO2016091778A1 (fr) | 2014-12-12 | 2015-12-07 | Microbille d'hydrogel de chitosane |
US15/535,313 US20170326275A1 (en) | 2014-12-12 | 2015-12-07 | Chitosan Hydrogel Microbead |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1462367A FR3029790B1 (fr) | 2014-12-12 | 2014-12-12 | Microbille d'hydrogel de chitosane |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3029790A1 FR3029790A1 (fr) | 2016-06-17 |
FR3029790B1 true FR3029790B1 (fr) | 2017-01-13 |
Family
ID=52589603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1462367A Active FR3029790B1 (fr) | 2014-12-12 | 2014-12-12 | Microbille d'hydrogel de chitosane |
Country Status (4)
Country | Link |
---|---|
US (1) | US20170326275A1 (fr) |
EP (1) | EP3229777A1 (fr) |
FR (1) | FR3029790B1 (fr) |
WO (1) | WO2016091778A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101666792B1 (ko) | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
KR101916193B1 (ko) * | 2016-08-25 | 2018-11-07 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 관절강 주사용 조성물 |
ES2671184B2 (es) * | 2016-11-16 | 2019-02-04 | Univ Miguel Hernandez De Elche | Formulacion para liberacion modificada de sustancias activas o farmacos, uso y procedimiento de obtencion |
CN109482110A (zh) * | 2017-09-12 | 2019-03-19 | 中国科学院兰州化学物理研究所苏州研究院 | 一种壳聚糖水凝胶的制备方法与应用 |
CN108125920A (zh) * | 2018-03-05 | 2018-06-08 | 清华大学 | 一种基于壳聚糖的滴丸剂基质微球材料及其制备方法 |
CN108904467A (zh) * | 2018-08-01 | 2018-11-30 | 青岛农业大学 | 壳聚糖-植酸钠空心纳米胶囊的制备工艺及其应用 |
CN108904780B (zh) * | 2018-08-24 | 2022-03-15 | 湖南金朋医疗器械有限公司 | 一种妇科凝胶剂及其制备方法 |
WO2020088577A1 (fr) * | 2018-11-02 | 2020-05-07 | Volt14 Solutions | Liant pour électrode de batterie |
KR102209051B1 (ko) * | 2019-04-03 | 2021-01-28 | 국민대학교산학협력단 | 하이드로겔 비드를 포함하는 화학센서, 및 상기 화학센서를 포함하는 용기 및 전자 제품 |
WO2021091040A1 (fr) * | 2019-11-04 | 2021-05-14 | 주식회사 엔도비전 | Hydrogel utilisant du chitosane dérivé de champignon, ou des dérivés de celui-ci, et son procédé de production |
CA3176918A1 (fr) * | 2020-04-17 | 2021-10-21 | Boston Scientific Scimed, Inc. | Compositions hemostatiques et procedes associes |
CN113125422B (zh) * | 2021-04-16 | 2023-07-25 | 合肥工业大学 | 化学发光水凝胶微珠的制备方法、制得的水凝胶微珠及其应用 |
CN116041801A (zh) * | 2023-02-14 | 2023-05-02 | 齐鲁工业大学(山东省科学院) | 一种壳聚糖-植酸纳米颗粒的制备方法与应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4122591C1 (en) * | 1991-07-08 | 1993-02-18 | Roland 8012 Ottobrunn De Bodmeier | Producing microcapsules of water insoluble polymer and active agent - includes dissolving or dispersing active agent in aq. polymer contg. gellable assistants |
EP2361640A1 (fr) * | 2010-02-25 | 2011-08-31 | Université de Liège | Culture cellulaire dans les billes d'hydrogel à base d'alginate chitosan |
CA2818894C (fr) * | 2010-11-23 | 2019-02-12 | Georgia Tech Research Corporation | Administration de proteines a partir de microvecteurs de cellules souches |
ES2770498T3 (es) * | 2012-08-28 | 2020-07-01 | Univ Geneve | Hidrogeles híbridos |
CN102920652B (zh) * | 2012-11-26 | 2014-04-02 | 昆明医科大学 | 蜂胶壳聚糖牙周缓释温敏原位凝胶及制备方法 |
CN103071156A (zh) * | 2012-12-12 | 2013-05-01 | 中国人民解放军第四军医大学 | 一种壳聚糖包裹负电荷金纳米粒及其制备方法和应用 |
BR102012033126B1 (pt) * | 2012-12-21 | 2022-01-04 | Universidade Estadual De Campinas - Unicamp | Processo de obtenção de produtos a base de quitosana e enriquecidos com arrabidaea chica |
-
2014
- 2014-12-12 FR FR1462367A patent/FR3029790B1/fr active Active
-
2015
- 2015-12-07 EP EP15807844.4A patent/EP3229777A1/fr not_active Withdrawn
- 2015-12-07 US US15/535,313 patent/US20170326275A1/en not_active Abandoned
- 2015-12-07 WO PCT/EP2015/078770 patent/WO2016091778A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP3229777A1 (fr) | 2017-10-18 |
US20170326275A1 (en) | 2017-11-16 |
WO2016091778A1 (fr) | 2016-06-16 |
FR3029790A1 (fr) | 2016-06-17 |
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Legal Events
Date | Code | Title | Description |
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PLFP | Fee payment |
Year of fee payment: 2 |
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PLSC | Publication of the preliminary search report |
Effective date: 20160617 |
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CD | Change of name or company name |
Owner name: SYNOLYNE PHARMA, BE Effective date: 20160905 |
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PLFP | Fee payment |
Year of fee payment: 3 |
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PLFP | Fee payment |
Year of fee payment: 4 |
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Year of fee payment: 6 |
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Year of fee payment: 7 |
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PLFP | Fee payment |
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PLFP | Fee payment |
Year of fee payment: 10 |