MA40768A - Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue - Google Patents
Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengueInfo
- Publication number
- MA40768A MA40768A MA040768A MA40768A MA40768A MA 40768 A MA40768 A MA 40768A MA 040768 A MA040768 A MA 040768A MA 40768 A MA40768 A MA 40768A MA 40768 A MA40768 A MA 40768A
- Authority
- MA
- Morocco
- Prior art keywords
- dengue virus
- mono
- indole derivatives
- substitute
- virus replication
- Prior art date
Links
- 241000725619 Dengue virus Species 0.000 title abstract 4
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 2
- -1 di-substituted indole Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
<!--startfragment-->la présente invention concerne des dérivés indole mono ou di-substitués (i) qui sont utiles pour prévenir ou traiter les infections par le virus de la dengue et concerne également lesdits composés destinés à être utilisés en tant que médicament, plus préférentiellement destinés à être utilisés en tant que médicament pour traiter ou prévenir les infections provoquées par le virus de la dengue. La présente invention concerne en outre des compositions pharmaceutiques ou des préparations combinées des composés, des compositions ou des préparations qui sont utilisées en tant que médicament, plus préférentiellement dans la prévention ou le traitement des infections provoquées par le virus de la dengue. L'invention concerne également des procédés de préparation des composés.<!--endfragment-->
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14187374 | 2014-10-01 | ||
| EP15159164 | 2015-03-16 | ||
| PCT/EP2015/072551 WO2016050841A1 (fr) | 2014-10-01 | 2015-09-30 | Dérivés indole mono ou di-substitués en tant qu'inhibiteurs de la réplication du virus de la dengue |
| EP15771136.7A EP3201176B1 (fr) | 2014-10-01 | 2015-09-30 | Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA40768A true MA40768A (fr) | 2017-09-08 |
| MA40768B1 MA40768B1 (fr) | 2019-03-29 |
Family
ID=54199687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA40768A MA40768B1 (fr) | 2014-10-01 | 2015-09-30 | Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9944598B2 (fr) |
| EP (1) | EP3201176B1 (fr) |
| JP (1) | JP6732736B2 (fr) |
| KR (1) | KR102478311B1 (fr) |
| CN (1) | CN107001264B (fr) |
| AU (1) | AU2015326930B2 (fr) |
| BR (1) | BR112017006299A2 (fr) |
| CA (1) | CA2959573A1 (fr) |
| CL (1) | CL2017000782A1 (fr) |
| CY (1) | CY1121874T1 (fr) |
| DK (1) | DK3201176T3 (fr) |
| EA (1) | EA032546B1 (fr) |
| ES (1) | ES2714074T3 (fr) |
| HR (1) | HRP20190199T1 (fr) |
| HU (1) | HUE041888T2 (fr) |
| IL (1) | IL251396A0 (fr) |
| LT (1) | LT3201176T (fr) |
| MA (1) | MA40768B1 (fr) |
| ME (1) | ME03360B (fr) |
| MX (1) | MX2017004299A (fr) |
| PH (1) | PH12017500571A1 (fr) |
| PL (1) | PL3201176T3 (fr) |
| PT (1) | PT3201176T (fr) |
| RS (1) | RS58461B1 (fr) |
| SG (1) | SG11201702463YA (fr) |
| SI (1) | SI3201176T1 (fr) |
| SM (1) | SMT201900162T1 (fr) |
| TW (1) | TWI681951B (fr) |
| UA (1) | UA121119C2 (fr) |
| UY (1) | UY36340A (fr) |
| WO (1) | WO2016050841A1 (fr) |
| ZA (1) | ZA201702301B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| JP6662865B2 (ja) | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| PL3201177T3 (pl) * | 2014-10-01 | 2019-05-31 | Janssen Pharmaceuticals Inc | Mono- lub di-podstawione indole jako inhibitory replikacji wirusa dengi |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) * | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CR20180496A (es) | 2016-03-31 | 2018-12-06 | Univ Leuven Kath | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| WO2017167950A1 (fr) | 2016-03-31 | 2017-10-05 | Janssen Pharmaceuticals, Inc. | Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue |
| CN109069482B (zh) * | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| JOP20170069B1 (ar) * | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| MX393586B (es) * | 2017-05-22 | 2025-03-24 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| PE20200342A1 (es) * | 2017-05-22 | 2020-02-14 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue |
| CN121358711A (zh) * | 2023-06-05 | 2026-01-16 | 载度思生命科学有限公司 | 治疗病毒感染的新的化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX336687B (es) * | 2009-06-30 | 2016-01-28 | Siga Technologies Inc | Tratamiento y prevencion de infecciones del virus del dengue. |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
-
2015
- 2015-09-30 EP EP15771136.7A patent/EP3201176B1/fr active Active
- 2015-09-30 PL PL15771136T patent/PL3201176T3/pl unknown
- 2015-09-30 HR HRP20190199TT patent/HRP20190199T1/hr unknown
- 2015-09-30 SM SM20190162T patent/SMT201900162T1/it unknown
- 2015-09-30 TW TW104132008A patent/TWI681951B/zh not_active IP Right Cessation
- 2015-09-30 SI SI201530603T patent/SI3201176T1/sl unknown
- 2015-09-30 BR BR112017006299-2A patent/BR112017006299A2/pt not_active Application Discontinuation
- 2015-09-30 CA CA2959573A patent/CA2959573A1/fr not_active Abandoned
- 2015-09-30 UA UAA201704215A patent/UA121119C2/uk unknown
- 2015-09-30 DK DK15771136.7T patent/DK3201176T3/en active
- 2015-09-30 AU AU2015326930A patent/AU2015326930B2/en not_active Expired - Fee Related
- 2015-09-30 ES ES15771136T patent/ES2714074T3/es active Active
- 2015-09-30 RS RS20190206A patent/RS58461B1/sr unknown
- 2015-09-30 KR KR1020177011122A patent/KR102478311B1/ko active Active
- 2015-09-30 CN CN201580053446.3A patent/CN107001264B/zh active Active
- 2015-09-30 ME MEP-2019-62A patent/ME03360B/fr unknown
- 2015-09-30 WO PCT/EP2015/072551 patent/WO2016050841A1/fr not_active Ceased
- 2015-09-30 SG SG11201702463YA patent/SG11201702463YA/en unknown
- 2015-09-30 LT LTEP15771136.7T patent/LT3201176T/lt unknown
- 2015-09-30 MX MX2017004299A patent/MX2017004299A/es unknown
- 2015-09-30 HU HUE15771136A patent/HUE041888T2/hu unknown
- 2015-09-30 PT PT15771136T patent/PT3201176T/pt unknown
- 2015-09-30 EA EA201790758A patent/EA032546B1/ru not_active IP Right Cessation
- 2015-09-30 JP JP2017513061A patent/JP6732736B2/ja active Active
- 2015-09-30 US US15/515,574 patent/US9944598B2/en active Active
- 2015-09-30 MA MA40768A patent/MA40768B1/fr unknown
- 2015-10-01 UY UY0001036340A patent/UY36340A/es unknown
-
2017
- 2017-03-27 IL IL251396A patent/IL251396A0/en unknown
- 2017-03-27 PH PH12017500571A patent/PH12017500571A1/en unknown
- 2017-03-31 ZA ZA2017/02301A patent/ZA201702301B/en unknown
- 2017-03-31 CL CL2017000782A patent/CL2017000782A1/es unknown
-
2019
- 2019-03-01 CY CY20191100257T patent/CY1121874T1/el unknown
Also Published As
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