JP2019131569A5 - - Google Patents
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- Publication number
- JP2019131569A5 JP2019131569A5 JP2019043934A JP2019043934A JP2019131569A5 JP 2019131569 A5 JP2019131569 A5 JP 2019131569A5 JP 2019043934 A JP2019043934 A JP 2019043934A JP 2019043934 A JP2019043934 A JP 2019043934A JP 2019131569 A5 JP2019131569 A5 JP 2019131569A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- keratitis
- disease
- diastereomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 206010023332 keratitis Diseases 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000002691 Choroiditis Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 208000003971 Posterior uveitis Diseases 0.000 claims 1
- 206010038910 Retinitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000000159 corneal neovascularization Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000035168 lymphangiogenesis Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361773773P | 2013-03-06 | 2013-03-06 | |
| US61/773,773 | 2013-03-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157335A Division JP6496786B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019131569A JP2019131569A (ja) | 2019-08-08 |
| JP2019131569A5 true JP2019131569A5 (enExample) | 2019-11-14 |
| JP6672500B2 JP6672500B2 (ja) | 2020-03-25 |
Family
ID=50382628
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561536A Active JP6196327B2 (ja) | 2013-03-06 | 2014-03-04 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157334A Active JP6602351B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157335A Active JP6496786B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2019043934A Active JP6672500B2 (ja) | 2013-03-06 | 2019-03-11 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561536A Active JP6196327B2 (ja) | 2013-03-06 | 2014-03-04 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157334A Active JP6602351B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
| JP2017157335A Active JP6496786B2 (ja) | 2013-03-06 | 2017-08-17 | 眼炎症性疾患の治療のためのホルミルペプチド受容体２のアゴニストの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9850264B2 (enExample) |
| EP (2) | EP3795148B1 (enExample) |
| JP (4) | JP6196327B2 (enExample) |
| KR (2) | KR102227201B1 (enExample) |
| CN (2) | CN105007909B (enExample) |
| AR (1) | AR095034A1 (enExample) |
| AU (3) | AU2014225992B2 (enExample) |
| BR (2) | BR112015021371B1 (enExample) |
| CA (2) | CA2898301C (enExample) |
| CL (3) | CL2015002485A1 (enExample) |
| ES (2) | ES3036990T3 (enExample) |
| IL (3) | IL241012B (enExample) |
| MX (2) | MX364916B (enExample) |
| MY (1) | MY207109A (enExample) |
| PH (3) | PH12020500285B1 (enExample) |
| RU (2) | RU2768730C2 (enExample) |
| SG (2) | SG11201507113RA (enExample) |
| TW (1) | TWI616200B (enExample) |
| WO (1) | WO2014138037A1 (enExample) |
| ZA (1) | ZA201505134B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA115043C2 (uk) * | 2011-10-26 | 2017-09-11 | Аллерган, Інк. | Амідні похідні n-карбамідзаміщених амінокислот як модулятори формілпептидного рецептора 1 (fprl-1) |
| KR20140145203A (ko) * | 2012-04-16 | 2014-12-22 | 알러간, 인코포레이티드 | 포르밀 펩타이드 수용체 2 조절물질로서 (2-우레이도아세트아미도)알킬 유도체 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| JP6101788B2 (ja) | 2012-05-16 | 2017-03-22 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ＡＬＸ受容体アゴニストとしての１−（ｐ−トリル）シクロプロピル置換架橋スピロ［２．４］ヘプタン誘導体 |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| CN105007909B (zh) * | 2013-03-06 | 2019-06-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
| RU2696487C2 (ru) | 2013-03-06 | 2019-08-02 | Аллерган, Инк. | Применение агонистов формилпептидного рецептора 2 для лечения дерматологических заболеваний |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| CN105377814B (zh) * | 2013-07-16 | 2018-04-03 | 阿勒根公司 | 作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物 |
| WO2015007830A1 (en) | 2013-07-18 | 2015-01-22 | Actelion Pharmaceuticals Ltd | Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| US9663457B2 (en) | 2014-04-09 | 2017-05-30 | Allergan, Inc. | Carbamoyl hydrazine derivatives as formyl peptide modulators |
| CA2948876A1 (en) | 2014-05-21 | 2015-11-26 | Allergan, Inc. | Imidazole derivatives as formyl peptide receptor modulators |
| WO2016149667A1 (en) * | 2015-03-19 | 2016-09-22 | University Of Maryland , Baltimore | Runx2 transcription factor inhibitors and uses thereof |
| CN107848962B (zh) | 2015-05-27 | 2021-04-09 | 杏林制药株式会社 | 脲衍生物或其药理学上可接受的盐 |
| WO2017172761A1 (en) * | 2016-03-28 | 2017-10-05 | Allergan, Inc. | Phenyl urea derivatives as n-formyl peptide receptor modulators |
| AU2017249047B2 (en) * | 2016-04-12 | 2021-08-05 | Allergan, Inc. | Phenyl urea derivatives as N-formyl peptide receptor modulators |
| MX2019003867A (es) | 2016-10-06 | 2019-08-05 | Daiichi Sankyo Co Ltd | Derivado de urea. |
| CN109134533B (zh) | 2017-06-27 | 2020-08-11 | 维眸生物科技（上海）有限公司 | 一种含磷化合物及其制备和应用 |
| CN107814773B (zh) * | 2017-11-13 | 2020-05-22 | 西安交通大学 | 含有喹唑啉酮的二芳基脲类化合物及其制备方法和应用 |
| RU2712229C2 (ru) * | 2018-05-17 | 2020-01-27 | Закрытое акционерное общество "Институт экспериментальной фармакологии" | Эфиры тригидроксигептаеновой кислоты в качестве агонистов fpr2 рецептора |
| KR102429281B1 (ko) * | 2020-05-25 | 2022-08-05 | (주)노바셀테크놀로지 | 신규 안구건조증 치료용 약학적 조성물 |
| IT202100004964A1 (it) * | 2021-03-03 | 2022-09-03 | Univ Degli Studi Di Bari Aldo Moro | Agonisti del recettore fpr2 (formyl peptide receptor 2) e loro uso nel trattamento del disturbo dello spettro autistico. |
| JP2022151437A (ja) * | 2021-03-26 | 2022-10-07 | 均 石井 | 網膜炎治療薬。 |
| WO2025233915A1 (en) * | 2024-05-10 | 2025-11-13 | Allgenesis Biotherapeutics Inc. | Use of an agonist of formyl peptide receptors 1 and 2 for treating ocular inflammatory diseases |
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|---|---|---|---|---|
| US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
| JPS63232846A (ja) | 1987-03-20 | 1988-09-28 | Haruo Ogura | 新規な固定相担体 |
| AU667995B2 (en) * | 1993-02-15 | 1996-04-18 | Bayer Aktiengesellschaft | New pseudopeptides having an antiviral action |
| US6423689B1 (en) * | 1997-12-22 | 2002-07-23 | Warner-Lambert Company | Peptidyl calcium channel blockers |
| AU6909300A (en) * | 1999-08-20 | 2001-03-19 | Merck & Co., Inc. | Substituted ureas as cell adhesion inhibitors |
| EP1162194A1 (en) | 2000-06-06 | 2001-12-12 | Aventis Pharma Deutschland GmbH | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use |
| DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| WO2004022529A2 (en) | 2002-09-05 | 2004-03-18 | Neurosearch A/S | Diarylurea derivatives and their use as chloride channel blockers |
| AU2003277575A1 (en) * | 2002-11-07 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Novel fprl1 ligands and use thereof |
| US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| WO2005047899A2 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| JP4769082B2 (ja) | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
| WO2006065755A2 (en) | 2004-12-13 | 2006-06-22 | Glaxo Group Limited | Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists |
| WO2007076055A2 (en) | 2005-12-22 | 2007-07-05 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| US20080008694A1 (en) * | 2006-07-05 | 2008-01-10 | Elgebaly Salwa A | Methods to prevent and treat diseases |
| EP2064234B1 (en) * | 2006-09-18 | 2011-11-02 | Compugen Ltd. | Bioactive peptides and method of using same |
| WO2009097997A1 (de) | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US20100035932A1 (en) * | 2008-08-07 | 2010-02-11 | Schepetkin Igor A | Novel formyl peptide receptor like 1 agonists that induce macrophage tumor necrosis factor alpha and computational structure-activity relationship analysis of thereof |
| WO2010104307A2 (ko) * | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
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| UA115043C2 (uk) | 2011-10-26 | 2017-09-11 | Аллерган, Інк. | Амідні похідні n-карбамідзаміщених амінокислот як модулятори формілпептидного рецептора 1 (fprl-1) |
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| KR20140145203A (ko) | 2012-04-16 | 2014-12-22 | 알러간, 인코포레이티드 | 포르밀 펩타이드 수용체 2 조절물질로서 (2-우레이도아세트아미도)알킬 유도체 |
| CN105007909B (zh) * | 2013-03-06 | 2019-06-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
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2014
- 2014-03-04 CN CN201480012204.5A patent/CN105007909B/zh active Active
- 2014-03-04 US US14/196,047 patent/US9850264B2/en active Active
- 2014-03-04 MY MYPI2019001743A patent/MY207109A/en unknown
- 2014-03-04 ES ES20205401T patent/ES3036990T3/es active Active
- 2014-03-04 BR BR112015021371-5A patent/BR112015021371B1/pt active IP Right Grant
- 2014-03-04 CA CA2898301A patent/CA2898301C/en active Active
- 2014-03-04 ES ES14712888T patent/ES2835825T3/es active Active
- 2014-03-04 KR KR1020157024036A patent/KR102227201B1/ko active Active
- 2014-03-04 EP EP20205401.1A patent/EP3795148B1/en active Active
- 2014-03-04 RU RU2018127997A patent/RU2768730C2/ru active
- 2014-03-04 EP EP14712888.8A patent/EP2964213B1/en active Active
- 2014-03-04 JP JP2015561536A patent/JP6196327B2/ja active Active
- 2014-03-04 WO PCT/US2014/020245 patent/WO2014138037A1/en not_active Ceased
- 2014-03-04 MX MX2015011593A patent/MX364916B/es active IP Right Grant
- 2014-03-04 SG SG11201507113RA patent/SG11201507113RA/en unknown
- 2014-03-04 PH PH1/2020/500285A patent/PH12020500285B1/en unknown
- 2014-03-04 KR KR1020207023766A patent/KR102290134B1/ko active Active
- 2014-03-04 SG SG10201801471RA patent/SG10201801471RA/en unknown
- 2014-03-04 CA CA3133264A patent/CA3133264A1/en active Pending
- 2014-03-04 RU RU2015136774A patent/RU2663911C2/ru active
- 2014-03-04 BR BR122017004254-8A patent/BR122017004254B1/pt active IP Right Grant
- 2014-03-04 MX MX2019005541A patent/MX393070B/es unknown
- 2014-03-04 CN CN201910497947.0A patent/CN110279684B/zh active Active
- 2014-03-04 AU AU2014225992A patent/AU2014225992B2/en active Active
- 2014-03-06 AR ARP140100732A patent/AR095034A1/es not_active Application Discontinuation
- 2014-03-06 TW TW103107761A patent/TWI616200B/zh active
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2015
- 2015-07-16 ZA ZA2015/05134A patent/ZA201505134B/en unknown
- 2015-08-24 PH PH12015501858A patent/PH12015501858B1/en unknown
- 2015-09-01 IL IL241012A patent/IL241012B/en active IP Right Grant
- 2015-09-04 CL CL2015002485A patent/CL2015002485A1/es unknown
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2017
- 2017-07-21 US US15/656,766 patent/US10208071B2/en active Active
- 2017-08-17 JP JP2017157334A patent/JP6602351B2/ja active Active
- 2017-08-17 JP JP2017157335A patent/JP6496786B2/ja active Active
- 2017-10-06 CL CL2017002526A patent/CL2017002526A1/es unknown
- 2017-10-06 CL CL2017002527A patent/CL2017002527A1/es unknown
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2018
- 2018-05-28 AU AU2018203719A patent/AU2018203719B2/en active Active
- 2018-11-27 IL IL263314A patent/IL263314B/en active IP Right Grant
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2019
- 2019-01-22 US US16/254,438 patent/US10899780B2/en active Active
- 2019-03-11 JP JP2019043934A patent/JP6672500B2/ja active Active
- 2019-09-06 AU AU2019226215A patent/AU2019226215B2/en active Active
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2020
- 2020-02-07 PH PH12020500286A patent/PH12020500286A1/en unknown
- 2020-03-11 IL IL273208A patent/IL273208A/en active IP Right Grant