JP2019068857A5 - - Google Patents
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- Publication number
- JP2019068857A5 JP2019068857A5 JP2019019707A JP2019019707A JP2019068857A5 JP 2019068857 A5 JP2019068857 A5 JP 2019068857A5 JP 2019019707 A JP2019019707 A JP 2019019707A JP 2019019707 A JP2019019707 A JP 2019019707A JP 2019068857 A5 JP2019068857 A5 JP 2019068857A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- microglobulin
- acid sequence
- nucleic acid
- human animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 29
- 150000007523 nucleic acids Chemical group 0.000 claims 29
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 19
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 16
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 101000937526 Mus musculus Beta-2-microglobulin Proteins 0.000 claims 8
- 102000047279 human B2M Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000001105 regulatory effect Effects 0.000 claims 6
- 108700024394 Exon Proteins 0.000 claims 4
- 241000283984 Rodentia Species 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 101000729860 Rattus norvegicus Beta-2-microglobulin Proteins 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552587P | 2011-10-28 | 2011-10-28 | |
| US201161552582P | 2011-10-28 | 2011-10-28 | |
| US61/552,587 | 2011-10-28 | ||
| US61/552,582 | 2011-10-28 | ||
| US201261700908P | 2012-09-14 | 2012-09-14 | |
| US61/700,908 | 2012-09-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017109327A Division JP6574457B2 (ja) | 2011-10-28 | 2017-06-01 | 遺伝子改変された主要組織適合複合体マウス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081774A Division JP2020146041A (ja) | 2011-10-28 | 2020-05-07 | 遺伝子改変された主要組織適合複合体マウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019068857A JP2019068857A (ja) | 2019-05-09 |
| JP2019068857A5 true JP2019068857A5 (https=) | 2019-12-19 |
| JP6866409B2 JP6866409B2 (ja) | 2021-04-28 |
Family
ID=47178940
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539029A Active JP6154391B2 (ja) | 2011-10-28 | 2012-10-26 | 遺伝子改変された主要組織適合複合体マウス |
| JP2017109327A Active JP6574457B2 (ja) | 2011-10-28 | 2017-06-01 | 遺伝子改変された主要組織適合複合体マウス |
| JP2019019707A Active JP6866409B2 (ja) | 2011-10-28 | 2019-02-06 | 遺伝子改変された主要組織適合複合体マウス |
| JP2020081774A Withdrawn JP2020146041A (ja) | 2011-10-28 | 2020-05-07 | 遺伝子改変された主要組織適合複合体マウス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539029A Active JP6154391B2 (ja) | 2011-10-28 | 2012-10-26 | 遺伝子改変された主要組織適合複合体マウス |
| JP2017109327A Active JP6574457B2 (ja) | 2011-10-28 | 2017-06-01 | 遺伝子改変された主要組織適合複合体マウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081774A Withdrawn JP2020146041A (ja) | 2011-10-28 | 2020-05-07 | 遺伝子改変された主要組織適合複合体マウス |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US9615550B2 (https=) |
| EP (4) | EP3262932B1 (https=) |
| JP (4) | JP6154391B2 (https=) |
| KR (3) | KR102295746B1 (https=) |
| CN (3) | CN107254480B (https=) |
| AU (3) | AU2012324016C1 (https=) |
| BR (1) | BR112014009259A2 (https=) |
| CA (2) | CA3074400C (https=) |
| CY (2) | CY1119657T1 (https=) |
| DK (2) | DK3262932T3 (https=) |
| ES (3) | ES2741649T3 (https=) |
| HK (1) | HK1249712B (https=) |
| HR (2) | HRP20171761T1 (https=) |
| HU (2) | HUE035652T2 (https=) |
| IL (3) | IL232097A (https=) |
| LT (2) | LT3262932T (https=) |
| MX (3) | MX391222B (https=) |
| MY (2) | MY164836A (https=) |
| NZ (1) | NZ734532A (https=) |
| PL (2) | PL3262932T3 (https=) |
| PT (2) | PT3262932T (https=) |
| RS (2) | RS56656B1 (https=) |
| SG (2) | SG11201400933VA (https=) |
| SI (2) | SI3262932T1 (https=) |
| SM (2) | SMT201900478T1 (https=) |
| WO (1) | WO2013063346A1 (https=) |
| ZA (1) | ZA201403085B (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| CN111484999B (zh) | 2013-02-20 | 2024-10-25 | 瑞泽恩制药公司 | 人源化的t细胞共受体的小鼠 |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| CA2902543A1 (en) * | 2013-03-11 | 2014-10-09 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| ES2613379T3 (es) | 2013-10-15 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Animales con IL-15 humanizada |
| CN105578876B (zh) * | 2013-10-18 | 2018-07-13 | 大鹏药品工业株式会社 | 制备表达hlai类的非人动物的方法 |
| RU2671101C1 (ru) | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| CN111690052B (zh) | 2014-04-08 | 2024-06-04 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| IL287519B2 (en) | 2014-06-19 | 2024-01-01 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| RU2726446C2 (ru) | 2014-11-24 | 2020-07-14 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN113412818B (zh) * | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| CN116059378A (zh) | 2014-12-10 | 2023-05-05 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
| EP4248744A3 (en) | 2015-04-06 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| ES2950399T3 (es) * | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| DK3422845T3 (da) | 2016-02-29 | 2021-08-30 | Regeneron Pharma | Gnavere med et humaniseret tmprss-gen |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
| RU2020112751A (ru) * | 2017-09-29 | 2021-10-29 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, у которых экспрессируется гуманизированный комплекс c1q |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| JP7361031B2 (ja) | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| EP3772927B1 (en) * | 2018-03-24 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL314733A (en) * | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| AU2020244827A1 (en) * | 2019-03-25 | 2021-09-30 | Alexis Bio, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same |
| KR102661779B1 (ko) | 2019-04-04 | 2024-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물 |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| MX2021015122A (es) | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| IL294356A (en) * | 2020-01-10 | 2022-08-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Genetically modified non-human animal with human or chimeric mhc protein complex |
| CN116848254B (zh) | 2020-12-16 | 2026-03-17 | 瑞泽恩制药公司 | 表达人源化Fcα受体的小鼠 |
| WO2022133155A1 (en) * | 2020-12-16 | 2022-06-23 | Xenotherapeutics, Inc. | Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs |
| CN118511853A (zh) | 2021-03-31 | 2024-08-20 | 瑞泽恩制药公司 | 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠 |
| US20250185635A1 (en) * | 2022-03-21 | 2025-06-12 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin and mhc loci |
| KR20250035053A (ko) | 2022-06-07 | 2025-03-11 | 리제너론 파아마슈티컬스, 인크. | T 세포 활성을 조절하기 위한 다중특이적 분자 및 이의 용도 |
| EP4536836A1 (en) | 2022-06-07 | 2025-04-16 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| AU2023347224A1 (en) | 2022-09-22 | 2025-03-20 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing components of human cellular immune system |
| WO2024159071A1 (en) | 2023-01-27 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Modified rhabdovirus glycoproteins and uses thereof |
| TW202520975A (zh) * | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
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-
2012
- 2012-10-26 SM SM20190478T patent/SMT201900478T1/it unknown
- 2012-10-26 EP EP17184955.7A patent/EP3262932B1/en active Active
- 2012-10-26 DK DK17184955.7T patent/DK3262932T3/da active
- 2012-10-26 MY MYPI2014000784A patent/MY164836A/en unknown
- 2012-10-26 HR HRP20171761TT patent/HRP20171761T1/hr unknown
- 2012-10-26 PT PT17184955T patent/PT3262932T/pt unknown
- 2012-10-26 HU HUE12787255A patent/HUE035652T2/en unknown
- 2012-10-26 SI SI201231650T patent/SI3262932T1/sl unknown
- 2012-10-26 CN CN201710347715.8A patent/CN107254480B/zh active Active
- 2012-10-26 EP EP19167619.6A patent/EP3563680B1/en active Active
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