JP2019506897A5 - - Google Patents
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- Publication number
- JP2019506897A5 JP2019506897A5 JP2018555851A JP2018555851A JP2019506897A5 JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5 JP 2018555851 A JP2018555851 A JP 2018555851A JP 2018555851 A JP2018555851 A JP 2018555851A JP 2019506897 A5 JP2019506897 A5 JP 2019506897A5
- Authority
- JP
- Japan
- Prior art keywords
- transgenic mouse
- mouse
- human
- crbn
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022020184A JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662280633P | 2016-01-19 | 2016-01-19 | |
| US62/280,633 | 2016-01-19 | ||
| PCT/US2017/013909 WO2017127414A1 (en) | 2016-01-19 | 2017-01-18 | Transgenic mouse expressing human cereblon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020184A Division JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506897A JP2019506897A (ja) | 2019-03-14 |
| JP2019506897A5 true JP2019506897A5 (https=) | 2020-03-05 |
Family
ID=59362645
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018555851A Pending JP2019506897A (ja) | 2016-01-19 | 2017-01-18 | ヒトのセレブロンを発現するトランスジェニックマウス |
| JP2022020184A Active JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022020184A Active JP7350911B2 (ja) | 2016-01-19 | 2022-02-14 | ヒトのセレブロンを発現するトランスジェニックマウス |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11963520B2 (https=) |
| EP (1) | EP3405790B1 (https=) |
| JP (2) | JP2019506897A (https=) |
| WO (1) | WO2017127414A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| EP3577459A4 (en) | 2017-02-03 | 2020-12-16 | Celgene Corporation | METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON |
| JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
| CN116121302A (zh) * | 2018-09-27 | 2023-05-16 | 公益财团法人实验动物中央研究所 | 免疫缺陷小鼠 |
| JP2022554346A (ja) | 2019-11-05 | 2022-12-28 | セルジーン コーポレーション | ２－（４－クロロフェニル）－ｎ－（（２－（２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－イル）メチル）－２，２－ジフルオロアセトアミドとの併用療法 |
| CN112980882A (zh) * | 2021-03-15 | 2021-06-18 | 上海科技大学 | Crbn基因在构建GSPT1敏感模型中的用途 |
| WO2025164957A1 (ko) * | 2024-01-31 | 2025-08-07 | 남부대학교산학협력단 | 인간화된 세레브론 넉인 마우스 모델 및 이를 이용한 다발성 골수종 항암화학요법의 효능 평가 방법 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| ATE455179T1 (de) | 1997-02-28 | 2010-01-15 | Kyowa Hakko Kirin Co Ltd | Humanes chromosomfragment und ein vektor, der dies enthält |
| AU4819101A (en) * | 2000-04-13 | 2001-10-30 | University Of British Columbia, The | Modulating cell survival by modulating huntingtin function |
| US6875904B2 (en) * | 2000-09-20 | 2005-04-05 | The Ohio State University Research Foundation | Animal model for identifying agents that inhibit or enhance CTLA4 signaling |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| CA2507882A1 (en) * | 2002-12-16 | 2004-07-22 | Genentech, Inc. | Transgenic mice expressing human cd20 |
| WO2008080052A1 (en) | 2006-12-22 | 2008-07-03 | Genentech, Inc. | Transgenic mice expressing humanized vegf |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| AU2012249491B2 (en) | 2011-04-29 | 2016-12-15 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| US9587281B2 (en) * | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| WO2014028445A2 (en) | 2012-08-14 | 2014-02-20 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| KR20140100731A (ko) | 2013-02-07 | 2014-08-18 | 광주과학기술원 | Ｃｒｂ ｎ ｋｏ 마우스의 제조방법 및 이의 용도 |
| US20160282354A1 (en) * | 2013-11-08 | 2016-09-29 | The Broad Institute, Inc. | Compositions and methods for selecting a treatment for b-cell neoplasias |
| US10272117B2 (en) | 2014-02-24 | 2019-04-30 | Celgene Corporation | Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| EP3577459A4 (en) | 2017-02-03 | 2020-12-16 | Celgene Corporation | METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON |
-
2017
- 2017-01-18 WO PCT/US2017/013909 patent/WO2017127414A1/en not_active Ceased
- 2017-01-18 EP EP17741841.5A patent/EP3405790B1/en active Active
- 2017-01-18 US US16/070,769 patent/US11963520B2/en active Active
- 2017-01-18 JP JP2018555851A patent/JP2019506897A/ja active Pending
-
2022
- 2022-02-14 JP JP2022020184A patent/JP7350911B2/ja active Active
-
2024
- 2024-03-19 US US18/609,867 patent/US20240389562A1/en active Pending
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