JP2020510418A5 - - Google Patents
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- JP2020510418A5 JP2020510418A5 JP2019545322A JP2019545322A JP2020510418A5 JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5 JP 2019545322 A JP2019545322 A JP 2019545322A JP 2019545322 A JP2019545322 A JP 2019545322A JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tfr
- animal
- polypeptide
- apical domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023085382A JP2023116513A (ja) | 2017-02-17 | 2023-05-24 | トランスフェリン受容体トランスジェニックモデル |
| JP2025036281A JP2025087857A (ja) | 2017-02-17 | 2025-03-07 | トランスフェリン受容体トランスジェニックモデル |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762460692P | 2017-02-17 | 2017-02-17 | |
| US62/460,692 | 2017-02-17 | ||
| US201762543658P | 2017-08-10 | 2017-08-10 | |
| US201762543559P | 2017-08-10 | 2017-08-10 | |
| US62/543,658 | 2017-08-10 | ||
| US62/543,559 | 2017-08-10 | ||
| US201762583314P | 2017-11-08 | 2017-11-08 | |
| US62/583,314 | 2017-11-08 | ||
| PCT/US2018/018302 WO2018152285A1 (en) | 2017-02-17 | 2018-02-15 | Transferrin receptor transgenic models |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085382A Division JP2023116513A (ja) | 2017-02-17 | 2023-05-24 | トランスフェリン受容体トランスジェニックモデル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510418A JP2020510418A (ja) | 2020-04-09 |
| JP2020510418A5 true JP2020510418A5 (https=) | 2021-03-11 |
| JP7669113B2 JP7669113B2 (ja) | 2025-04-28 |
Family
ID=61628463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545322A Active JP7669113B2 (ja) | 2017-02-17 | 2018-02-15 | トランスフェリン受容体トランスジェニックモデル |
| JP2023085382A Pending JP2023116513A (ja) | 2017-02-17 | 2023-05-24 | トランスフェリン受容体トランスジェニックモデル |
| JP2025036281A Pending JP2025087857A (ja) | 2017-02-17 | 2025-03-07 | トランスフェリン受容体トランスジェニックモデル |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023085382A Pending JP2023116513A (ja) | 2017-02-17 | 2023-05-24 | トランスフェリン受容体トランスジェニックモデル |
| JP2025036281A Pending JP2025087857A (ja) | 2017-02-17 | 2025-03-07 | トランスフェリン受容体トランスジェニックモデル |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP3583118B1 (https=) |
| JP (3) | JP7669113B2 (https=) |
| KR (1) | KR102637590B1 (https=) |
| CN (1) | CN110382526B (https=) |
| AU (1) | AU2018221704B2 (https=) |
| CA (1) | CA3053370A1 (https=) |
| IL (1) | IL268659A (https=) |
| SG (1) | SG11201907419PA (https=) |
| WO (1) | WO2018152285A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| WO2019246071A1 (en) | 2018-06-18 | 2019-12-26 | Denali Therapeutics Inc. | Fusion proteins comprising progranulin |
| WO2021133907A1 (en) | 2019-12-23 | 2021-07-01 | Denali Therapeutics Inc. | Progranulin variants |
| CN112243953B (zh) * | 2020-07-15 | 2022-02-11 | 吉林医药学院 | TfR1肺组织特异性敲除小鼠模型及其构建方法和应用 |
| EP4229192A1 (en) | 2020-10-14 | 2023-08-23 | Denali Therapeutics Inc. | Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof |
| CN112501124A (zh) * | 2020-11-27 | 2021-03-16 | 领诺(上海)医药科技有限公司 | 稳定表达人转铁蛋白受体1细胞株的制备方法及其应用 |
| JP2024525991A (ja) * | 2021-07-16 | 2024-07-12 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | ヒト又はキメラｔｆｒ１を有する遺伝子組換え非ヒト動物 |
| JP2025503437A (ja) | 2021-12-17 | 2025-02-04 | デナリ セラピューティクス インコーポレイテッド | ポリペプチド操作、ライブラリー、ならびに操作されたｃｄ９８重鎖及びトランスフェリン受容体結合ポリペプチド |
| AU2022415476A1 (en) | 2021-12-17 | 2024-07-04 | Denali Therapeutics Inc. | Fusion proteins comprising alpha-l-iduronidase enzymes and methods |
| WO2023192288A1 (en) | 2022-03-28 | 2023-10-05 | Denali Therapeutics Inc. | Monovalent anti-trem2 binding molecules and methods of use thereof |
| IL317261A (en) * | 2022-07-29 | 2025-01-01 | Regeneron Pharma | Non-human animals containing a modified transferrin receptor locus |
| WO2024160736A1 (en) | 2023-01-30 | 2024-08-08 | Isar Bioscience Gmbh | Human anti-trem2 antibody for treating neurodegenerative disorders |
| CN116784280B (zh) * | 2023-08-10 | 2025-08-19 | 广东药康生物科技有限公司 | 一种tfrc人源化小鼠模型的构建方法及其应用 |
| TW202542190A (zh) | 2023-12-20 | 2025-11-01 | 美商戴納立製藥公司 | 包含酸性α—葡萄糖苷酶之融合蛋白及其方法 |
| WO2026006173A1 (en) | 2024-06-24 | 2026-01-02 | Denali Therapeutics Inc. | Fusion proteins comprising modified glucocerebrosidase polypeptides and methods thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5898094A (en) | 1996-10-21 | 1999-04-27 | University Of South Florida | Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes |
| US6175057B1 (en) | 1997-10-08 | 2001-01-16 | The Regents Of The University Of California | Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy |
| EP1620564A4 (en) * | 2003-04-18 | 2008-03-12 | Cytovia Inc | METHOD FOR TREATING DISEASES RESPONSING TO APOPTOSIS INDUCTION AND SCREENING TESTS |
| CA2720903C (en) | 2008-04-14 | 2019-01-15 | Sangamo Biosciences, Inc. | Linear donor constructs for targeted integration |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| EP2660318A1 (en) | 2010-02-09 | 2013-11-06 | Sangamo BioSciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
| US8476485B2 (en) | 2010-06-24 | 2013-07-02 | Academia Sinica | Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function |
| US9232775B2 (en) | 2012-08-03 | 2016-01-12 | Industry-Academic Cooperation Foundation, Yonsei University | Genetically engineered mouse model for autism spectrum disorder having deletion of Shank2 gene and use thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CN105283552A (zh) | 2013-03-13 | 2016-01-27 | 澳大利亚核科学和技术组织 | 具有非功能性tspo基因的转基因非人类生物体 |
| EP3594240B1 (en) * | 2013-05-20 | 2023-12-06 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies and methods of use |
| EP3988649B1 (en) | 2013-09-18 | 2024-11-27 | Kymab Limited | Methods, cells and organisms |
| CN103897033A (zh) * | 2014-03-31 | 2014-07-02 | 中国药科大学 | 转铁蛋白受体TfR特异性结合肽及其应用 |
| US10508151B2 (en) * | 2014-11-19 | 2019-12-17 | Genentech, Inc. | Anti-transferrin receptor antibodies and methods of use |
| CN107531788B (zh) * | 2015-06-24 | 2022-06-21 | 豪夫迈·罗氏有限公司 | 对her2和血脑屏障受体特异性的三特异性抗体及使用方法 |
| CA3053381A1 (en) * | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Engineered polypeptides |
-
2018
- 2018-02-15 WO PCT/US2018/018302 patent/WO2018152285A1/en not_active Ceased
- 2018-02-15 AU AU2018221704A patent/AU2018221704B2/en active Active
- 2018-02-15 KR KR1020197025801A patent/KR102637590B1/ko active Active
- 2018-02-15 EP EP18711190.1A patent/EP3583118B1/en active Active
- 2018-02-15 CA CA3053370A patent/CA3053370A1/en active Pending
- 2018-02-15 SG SG11201907419PA patent/SG11201907419PA/en unknown
- 2018-02-15 EP EP25180359.9A patent/EP4628586A3/en active Pending
- 2018-02-15 CN CN201880012330.9A patent/CN110382526B/zh active Active
- 2018-02-15 JP JP2019545322A patent/JP7669113B2/ja active Active
-
2019
- 2019-08-12 IL IL26865919A patent/IL268659A/en unknown
-
2023
- 2023-05-24 JP JP2023085382A patent/JP2023116513A/ja active Pending
-
2025
- 2025-03-07 JP JP2025036281A patent/JP2025087857A/ja active Pending
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