CN110382526B - 转铁蛋白受体转基因模型 - Google Patents

转铁蛋白受体转基因模型 Download PDF

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CN110382526B
CN110382526B CN201880012330.9A CN201880012330A CN110382526B CN 110382526 B CN110382526 B CN 110382526B CN 201880012330 A CN201880012330 A CN 201880012330A CN 110382526 B CN110382526 B CN 110382526B
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CN110382526A (zh
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马克·S·丹尼斯
亚当·P·西尔弗曼
乔伊·余·祖切罗
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Denali Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/10—Mammal
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    • C07K2319/00—Fusion polypeptide
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
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CN201880012330.9A 2017-02-17 2018-02-15 转铁蛋白受体转基因模型 Active CN110382526B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543658P 2017-08-10 2017-08-10
US201762543559P 2017-08-10 2017-08-10
US62/543,658 2017-08-10
US62/543,559 2017-08-10
US201762583314P 2017-11-08 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018302 WO2018152285A1 (en) 2017-02-17 2018-02-15 Transferrin receptor transgenic models

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CN110382526A CN110382526A (zh) 2019-10-25
CN110382526B true CN110382526B (zh) 2023-12-26

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JP (3) JP7669113B2 (https=)
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CN (1) CN110382526B (https=)
AU (1) AU2018221704B2 (https=)
CA (1) CA3053370A1 (https=)
IL (1) IL268659A (https=)
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EP4229192A1 (en) 2020-10-14 2023-08-23 Denali Therapeutics Inc. Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
CN112501124A (zh) * 2020-11-27 2021-03-16 领诺(上海)医药科技有限公司 稳定表达人转铁蛋白受体1细胞株的制备方法及其应用
JP2024525991A (ja) * 2021-07-16 2024-07-12 バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド ヒト又はキメラｔｆｒ１を有する遺伝子組換え非ヒト動物
JP2025503437A (ja) 2021-12-17 2025-02-04 デナリ セラピューティクス インコーポレイテッド ポリペプチド操作、ライブラリー、ならびに操作されたｃｄ９８重鎖及びトランスフェリン受容体結合ポリペプチド
AU2022415476A1 (en) 2021-12-17 2024-07-04 Denali Therapeutics Inc. Fusion proteins comprising alpha-l-iduronidase enzymes and methods
WO2023192288A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
IL317261A (en) * 2022-07-29 2025-01-01 Regeneron Pharma Non-human animals containing a modified transferrin receptor locus
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CN116784280B (zh) * 2023-08-10 2025-08-19 广东药康生物科技有限公司 一种tfrc人源化小鼠模型的构建方法及其应用
TW202542190A (zh) 2023-12-20 2025-11-01 美商戴納立製藥公司 包含酸性α—葡萄糖苷酶之融合蛋白及其方法
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JP2020510418A (ja) 2020-04-09
EP3583118C0 (en) 2025-06-11
JP2023116513A (ja) 2023-08-22
JP7669113B2 (ja) 2025-04-28
CN110382526A (zh) 2019-10-25
EP3583118A1 (en) 2019-12-25
KR20190135993A (ko) 2019-12-09
EP4628586A2 (en) 2025-10-08
KR102637590B1 (ko) 2024-02-15
IL268659A (en) 2019-10-31
WO2018152285A1 (en) 2018-08-23
SG11201907419PA (en) 2019-09-27
AU2018221704B2 (en) 2021-08-19
JP2025087857A (ja) 2025-06-10
AU2018221704A1 (en) 2019-09-19
EP3583118B1 (en) 2025-06-11
CA3053370A1 (en) 2018-08-23
EP4628586A3 (en) 2026-01-14

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