JP2016510998A5 - - Google Patents
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- JP2016510998A5 JP2016510998A5 JP2016501146A JP2016501146A JP2016510998A5 JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5 JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016501146 A JP2016501146 A JP 2016501146A JP 2016510998 A5 JP2016510998 A5 JP 2016510998A5
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- JP
- Japan
- Prior art keywords
- mouse
- polypeptide
- human
- item
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/793,812 US9591835B2 (en) | 2011-10-28 | 2013-03-11 | Genetically modified major histocompatibility complex animals |
| US13/793,812 | 2013-03-11 | ||
| PCT/US2014/023076 WO2014164640A1 (en) | 2013-03-11 | 2014-03-11 | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class i molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016510998A JP2016510998A (ja) | 2016-04-14 |
| JP2016510998A5 true JP2016510998A5 (https=) | 2017-04-13 |
| JP6456351B2 JP6456351B2 (ja) | 2019-01-23 |
Family
ID=50513441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501146A Active JP6456351B2 (ja) | 2013-03-11 | 2014-03-11 | キメラ主要組織適合複合体（ｍｈｃ）クラスｉ分子を発現する遺伝子導入マウス |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2967014B1 (https=) |
| JP (1) | JP6456351B2 (https=) |
| KR (1) | KR102313053B1 (https=) |
| CN (1) | CN105188358B (https=) |
| AU (2) | AU2014249150B2 (https=) |
| CA (1) | CA2902543A1 (https=) |
| ES (1) | ES2764829T3 (https=) |
| WO (1) | WO2014164640A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| CN111484999B (zh) | 2013-02-20 | 2024-10-25 | 瑞泽恩制药公司 | 人源化的t细胞共受体的小鼠 |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| CA2959821C (en) | 2014-10-24 | 2024-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of MHC class I positive cells and for overcoming resistance to anti-CD47 agents/SIRPA |
| WO2016065245A1 (en) | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
| EP4248744A3 (en) * | 2015-04-06 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| CN109456942A (zh) * | 2017-09-06 | 2019-03-12 | 亘喜生物科技（上海）有限公司 | 通用型嵌合抗原受体t细胞制备技术 |
| EP3978607B1 (en) * | 2019-05-27 | 2025-08-20 | Transgenic Inc. | Exon-humanized mouse |
| US10841728B1 (en) | 2019-10-10 | 2020-11-17 | Boomcloud 360, Inc. | Multi-channel crosstalk processing |
| IL294356A (en) * | 2020-01-10 | 2022-08-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Genetically modified non-human animal with human or chimeric mhc protein complex |
| CN118511853A (zh) | 2021-03-31 | 2024-08-20 | 瑞泽恩制药公司 | 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠 |
| EP4215042A1 (en) | 2022-01-21 | 2023-07-26 | Max-Delbrück-Centrum für Molekulare Medizin | A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489742A (en) * | 1990-10-23 | 1996-02-06 | Board Of Regents, The University Of Texas System | Transgenic rats and animal models of inflammatory disease |
| US20020151690A1 (en) * | 1997-08-12 | 2002-10-17 | Luxemburg Alain T | Purification of antigen-specific t cells |
| HUP0200958A3 (en) * | 1999-04-23 | 2004-11-29 | Pharmexa As | Method for down-regulating il5 activity |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2002047474A1 (en) * | 2000-12-13 | 2002-06-20 | Sumitomo Pharmaceuticals Company, Limited | Transgenic animal expressing hla-a24 and utilization thereof |
| FR2827302B1 (fr) * | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
| EP1470161A1 (en) * | 2002-01-18 | 2004-10-27 | Inovio AS | Bispecific antibody dna constructs for intramuscular administration |
| SE0301109D0 (sv) * | 2003-04-14 | 2003-04-14 | Mallen Huang | Nucleotide vaccine composition |
| US7663017B2 (en) * | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| EP1878342A1 (en) * | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses |
| SMT201900478T1 (it) * | 2011-10-28 | 2019-09-09 | Regeneron Pharma | Topi con complesso maggiore di istocompatibilita' geneticamente modificati |
-
2014
- 2014-03-11 CA CA2902543A patent/CA2902543A1/en active Pending
- 2014-03-11 ES ES14718226T patent/ES2764829T3/es active Active
- 2014-03-11 CN CN201480025263.6A patent/CN105188358B/zh active Active
- 2014-03-11 WO PCT/US2014/023076 patent/WO2014164640A1/en not_active Ceased
- 2014-03-11 AU AU2014249150A patent/AU2014249150B2/en active Active
- 2014-03-11 JP JP2016501146A patent/JP6456351B2/ja active Active
- 2014-03-11 EP EP14718226.5A patent/EP2967014B1/en active Active
- 2014-03-11 KR KR1020157028380A patent/KR102313053B1/ko active Active
-
2020
- 2020-07-01 AU AU2020204410A patent/AU2020204410C1/en active Active
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