JP2016506761A5 - - Google Patents
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- JP2016506761A5 JP2016506761A5 JP2015558224A JP2015558224A JP2016506761A5 JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5 JP 2015558224 A JP2015558224 A JP 2015558224A JP 2015558224 A JP2015558224 A JP 2015558224A JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mouse
- mhc
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766762P | 2013-02-20 | 2013-02-20 | |
| US61/766,762 | 2013-02-20 | ||
| US201361890915P | 2013-10-15 | 2013-10-15 | |
| US61/890,915 | 2013-10-15 | ||
| PCT/US2014/017395 WO2014130671A1 (en) | 2013-02-20 | 2014-02-20 | Mice expressing humanized t-cell co-receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Division JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506761A JP2016506761A (ja) | 2016-03-07 |
| JP2016506761A5 true JP2016506761A5 (https=) | 2017-03-23 |
| JP6444895B2 JP6444895B2 (ja) | 2018-12-26 |
Family
ID=50236327
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558224A Active JP6444895B2 (ja) | 2013-02-20 | 2014-02-20 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9848587B2 (https=) |
| EP (3) | EP2958938B1 (https=) |
| JP (5) | JP6444895B2 (https=) |
| KR (5) | KR102714111B1 (https=) |
| CN (2) | CN105164153B (https=) |
| AU (4) | AU2014218897C1 (https=) |
| CA (1) | CA2900832A1 (https=) |
| CY (1) | CY1121979T1 (https=) |
| DK (1) | DK2958938T3 (https=) |
| ES (2) | ES2987445T3 (https=) |
| HR (1) | HRP20191280T1 (https=) |
| HU (1) | HUE045478T2 (https=) |
| LT (1) | LT2958938T (https=) |
| PL (1) | PL2958938T3 (https=) |
| PT (1) | PT2958938T (https=) |
| RS (1) | RS58962B1 (https=) |
| SI (1) | SI2958938T1 (https=) |
| SM (1) | SMT201900429T1 (https=) |
| WO (1) | WO2014130671A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| DK3590332T3 (da) | 2011-10-28 | 2022-05-23 | Regeneron Pharma | Genmodificerede mus, der eksprimerer kimære major histokompatibilitetskompleks (MHC) II-molekyler |
| SI2770821T1 (en) | 2011-10-28 | 2018-01-31 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex of mice |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| KR102714111B1 (ko) * | 2013-02-20 | 2024-10-11 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| PL2958937T3 (pl) | 2013-02-22 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| CN105592695B (zh) | 2013-09-23 | 2018-04-10 | 瑞泽恩制药公司 | 具有人源化信号调节蛋白基因的非人动物 |
| CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| HUE051088T2 (hu) | 2014-04-08 | 2021-03-01 | Regeneron Pharma | Humanizált FC-gamma receptorokkal rendelkezõ nem humán élõlények |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| ES2783424T3 (es) | 2014-06-19 | 2020-09-17 | Regeneron Pharma | Animales no humanos que tienen un gen de muerte celular programada 1 humanizado |
| CA2959428A1 (en) | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| RU2020122439A (ru) | 2014-11-24 | 2020-09-24 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, экспрессирующие гуманизированный комплекс cd3 |
| SI3086637T1 (sl) | 2014-12-05 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Nehumane živali s humaniziranim označevalcem diferenciacije gena CD47 |
| HUE052606T2 (hu) * | 2014-12-09 | 2021-05-28 | Regeneron Pharma | Humanizált differenciációs klaszter 274 génnel rendelkezõ nem humán állatok |
| CN113349159B (zh) * | 2015-04-06 | 2022-11-11 | 瑞泽恩制药公司 | 非人动物中的人源化t细胞介导的免疫应答 |
| JP2018531593A (ja) * | 2015-09-11 | 2018-11-01 | アジェナス インコーポレイテッド | 操作された宿主細胞及びそれらの使用方法 |
| SG11201803409UA (en) | 2015-11-20 | 2018-05-30 | Regeneron Pharma | Non-human animals having a humanized lymphocyte-activation gene 3 |
| WO2017150763A1 (ko) * | 2016-02-29 | 2017-09-08 | (주)메디톡스 | 인간 cd3 발현 동물모델 및 이의 용도 |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
| IL310006A (en) | 2017-11-30 | 2024-03-01 | Regeneron Pharma | Non-human animals containing a humanized TRKB locus |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| MX2020011023A (es) * | 2018-04-19 | 2021-01-29 | Baylor College Medicine | Reprogramación de células t cd4 en células cd8 citotóxicas por expresión forzada de cd8ab y receptores de células t restringidos de clase 1. |
| IL278267B2 (en) | 2018-07-16 | 2025-02-01 | Regeneron Pharma | Non-human animal models of DITRA disease and their uses |
| US12234473B2 (en) | 2020-12-31 | 2025-02-25 | Immatics US, Inc. | CD8 polypeptides, compositions, and methods of using thereof |
| AU2022249328A1 (en) | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| IL319406A (en) | 2022-09-22 | 2025-05-01 | Regeneron Pharma | Genetically modified mice expressing components of the human cellular immune system |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| GB2640828A (en) | 2024-04-22 | 2025-11-12 | T Therapeutics Ltd | Methods and products for the generation and identification of T cells and TCRs |
| GB2642411A (en) | 2024-04-22 | 2026-01-14 | T Therapeutics Ltd | T Cell Receptor identification and provision |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5958678A (en) * | 1986-08-21 | 1999-09-28 | The Trustees Of Columbia University In The City Of New York | DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
| US5574205A (en) | 1989-07-25 | 1996-11-12 | Cell Genesys | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| AU633958B2 (en) | 1989-07-25 | 1993-02-11 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| GB9100481D0 (en) | 1991-01-10 | 1991-02-20 | Inst Nat Sante Rech Med | Genetically engineered mice |
| AU2661692A (en) | 1991-09-19 | 1993-04-27 | President And Fellows Of Harvard College | Transgenic mhc class i and class ii antigen-deficient mammals |
| EP0663952A4 (en) | 1992-09-11 | 1997-06-11 | Univ California | Transgenic non-human animals having targeted lymphocyte transduction genes. |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| GB9315303D0 (en) | 1993-07-23 | 1993-09-08 | Zeneca Ltd | Polypeptide |
| US5965787A (en) | 1995-08-31 | 1999-10-12 | Mayo Foundation For Medical Education And Research | HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis |
| US6002066A (en) | 1996-01-16 | 1999-12-14 | Ortho Pharmaceutical Corp. | H2-M modified transgenic mice |
| EP0910409A4 (en) | 1996-03-05 | 2003-03-19 | Scripps Research Inst | RECOMBINANT GENE CONSTRUCTS ENCODING T-CELL RECEPTORS SPECIFIC TO HUMAN-RESTRICTED TUMORANTANTIGENS |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| DK1017721T3 (da) | 1997-09-16 | 2009-04-20 | Univ Oregon Health & Science | Rekombinante MHC molekyler, der kan anvendes til manipulation af antigenspecifikke T-celler |
| US6372955B1 (en) | 1998-02-17 | 2002-04-16 | Ortho Mcneil Pharmaceutical, Inc. | Methods for Producing B cells and antibodies from H2-O modified transgenic mice |
| WO2001027291A1 (en) | 1999-10-12 | 2001-04-19 | Institut Pasteur | Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050050580A1 (en) | 2000-12-13 | 2005-03-03 | Masashi Gotoh | Transgenic animal expressing hla-a24 and utilization thereof |
| EP1409646B1 (en) | 2000-12-19 | 2012-06-13 | Altor BioScience Corporation | Transgenic animals comprising a humanized immune system |
| ATE438710T1 (de) | 2001-05-15 | 2009-08-15 | Ortho Mcneil Janssen Pharm | Ex-vivo-priming zur erzeugung cd40-ligand spezifischer zytotoxischer t-lymphozyten zur behandlung von autoimmun- und allergischen erkrankungen |
| FR2827302B1 (fr) * | 2001-07-13 | 2003-10-10 | Genoway | Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations |
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| US7663017B2 (en) | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
| WO2005085438A1 (ja) | 2004-03-09 | 2005-09-15 | Nagoya Industrial Science Research Institute | ヒト関節リウマチの病態を再現するトランスジェニック非ヒト哺乳動物 |
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| EP2262898B1 (en) | 2008-03-07 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Es cell-derived mice from diploid host embryo injection |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| US20090328240A1 (en) | 2008-06-24 | 2009-12-31 | Sing George L | Genetically modified mice as predictors of immune response |
| EP2346994B1 (en) | 2008-09-30 | 2022-02-16 | Ablexis, LLC | Knock-in mice for the production of chimeric antibodies |
| US9277999B2 (en) * | 2009-02-27 | 2016-03-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Joint bioscaffolds |
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| GB2472108B (en) * | 2009-08-27 | 2011-07-13 | Budha Singh Dhinjan | Wall bead |
| SI2501817T2 (sl) * | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US9185889B2 (en) | 2010-02-15 | 2015-11-17 | Indiana University Research And Technology Corporation | CD4 T-cells and CD8zeta cells involved in mammalian host response to epithelial cell infections and uses thereof |
| SG183867A1 (en) * | 2010-03-11 | 2012-10-30 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| WO2012039779A1 (en) | 2010-09-24 | 2012-03-29 | The United States Of America As Represented By The Secretary Of The Navy | Humanized transgenic mouse model |
| DK3590332T3 (da) | 2011-10-28 | 2022-05-23 | Regeneron Pharma | Genmodificerede mus, der eksprimerer kimære major histokompatibilitetskompleks (MHC) II-molekyler |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| WO2013063556A1 (en) | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SI2770821T1 (en) | 2011-10-28 | 2018-01-31 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex of mice |
| CA2887706C (en) | 2012-11-05 | 2022-08-02 | Regeneron Pharmaceuticals | Genetically modified non-human animals and methods of use thereof |
| KR102714111B1 (ko) * | 2013-02-20 | 2024-10-11 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| PL2958937T3 (pl) | 2013-02-22 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej |
| JP6456351B2 (ja) | 2013-03-11 | 2019-01-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ主要組織適合複合体（ｍｈｃ）クラスｉ分子を発現する遺伝子導入マウス |
| CA3249218A1 (en) | 2013-03-11 | 2026-03-02 | Regeneron Pharmaceuticals, Inc. | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
| CN113349159B (zh) | 2015-04-06 | 2022-11-11 | 瑞泽恩制药公司 | 非人动物中的人源化t细胞介导的免疫应答 |
| JP7172900B2 (ja) * | 2019-07-26 | 2022-11-16 | 株式会社デンソー | 走行中給電システム |
-
2014
- 2014-02-20 KR KR1020237031201A patent/KR102714111B1/ko active Active
- 2014-02-20 WO PCT/US2014/017395 patent/WO2014130671A1/en not_active Ceased
- 2014-02-20 EP EP14708430.5A patent/EP2958938B1/en active Active
- 2014-02-20 HR HRP20191280TT patent/HRP20191280T1/hr unknown
- 2014-02-20 RS RS20190870A patent/RS58962B1/sr unknown
- 2014-02-20 ES ES19159217T patent/ES2987445T3/es active Active
- 2014-02-20 CN CN201480021698.3A patent/CN105164153B/zh active Active
- 2014-02-20 SI SI201431279T patent/SI2958938T1/sl unknown
- 2014-02-20 KR KR1020227006387A patent/KR102579405B1/ko active Active
- 2014-02-20 KR KR1020247032785A patent/KR20240147707A/ko active Pending
- 2014-02-20 PL PL14708430T patent/PL2958938T3/pl unknown
- 2014-02-20 AU AU2014218897A patent/AU2014218897C1/en active Active
- 2014-02-20 JP JP2015558224A patent/JP6444895B2/ja active Active
- 2014-02-20 PT PT14708430T patent/PT2958938T/pt unknown
- 2014-02-20 DK DK14708430.5T patent/DK2958938T3/da active
- 2014-02-20 CA CA2900832A patent/CA2900832A1/en active Pending
- 2014-02-20 HU HUE14708430A patent/HUE045478T2/hu unknown
- 2014-02-20 LT LTEP14708430.5T patent/LT2958938T/lt unknown
- 2014-02-20 CN CN202010208901.5A patent/CN111484999B/zh active Active
- 2014-02-20 US US14/185,301 patent/US9848587B2/en active Active
- 2014-02-20 EP EP19159217.9A patent/EP3543253B1/en active Active
- 2014-02-20 KR KR1020217032326A patent/KR102369454B1/ko active Active
- 2014-02-20 EP EP24155637.2A patent/EP4374690A3/en active Pending
- 2014-02-20 ES ES14708430T patent/ES2736052T3/es active Active
- 2014-02-20 SM SM20190429T patent/SMT201900429T1/it unknown
- 2014-02-20 KR KR1020157025675A patent/KR102313047B1/ko active Active
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2017
- 2017-10-06 US US15/727,057 patent/US10820581B2/en active Active
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2018
- 2018-05-25 JP JP2018100545A patent/JP6752842B2/ja active Active
- 2018-11-30 AU AU2018271383A patent/AU2018271383B2/en active Active
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2019
- 2019-07-12 CY CY20191100749T patent/CY1121979T1/el unknown
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2020
- 2020-08-19 JP JP2020138641A patent/JP7261772B2/ja active Active
- 2020-09-24 US US17/031,255 patent/US12063915B2/en active Active
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2021
- 2021-12-22 AU AU2021290271A patent/AU2021290271B2/en active Active
-
2022
- 2022-06-13 JP JP2022094953A patent/JP2022121465A/ja active Pending
-
2023
- 2023-11-08 JP JP2023191033A patent/JP2023184695A/ja active Pending
-
2024
- 2024-07-09 US US18/766,891 patent/US20250000070A1/en active Pending
-
2025
- 2025-01-10 AU AU2025200206A patent/AU2025200206A1/en active Pending
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