JP2018513683A5 - - Google Patents
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- JP2018513683A5 JP2018513683A5 JP2017552483A JP2017552483A JP2018513683A5 JP 2018513683 A5 JP2018513683 A5 JP 2018513683A5 JP 2017552483 A JP2017552483 A JP 2017552483A JP 2017552483 A JP2017552483 A JP 2017552483A JP 2018513683 A5 JP2018513683 A5 JP 2018513683A5
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- JP
- Japan
- Prior art keywords
- human
- polypeptide
- endogenous
- mhc
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 225
- 229920001184 polypeptide Polymers 0.000 claims description 221
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 221
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 91
- 108091008874 T cell receptors Proteins 0.000 claims description 89
- 239000002773 nucleotide Substances 0.000 claims description 84
- 125000003729 nucleotide group Chemical group 0.000 claims description 84
- 150000007523 nucleic acids Chemical group 0.000 claims description 80
- 230000001086 cytosolic effect Effects 0.000 claims description 57
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 55
- 108090000623 proteins and genes Proteins 0.000 claims description 54
- 210000004027 cell Anatomy 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 40
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 39
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims description 29
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 28
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 27
- 230000001105 regulatory effect Effects 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 23
- 108091007433 antigens Proteins 0.000 claims description 23
- 102000036639 antigens Human genes 0.000 claims description 23
- 108020004707 nucleic acids Proteins 0.000 claims description 21
- 102000039446 nucleic acids Human genes 0.000 claims description 21
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 12
- 239000013604 expression vector Substances 0.000 claims description 12
- 102000047279 human B2M Human genes 0.000 claims description 9
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 8
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 8
- 230000006801 homologous recombination Effects 0.000 claims description 8
- 238000002744 homologous recombination Methods 0.000 claims description 8
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108091026890 Coding region Proteins 0.000 claims description 4
- 101000986086 Homo sapiens HLA class I histocompatibility antigen, A alpha chain Proteins 0.000 claims description 4
- GTJASUYQSYEAFD-NPRBSQQLSA-N 102643-50-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)[C@@H](C)O)C1=CC=CC=C1 GTJASUYQSYEAFD-NPRBSQQLSA-N 0.000 claims description 3
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 3
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 3
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 241000283984 Rodentia Species 0.000 claims description 3
- 108010050138 synthetic joining segment peptide Proteins 0.000 claims description 3
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 2
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 2
- 101000986087 Homo sapiens HLA class I histocompatibility antigen, B alpha chain Proteins 0.000 claims description 2
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000004602 germ cell Anatomy 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 14
- 230000003796 beauty Effects 0.000 claims 5
- 108700005092 MHC Class II Genes Proteins 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 102000043131 MHC class II family Human genes 0.000 claims 2
- 108091054438 MHC class II family Proteins 0.000 claims 2
- 101100096028 Mus musculus Smok1 gene Proteins 0.000 claims 2
- 108700031361 Brachyury Proteins 0.000 claims 1
- 108010051539 HLA-DR2 Antigen Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000003918 fraction a Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 description 4
- 101100263837 Bovine ephemeral fever virus (strain BB7721) beta gene Proteins 0.000 description 2
- 101100316840 Enterobacteria phage P4 Beta gene Proteins 0.000 description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 2
- 108010075704 HLA-A Antigens Proteins 0.000 description 2
- 108010053491 HLA-DR beta-Chains Proteins 0.000 description 2
- 101150087698 alpha gene Proteins 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 108010086786 HLA-DQA1 antigen Proteins 0.000 description 1
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 102000048974 human HLA-B Human genes 0.000 description 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 108700043516 mouse H-2Kb Proteins 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143687P | 2015-04-06 | 2015-04-06 | |
| US62/143,687 | 2015-04-06 | ||
| US201562158804P | 2015-05-08 | 2015-05-08 | |
| US62/158,804 | 2015-05-08 | ||
| US201562186935P | 2015-06-30 | 2015-06-30 | |
| US62/186,935 | 2015-06-30 | ||
| PCT/US2016/026260 WO2016164492A2 (en) | 2015-04-06 | 2016-04-06 | Humanized t cell mediated immune responses in non-human animals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020085069A Division JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513683A JP2018513683A (ja) | 2018-05-31 |
| JP2018513683A5 true JP2018513683A5 (https=) | 2019-05-23 |
| JP6796597B2 JP6796597B2 (ja) | 2020-12-09 |
Family
ID=56926255
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552483A Active JP6796597B2 (ja) | 2015-04-06 | 2016-04-06 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2020085069A Withdrawn JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2022122754A Withdrawn JP2022140609A (ja) | 2015-04-06 | 2022-08-01 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2023179453A Active JP7763820B2 (ja) | 2015-04-06 | 2023-10-18 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2024114035A Active JP7555515B1 (ja) | 2015-04-06 | 2024-07-17 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2025177694A Pending JP2026009189A (ja) | 2015-04-06 | 2025-10-22 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020085069A Withdrawn JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2022122754A Withdrawn JP2022140609A (ja) | 2015-04-06 | 2022-08-01 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2023179453A Active JP7763820B2 (ja) | 2015-04-06 | 2023-10-18 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2024114035A Active JP7555515B1 (ja) | 2015-04-06 | 2024-07-17 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2025177694A Pending JP2026009189A (ja) | 2015-04-06 | 2025-10-22 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US11259510B2 (https=) |
| EP (2) | EP4248744A3 (https=) |
| JP (6) | JP6796597B2 (https=) |
| KR (2) | KR102699643B1 (https=) |
| CN (2) | CN113349159B (https=) |
| AU (3) | AU2016246698B2 (https=) |
| CA (2) | CA3223798A1 (https=) |
| DK (1) | DK3280257T3 (https=) |
| ES (1) | ES2954865T3 (https=) |
| FI (1) | FI3280257T3 (https=) |
| HR (1) | HRP20231039T1 (https=) |
| HU (1) | HUE064168T2 (https=) |
| IL (4) | IL318990A (https=) |
| LT (1) | LT3280257T (https=) |
| MX (2) | MX2017012829A (https=) |
| NZ (1) | NZ736031A (https=) |
| PL (1) | PL3280257T3 (https=) |
| PT (1) | PT3280257T (https=) |
| RS (1) | RS64540B1 (https=) |
| RU (1) | RU2732628C2 (https=) |
| SG (2) | SG11201707691WA (https=) |
| SI (1) | SI3280257T1 (https=) |
| SM (1) | SMT202300408T1 (https=) |
| WO (1) | WO2016164492A2 (https=) |
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| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| DK3590332T3 (da) | 2011-10-28 | 2022-05-23 | Regeneron Pharma | Genmodificerede mus, der eksprimerer kimære major histokompatibilitetskompleks (MHC) II-molekyler |
| SI2770821T1 (en) | 2011-10-28 | 2018-01-31 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex of mice |
| LT3424947T (lt) | 2011-10-28 | 2021-03-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos t ląstelių receptorių pelės |
| KR102714111B1 (ko) | 2013-02-20 | 2024-10-11 | 리제너론 파아마슈티컬스, 인크. | 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스 |
| PL2958937T3 (pl) | 2013-02-22 | 2019-01-31 | Regeneron Pharmaceuticals, Inc. | Myszy ekspresjonujące humanizowany główny układ zgodności tkankowej |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| SG11201803409UA (en) | 2015-11-20 | 2018-05-30 | Regeneron Pharma | Non-human animals having a humanized lymphocyte-activation gene 3 |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| HUE061619T2 (hu) | 2016-06-03 | 2023-07-28 | Regeneron Pharma | Exogén terminális dezoxinukleotid-transzferázt expresszáló rágcsálók |
| MX394999B (es) | 2017-09-29 | 2025-03-24 | Regeneron Pharma | Animales no humanos que comprenden un locus ttr humanizado y metodos de uso |
| KR20200075851A (ko) * | 2017-10-19 | 2020-06-26 | 셀렉티스 | 개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합 |
| IL310006A (en) | 2017-11-30 | 2024-03-01 | Regeneron Pharma | Non-human animals containing a humanized TRKB locus |
| EP3940382B1 (en) | 2018-03-24 | 2024-07-03 | Regeneron Pharmaceuticals, Inc. | Methods for identifying hla-associated tumor peptides |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| IL278267B2 (en) | 2018-07-16 | 2025-02-01 | Regeneron Pharma | Non-human animal models of DITRA disease and their uses |
| KR102933479B1 (ko) | 2018-10-23 | 2026-03-04 | 리제너론 파아마슈티컬스, 인크. | Ny-eso-1 t 세포 수용체 및 이의 사용 방법 |
| WO2020092736A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US12264189B2 (en) | 2018-10-31 | 2025-04-01 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| ES2966625T3 (es) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Roedores que comprenden un locus del factor de coagulación 12 humanizado |
| EP3962938A4 (en) * | 2019-05-01 | 2023-07-05 | PACT Pharma, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING CD8 MODIFIED T LYMPHOCYTE CELL THERAPY |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| US11622547B2 (en) | 2019-06-07 | 2023-04-11 | Regeneran Pharmaceuticals, Inc. | Genetically modified mouse that expresses human albumin |
| CN114616467B (zh) * | 2019-10-03 | 2026-04-07 | 瑞泽恩制药公司 | 筛选原代人类细胞中的同源t细胞和表位反应性的高通量方法 |
| IL294988A (en) | 2020-01-24 | 2022-09-01 | Regeneron Pharma | Antigen preferentially expressed in melanoma t-cell receptors (prame) and methods of using them |
| AU2022249328A1 (en) * | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| WO2023092119A2 (en) | 2021-11-22 | 2023-05-25 | Ludwig Institute For Cancer Research Ltd | Methods for predicting responsiveness to a cancer therapy |
| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
| CN115074368B (zh) * | 2022-06-09 | 2023-08-08 | 澳门科技大学 | 一种耐药型类风湿性关节炎动物模型的构建及其应用 |
| IL319406A (en) | 2022-09-22 | 2025-05-01 | Regeneron Pharma | Genetically modified mice expressing components of the human cellular immune system |
| KR20250089551A (ko) | 2022-10-31 | 2025-06-18 | 리제너론 파마슈티칼스 인코포레이티드 | 입양 세포 요법과 표적 면역사이토카인을 조합하여 이용한 암 치료 방법 |
| WO2024112806A1 (en) * | 2022-11-21 | 2024-05-30 | Moonwalk Biosciences, Inc. | Generation and use of epigenetic maps for drug discovery |
| KR20250169609A (ko) | 2023-04-07 | 2025-12-03 | 리제너론 파마슈티칼스 인코포레이티드 | 림포톡신 β 수용체 작용제를 이용한 암 치료 방법 |
| CN121335919A (zh) | 2023-05-25 | 2026-01-13 | 瑞泽恩制药公司 | 结合呈递的hpv16、mart1、cmv、ebv或流感肽的t细胞受体 |
| TW202520975A (zh) * | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
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| WO2026006734A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Off-target peptide-mhc complex conformation modeling systems and methods for antigen-recognition molecule development |
| WO2026006724A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Prame off-target peptides and uses thereof |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
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